Xuesi Max Shao, MD
Title Associate Professor
Institution Charles R. Drew University of Medicine and Science
Department Internal Medicine
School College of Medicine
Address 1731 E. 120th Street


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Education & Training
Teaching
NIH Awarded Grants
Publications
1. Shao XM, Friedman TC. Last Word on Viewpoint: pH Buffer capacity and pharmacokinetics: two remaining questions. J Appl Physiol (1985). 2020 Apr 01; 128(4):1063-1064.
  View in: PubMed
 
2. Shao XM, Fang ZT. Severe Acute Toxicity of Inhaled Nicotine and e-Cigarettes: Seizures and Cardiac Arrhythmia. Chest. 2020 Mar; 157(3):506-508.
  View in: PubMed
 
3. Zhang P, Li Y, Fu Y, Huang L, Liu B, Zhang L, Shao XM, Xiao D. Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. Int J Biol Sci. 2020; 16(8):1349-1362.
  View in: PubMed
 
4. Shao XM, Friedman TC. Pod-mod vs. conventional e-cigarettes: nicotine chemistry, pH, and health effects. J Appl Physiol (1985). 2020 Apr 01; 128(4):1056-1058.
  View in: PubMed
 
5. Sun X, Thörn Pérez C, Halemani D N, Shao XM, Greenwood M, Heath S, Feldman JL, Kam K. Opioids modulate an emergent rhythmogenic process to depress breathing. Elife. 2019 12 16; 8.
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6. Kao L, Azimov R, Shao XM, Abuladze N, Newman D, Zhekova H, Noskov S, Pushkin A, Kurtz I. SLC4A11 function: evidence for H+(OH-) and NH3-H+ transport. Am J Physiol Cell Physiol. 2020 02 01; 318(2):C392-C405.
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7. Shao XM, Lopez B, Nathan D, Wilson J, Bankole E, Tumoyan H, Munoz A, Espinoza-Derout J, Hasan KM, Chang S, Du C, Sinha-Hikim AP, Lutfy K, Friedman TC. A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 Oct 01; 326:108376.
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8. Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL, Sinha S, Simmons Z, Mtume N, Liu Y, Roos KP, Sinha-Hikim AP, Friedman TC. Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H445-H459.
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9. Espinoza-Derout J, Shao XM, Bankole E, Hasan KM, Mtume N, Liu Y, Sinha-Hikim AP, Friedman TC. Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis. Front Endocrinol (Lausanne). 2019; 10:320.
  View in: PubMed
 
10. Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 06; 69(6):2442-2454.
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11. Shao XM, Liu S, Lee ES, Fung D, Pei H, Liang J, Mudgway R, Zhang J, Feldman JL, Zhu Y, Louie S, Xie XS. Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers. J Appl Physiol (1985). 2018 11 01; 125(5):1555-1562.
  View in: PubMed
 
12. Liu Z, Lindemeyer AK, Liang J, Wallner M, Shao XM, Shao Y, Tao Y, Olsen RW. Flavonoids isolated from Tibetan medicines, binding to GABAA receptor and the anticonvulsant activity. Phytomedicine. 2018 Nov 15; 50:1-7.
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13. Shao XM. High altitude exposure during pregnancy enhances the vulnerability of fetal heart dysfunction to ischemic stress: Epigenetic mechanisms. Int J Cardiol. 2019 01 01; 274:59-60.
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14. Huynh KW, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, Newman D, Azimov R, Pushkin A, Zhou ZH, Kurtz I. CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1. Nat Commun. 2018 03 02; 9(1):900.
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15. Shao XM, López-Valdés HE, Liang J, Feldman JL. Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats. Sci Rep. 2017 12 05; 7(1):16974.
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16. Lindemeyer AK, Shen Y, Yazdani F, Shao XM, Spigelman I, Davies DL, Olsen RW, Liang J. a2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus. Mol Pharmacol. 2017 08; 92(2):101-112.
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17. Kao L, Azimov R, Shao XM, Frausto RF, Abuladze N, Newman D, Aldave AJ, Kurtz I. Multifunctional ion transport properties of human SLC4A11: comparison of the SLC4A11-B and SLC4A11-C variants. Am J Physiol Cell Physiol. 2016 Nov 01; 311(5):C820-C830.
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18. Shao XM, Kao L, Kurtz I. A novel delta current method for transport stoichiometry estimation. BMC Biophys. 2014; 7(1):14.
  View in: PubMed
 
19. Liang J, López-Valdés HE, Martínez-Coria H, Lindemeyer AK, Shen Y, Shao XM, Olsen RW. Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer's disease. Neurochem Res. 2014 Jun; 39(6):1171-81.
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20. Liang J, Lindemeyer AK, Suryanarayanan A, Meyer EM, Marty VN, Ahmad SO, Shao XM, Olsen RW, Spigelman I. Plasticity of GABA(A) receptor-mediated neurotransmission in the nucleus accumbens of alcohol-dependent rats. J Neurophysiol. 2014 Jul 01; 112(1):39-50.
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21. Liang J, Shen Y, Shao XM, Scott MB, Ly E, Wong S, Nguyen A, Tan K, Kwon B, Olsen RW, Spigelman I. Dihydromyricetin prevents fetal alcohol exposure-induced behavioral and physiological deficits: the roles of GABAA receptors in adolescence. Neurochem Res. 2014 Jun; 39(6):1147-61.
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22. Zhu Q, Shao XM, Kao L, Azimov R, Weinstein AM, Newman D, Liu W, Kurtz I. Missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis. Am J Physiol Cell Physiol. 2013 Aug 15; 305(4):C392-405.
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23. Shao XM, Xu B, Liang J, Xie XS, Zhu Y, Feldman JL. Nicotine delivery to rats via lung alveolar region-targeted aerosol technology produces blood pharmacokinetics resembling human smoking. Nicotine Tob Res. 2013 Jul; 15(7):1248-58.
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24. Kao L, Abuladze N, Shao XM, McKeegan K, Kurtz I. A new technique for multiple re-use of planar patch clamp chips. J Neurosci Methods. 2012 Jul 15; 208(2):205-10.
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25. Tan W, Sherman D, Turesson J, Shao XM, Janczewski WA, Feldman JL. Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat. J Comp Neurol. 2012 Feb 15; 520(3):606-19.
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26. Shen Y, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012 Jan 04; 32(1):390-401.
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27. Kao L, Kurtz LM, Shao X, Papadopoulos MC, Liu L, Bok D, Nusinowitz S, Chen B, Stella SL, Andre M, Weinreb J, Luong SS, Piri N, Kwong JM, Newman D, Kurtz I. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011 Sep 16; 286(37):32563-74.
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28. Shao XM, Feldman JL. Central cholinergic regulation of respiration: nicotinic receptors. Acta Pharmacol Sin. 2009 Jun; 30(6):761-70.
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29. Xiao C, Shao XM, Olive MF, Griffin WC, Li KY, Krnjevic K, Zhou C, Ye JH. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology. 2009 Jan; 34(2):307-18.
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30. Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL. Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci. 2008 May; 11(5):538-40.
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31. Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL. Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. J Neurosci. 2008 Jan 09; 28(2):519-28.
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32. Shao XM, Feldman JL. Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC. J Neurosci Methods. 2007 Mar 15; 160(2):256-63.
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33. Shao XM, Feldman JL. Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials. J Neurosci Methods. 2007 Jan 15; 159(1):108-15.
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34. Feng JM, Hu YK, Xie LH, Colwell CS, Shao XM, Sun XP, Chen B, Tang H, Campagnoni AT. Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity. 2006 Jun; 24(6):717-27.
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35. Shao XM, Ge Q, Feldman JL. Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat. J Physiol. 2003 Mar 01; 547(Pt 2):543-53.
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36. Shao XM, Feldman JL. Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern. J Neurophysiol. 2002 Oct; 88(4):1851-8.
  View in: PubMed
 
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Nicotine


  • Receptors, Nicotinic


  • Respiratory Center


  • Animals


  • Respiration


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Keyword
Last Name
Institution
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Keywords   
Nicotine
Receptors, Nicotinic
Respiratory Center
Animals
Respiration
See all (246) keywords
Co-Authors  
Espinoza-Derout, Jorge
Friedman, Theodore
Hasan, Kamrul
Sinha-Hikim, Amiya
Sinha-Hikim, Indrani
See all (6) people
Physical Neighbors  
Red eagle, Alexander
Lu, Julie
Lee, Martin
Kim, Melvie
Liu, Yan-Jun


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