Thomas R. Magee, PhD
Title Associate Professor
Institution Charles R. Drew University of Medicine and Science
Department Health & Life Sciences
School College of Science and Health
Address 1731 E. 120th Street, Building E


Telephone (323) 357-3455
Fax
Email
Education & Training
Teaching
NIH Awarded Grants
Publications
1. Magee T. Imaging of the post-operative shoulder: does injection of iodinated contrast in addition to MR contrast during arthrography improve diagnostic accuracy and patient throughput? Skeletal Radiol. 2018 Sep; 47(9):1253-1261.
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2. Huard K, Ahn K, Amor P, Beebe DA, Borzilleri KA, Chrunyk BA, Coffey SB, Cong Y, Conn EL, Culp JS, Dowling MS, Gorgoglione MF, Gutierrez JA, Knafels JD, Lachapelle EA, Pandit J, Parris KD, Perez S, Pfefferkorn JA, Price DA, Raymer B, Ross TT, Shavnya A, Smith AC, Subashi TA, Tesz GJ, Thuma BA, Tu M, Weaver JD, Weng Y, Withka JM, Xing G, Magee TV. Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). J Med Chem. 2017 09 28; 60(18):7835-7849.
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3. Ahn K, Boehm M, Brown MF, Calloway J, Che Y, Chen J, Fennell KF, Geoghegan KF, Gilbert AM, Gutierrez JA, Kalgutkar AS, Lanba A, Limberakis C, Magee TV, O'Doherty I, Oliver R, Pabst B, Pandit J, Parris K, Pfefferkorn JA, Rolph TP, Patel R, Schuff B, Shanmugasundaram V, Starr JT, Varghese AH, Vera NB, Vernochet C, Yan J. Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. ACS Chem Biol. 2016 09 16; 11(9):2529-40.
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4. Magee T. Utility of pre- and post-MR arthrogram imaging of the shoulder: effect on patient care. Br J Radiol. 2016 Jun; 89(1062):20160028.
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5. Huard K, Gosset JR, Montgomery JI, Gilbert A, Hayward MM, Magee TV, Cabral S, Uccello DP, Bahnck K, Brown J, Purkal J, Gorgoglione M, Lanba A, Futatsugi K, Herr M, Genung NE, Aspnes G, Polivkova J, Garcia-Irizarry CN, Li Q, Canterbury D, Niosi M, Vera NB, Li Z, Khunte B, Siderewicz J, Rolph T, Erion DM. Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem. 2016 Feb 11; 59(3):1165-75.
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6. Huard K, Brown J, Jones JC, Cabral S, Futatsugi K, Gorgoglione M, Lanba A, Vera NB, Zhu Y, Yan Q, Zhou Y, Vernochet C, Riccardi K, Wolford A, Pirman D, Niosi M, Aspnes G, Herr M, Genung NE, Magee TV, Uccello DP, Loria P, Di L, Gosset JR, Hepworth D, Rolph T, Pfefferkorn JA, Erion DM. Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5). Sci Rep. 2015 Dec 01; 5:17391.
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7. Magee T. Usefulness of Unenhanced MRI and MR Arthrography of the Shoulder in Detection of Unstable Labral Tears. AJR Am J Roentgenol. 2015 Nov; 205(5):1056-60.
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8. Huard K, Londregan AT, Tesz G, Bahnck KB, Magee TV, Hepworth D, Polivkova J, Coffey SB, Pabst BA, Gosset JR, Nigam A, Kou K, Sun H, Lee K, Herr M, Boehm M, Carpino PA, Goodwin B, Perreault C, Li Q, Jorgensen CC, Tkalcevic GT, Subashi TA, Ahn K. Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3. J Med Chem. 2015 Sep 24; 58(18):7164-72.
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9. Magee TV. Progress in discovery of small-molecule modulators of protein-protein interactions via fragment screening. Bioorg Med Chem Lett. 2015 Jun 15; 25(12):2461-8.
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10. Magee T. Accuracy of 3-T MR arthrography versus conventional 3-T MRI of elbow tendons and ligaments compared with surgery. AJR Am J Roentgenol. 2015 Jan; 204(1):W70-5.
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11. Magee T. Accuracy of 3-Tesla MR and MR arthrography in diagnosis of meniscal retear in the post-operative knee. Skeletal Radiol. 2014 Aug; 43(8):1057-64.
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12. Magee TR, Ross MG, Wedekind L, Desai M, Kjos S, Belkacemi L. Gestational diabetes mellitus alters apoptotic and inflammatory gene expression of trophobasts from human term placenta. J Diabetes Complications. 2014 Jul-Aug; 28(4):448-59.
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13. Magee T. MR versus MR arthrography in detection of supraspinatus tendon tears in patients without previous shoulder surgery. Skeletal Radiol. 2014 Jan; 43(1):43-8.
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14. Magee T. Prevalence of HAGL lesions and associated abnormalities on shoulder MR examination. Skeletal Radiol. 2014 Mar; 43(3):307-13.
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15. Burt D, Crowell SJ, Ackley DC, Magee TV, Aubrecht J. Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics. Drug Chem Toxicol. 2014 Apr; 37(2):204-12.
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16. Magee TV, Brown MF, Starr JT, Ackley DC, Abramite JA, Aubrecht J, Butler A, Crandon JL, Dib-Hajj F, Flanagan ME, Granskog K, Hardink JR, Huband MD, Irvine R, Kuhn M, Leach KL, Li B, Lin J, Luke DR, MacVane SH, Miller AA, McCurdy S, McKim JM, Nicolau DP, Nguyen TT, Noe MC, O'Donnell JP, Seibel SB, Shen Y, Stepan AF, Tomaras AP, Wilga PC, Zhang L, Xu J, Chen JM. Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections. J Med Chem. 2013 Jun 27; 56(12):5079-93.
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17. Magee TV, Han S, McCurdy SP, Nguyen TT, Granskog K, Marr ES, Maguire BA, Huband MD, Chen JM, Subashi TA, Shanmugasundaram V. Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. Bioorg Med Chem Lett. 2013 Mar 15; 23(6):1727-31.
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18. Wolfe D, Gong M, Han G, Magee TR, Ross MG, Desai M. Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring. Am J Obstet Gynecol. 2012 Oct; 207(4):308.e1-6.
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19. Lau WF, Withka JM, Hepworth D, Magee TV, Du YJ, Bakken GA, Miller MD, Hendsch ZS, Thanabal V, Kolodziej SA, Xing L, Hu Q, Narasimhan LS, Love R, Charlton ME, Hughes S, van Hoorn WP, Mills JE. Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics. J Comput Aided Mol Des. 2011 Jul; 25(7):621-36.
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20. Khorram NM, Magee TR, Wang C, Desai M, Ross M, Khorram O. Maternal undernutrition programs offspring adrenal expression of steroidogenic enzymes. Reprod Sci. 2011 Oct; 18(10):931-40.
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21. Magee TR, Tafti SA, Desai M, Liu Q, Ross MG, Nast CC. Maternal undernourished fetal kidneys exhibit differential regulation of nephrogenic genes including downregulation of the Notch signaling pathway. Reprod Sci. 2011 Jun; 18(6):563-76.
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22. Magee TV, Ripp SL, Li B, Buzon RA, Chupak L, Dougherty TJ, Finegan SM, Girard D, Hagen AE, Falcone MJ, Farley KA, Granskog K, Hardink JR, Huband MD, Kamicker BJ, Kaneko T, Knickerbocker MJ, Liras JL, Marra A, Medina I, Nguyen TT, Noe MC, Obach RS, O'Donnell JP, Penzien JB, Reilly UD, Schafer JR, Shen Y, Stone GG, Strelevitz TJ, Sun J, Tait-Kamradt A, Vaz AD, Whipple DA, Widlicka DW, Wishka DG, Wolkowski JP, Flanagan ME. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009 Dec 10; 52(23):7446-57.
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23. Magee T. Comparison of 3-T MRI and arthroscopy of intrinsic wrist ligament and TFCC tears. AJR Am J Roentgenol. 2009 Jan; 192(1):80-5.
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24. Magee T. 3-T MRI of the shoulder: is MR arthrography necessary? AJR Am J Roentgenol. 2009 Jan; 192(1):86-92.
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25. Khorram O, Han G, Magee T. Cigarette smoke inhibits endometrial epithelial cell proliferation through a nitric oxide-mediated pathway. Fertil Steril. 2010 Jan; 93(1):257-63.
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26. Magee T. MR findings of meniscal extrusion correlated with arthroscopy. J Magn Reson Imaging. 2008 Aug; 28(2):466-70.
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27. Magee TR, Han G, Cherian B, Khorram O, Ross MG, Desai M. Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring. Am J Obstet Gynecol. 2008 Sep; 199(3):271.e1-5.
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28. Abdel-Hakeem AK, Henry TQ, Magee TR, Desai M, Ross MG, Mansano RZ, Torday JS, Nast CC. Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression. Am J Obstet Gynecol. 2008 Sep; 199(3):252.e1-7.
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29. Cantini LP, Ferrini MG, Vernet D, Magee TR, Qian A, Gelfand RA, Rajfer J, Gonzalez-Cadavid NF. Profibrotic role of myostatin in Peyronie's disease. J Sex Med. 2008 Jul; 5(7):1607-22.
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30. Belkacemi L, Beall MH, Magee TR, Pourtemour M, Ross MG. AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells. Life Sci. 2008 Jun 20; 82(25-26):1272-80.
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31. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, Gonzalez-Cadavid NF. Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int. 2008 May; 101(9):1156-64.
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32. Magee T. Three-Tesla MR imaging of the knee. Radiol Clin North Am. 2007 Nov; 45(6):1055-62, vii.
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33. Magee T. Can isotropic fast gradient echo imaging be substituted for conventional T1 weighted sequences in shoulder MR arthrography at 3 Tesla? J Magn Reson Imaging. 2007 Jul; 26(1):118-22.
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34. Magee TR, Kovanecz I, Davila HH, Ferrini MG, Cantini L, Vernet D, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF. Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. J Sex Med. 2007 May; 4(3):633-643.
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35. Magee T. Three-tesla MR imaging of the knee. Magn Reson Imaging Clin N Am. 2007 Feb; 15(1):125-32.
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36. Peterson JJ, Bancroft LW, Kransdorf MJ, Berquist TH, Magee TH, Murray PM. Evaluation of collateral ligament injuries of the metacarpophalangeal joints with magnetic resonance imaging and magnetic resonance arthrography. Curr Probl Diagn Radiol. 2007 Jan-Feb; 36(1):11-20.
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37. Magee TH, Williams D. Sensitivity and specificity in detection of labral tears with 3.0-T MRI of the shoulder. AJR Am J Roentgenol. 2006 Dec; 187(6):1448-52.
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38. Magee T, Williams D. 3.0-T MRI of the supraspinatus tendon. AJR Am J Roentgenol. 2006 Oct; 187(4):881-6.
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39. Magee TR, Artaza JN, Ferrini MG, Vernet D, Zuniga FI, Cantini L, Reisz-Porszasz S, Rajfer J, Gonzalez-Cadavid NF. Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. J Gene Med. 2006 Sep; 8(9):1171-81.
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40. Magee T, Williams D. 3.0-T MRI of meniscal tears. AJR Am J Roentgenol. 2006 Aug; 187(2):371-5.
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41. Ramnath RR, Magee T, Wasudev N, Murrah R. Accuracy of 3-T MRI using fast spin-echo technique to detect meniscal tears of the knee. AJR Am J Roentgenol. 2006 Jul; 187(1):221-5.
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42. Vernet D, Magee T, Qian A, Nolazco G, Rajfer J, Gonzalez-Cadavid N. Phosphodiesterase type 5 is not upregulated by tadalafil in cultures of human penile cells. J Sex Med. 2006 Jan; 3(1):84-94; discussion 94-5.
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43. Vernet D, Nolazco G, Cantini L, Magee TR, Qian A, Rajfer J, Gonzalez-Cadavid NF. Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. Biol Reprod. 2005 Dec; 73(6):1199-210.
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44. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Meerasahib MF, Fareez MM, Gonzalez-Cadavid NF. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology. 2005 Aug; 146(8):3547-57.
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45. Davila HH, Magee TR, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF. Peyronie's disease associated with increase in plasminogen activator inhibitor in fibrotic plaque. Urology. 2005 Apr; 65(4):645-8.
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46. Magee T, Williams D. Detection of meniscal tears and marrow lesions using coronal MRI. AJR Am J Roentgenol. 2004 Nov; 183(5):1469-73.
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47. Magee T, Williams D, Mani N. Shoulder MR arthrography: which patient group benefits most? AJR Am J Roentgenol. 2004 Oct; 183(4):969-74.
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48. Davila HH, Magee TR, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease. Biol Reprod. 2004 Nov; 71(5):1568-77.
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49. Magee T, Shapiro M, Williams D. Usefulness of simultaneous acquisition of spatial harmonics technique for MRI of the knee. AJR Am J Roentgenol. 2004 Jun; 182(6):1411-5.
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50. Magee T, Shapiro M, Williams D. Prevalence of meniscal radial tears of the knee revealed by MRI after surgery. AJR Am J Roentgenol. 2004 Apr; 182(4):931-6.
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51. Magee T, Shapiro M, Williams D. Comparison of high-field-strength versus low-field-strength MRI of the shoulder. AJR Am J Roentgenol. 2003 Nov; 181(5):1211-5.
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52. Magee T, Shapiro M, Hewell G, Williams D. Complications of rotator cuff surgery in which bioabsorbable anchors are used. AJR Am J Roentgenol. 2003 Nov; 181(5):1227-31.
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53. Magee T, Shapiro M, Williams D, Ramnath RR, Simon J. Usefulness of the simultaneous acquisition of spatial harmonics technique during MRI of the shoulder. AJR Am J Roentgenol. 2003 Oct; 181(4):961-4.
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54. Magee T, Shapiro M, Rodriguez J, Williams D. MR arthrography of postoperative knee: for which patients is it useful? Radiology. 2003 Oct; 229(1):159-63.
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55. Ferrini MG, Magee TR, Vernet D, Rajfer J, González-Cadavid NF. Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection. J Comp Neurol. 2003 Mar 24; 458(1):46-61.
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56. Vernet D, Ferrini MG, Valente EG, Magee TR, Bou-Gharios G, Rajfer J, Gonzalez-Cadavid NF. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric Oxide. 2002 Dec; 7(4):262-76.
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57. Magee T, Shapiro M, Williams D. MR accuracy and arthroscopic incidence of meniscal radial tears. Skeletal Radiol. 2002 Dec; 31(12):686-9.
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58. Magee TR, Ferrini M, Garban HJ, Vernet D, Mitani K, Rajfer J, Gonzalez-Cadavid NF. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod. 2002 Sep; 67(3):1033-41.
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59. Magee TR, Ferrini M, Garban HJ, Vernet D, Mitani K, Rajfer J, Gonzalez-Cadavid NF. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod. 2002 Jul; 67(1):20-8.
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60. Magee T, Rosenthal H. Skeletal muscle metastases at sites of documented trauma. AJR Am J Roentgenol. 2002 Apr; 178(4):985-8.
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61. Magee TR, Qian A, Rajfer J, Sander FC, Levine LA, Gonzalez-Cadavid NF. Gene expression profiles in the Peyronie's disease plaque. Urology. 2002 Mar; 59(3):451-7.
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62. Rajfer J, Magee T, Gonzalez-Cadavid N. Future strategies for treating erectile dysfunction. Rev Urol. 2002; 4 Suppl 3:S48-53.
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Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Magnetic Resonance Imaging


  • Shoulder Joint


  • Arthrography


  • Shoulder Injuries


  • Tendon Injuries


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Keyword
Last Name
Institution
Department
School
    
 
 
 
Keywords   
Magnetic Resonance Imaging
Shoulder Joint
Arthrography
Shoulder Injuries
Tendon Injuries
See all (337) keywords
Co-Authors  
Artaza, Jorge
Ferrini, Monica
Gonzalez-Cadavid, Nestor
Khorram, Omid
Tsao, James
See all (5) people
Physical Neighbors  
Shukla, Bikau
Rodrigo, Enrico
Lockett, Lejeune
Nealy, Schetema
Chaban, Victor


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