Mamdooh H Ghoneum, PhD
Title Associate Professor
Institution Charles R. Drew University of Medicine and Science
Department Surgery
School College of Medicine
Address 1731 E. 120th Street, Hawkins Building


Telephone (323) 563-5953
Fax
Email
Overview
Dr. Ghoneum is an internationally recognized immunologist who is an expert in the area of cancer immune therapy. He has published 90 articles and 130 abstracts, including 11 books in Japanese and in English related to cancer immunology. He holds 3 patents for inventing 3 biological response modifiers (BRMs) for the treatment of cancer. Dr. Ghoneum's contribution to immunotherapy is introducing and patenting several new non-toxic BRMs that activate different arms of the immune system such as NK, T, and dendritic cells and induce apoptosis of cancer cells. The most extensively studied of these BRMs is called arabinoxylan MGN-3. In the most recent human clinical trials, MGN-3 was demonstrated to enhance the anti-cancer activity of chemotherapy for the treatment of hepatocellular carcinoma (HCC). This is the first time that a natural BRM was shown to be effective for the treatment of HCC. Dr. Ghoenum has received several international awards from: The American Cancer Society (1993), Japan Functional Food Research Association (JAFRA) (2002), and The Filipino-Chinese Medical Society (2005). In 2007 he was nominated for the annual $1 million prestigious Gotham Prize in Cancer Research for his novel discovery of using baker's yeast for the treatment of cancer. He created a video to educate the public about a new cancer therapy. He had special accelerated promotion. He has been awarded numerous research grants from NIH-MBRS and major research institutions in Japan. He has been a reviewer for the NIH Study Section Member. He has been an organizer for annual workshops between the Japanese Immunology Society and Charles Drew University since 1990. He is a member of several Scientific Societies, including the American Association for Cancer Research (AACR). Dr. Ghoneum's goal is to expand MGN-3 immunotherapy for the treatment of cancer in multiple clinical trials, and in addition to emphasize the importance of his novel approach for using yeast therapy for the treatment of cancer metastasis.
Education & Training
Teaching
NIH Awarded Grants
Publications
1. Badr El-Din NK, Shabana SM, Abdulmajeed BA, Ghoneum M. A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation. BMC Complement Med Ther. 2020 Apr 28; 20(1):127.
  View in: PubMed
 
2. Badr El-Din NK, Ali DA, Othman R, French SW, Ghoneum M. Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats. Biomed Pharmacother. 2020 Jun; 126:110064.
  View in: PubMed
 
3. Badr El-Din NK, Areida SK, Ahmed KO, Ghoneum M. Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma†. J Radiat Res. 2019 Nov 22; 60(6):747-758.
  View in: PubMed
 
4. Ghoneum M, Badr El-Din NK, Mahmoud AZ, Tolentino L, Pan D, Hassan TA. Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor. Oncol Rep. 2019 Jun; 41(6):3155-3166.
  View in: PubMed
 
5. Ghoneum MH, Gimzewski JK, Ghoneum AD, Agrawal S. Potential role of MRN-100, an iron-based compound, in upregulating production of cytokine IL-10 in human dendritic cells to promote an anti-inflammatory response in vitro. Int J Immunopathol Pharmacol. 2019 Jan-Dec; 33:2058738419844932.
  View in: PubMed
 
6. Ghoneum MH, Gimzewski JK, Ghoneum A, Katano H, Paw U CN, Agrawal A. Inhibition of TRPV1 Channel Activity in Human CD4? T Cells by Nanodiamond and Nanoplatinum Liquid, DPV576. Nanomaterials (Basel). 2018 Sep 29; 8(10).
  View in: PubMed
 
7. Elwakkad A, Ghoneum M, El-Sawi M, Mohamed SI, Gamal El Din AA, Pan D, Elqattan GM. Baker's Yeast Induces Apoptotic Effects and Histopathological Changes on Skin Tumors in Mice. Cogent Med. 2018; 5(1).
  View in: PubMed
 
8. Elsaid AF, Shaheen M, Ghoneum M. Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial. Exp Ther Med. 2018 Mar; 15(3):2313-2320.
  View in: PubMed
 
9. Ghoneum MH, Ogura T, Gimzewski JK, Ghoneum AD, Henary MC, Agrawal S. Marina crystal minerals (MCM) activate human dendritic cells to induce CD4+ and CD8+ T cell responses in vitro. Int J Immunopathol Pharmacol. 2018 Jan-Dec; 32:2058738418797768.
  View in: PubMed
 
10. Badr El-Din NK, Mahmoud AZ, Hassan TA, Ghoneum M. Baker's Yeast Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro. Integr Cancer Ther. 2018 06; 17(2):542-550.
  View in: PubMed
 
11. Ghoneum MH, Katano H, Agrawal S, Ganguly S, Agrawal A. Effect of Nanodiamond and Nanoplatinum Liquid, DPV576, on Human Primary Keratinocytes. J Biomed Nanotechnol. 2017 Jan; 13(1):110-16.
  View in: PubMed
 
12. Salama H, Medhat E, Shaheen M, Zekri AN, Darwish T, Ghoneum M. Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial. Int J Immunopathol Pharmacol. 2016 Dec; 29(4):647-653.
  View in: PubMed
 
13. Badr El-Din NK, Ali DA, Alaa El-Dein M, Ghoneum M. Enhancing the Apoptotic Effect of a Low Dose of Paclitaxel on Tumor Cells in Mice by Arabinoxylan Rice Bran (MGN-3/Biobran). Nutr Cancer. 2016 Aug-Sep; 68(6):1010-20.
  View in: PubMed
 
14. Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L, Ghoneum M. Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integr Cancer Ther. 2016 12; 15(4):NP26-NP34.
  View in: PubMed
 
15. Ghoneum M, Felo N, Agrawal S, Agrawal A. A novel kefir product (PFT) activates dendritic cells to induce CD4+T and CD8+T cell responses in vitro. Int J Immunopathol Pharmacol. 2015 Dec; 28(4):488-96.
  View in: PubMed
 
16. Ghoneum M, Felo N. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep. 2015 Oct; 34(4):1659-66.
  View in: PubMed
 
17. Ghoneum MH, Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L. Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci. 2015; 11(3):295-303.
  View in: PubMed
 
18. Ghoneum M, Gimzewski J. Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. Int J Oncol. 2014 Mar; 44(3):830-7.
  View in: PubMed
 
19. Ghoneum M, Badr El-Din NK, Ali DA, El-Dein MA. Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro. Anticancer Res. 2014 Jan; 34(1):81-7.
  View in: PubMed
 
20. Ghoneum M, Elbaghdady HA, El-Shebly AA, Pan D, Assanah E, Lawson G. Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in ?-radiated Nile tilapia, Oreochromis niloticus. J Radiat Res. 2013 Sep; 54(5):852-62.
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21. Ghoneum M, Badr El-Din NK, Abdel Fattah SM, Tolentino L. Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body ?-irradiation in mice via restoration of hematopoietic tissues. J Radiat Res. 2013 May; 54(3):419-29.
  View in: PubMed
 
22. Bang MH, Van Riep T, Thinh NT, Song le H, Dung TT, Van Truong L, Van Don L, Ky TD, Pan D, Shaheen M, Ghoneum M. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 2010 Dec; 30(12):5145-51.
  View in: PubMed
 
23. Ghoneum M, Ghoneum A, Gimzewski J. Nanodiamond and nanoplatinum liquid, DPV576, activates human monocyte-derived dendritic cells in vitro. Anticancer Res. 2010 Oct; 30(10):4075-9.
  View in: PubMed
 
24. Badr El-Din NK, Noaman E, Fattah SM, Ghoneum M. Reversal of age-associated oxidative stress in rats by MRN-100, a hydro-ferrate fluid. In Vivo. 2010 Jul-Aug; 24(4):525-33.
  View in: PubMed
 
25. Ghoneum M, Ghoneum A, Tolentino L, Gimzewski J. Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material. In Vivo. 2010 Mar-Apr; 24(2):141-6.
  View in: PubMed
 
26. Ghoneum M, Tolentino L, Seto Y. Phenotypic correction of Age-associated functional decline in murine immune cells by Thymax, a thymic extract. In Vivo. 2009 Nov-Dec; 23(6):895-902.
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27. Ghoneum M, Seto Y, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extract. Anticancer Res. 2009 Nov; 29(11):4367-71.
  View in: PubMed
 
28. Ghoneum M, Gollapudi S. Susceptibility of the human LNCaP prostate cancer cells to the apoptotic effect of marina crystal minerals (MCM) in vitro. Oncol Rep. 2009 Jul; 22(1):155-9.
  View in: PubMed
 
29. Ghoneum M, Matsuura M, Gollapudi S. An iron-based beverage, HydroFerrate fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitro. Nutr J. 2009 May 02; 8:18.
  View in: PubMed
 
30. Ghoneum M, Matsuura M, Braga M, Gollapudi S. S. cerevisiae induces apoptosis in human metastatic breast cancer cells by altering intracellular Ca2+ and the ratio of Bax and Bcl-2. Int J Oncol. 2008 Sep; 33(3):533-9.
  View in: PubMed
 
31. Noaman E, Badr El-Din NK, Bibars MA, Abou Mossallam AA, Ghoneum M. Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett. 2008 Sep 18; 268(2):348-59.
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32. Ghoneum M, Seto Y, Sato S, Ghoneum A, Braga M, Gollapudi S. Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway. Anticancer Res. 2008 May-Jun; 28(3A):1603-9.
  View in: PubMed
 
33. Gollapudi S, Ghoneum M. MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer Detect Prev. 2008; 32(1):1-6.
  View in: PubMed
 
34. Ghoneum M, Shaheen M. MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro. Evid Based Complement Alternat Med. 2010 Dec; 7(4):427-32.
  View in: PubMed
 
35. Badr El-Din NK, Noaman E, Ghoneum M. In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice. Nutr Cancer. 2008; 60(2):235-44.
  View in: PubMed
 
36. Ghoneum M, Badr El-Din NK, Noaman E, Tolentino L. Saccharomyces cerevisiae, the Baker's Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice. Cancer Immunol Immunother. 2008 Apr; 57(4):581-92.
  View in: PubMed
 
37. Ghoneum M, Wang L, Agrawal S, Gollapudi S. Yeast therapy for the treatment of breast cancer: a nude mice model study. In Vivo. 2007 Mar-Apr; 21(2):251-8.
  View in: PubMed
 
38. Ghoneum M, Gollapudi S. Apoptosis of breast cancer MCF-7 cells in vitro is induced specifically by yeast and not by fungal mycelia. Anticancer Res. 2006 May-Jun; 26(3A):2013-22.
  View in: PubMed
 
39. Ghoneum M, Gollapudi S. Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells. Anticancer Res. 2005 Nov-Dec; 25(6B):4187-96.
  View in: PubMed
 
40. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):859-70.
  View in: PubMed
 
41. Ghoneum M, Hamilton J, Brown J, Gollapudi S. Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):981-9.
  View in: PubMed
 
42. Ghoneum M, Abedi S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J Pharm Pharmacol. 2004 Dec; 56(12):1581-8.
  View in: PubMed
 
43. Ghoneum M, Saglie R, Brown J, Regala C. Actinobacillus actinomycetemcomitans suppresses rat natural killer cell activity in vivo. Acta Otolaryngol. 2004 Jun; 124(5):621-7.
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44. Ghoneum M, Gollapudi S. Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2004 May-Jun; 24(3a):1455-63.
  View in: PubMed
 
45. Ghoneum M, Gollapudi S. Phagocytosis of Candida albicans by metastatic and non metastatic human breast cancer cell lines in vitro. Cancer Detect Prev. 2004; 28(1):17-26.
  View in: PubMed
 
46. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett. 2003 Nov 10; 201(1):41-9.
  View in: PubMed
 
47. Ghoneum M, Grewal I, Brown J, Osborne R, Elembabi H, Gill G. Phagocytosis of candida albicans by lymphatic tumour cells in vitro. Acta Histochem. 2003; 105(2):127-33.
  View in: PubMed
 
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Apoptosis


  • Xylans


  • Breast Neoplasms


  • Saccharomyces cerevisiae


  • Carcinoma, Ehrlich Tumor


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Keyword
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Keywords   
Apoptosis
Xylans
Breast Neoplasms
Saccharomyces cerevisiae
Carcinoma, Ehrlich Tumor
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Co-Authors  
Pan, Deyu
Shaheen, Magda
Tolentino, Lucilene
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Physical Neighbors  
Basgen, John
Ferrini, Monica
Singh, Rajan
Pervin, Shehla
Hsia, Stanley


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