Theodore C. Friedman, MD, PhD
Title Professor
Institution Charles R. Drew University of Medicine and Science
Department Internal Medicine
School College of Medicine
Address 1731 E. 120th Street, Hawkins Building, Room 3087
Telephone (310) 668-5197
Fax
Email
Narrative
Dr. Friedman's basic science research interests are in pro-hormone processing as related to drug addiction, diabetes, thyroid disease and obesity as well as substance abuse and the hypothalamic-pituitary-adrenal axis. He also is studying how glucocorticoids and enzymes that regulate their tissue levels are involved in diabetes and obesity. His clinical research interests are adrenal and pituitary disorders and he has an NIH-funded clinical trial giving testosterone to women with hypopituitarism. His clinic interests includes difficult to diagnose pituitary, adrenal and thyroid disorders. He is one of the world's experts on Cushing's syndrome. He also wrote a popular lay book on thyroid diseases.
Education & Training
NIH Awarded Grants
Publications
1. Mojtahedzadeh M, Lee ML, Friedman TC. Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population. J Diabetes Complications. 2015 Jul 2.
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2. Wang Y, Yan C, Liu L, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y. 11ß-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab. 2015 Jan 1; 308(1):E84-95.
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3. Sinha-Hikim I, Duran P, Shen R, Lee M, Friedman TC, Davidson MB. Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res. 2015 Apr; 47(4):280-3.
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4. Ivey R, Desai M, Green K, Sinha-Hikim I, Friedman TC, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res. 2014 Jul; 46(8):568-73.
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5. Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72.
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6. Wang Y, Liu L, Du H, Nagaoka Y, Fan W, Lutfy K, Friedman TC, Jiang M, Liu Y. Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab. 2014 Mar; 306(5):E543-51.
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7. Natividad LA, Torres OV, Friedman TC, O'Dell LE. Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. Behav Brain Res. 2013 Nov 15; 257:275-85.
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8. Liu L, Nagashima K, Yasuda T, Liu Y, Hu HR, He G, Feng B, Zhao M, Zhuang L, Zheng T, Friedman TC, Xiang K. Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes. Diabetologia. 2013 Dec; 56(12):2609-18.
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9. Ren X, Lutfy K, Mangubat M, Ferrini MG, Lee ML, Liu Y, Friedman TC. Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes. 2013; 2013:764742.
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10. Nie Y, Ferrini MG, Liu Y, Anghel A, Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109.
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11. O'Dell LE, Natividad LA, Pipkin JA, Roman F, Torres I, Jurado J, Torres OV, Friedman TC, Tenayuca JM, Nazarian A. Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes. Addict Biol. 2014 Nov; 19(6):1006-19.
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12. Du H, Liu L, Wang Y, Nakagawa Y, Lyzlov A, Lutfy K, Friedman TC, Peng X, Liu Y. Specific reduction of G6PT may contribute to downregulation of hepatic 11ß-HSD1 in diabetic mice. J Mol Endocrinol. 2013 Apr; 50(2):167-78.
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13. Friedman TC. Facing facts: the impact of the face-to-face requirement. J Palliat Med. 2013 Feb; 16(2):120-1.
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14. Teruya SA, Bazargan-Hejazi S, Mojtahedzadeh M, Doshi M, Russell K, Parker-Kelly D, Friedman TC. A Review of Programs, Components and Outcomes in Biomedical Research Faculty Development. Int J Univ Teach Fac Dev. 2013; 4(4):223-236.
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15. Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20.
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16. Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013 Feb; 36(2):260-6.
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17. Tweed JO, Hsia SH, Lutfy K, Friedman TC. The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab. 2012 Jul; 23(7):334-42.
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18. Nguyen AT, Marquez P, Hamid A, Kieffer B, Friedman TC, Lutfy K. The rewarding action of acute cocaine is reduced in ß-endorphin deficient but not in µ opioid receptor knockout mice. Eur J Pharmacol. 2012 Jul 5; 686(1-3):50-4.
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19. Friedman TC, Bloom AM. When death precedes birth: experience of a palliative care team on a labor and delivery unit. J Palliat Med. 2012 Mar; 15(3):274-6.
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20. Rajavashisth TB, Shaheen M, Norris KC, Pan D, Sinha SK, Ortega J, Friedman TC. Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. BMJ Open. 2012; 2:e000494.
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21. Lutfy K, Aimiuwu O, Mangubat M, Shin CS, Nerio N, Gomez R, Liu Y, Friedman TC. Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. J Neurochem. 2012 Mar; 120(6):1108-16.
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22. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26.
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23. Friedman TC. Vitamin D supplementation to prevent the progression of prediabetes to diabetes: getting closer to a recommendation. Transl Res. 2011 Nov; 158(5):273-5.
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24. Wang Y, Nakagawa Y, Liu L, Wang W, Ren X, Anghel A, Lutfy K, Friedman TC, Liu Y. Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. Diabetologia. 2011 Feb; 54(2):440-50.
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25. Parikh D, Hamid A, Friedman TC, Nguyen K, Tseng A, Marquez P, Lutfy K. Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration. Eur J Pharmacol. 2011 Jan 15; 650(2-3):563-7.
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26. Friedman TC, Ghods DE, Shahinian HK, Zachery L, Shayesteh N, Seasholtz S, Zuckerbraun E, Lee ML, McCutcheon IE. High prevalence of normal tests assessing hypercortisolism in subjects with mild and episodic Cushing's syndrome suggests that the paradigm for diagnosis and exclusion of Cushing's syndrome requires multiple testing. Horm Metab Res. 2010 Nov; 42(12):874-81.
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27. Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ß-cell regeneration. Islets. 2010 May-Jun; 2(3):149-55.
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28. Anghel A, Jamieson CA, Ren X, Young J, Porche R, Ozigbo E, Ghods DE, Lee ML, Liu Y, Lutfy K, Friedman TC. Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience. 2010 May 5; 167(2):554-66.
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29. Chen J, Patel R, Friedman TC, Jones KS. The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. Int J Comp Psychol. 2010; 23(1):82-90.
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30. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010 Feb; 31(1):98-132.
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31. Thomson S, Koren G, Fraser LA, Rieder M, Friedman TC, Van Uum SH. Hair analysis provides a historical record of cortisol levels in Cushing's syndrome. Exp Clin Endocrinol Diabetes. 2010 Feb; 118(2):133-8.
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32. Pall ME, Lao MC, Patel SS, Lee ML, Ghods DE, Chandler DW, Friedman TC. Testosterone and bioavailable testosterone help to distinguish between mild Cushing's syndrome and polycystic ovarian syndrome. Horm Metab Res. 2008 Nov; 40(11):813-8.
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33. Espinosa VP, Liu Y, Ferrini M, Anghel A, Nie Y, Tripathi PV, Porche R, Jansen E, Stuart RC, Nillni EA, Lutfy K, Friedman TC. Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Neuroscience. 2008 Oct 15; 156(3):788-99.
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34. Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC. Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J Mol Endocrinol. 2008 Aug; 41(2):53-64.
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35. Fraser LA, Morrison D, Morley-Forster P, Paul TL, Tokmakejian S, Larry Nicholson R, Bureau Y, Friedman TC, Van Uum SH. Oral opioids for chronic non-cancer pain: higher prevalence of hypogonadism in men than in women. Exp Clin Endocrinol Diabetes. 2009 Jan; 117(1):38-43.
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36. Yuen KC, Cook DM, Sahasranam P, Patel P, Ghods DE, Shahinian HK, Friedman TC. Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels. Clin Endocrinol (Oxf). 2008 Aug; 69(2):292-8.
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37. Sahasranam P, Tran MT, Mohamed H, Friedman TC. Multiglandular parathyroid carcinoma: a case report and brief review. South Med J. 2007 Aug; 100(8):841-4.
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38. Friedman TC, Zuckerbraun E, Lee ML, Kabil MS, Shahinian H. Dynamic pituitary MRI has high sensitivity and specificity for the diagnosis of mild Cushing's syndrome and should be part of the initial workup. Horm Metab Res. 2007 Jun; 39(6):451-6.
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39. Lutfy K, Brown MC, Nerio N, Aimiuwu O, Tran B, Anghel A, Friedman TC. Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis. J Neurochem. 2006 Dec; 99(5):1321-7.
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40. Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86.
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41. Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006 Nov; 147(11):5061-8.
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42. Friedman TC. An update on the overnight dexamethasone suppression test for the diagnosis of Cushing's syndrome: limitations in patients with mild and/or episodic hypercortisolism. Exp Clin Endocrinol Diabetes. 2006 Jul; 114(7):356-60.
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43. Marquez P, Baliram R, Gajawada N, Friedman TC, Lutfy K. Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine. Behav Neurosci. 2006 Feb; 120(1):10-5.
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44. McGirr R, Ejbick CE, Carter DE, Andrews JD, Nie Y, Friedman TC, Dhanvantari S. Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology. 2005 Oct; 146(10):4514-23.
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45. Hardiman A, Friedman TC, Grunwald WC, Furuta M, Zhu Z, Steiner DF, Cool DR. Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. J Mol Endocrinol. 2005 Jun; 34(3):739-51.
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46. Shen X, Li QL, Brent GA, Friedman TC. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E236-45.
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47. Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes. 2005 Jan; 54(1):32-40.
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48. Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest. 2004 Aug; 114(3):357-69.
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49. Shen X, Li QL, Brent GA, Friedman TC. Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements. J Mol Endocrinol. 2004 Aug; 33(1):21-33.
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50. Wang C, Swerdloff R, Kipnes M, Matsumoto AM, Dobs AS, Cunningham G, Katznelson L, Weber TJ, Friedman TC, Snyder P, Levine HL. New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. J Clin Endocrinol Metab. 2004 Aug; 89(8):3821-9.
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51. Friedman TC. Prolactinomas. N Engl J Med. 2004 Mar 4; 350(10):1054-7; author reply 1054-7.
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52. Choi HJ, Cornford M, Wang L, Sun J, Friedman TC. Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism. Pituitary. 2004; 7(2):111-4.
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53. Friedman TC, Shahinian H. Bilateral cerebral aneurysms impinging on the pituitary. Pituitary. 2004; 7(3):193-4.
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54. Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman TC. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes. 2003 Jun; 52(6):1409-16.
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55. Li QL, Naqvi S, Shen X, Liu YJ, Lindberg I, Friedman TC. Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues. Regul Pept. 2003 Feb 28; 110(3):197-205.
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56. Friedman TC, Norris KC. The role of vitamin D in mild to moderate chronic kidney disease. Trends Endocrinol Metab. 2002 Jul; 13(5):189-94.
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57. Padero MC, Bhasin S, Friedman TC. Androgen supplementation in older women: too much hype, not enough data. J Am Geriatr Soc. 2002 Jun; 50(6):1131-40.
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58. Nakashima M, Nie Y, Li QL, Friedman TC. Up-regulation of splenic prohormone convertases PC1 and PC2 in diabetic rats. Regul Pept. 2001 Dec 15; 102(2-3):135-45.
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59. Friedman TC, Echeverry D, Poland RE. Orthostatic hypotension and chronic fatigue syndrome. JAMA. 2001 Mar 21; 285(11):1442; author reply 1443.
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60. Friedman TC. Reflections on going home. J Palliat Med. 2001; 4(2):205-7.
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61. Li QL, Jansen E, Brent GA, Friedman TC. Regulation of prohormone convertase 1 (PC1) by thyroid hormone. Am J Physiol Endocrinol Metab. 2001 Jan; 280(1):E160-70.
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62. García-Borreguero D, Wehr TA, Larrosa O, Granizo JJ, Hardwick D, Chrousos GP, Friedman TC. Glucocorticoid replacement is permissive for rapid eye movement sleep and sleep consolidation in patients with adrenal insufficiency. J Clin Endocrinol Metab. 2000 Nov; 85(11):4201-6.
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63. Li QL, Jansen E, Brent GA, Naqvi S, Wilber JF, Friedman TC. Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor. Endocrinology. 2000 Sep; 141(9):3256-66.
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64. Nawab SS, Miller CS, Dale JK, Greenberg BD, Friedman TC, Chrousos GP, Straus SE, Rosenthal NE. Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls. Psychiatry Res. 2000 Jul 24; 95(1):67-74.
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65. Nie Y, Nakashima M, Brubaker PL, Li QL, Perfetti R, Jansen E, Zambre Y, Pipeleers D, Friedman TC. Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. J Clin Invest. 2000 Apr; 105(7):955-65.
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66. Li QL, Jansen E, Friedman TC. Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines. Mol Cell Endocrinol. 1999 Dec 20; 158(1-2):143-52.
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67. Yanovski JA, Miller KD, Kino T, Friedman TC, Chrousos GP, Tsigos C, Falloon J. Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-associated lipodystrophy. J Clin Endocrinol Metab. 1999 Jun; 84(6):1925-31.
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68. Friedman TC, Adesanya A, Poland RE. Low-dose hydrocortisone for chronic fatigue syndrome. JAMA. 1999 May 26; 281(20):1888-9.
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69. Shimon I, Yan X, Magoffin DA, Friedman TC, Melmed S. Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J Clin Endocrinol Metab. 1998 Nov; 83(11):4059-64.
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70. Friedman TC, Papanicolaou DA. Comment on high urinary free cortisol excretion in a patient with psychogenic polydipsia. J Clin Endocrinol Metab. 1998 Sep; 83(9):3378-9.
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71. Li QL, Yano H, Ren SG, Li X, Friedman TC, Melmed S. Leukemia inhibitory factor (LIF) modulates pro-opiomelanocortin (POMC) gene regulation in stably transfected AtT-20 cells overexpressing LIF. Endocrine. 1997 Dec; 7(3):325-30.
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72. Yanovski JA, Friedman TC, Nieman LK, Chrousos GP, Cutler GB, Doppman JL, Kalogeras KT. Inferior petrosal sinus AVP in patients with Cushing's syndrome. Clin Endocrinol (Oxf). 1997 Aug; 47(2):199-206.
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73. Taymans SE, DeVries AC, DeVries MB, Nelson RJ, Friedman TC, Castro M, Detera-Wadleigh S, Carter CS, Chrousos GP. The hypothalamic-pituitary-adrenal axis of prairie voles (Microtus ochrogaster): evidence for target tissue glucocorticoid resistance. Gen Comp Endocrinol. 1997 Apr; 106(1):48-61.
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74. Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP. The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism. J Clin Endocrinol Metab. 1997 Mar; 82(3):912-9.
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75. Ting P, Cushenberry PA, Friedman TC, Loh YP. Enhanced brain opioid receptor activity precedes blood-brain barrier disruption. Acta Neurochir Suppl. 1997; 70:250-3.
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76. Friedman TC, Mastorakos G, Newman TD, Mullen NM, Horton EG, Costello R, Papadopoulos NM, Chrousos GP. Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. Endocr J. 1996 Dec; 43(6):645-55.
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77. Yanovski JA, Yanovski SZ, Friedman TC, Loh YP, Jayasvasti V, Cutler GB, Chrousos GP. Etiology of the differences in corticotropin-releasing hormone-induced adrenocorticotropin secretion of black and white women. J Clin Endocrinol Metab. 1996 Sep; 81(9):3307-11.
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78. Friedman TC, Yanovski JA, Nieman LK, Doppman JL, Cutler GB, Oldfield EH, Gold PM, Chrousos GP, Kalogeras KT. Inferior petrosal sinus arginine vasopressin concentrations in normal volunteers and patients with Cushing's disease. J Clin Endocrinol Metab. 1996 Aug; 81(8):3068-72.
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79. Kalogeras KT, Nieman LK, Friedman TC, Doppman JL, Cutler GB, Chrousos GP, Wilder RL, Gold PW, Yanovski JA. Inferior petrosal sinus sampling in healthy subjects reveals a unilateral corticotropin-releasing hormone-induced arginine vasopressin release associated with ipsilateral adrenocorticotropin secretion. J Clin Invest. 1996 May 1; 97(9):2045-50.
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80. Mastorakos G, Scopa CD, Kao LC, Vryonidou A, Friedman TC, Kattis D, Phenekos C, Rabin D, Chrousos GP. Presence of immunoreactive corticotropin-releasing hormone in human endometrium. J Clin Endocrinol Metab. 1996 Mar; 81(3):1046-50.
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81. Friedman TC, Cool DR, Jayasvasti V, Louie D, Loh YP. Processing of pro-opiomelanocortin in GH3 cells: inhibition by prohormone convertase 2 (PC2) antisense mRNA. Mol Cell Endocrinol. 1996 Jan 15; 116(1):89-96.
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82. Crofford LJ, Sano H, Karalis K, Webster EA, Friedman TC, Chrousos GP, Wilder RL. Local expression of corticotropin-releasing hormone in inflammatory arthritis. Ann N Y Acad Sci. 1995 Dec 29; 771:459-71.
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83. Nillni EA, Friedman TC, Todd RB, Birch NP, Loh YP, Jackson IM. Pro-thyrotropin-releasing hormone processing by recombinant PC1. J Neurochem. 1995 Dec; 65(6):2462-72.
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84. Friedman TC, Loh YP, Cawley NX, Birch NP, Huang SS, Jackson IM, Nillni EA. Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes. Endocrinology. 1995 Oct; 136(10):4462-72.
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85. Mastorakos G, Bouzas EA, Silver PB, Sartani G, Friedman TC, Chan CC, Caspi RR, Chrousos GP. Immune corticotropin-releasing hormone is present in the eyes of and promotes experimental autoimmune uveoretinitis in rodents. Endocrinology. 1995 Oct; 136(10):4650-8.
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86. Friedman TC, Yanovski JA. Morning plasma free cortisol: inability to distinguish patients with mild Cushing syndrome from patients with pseudo-Cushing states. J Endocrinol Invest. 1995 Oct; 18(9):696-701.
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87. Friedman TC, Yanovski JA, Jayasvasti V, Yanovski SZ, Koenig RJ, Wilk S. Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: influence of weight and thyroid status. J Clin Endocrinol Metab. 1995 Apr; 80(4):1086-9.
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88. Pu LP, Hayes WP, Mill JF, Ghose S, Friedman TC, Loh YP. Frog prohormone convertase PC2 mRNA has a mammalian-like expression pattern in the central nervous system and is colocalized with a subset of thyrotropin-releasing hormone-expressing neurons. J Comp Neurol. 1995 Mar 27; 354(1):71-86.
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89. Friedman TC, Gordon VM, Leppla SH, Klimpel KR, Birch NP, Loh YP. In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes. Arch Biochem Biophys. 1995 Jan 10; 316(1):5-13.
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90. Vgontzas AN, Friedman TC, Chrousos GP, Bixler EO, Vela-Bueno A, Kales A. Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. Peptides. 1995; 16(6):1153-6.
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91. Loh YP, Cawley NX, Friedman TC, Pu LP. Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion. Adv Exp Med Biol. 1995; 362:519-27.
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92. Azaryan AV, Friedman TC, Cawley NX, Loh YP. Characteristics of YAP3, a new prohormone processing aspartic protease from S. cerevisiae. Adv Exp Med Biol. 1995; 362:569-72.
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93. Friedman TC, García-Borreguero D, Hardwick D, Akuete CN, Doppman JL, Dorn LD, Barker CN, Yanovski JA, Chrousos GP. Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome. Neuroendocrinology. 1994 Dec; 60(6):626-34.
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94. Scopa CD, Mastorakos G, Friedman TC, Melachrinou M, Merino MJ, Chrousos GP. Presence of immunoreactive corticotropin releasing hormone in thyroid lesions. Am J Pathol. 1994 Nov; 145(5):1159-67.
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95. Mastorakos G, Scopa CD, Vryonidou A, Friedman TC, Kattis D, Phenekos C, Merino MJ, Chrousos GP. Presence of immunoreactive corticotropin-releasing hormone in normal and polycystic human ovaries. J Clin Endocrinol Metab. 1994 Oct; 79(4):1191-7.
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96. Friedman TC, Loh YP, Birch NP. In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3). Endocrinology. 1994 Sep; 135(3):854-62.
  View in: PubMed
 
97. Auchus RJ, Mastorakos G, Friedman TC, Chrousos GP. Corticotropin-releasing hormone production by a small cell carcinoma in a patient with ACTH-dependent Cushing's syndrome. J Endocrinol Invest. 1994 Jun; 17(6):447-52.
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98. Friedman TC, Garcia-Borreguero D, Hardwick D, Akuete CN, Stambuk MK, Dorn LD, Starkman MN, Loh YP, Chrousos GP. Diurnal rhythm of plasma delta-sleep-inducing peptide in humans: evidence for positive correlation with body temperature and negative correlation with rapid eye movement and slow wave sleep. J Clin Endocrinol Metab. 1994 May; 78(5):1085-9.
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99. Bouzas EA, Mastorakos G, Friedman TC, Scott MH, Chrousos GP, Kaiser-Kupfer MI. Posterior subcapsular cataract in endogenous Cushing syndrome: an uncommon manifestation. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3497-500.
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100. Friedman TC, Chrousos GP. Transsphenoidal resection in Cushing's disease: definition of success. Clin Endocrinol (Oxf). 1993 Dec; 39(6):701.
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Hydrocortisone
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Co-Authors  
Lee, Martin
Liu, Yan-Jun
Shaheen, Magda
Sinha-Hikim, Amiya
Sinha-Hikim, Indrani
See all (13) people
Physical Neighbors  
Vadgama, Jaydutt
Ferrini, Monica
Sinha, Satyesh
Pervin, Shehla
Chaban, Victor


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