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Amiya Sinha-Hikim, PhD

TitleProfessor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-5974
FaxNot Available
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    Overview
    overview
    I am an experienced researcher and have worked in various medical schools in the United States since 1985. During these years I have advanced from a Rockefeller Foundation post-doctoral fellow at Harvard Medical School, through the professorial ranks, to a full Professor at David Geffen School of Medicine at UCLA. In 2010, I joined Charles R. Drew University (CDU) of Medicine and science. During this period I have contributed to research in translational and biomedical sciences. Additionally, during my tennure as a Director Molecular Cytology Core, General Clinical Research Center, Harbor UCLA Medical Center and as a Program Director of MBRS SCORE Program in CDU, I provided hands-on training to our students and faculties to increase their familiarities in various instruments as wells to advance their research career in biomedical science.

    My research for past several years has centered on cardio-metabolic diseases targeted to define the contribution of nicotine (either parenterally administered of delivered via electronic nicotine delivery system) and obesity to the development of nonalcoholic fatty liver disease, muscle steatosis, and cardiomyopathy. I have published over 130 peer-reviewed articles in premier journals including Apoptosis, Biology of Reproduction, Endocrinology, Molecular Endocrinology, Journal of Clinical Investigation, Genes & Development., and Hepatology. More recently,, I have published an editorial and co-edited an e-book on obesity, smoking, and fatty liver disease. I also authored 14 book chapters, and co-authored a highly regarded book entitled "Histological and Histopathological Evaluation of the Testis".

    Currently, I am actively involved in research training of high school, undergraduate, medical students, Ph.D., and M.D. postdoctoral fellows.

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hasan KM, Parveen M, Pena A, Bautista F, Rivera JC, Huerta RR, Martinez E, Espinoza-Derout J, Sinha-Hikim AP, Friedman TC. Fatty Acid Excess Dysregulates CARF to Initiate the Development of Hepatic Steatosis. Cells. 2023 04 01; 12(7). PMID: 37048142; PMCID: PMC10093423.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Espinoza-Derout J, Shao XM, Lao CJ, Hasan KM, Rivera JC, Jordan MC, Echeverria V, Roos KP, Sinha-Hikim AP, Friedman TC. Electronic Cigarette Use and the Risk of Cardiovascular Diseases. Front Cardiovasc Med. 2022; 9:879726. PMID: 35463745; PMCID: PMC9021536.
      Citations: 6     
    3. Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome. Front Endocrinol (Lausanne). 2021; 12:667066. PMID: 34168615; PMCID: PMC8218903.
      Citations: 20     Fields:    Translation:Humans
    4. Hasan KM, Munoz A, Tumoyan H, Parveen M, Espinoza-Derout J, Shao XM, Mahata SK, Friedman TC, Sinha-Hikim AP. Adverse effects of fetal exposure of electronic-cigarettes and high-fat diet on male neonatal hearts. Exp Mol Pathol. 2021 02; 118:104573. PMID: 33212125; PMCID: PMC8501912.
      Citations:    Fields:    Translation:AnimalsCells
    5. Hasan KM, Friedman TC, Parveen M, Espinoza-Derout J, Bautista F, Razipour MM, Shao XM, Jordan MC, Roos KP, Mahata SK, Sinha-Hikim AP. Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice. PLoS One. 2020; 15(10):e0239671. PMID: 33002059; PMCID: PMC7529198.
      Citations: 6     Fields:    Translation:Animals
    6. Shao XM, Lopez B, Nathan D, Wilson J, Bankole E, Tumoyan H, Munoz A, Espinoza-Derout J, Hasan KM, Chang S, Du C, Sinha-Hikim AP, Lutfy K, Friedman TC. A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 10 01; 326:108376. PMID: 31361999; PMCID: PMC6717674.
      Citations: 15     Fields:    Translation:Animals
    7. Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL, Sinha S, Simmons Z, Mtume N, Liu Y, Roos KP, Sinha-Hikim AP, Friedman TC. Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H445-H459. PMID: 31172811; PMCID: PMC6732484.
      Citations: 34     Fields:    Translation:AnimalsCellsPHPublic Health
    8. Espinoza-Derout J, Shao XM, Bankole E, Hasan KM, Mtume N, Liu Y, Sinha-Hikim AP, Friedman TC. Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis. Front Endocrinol (Lausanne). 2019; 10:320. PMID: 31214115; PMCID: PMC6558099.
      Citations: 10     Fields:    
    9. Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 06; 69(6):2442-2454. PMID: 30664268; PMCID: PMC6636679.
      Citations: 16     Fields:    Translation:HumansAnimals
    10. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360; PMCID: PMC5776480.
      Citations: 12     Fields:    Translation:AnimalsCells
    11. Sinha-Hikim AP, Mahata SK. Editorial: Obesity, Smoking, and Fatty Liver Disease. Front Endocrinol (Lausanne). 2018; 9:1. PMID: 29403440; PMCID: PMC5778120.
      Citations: 1     Fields:    
    12. Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Front Endocrinol (Lausanne). 2017; 8:23. PMID: 28239368; PMCID: PMC5300964.
      Citations: 18     Fields:    
    13. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. PMID: 27917437; PMCID: PMC5813800.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 02; 232(2):137-153. PMID: 27799464; PMCID: PMC5287349.
      Citations: 3     Fields:    Translation:AnimalsCells
    15. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):823. PMID: 26809511; PMCID: PMC5585018.
      Citations:    Fields:    
    16. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):693-712. PMID: 26572539; PMCID: PMC5529139.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    17. Sinha I, Sinha-Hikim AP, Wagers AJ, Sinha-Hikim I. Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model. Cell Tissue Res. 2014 Sep; 357(3):815-21. PMID: 24859218; PMCID: PMC4149819.
      Citations: 21     Fields:    Translation:AnimalsCells
    18. Ivey R, Desai M, Green K, Sinha-Hikim I, Friedman TC, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res. 2014 Jul; 46(8):568-73. PMID: 24830635; PMCID: PMC4327908.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72. PMID: 24424058; PMCID: PMC3929732.
      Citations: 16     Fields:    Translation:AnimalsCells
    20. Sinha-Hikim I, Sinha-Hikim AP, Parveen M, Shen R, Goswami R, Tran P, Crum A, Norris KC. Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging. J Gerontol A Biol Sci Med Sci. 2013 Jul; 68(7):749-59. PMID: 23459206; PMCID: PMC3674717.
      Citations: 23     Fields:    Translation:Animals
    21. Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20. PMID: 23093702; PMCID: PMC3512067.
      Citations: 28     Fields:    Translation:AnimalsCells
    22. Chang YF, Lee-Chang JS, Imam JS, Buddavarapu KC, Subaran SS, Sinha-Hikim AP, Gorospe M, Rao MK. Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5750-5. PMID: 22447776; PMCID: PMC3326518.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. PMID: 22138237; PMCID: PMC3444240.
      Citations: 29     Fields:    Translation:Animals
    24. Chang YF, Lee-Chang JS, Harris KY, Sinha-Hikim AP, Rao MK. Role of ß-catenin in post-meiotic male germ cell differentiation. PLoS One. 2011; 6(11):e28039. PMID: 22125654; PMCID: PMC3220672.
      Citations: 17     Fields:    Translation:AnimalsCells
    25. Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata SK, Sinha-Hikim AP. Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 2011 Jun; 16(6):563-73. PMID: 21424555; PMCID: PMC4701037.
      Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    26. Sinha-Hikim I, Sinha-Hikim AP, Shen R, Kim HJ, Kim H, French SW, Vaziri ND, Vaziri ND, Crum AC, Crum A, Rajavashisth TB, Norris KC. A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol. 2011 Aug; 91(1):419-28. PMID: 21570964; PMCID: PMC3191382.
      Citations: 24     Fields:    Translation:AnimalsCells
    27. Jia Y, Castellanos J, Wang C, Sinha-Hikim I, Lue Y, Swerdloff RS, Sinha-Hikim AP. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biol Reprod. 2009 Apr; 80(4):771-80. PMID: 19109224; PMCID: PMC2804830.
      Citations: 24     Fields:    Translation:AnimalsCells
    28. Rao MK, Pham J, Imam JS, MacLean JA, Murali D, Furuta Y, Sinha-Hikim AP, Wilkinson MF. Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev. 2006 Jan 15; 20(2):147-52. PMID: 16418481; PMCID: PMC1356106.
      Citations: 45     Fields:    Translation:AnimalsCells
    29. Sinha I, Sinha-Hikim AP, Hannawa KK, Henke PK, Eagleton MJ, Stanley JC, Upchurch GR. Mitochondrial-dependent apoptosis in experimental rodent abdominal aortic aneurysms. Surgery. 2005 Oct; 138(4):806-11. PMID: 16269312.
      Citations: 11     Fields:    Translation:AnimalsCells
    30. Bonavera JJ, Swerdloff RS, Leung A, Lue YH, Baravarian S, Superlano L, Sinha-Hikim AP, Wang C. In the male brown-Norway (BN) male rat, reproductive aging is associated with decreased LH-pulse amplitude and area. J Androl. 1997 Jul-Aug; 18(4):359-65. PMID: 9283947.
      Citations: 11     Fields:    Translation:Animals
    31. Wang C, Sinha-Hikim A, Leung A. The anti-progestin CDB 2914 has no antifertility effect in male rats. Contraception. 1995 Mar; 51(3):215-8. PMID: 7621692.
      Citations: 1     Fields:    Translation:AnimalsCells
    32. Wang C, Leung A, Sinha-Hikim AP. Reproductive aging in the male brown-Norway rat: a model for the human. Endocrinology. 1993 Dec; 133(6):2773-81. PMID: 8243304.
      Citations: 40     Fields:    Translation:AnimalsCells
    33. Sinha-Hikim AP, Swerdloff RS. Temporal and stage-specific changes in spermatogenesis of rat after gonadotropin deprivation by a potent gonadotropin-releasing hormone antagonist treatment. Endocrinology. 1993 Nov; 133(5):2161-70. PMID: 8404667.
      Citations: 13     Fields:    Translation:AnimalsCells
    34. Ghosh S, Sinha-Hikim AP, Russell LD. Further observations of stage-specific effects seen after short-term hypophysectomy in the rat. Tissue Cell. 1991; 23(5):613-30. PMID: 1776153.
      Citations: 8     Fields:    Translation:AnimalsCells
    35. Chakraborty J, Sinha-Hikim AP, Jhunjhunwala J. A simple method for quantitative analysis of human testicular biopsies from epon sections. Ann N Y Acad Sci. 1984; 438:481-4. PMID: 6598333.
      Citations: 2     Fields:    Translation:HumansCells
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