John Basgen
Title Instructor
Institution Charles R. Drew University of Medicine and Science
Department Preventive and Social Medicine
School College of Medicine
Address 1731 E. 120th Street, Hawkins Building

Telephone (323) 357-3668
My primary research interest is the structure and function of diabetic kidney disease.  I have spent more than 35 years studying the relationships between kidney structure and function in patients with diabetes and other renal diseases and animal models of kidney disease.   I have extensive training in the theory and use of stereological techniques related to the structure of the kidney and other organs.  At Charles R. Drew University I am Director of the Morphometry and Stereology Laboratory where I enjoy teaching morphometric techniques to students and colleagues and continue my research related to the structure and function of the kidney.
Education & Training
NIH Awarded Grants
Project TitleProject NumberFY
1. Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. J Am Soc Nephrol. 2018 11; 29(11):2641-2657.
  View in: PubMed
2. Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 12 08; 358(6368):1332-1336.
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3. Mansouri E, Basgen J, Saremy S. The effects of pomegranate extract on normal adult rat kidney: A stereological study. Vet Res Forum. 2016; 7(1):1-6.
  View in: PubMed
4. Singh R, Parveen M, Basgen JM, Fazel S, Meshesha MF, Thames EC, Moore B, Martinez L, Howard CB, Vergnes L, Reue K, Pervin S. Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res. 2016 Jan; 14(1):78-92.
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5. Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN. Dendrin ablation prolongs life span by delaying kidney failure. Am J Pathol. 2015 Aug; 185(8):2143-57.
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6. Schwartzman M, Reginensi A, Wong JS, Basgen JM, Meliambro K, Nicholas SB, D'Agati V, McNeill H, Campbell KN. Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure. J Am Soc Nephrol. 2016 Jan; 27(1):216-26.
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7. Basgen JM, Sobin C. Early chronic low-level lead exposure produces glomerular hypertrophy in young C57BL/6J mice. Toxicol Lett. 2014 Feb 10; 225(1):48-56.
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8. Nicholas SB, Basgen JM, Sinha S. Using stereologic techniques for podocyte counting in the mouse: shifting the paradigm. Am J Nephrol. 2011; 33 Suppl 1:1-7.
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9. Bai XY, Basgen JM. Podocyte number in the maturing rat kidney. Am J Nephrol. 2011; 33(1):91-6.
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10. Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J. Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). Am J Nephrol. 2006; 26(5):430-6.
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11. Basgen JM, Nicholas SB, Mauer M, Rozen S, Nyengaard JR. Comparison of methods for counting cells in the mouse glomerulus. Nephron Exp Nephrol. 2006; 103(4):e139-48.
  View in: PubMed
12. Nicholas SB, Mauer M, Basgen JM, Aguiniga E, Chon Y. Effect of angiotensin II on glomerular structure in streptozotocin-induced diabetic rats. Am J Nephrol. 2004 Sep-Oct; 24(5):549-56.
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13. Caramori ML, Basgen JM, Mauer M. Glomerular structure in the normal human kidney: differences between living and cadaver donors. J Am Soc Nephrol. 2003 Jul; 14(7):1901-3.
  View in: PubMed
14. Najafian B, Basgen JM, Mauer M. Estimating mean glomerular volume using two arbitrary parallel sections. J Am Soc Nephrol. 2002 Nov; 13(11):2697-705.
  View in: PubMed
15. Katz A, Caramori ML, Sisson-Ross S, Groppoli T, Basgen JM, Mauer M. An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients. Kidney Int. 2002 Jun; 61(6):2058-66.
  View in: PubMed
16. Degenhardt TP, Alderson NL, Arrington DD, Beattie RJ, Basgen JM, Steffes MW, Thorpe SR, Baynes JW. Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat. Kidney Int. 2002 Mar; 61(3):939-50.
  View in: PubMed
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Kidney Glomerulus

  • Podocytes

  • Kidney Diseases

  • Kidney

  • Lead Poisoning

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Pervin, Shehla
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Sinha-Hikim, Amiya
Sinha-Hikim, Indrani
Davidson, Mayer
Sinha, Satyesh
Chaban, Victor

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