Kenneth Lewis, MD
Title Assistant Professor
Institution Charles R. Drew University of Medicine and Science
Department Surgery
School College of Medicine
Address 1731 E. 120th Street


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Education & Training
Teaching
NIH Awarded Grants
Project TitleProject NumberFY
Publications
1. Bagchi DP, Li Z, Corsa CA, Hardij J, Mori H, Learman BS, Lewis KT, Schill RL, Romanelli SM, MacDougald OA. Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction. Mol Metab. 2020 Apr 20; 39:100992.
  View in: PubMed
 
2. Naik AR, Kuhn ER, Lewis KT, Kokotovich KM, Maddipati KR, Chen X, Hörber JHK, Taatjes DJ, Potoff JJ, Jena BP. Self-Assembly and Biogenesis of the Cellular Membrane are Dictated by Membrane Stretch and Composition. J Phys Chem B. 2019 08 15; 123(32):6997-7005.
  View in: PubMed
 
3. Li Z, Hardij J, Evers SS, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Bagchi DP, Romanelli SM, Kim KS, Bowers E, Griffin C, Seeley RJ, Singer K, Sandoval DA, Rosen CJ, MacDougald OA. G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche. J Clin Invest. 2019 05 06; 129(6):2404-2416.
  View in: PubMed
 
4. Subramaniam RM, Bradshaw ML, Lewis K, Pinho D, Shah C, Walker RC. ACR Practice Parameter for the Performance of Gallium-68 DOTATATE PET/CT for Neuroendocrine Tumors. Clin Nucl Med. 2018 Dec; 43(12):899-908.
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5. Lewis KT, MacDougald OA. Bone: Bone marrow adipocytes in 3D. Nat Rev Endocrinol. 2018 05; 14(5):254-255.
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6. Lewis KT, Naik AR, Laha SS, Wang S, Mao G, Kuhn E, Jena BP. Secretion induces cell pH dynamics impacting assembly-disassembly of the fusion protein complex: A combined fluorescence and atomic force microscopy study. Semin Cell Dev Biol. 2018 01; 73:57-63.
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7. Jena BP, Stemmer PM, Wang S, Mao G, Lewis KT, Walz DA. Human Platelet Vesicles Exhibit Distinct Size and Proteome. J Proteome Res. 2017 07 07; 16(7):2333-2338.
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8. Lewis KT, Maddipati KR, Naik AR, Jena BP. Unique Lipid Chemistry of Synaptic Vesicle and Synaptosome Membrane Revealed Using Mass Spectrometry. ACS Chem Neurosci. 2017 06 21; 8(6):1163-1169.
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9. Arachchige MP, Laha SS, Naik AR, Lewis KT, Naik R, Jena BP. Functionalized nanoparticles enable tracking the rapid entry and release of doxorubicin in human pancreatic cancer cells. Micron. 2017 Jan; 92:25-31.
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10. Karmaus AL, Toole CM, Filer DL, Lewis KC, Martin MT. High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells. Toxicol Sci. 2016 Apr; 150(2):323-32.
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11. Naik AR, Kulkarni SP, Lewis KT, Taatjes DJ, Jena BP. Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells. Endocrinology. 2016 Jan; 157(1):54-60.
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12. Naik AR, Lewis KT, Jena BP. The neuronal porosome complex in health and disease. Exp Biol Med (Maywood). 2016 Jan; 241(2):115-30.
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13. Gonzalez D, Melloni C, Poindexter BB, Yogev R, Atz AM, Sullivan JE, Mendley SR, Delmore P, Delinsky A, Zimmerman K, Lewandowski A, Harper B, Lewis KC, Benjamin DK, Cohen-Wolkowiez M. Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots. Bioanalysis. 2015; 7(9):1137-49.
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14. Rajagopal A, Kulkarni S, Lewis KT, Chen X, Maarouf A, Kelly CV, Taatjes DJ, Jena BP. Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function. J Proteomics. 2015 Jan 30; 114:83-92.
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15. Lewis KT, Maddipati KR, Taatjes DJ, Jena BP. Neuronal porosome lipidome. J Cell Mol Med. 2014 Oct; 18(10):1927-37.
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16. Nguyen PC, Lewis KB, Ettinger RA, Schuman JT, Lin JC, Healey JF, Meeks SL, Lollar P, Pratt KP. High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance. Blood. 2014 Apr 24; 123(17):2732-9.
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17. Hou X, Lewis KT, Wu Q, Wang S, Chen X, Flack A, Mao G, Taatjes DJ, Sun F, Jena BP. Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR). J Proteomics. 2014 Jan 16; 96:82-91.
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18. Kovari LC, Brunzelle JS, Lewis KT, Cho WJ, Lee JS, Taatjes DJ, Jena BP. X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release. Micron. 2014 Jan; 56:37-43.
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19. Lewis KB, Hughes RJ, Epstein MS, Josephson NC, Kempton CL, Kessler CM, Key NS, Howard TE, Kruse-Jarres R, Lusher JM, Walsh CE, Watts RG, Ettinger RA, Pratt KP. Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance. PLoS One. 2013; 8(5):e61120.
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20. Watanabe M, Sheriff S, Lewis KB, Cho J, Tinch SL, Balasubramaniam A, Kennedy MA. Metabolic Profiling Comparison of Human Pancreatic Ductal Epithelial Cells and Three Pancreatic Cancer Cell Lines using NMR Based Metabonomics. J Mol Biomark Diagn. 2012 Apr; 3(2).
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21. Maurer MF, Garrigues U, Jaspers SR, Meengs B, Rixon MW, Stevens BL, Lewis KB, Julien SH, Bukowski TR, Wolf AC, Hamacher NB, Snavely M, Dillon SR. Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodies. MAbs. 2012 Jan-Feb; 4(1):69-83.
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22. Watanabe M, Sheriff S, Lewis KB, Tinch SL, Cho J, Balasubramaniam A, Kennedy MA. HMGA-targeted phosphorothioate DNA aptamers increase sensitivity to gemcitabine chemotherapy in human pancreatic cancer cell lines. Cancer Lett. 2012 Feb 01; 315(1):18-27.
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23. Shah C, Antonucci JV, Wilkinson JB, Wallace M, Ghilezan M, Chen P, Lewis K, Mitchell C, Vicini F. Twelve-year clinical outcomes and patterns of failure with accelerated partial breast irradiation versus whole-breast irradiation: results of a matched-pair analysis. Radiother Oncol. 2011 Aug; 100(2):210-4.
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24. Ruiz J, Beadle JR, Buller RM, Schreiwer J, Prichard MN, Keith KA, Lewis KC, Hostetler KY. Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine. Bioorg Med Chem. 2011 May 01; 19(9):2950-8.
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25. Dillon SR, Harder B, Lewis KB, Moore MD, Liu H, Bukowski TR, Hamacher NB, Lantry MM, Maurer M, Krejsa CM, Ellsworth JL, Pederson S, Elkon KB, Wener MH, Dall'Era M, Gross JA. B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin. Arthritis Res Ther. 2010; 12(2):R48.
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26. Mabry R, Lewis KE, Moore M, McKernan PA, Bukowski TR, Bontadelli K, Brender T, Okada S, Lum K, West J, Kuijper JL, Ardourel D, Franke S, Lockwood L, Vu T, Frank A, Appleby MW, Wolf A, Reardon B, Hamacher NB, Stevens B, Lewis P, Lewis KB, Gilbertson DG, Lantry M, Julien SH, Ostrander C, Chan C, Byrnes-Blake K, Brody J, Presnell S, Meengs B, Levin SD, Snavely M. Engineering of stable bispecific antibodies targeting IL-17A and IL-23. Protein Eng Des Sel. 2010 Mar; 23(3):115-27.
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27. Lewis KB, Meengs B, Bondensgaard K, Chin L, Hughes SD, Kjaer B, Lund S, Wang L. Comparison of the ability of wild type and stabilized human IgG(4) to undergo Fab arm exchange with endogenous IgG(4)in vitro and in vivo. Mol Immunol. 2009 Oct; 46(16):3488-94.
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28. Edwards TL, Lewis K, Velez DR, Dudek S, Ritchie MD. Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models. Hum Hered. 2009; 67(3):183-92.
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29. Rich RL, Papalia GA, Flynn PJ, Furneisen J, Quinn J, Klein JS, Katsamba PS, Waddell MB, Scott M, Thompson J, Berlier J, Corry S, Baltzinger M, Zeder-Lutz G, Schoenemann A, Clabbers A, Wieckowski S, Murphy MM, Page P, Ryan TE, Duffner J, Ganguly T, Corbin J, Gautam S, Anderluh G, Bavdek A, Reichmann D, Yadav SP, Hommema E, Pol E, Drake A, Klakamp S, Chapman T, Kernaghan D, Miller K, Schuman J, Lindquist K, Herlihy K, Murphy MB, Bohnsack R, Andrien B, Brandani P, Terwey D, Millican R, Darling RJ, Wang L, Carter Q, Dotzlaf J, Lopez-Sagaseta J, Campbell I, Torreri P, Hoos S, England P, Liu Y, Abdiche Y, Malashock D, Pinkerton A, Wong M, Lafer E, Hinck C, Thompson K, Primo CD, Joyce A, Brooks J, Torta F, Bagge Hagel AB, Krarup J, Pass J, Ferreira M, Shikov S, Mikolajczyk M, Abe Y, Barbato G, Giannetti AM, Krishnamoorthy G, Beusink B, Satpaev D, Tsang T, Fang E, Partridge J, Brohawn S, Horn J, Pritsch O, Obal G, Nilapwar S, Busby B, Gutierrez-Sanchez G, Gupta RD, Canepa S, Witte K, Nikolovska-Coleska Z, Cho YH, D'Agata R, Schlick K, Calvert R, Munoz EM, Hernaiz MJ, Bravman T, Dines M, Yang MH, Puskas A, Boni E, Li J, Wear M, Grinberg A, Baardsnes J, Dolezal O, Gainey M, Anderson H, Peng J, Lewis M, Spies P, Trinh Q, Bibikov S, Raymond J, Yousef M, Chandrasekaran V, Feng Y, Emerick A, Mundodo S, Guimaraes R, McGirr K, Li YJ, Hughes H, Mantz H, Skrabana R, Witmer M, Ballard J, Martin L, Skladal P, Korza G, Laird-Offringa I, Lee CS, Khadir A, Podlaski F, Neuner P, Rothacker J, Rafique A, Dankbar N, Kainz P, Gedig E, Vuyisich M, Boozer C, Ly N, Toews M, Uren A, Kalyuzhniy O, Lewis K, Chomey E, Pak BJ, Myszka DG. A global benchmark study using affinity-based biosensors. Anal Biochem. 2009 Mar 15; 386(2):194-216.
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30. Ellsworth JL, Maurer M, Harder B, Hamacher N, Lantry M, Lewis KB, Rene S, Byrnes-Blake K, Underwood S, Waggie KS, Visich J, Lewis KE. Targeting immune complex-mediated hypersensitivity with recombinant soluble human FcgammaRIA (CD64A). J Immunol. 2008 Jan 01; 180(1):580-9.
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31. Lewis KC, Simpkins JD. An interview with Kenneth C. Lewis, Ph.D., CEO, and Joseph D. Simpkins, Vice President, Software, OpAns (Optimized Analytical Solutions), Durham, NC. Interview by Vicki Glaser. Assay Drug Dev Technol. 2007 Dec; 5(6):695-702.
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32. Donnelly EF, Price RR, Lewis KG, Pickens DR. Polychromatic phase-contrast computed tomography. Med Phys. 2007 Aug; 34(8):3165-8.
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33. Bishop PD, Lewis KB, Schultz J, Walker KM. Comparison of recombinant human thrombin and plasma-derived human alpha-thrombin. Semin Thromb Hemost. 2006 Apr; 32 Suppl 1:86-97.
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34. Donnelly EF, Lewis KG, Wolske KM, Pickens DR, Price RR. Characterization of the phase-contrast radiography edge-enhancement effect in a cabinet x-ray system. Phys Med Biol. 2006 Jan 07; 51(1):21-30.
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35. Lawson WE, Polosukhin VV, Stathopoulos GT, Zoia O, Han W, Lane KB, Li B, Donnelly EF, Holburn GE, Lewis KG, Collins RD, Hull WM, Glasser SW, Whitsett JA, Blackwell TS. Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am J Pathol. 2005 Nov; 167(5):1267-77.
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36. Ponce RA, Visich JE, Heffernan JK, Lewis KB, Pederson S, Lebel E, Andrews-Jones L, Elliott G, Palmer TE, Rogge MC. Preclinical safety and pharmacokinetics of recombinant human factor XIII. Toxicol Pathol. 2005; 33(4):495-506.
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37. Freeman KW, Nolen G, Tyson J, Lewis KD, Greifeld R, Gulati R. How CEOs manage growth agendas. Harv Bus Rev. 2004 Jul-Aug; 82(7-8):124-32, 189.
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38. Lewis KS, Kleper AL. Legal issues confronting the occupational physician. Occup Med. 2002 Oct-Dec; 17(4):625-35.
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39. Jahr JS, Nesargi SB, Lewis K, Johnson C. Blood substitutes and oxygen therapeutics: an overview and current status. Am J Ther. 2002 Sep-Oct; 9(5):437-43.
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Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Microscopy, Atomic Force


  • Synaptosomes


  • Immunoglobulin G


  • Adipocytes


  • Secretory Vesicles


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Keywords   
Microscopy, Atomic Force
Synaptosomes
Immunoglobulin G
Adipocytes
Secretory Vesicles
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Physical Neighbors  
Mandal, Ashis
Halajyan, Galust
Girod, Julian
Anderson, Maxine
Scott, Rosalyn


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