Monica Gabriela Ferrini, PhD
Title Associate Professor
Institution Charles R. Drew University of Medicine and Science
Department Health & Life Sciences
School College of Medicine
Address 1731 E. 120th Street, Hawkins Building


Telephone (323) 563-5962
Fax
Email
Education & Training
Teaching
Publications
1. Nguyen S, Castellanos KA, Abraham A, Ferrini MG. Reduction of oxidative stress markers in the corpora cavernosa and media of penile dorsal artery in middle-aged rats treated with COMP-4. Int J Impot Res. 2020 Jan 31.
  View in: PubMed
 
2. Rajfer RA, Flores M, Abraham A, Garcia E, Hinojosa N, Desai M, Artaza JN, Ferrini MG. Prevention of Osteoporosis in the Ovariectomized Rat by Oral Administration of a Nutraceutical Combination That Stimulates Nitric Oxide Production. J Osteoporos. 2019; 2019:1592328.
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3. Ferrini MG, Abraham A, Nguyen S, Luna R, Flores M, Artaza JN, Graciano L, Rajfer J. Exogenous l-ARGININE does not stimulate production OF NO or cGMP within the rat corporal smooth muscle cells in culture. Nitric Oxide. 2019 08 01; 89:64-70.
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4. Ferrini MG, Garcia E, Abraham A, Artaza JN, Nguyen S, Rajfer J. Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells. Nitric Oxide. 2018 06 01; 76:81-86.
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5. Desai M, Ferrini MG, Han G, Jellyman JK, Ross MG. In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators. Environ Res. 2018 07; 164:45-52.
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6. Braga M, Simmons Z, Norris KC, Ferrini MG, Artaza JN. Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells. Endocr Connect. 2017 Apr; 6(3):139-150.
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7. Ferrini MG, Gonzalez-Cadavid NF, Rajfer J. Aging related erectile dysfunction-potential mechanism to halt or delay its onset. Transl Androl Urol. 2017 Feb; 6(1):20-27.
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8. Ferrini MG, Hlaing SM, Chan A, Artaza JN. Treatment with a combination of ginger, L-citrulline, muira puama and Paullinia cupana can reverse the progression of corporal smooth muscle loss, fibrosis and veno-occlusive dysfunction in the aging rat. Andrology (Los Angel). 2015 Jun; 4(1).
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9. Garcia LA, Hlaing SM, Gutierrez RA, Sanchez MD, Kovanecz I, Artaza JN, Ferrini MG. Sildenafil attenuates inflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damage. Int J Mol Sci. 2014 Sep 26; 15(10):17204-20.
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10. Hlaing SM, Garcia LA, Contreras JR, Norris KC, Ferrini MG, Artaza JN. 1,25-Vitamin D3 promotes cardiac differentiation through modulation of the WNT signaling pathway. J Mol Endocrinol. 2014 Dec; 53(3):303-17.
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11. Nardicchi V, Ferrini M, Pilolli F, Angeli EB, Persichetti E, Beccari T, Mannucci R, Arcuri C, Donato R, Dorman RV, Goracci G. NGF induces the expression of group IIA secretory phospholipase A2 in PC12 cells: the newly synthesized enzyme is addressed to growing neurites. Mol Neurobiol. 2014 Aug; 50(1):15-25.
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12. Ren X, Lutfy K, Mangubat M, Ferrini MG, Lee ML, Liu Y, Friedman TC. Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes. 2013; 2013:764742.
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13. Nie Y, Ferrini MG, Liu Y, Anghel A, Paez Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109.
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14. Garcia LA, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)(2)vitamin D(3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2)C(12) skeletal muscle cells. J Steroid Biochem Mol Biol. 2013 Jan; 133:1-11.
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15. Hlaing SM, Garcia LA, Kovanecz I, Martinez RA, Shah S, Artaza JN, Ferrini MG. Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat. BJU Int. 2013 Jan; 111(1):159-70.
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16. Ferrini MG, Moon J, Rivera S, Rajfer J, Gonzalez-Cadavid NF. Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-ß1 therapies in inducible nitric oxide synthase-deficient mice. BJU Int. 2012 Feb; 109(4):586-93.
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17. Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology. 2011 Aug; 152(8):2976-86.
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18. Sirad F, Hlaing S, Kovanecz I, Artaza JN, Garcia LA, Rajfer J, Ferrini MG. Sildenafil promotes smooth muscle preservation and ameliorates fibrosis through modulation of extracellular matrix and tissue growth factor gene expression after bilateral cavernosal nerve resection in the rat. J Sex Med. 2011 Apr; 8(4):1048-60.
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19. Ferrini MG, Rivera S, Moon J, Vernet D, Rajfer J, Gonzalez-Cadavid NF. The genetic inactivation of inducible nitric oxide synthase (iNOS) intensifies fibrosis and oxidative stress in the penile corpora cavernosa in type 1 diabetes. J Sex Med. 2010 Sep; 7(9):3033-44.
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20. Goracci G, Ferrini M, Nardicchi V. Low molecular weight phospholipases A2 in mammalian brain and neural cells: roles in functions and dysfunctions. Mol Neurobiol. 2010 Jun; 41(2-3):274-89.
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21. Artaza JN, Sirad F, Ferrini MG, Norris KC. 1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells. J Steroid Biochem Mol Biol. 2010 Mar; 119(1-2):73-83.
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22. Ho MH, Heydarkhan S, Vernet D, Kovanecz I, Ferrini MG, Bhatia NN, Gonzalez-Cadavid NF. Stimulating vaginal repair in rats through skeletal muscle-derived stem cells seeded on small intestinal submucosal scaffolds. Obstet Gynecol. 2009 Aug; 114(2 Pt 1):300-9.
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23. Toblli JE, Ferrini MG, Cao G, Vernet D, Angerosa M, Gonzalez-Cadavid NF. Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus. Nephrol Dial Transplant. 2009 Aug; 24(8):2384-91.
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24. Kovanecz I, Nolazco G, Ferrini MG, Toblli JE, Heydarkhan S, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunction. BJU Int. 2009 May; 103(10):1396-404.
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25. Ferrini MG, Kovanecz I, Sanchez S, Umeh C, Rajfer J, Gonzalez-Cadavid NF. Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat. J Sex Med. 2009 Feb; 6(2):415-28.
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26. Cantini LP, Ferrini MG, Vernet D, Magee TR, Qian A, Gelfand RA, Rajfer J, Gonzalez-Cadavid NF. Profibrotic role of myostatin in Peyronie's disease. J Sex Med. 2008 Jul; 5(7):1607-22.
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27. Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL, Gonzalez-Cadavid NF, Sinha-Hikim I. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis. 2008 Jun; 13(6):822-32.
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28. De Nicola AF, Pietranera L, Beauquis J, Ferrini MG, Saravia FE. Steroid protection in aging and age-associated diseases. Exp Gerontol. 2009 Jan-Feb; 44(1-2):34-40.
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29. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, Gonzalez-Cadavid NF. Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int. 2008 May; 101(9):1156-64.
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30. Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF. Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol. 2008 Feb; 196(2):235-49.
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31. Kovanecz I, Rambhatla A, Ferrini MG, Vernet D, Sanchez S, Rajfer J, Gonzalez-Cadavid N. Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection. BJU Int. 2008 Jan; 101(2):203-10.
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32. Nardicchi V, Macchioni L, Ferrini M, Goracci G. The presence of a secretory phospholipase A2 in the nuclei of neuronal and glial cells of rat brain cortex. Biochim Biophys Acta. 2007 Nov; 1771(11):1345-52.
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33. Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Ageing-related corpora veno-occlusive dysfunction in the rat is ameliorated by pioglitazone. BJU Int. 2007 Oct; 100(4):867-74.
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34. Khorram O, Momeni M, Ferrini M, Desai M, Ross MG. In utero undernutrition in rats induces increased vascular smooth muscle content in the offspring. Am J Obstet Gynecol. 2007 May; 196(5):486.e1-8.
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35. Magee TR, Kovanecz I, Davila HH, Ferrini MG, Cantini L, Vernet D, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF. Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. J Sex Med. 2007 May; 4(3):633-643.
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36. Ferrini MG, Nolazco G, Vernet D, Gonzalez-Cadavid NF, Berman J. Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis. Fertil Steril. 2006 Oct; 86(4 Suppl):1152-63.
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37. Magee TR, Artaza JN, Ferrini MG, Vernet D, Zuniga FI, Cantini L, Reisz-Porszasz S, Rajfer J, Gonzalez-Cadavid NF. Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. J Gene Med. 2006 Sep; 8(9):1171-81.
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38. Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86.
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39. Ferrini MG, Davila HH, Kovanecz I, Sanchez SP, Gonzalez-Cadavid NF, Rajfer J. Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat. Urology. 2006 Aug; 68(2):429-35.
  View in: PubMed
 
40. Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus. BJU Int. 2006 Jul; 98(1):116-24.
  View in: PubMed
 
41. Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's disease. BJU Int. 2006 Mar; 97(3):625-33.
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42. De Nicola AF, Saravia FE, Beauquis J, Pietranera L, Ferrini MG. Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function. Front Horm Res. 2006; 35:157-168.
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43. Hikim AP, Vera Y, Vernet D, Castanares M, Diaz-Romero M, Ferrini M, Swerdloff RS, Gonzalez-Cadavid NF, Wang C. Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway rats. J Gerontol A Biol Sci Med Sci. 2005 Jun; 60(6):702-8.
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44. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem. 2004 Jun 11; 279(24):25689-95.
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45. Ferrini MG, Davila HH, Valente EG, Gonzalez-Cadavid NF, Rajfer J. Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media. Cardiovasc Res. 2004 Mar 01; 61(4):796-805.
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46. Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF. L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures. Nitric Oxide. 2003 Dec; 9(4):229-44.
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47. Ferrini MG, Magee TR, Vernet D, Rajfer J, González-Cadavid NF. Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection. J Comp Neurol. 2003 Mar 24; 458(1):46-61.
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48. Vernet D, Ferrini MG, Valente EG, Magee TR, Bou-Gharios G, Rajfer J, Gonzalez-Cadavid NF. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric Oxide. 2002 Dec; 7(4):262-76.
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49. Magee TR, Ferrini M, Garban HJ, Vernet D, Mitani K, Rajfer J, Gonzalez-Cadavid NF. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod. 2002 Sep; 67(3):1033-41.
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50. Magee TR, Ferrini M, Garban HJ, Vernet D, Mitani K, Rajfer J, Gonzalez-Cadavid NF. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod. 2002 Jul; 67(1):20-8.
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51. Ferrini M, Bisagno V, Piroli G, Grillo C, González Deniselle MC, De Nicola AF. Effects of estrogens on choline-acetyltransferase immunoreactivity and GAP-43 mRNA in the forebrain of young and aging male rats. Cell Mol Neurobiol. 2002 Jun; 22(3):289-301.
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52. Wang C, Hikim AS, Ferrini M, Bonavera JJ, Vernet D, Leung A, Lue YH, Gonzalez-Cadavid NF, Swerdloff RS. Male reproductive ageing: using the brown Norway rat as a model for man. Novartis Found Symp. 2002; 242:82-95; discussion 95-7.
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Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Penis


  • Piperazines


  • Animals


  • Fibrosis


  • Phosphodiesterase 5 Inhibitors


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Keyword
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Keywords   
Penis
Piperazines
Animals
Fibrosis
Phosphodiesterase 5 Inhibitors
See all (310) keywords
Co-Authors  
Artaza, Jorge
Friedman, Theodore
Gonzalez-Cadavid, Nestor
Magee, Thomas
Tsao, James
See all (11) people
Physical Neighbors  
Sinha-Hikim, Indrani
Vadgama, Jaydutt
Ghoneum, Mamdooh
Davidson, Mayer
Chaban, Victor


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