Shehla Pervin, PhD
Title Associate Professor
Institution Charles R. Drew University of Medicine and Science
Department Internal Medicine
School College of Medicine
Address 1731 E. 120th Street, Hawkins Building


Telephone (323) 563-9342
Fax
Email
Education & Training
Teaching
NIH Awarded Grants
Publications
1. Singh R, Pervin S, Lee SJ, Kuo A, Grijalva V, David J, Vergnes L, Reddy ST. Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases. Diabetes Metab Syndr Obes. 2018; 11:65-84.
  View in: PubMed
 
2. Pervin S, Singh V, Tucker A, Collazo J, Singh R. Modulation of transforming growth factor-ß/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders. Horm Mol Biol Clin Investig. 2017 Sep 09; 31(2).
  View in: PubMed
 
3. Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S. Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017 05 01; 158(5):1217-1230.
  View in: PubMed
 
4. Howard CB, McDowell R, Feleke K, Deer E, Stamps S, Thames E, Singh V, Pervin S. Chemotherapeutic Vulnerability of Triple-negative Breast Cancer Cell-derived Tumors to Pretreatment with Vernonia amygdalina Aqueous Extracts. Anticancer Res. 2016 Aug; 36(8):3933-43.
  View in: PubMed
 
5. Martinez L, Thames E, Kim J, Chaudhuri G, Singh R, Pervin S. Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis. BMC Cancer. 2016 07 29; 16:559.
  View in: PubMed
 
6. Howard CB, Johnson WK, Pervin S, Izevbigie EB. Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina. Botanics. 2015; 5:65-76.
  View in: PubMed
 
7. Singh R, Parveen M, Basgen JM, Fazel S, Meshesha MF, Thames EC, Moore B, Martinez L, Howard CB, Vergnes L, Reue K, Pervin S. Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res. 2016 Jan; 14(1):78-92.
  View in: PubMed
 
8. Singh R, Braga M, Pervin S. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling. Front Cell Dev Biol. 2014; 2:60.
  View in: PubMed
 
9. Braga M, Reddy ST, Vergnes L, Pervin S, Grijalva V, Stout D, David J, Li X, Tomasian V, Reid CB, Norris KC, Devaskar SU, Reue K, Singh R. Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res. 2014 Mar; 55(3):375-84.
  View in: PubMed
 
10. Singh R, Avliyakulov NK, Braga M, Haykinson MJ, Martinez L, Singh V, Parveen M, Chaudhuri G, Pervin S. Proteomic identification of mitochondrial targets of arginase in human breast cancer. PLoS One. 2013; 8(11):e79242.
  View in: PubMed
 
11. Braga M, Pervin S, Norris K, Bhasin S, Singh R. Inhibition of in vitro and in vivo brown fat differentiation program by myostatin. Obesity (Silver Spring). 2013 Jun; 21(6):1180-8.
  View in: PubMed
 
12. Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, Chaudhuri G, Norris K, Singh R. Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy. PLoS One. 2013; 8(1):e53287.
  View in: PubMed
 
13. Braga M, Bhasin S, Jasuja R, Pervin S, Singh R. Testosterone inhibits transforming growth factor-ß signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Mol Cell Endocrinol. 2012 Mar 05; 350(1):39-52.
  View in: PubMed
 
14. Pervin S, Chaudhuri G, Singh R. NO to breast: when, why and why not? Curr Pharm Des. 2010; 16(4):451-62.
  View in: PubMed
 
15. Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15; 22(22):3121-34.
  View in: PubMed
 
16. Singh R, Bhasin S, Braga M, Artaza JN, Pervin S, Taylor WE, Krishnan V, Sinha SK, Rajavashisth TB, Jasuja R. Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology. 2009 Mar; 150(3):1259-68.
  View in: PubMed
 
17. Pervin S, Tran AH, Zekavati S, Fukuto JM, Singh R, Chaudhuri G. Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis. Cancer Res. 2008 Jun 15; 68(12):4862-74.
  View in: PubMed
 
18. Pervin S, Singh R, Chaudhuri G. Nitric oxide, N omega-hydroxy-L-arginine and breast cancer. Nitric Oxide. 2008 Sep; 19(2):103-6.
  View in: PubMed
 
19. Pervin S, Singh R, Hernandez E, Wu G, Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 2007 Jan 01; 67(1):289-99.
  View in: PubMed
 
20. Pervin S, Singh R, Freije WA, Chaudhuri G. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer Res. 2003 Dec 15; 63(24):8853-60.
  View in: PubMed
 
21. Pervin S, Singh R, Chaudhuri G. Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt. Cancer Res. 2003 Sep 01; 63(17):5470-9.
  View in: PubMed
 
22. Singh R, Pervin S, Chaudhuri G. Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-L-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine. J Biol Chem. 2002 Oct 04; 277(40):37630-6.
  View in: PubMed
 
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Breast Neoplasms


  • Nitric Oxide


  • Adipose Tissue, Brown


  • Follistatin


  • Apoptosis


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Keyword
Last Name
Institution
Department
School
    
 
 
 
Keywords   
Breast Neoplasms
Nitric Oxide
Adipose Tissue, Brown
Follistatin
Apoptosis
See all (191) keywords
Co-Authors  
Artaza, Jorge
Basgen, John
Rajavashisth, Tripathi
Singh, Rajan
Sinha, Satyesh
See all (5) people
Physical Neighbors  
Basgen, John
Ghoneum, Mamdooh
Gonzalez-Cadavid, Nestor
Singh, Rajan
Rajavashisth, Tripathi


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