Tripathi B. Rajavashisth, PhD
Title Professor
Institution Charles R. Drew University of Medicine and Science
Department Internal Medicine
School College of Medicine
Address 1731 E. 120th Street, Hawkins Building


Telephone (323) 563-4898
Fax
Email
Overview
Our seminal research work on linking inflammatory pathways to lipid dysfunctions to the genesis and progression of vascular pathologies is globally recognized. We importantly contributed to research findings revealing aspects of lineage commitment of stem cells to differentiated mononuclear phagocytic lineage cells and their pathological migration, growth and survival inside the vessel wall. The current research in our laboratory combines biochemical, molecular and genetic approaches to study the role of pro-inflammatory molecules in the development and disruption of atherosclerotic plaques. We are also experimenting on therapeutic approaches to inhibit the development of arterial lesions in animal models. Additionally, our laboratory is involved in studies using a variety of novel interventional approaches to favorably modify inflammatory cell signaling pathways. These studies have resulted in US and international patent applications. The titles of individual research project in my laboratory are as follows: a) M-CSF isoforms in atherosclerosis; b) Role of M-CSF in the pathogenesis of atherosclerosis: the next phase; c) M-CSF inhibition for prevention of atherosclerosis and restenosis; d) Mechanisms of calcification in atherosclerotic plaque; and e) Medicinal effects of Cannabis on inflammatory syndromes. In our research on medicinal effects of Cannabis in collaboration with Omics Biotechnology, Inc, we have observed that low to moderate doses of Cannabis have beneficial effects on diabetes mellitus(DM) and other conditions that ultimately precipitate in some form of CVD in South Asian Indian human populations. Recently, using the NHANES III database on Cannabis use, we have observed a similar decreased prevalence of DM in Cannabis users. These results have led us to systematically perform animal experimentation. Though many sources of genomic information exist on the World Wide Web, a source of concise cardio-neurovascular information in general and on minorities in particular does not currently exist. To provide this information, we have initiated the development of the Cardio-NeuroVascular-database (Canvas) to study the functional genome of diverse cardiovascular and neurovascular pathologies. Canvas provides information on potential candidate genes for mutational analysis, genes for custom microarray analysis, and information for additional research and clinical interests. The format of the database allows continuous updates as additional information becomes available. Canvas provides an invaluable service to those interested in obtaining information on cardiovascular and neurovascular genes and diseases to explore hypotheses that may provide new insights into specific polymorphisms and haplotype variants linked to clinical outcomes and found preferentially in minority populations.
Education & Training
Teaching
NIH Awarded Grants
Project TitleProject NumberFY
CCHD DEVELOPMENT CORE: CHRONIC KIDNEY DISEASE3U54RR019234-05S22009
CCHD DEVELOPMENT CORE: CHRONIC KIDNEY DISEASE3U54RR019234-05S12008
CCHD DEVELOPMENT CORE: CHRONIC KIDNEY DISEASE5U54RR019234-052007
Publications
1. Sinha SK, Nicholas SB, Sung JH, Correa A, Rajavashisth TB, Norris KC, Lee JE. hs-CRP Is Associated With Incident Diabetic Nephropathy: Findings From the Jackson Heart Study. Diabetes Care. 2019 Nov; 42(11):2083-2089.
  View in: PubMed
 
2. Mishra V, Sinha SK, Rajavashisth TB. Role of macrophage colony-stimulating factor in the development of neointimal thickening following arterial injury. Cardiovasc Pathol. 2016 Jul-Aug; 25(4):284-292.
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3. Qiao JH, Mishra V, Fishbein MC, Sinha SK, Rajavashisth TB. Multinucleated giant cells in atherosclerotic plaques of human carotid arteries: Identification of osteoclast-like cells and their specific proteins in artery wall. Exp Mol Pathol. 2015 Dec; 99(3):654-62.
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4. Sinha SK, Mishra V, Nagwani S, Rajavashisth TB. Effects of G-CSF on serum cholesterol and development of atherosclerotic plaque in apolipoprotein E-deficient mice. Int J Clin Exp Med. 2014; 7(8):1979-89.
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5. Sinha SK, Shaheen M, Rajavashisth TB, Pan D, Norris KC, Nicholas SB. Association of race/ethnicity, inflammation, and albuminuria in patients with diabetes and early chronic kidney disease. Diabetes Care. 2014 Apr; 37(4):1060-8.
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6. Sinha SK, Asotra K, Uzui H, Nagwani S, Mishra V, Rajavashisth TB. Nuclear localization of catalytically active MMP-2 in endothelial cells and neurons. Am J Transl Res. 2014; 6(2):155-62.
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7. Rajavashisth TB, Shaheen M, Norris KC, Pan D, Sinha SK, Ortega J, Friedman TC. Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. BMJ Open. 2012; 2:e000494.
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8. Uzui H, Sinha SK, Rajavashisth TB. 17ß-estradiol inhibits oxidized low-density lipoprotein-induced increase in matrix metalloproteinase-9 expression in human macrophages. J Investig Med. 2011 Oct; 59(7):1104-8.
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9. Sinha-Hikim I, Sinha-Hikim AP, Shen R, Kim HJ, Kim H, French SW, Vaziri ND, Vaziri ND, Crum AC, Crum A, Rajavashisth TB, Norris KC. A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol. 2011 Aug; 91(1):419-28.
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10. Singh R, Bhasin S, Braga M, Artaza JN, Pervin S, Taylor WE, Krishnan V, Sinha SK, Rajavashisth TB, Jasuja R. Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology. 2009 Mar; 150(3):1259-68.
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11. Qiao JH, Doherty TM, Fishbein MC, Salusky IB, Luthringer DL, Fitzpatrick LA, Shah PK, Rajavashisth TB. Calcification of the coronary arteries in the absence of atherosclerotic plaque. Mayo Clin Proc. 2005 Jun; 80(6):807-9.
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12. Neyer J, Espinoza C, Luppen L, Dohety TM, Tripathi SC, Uzui H, Tripathi PV, Lee G, Shah PK, Rajavashisth TB. A comparison of anion-exchange and steric-exclusion HPLC assays of mouse plasma lipoproteins. J Lipid Res. 2005 Aug; 46(8):1786-95.
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13. Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, Fishbein MC, Detrano RC, Shah PK, Rajavashisth TB. Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev. 2004 Aug; 25(4):629-72.
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14. Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10679-84.
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15. Doherty TM, Fitzpatrick LA, Shaheen A, Rajavashisth TB, Detrano RC. Genetic determinants of arterial calcification associated with atherosclerosis. Mayo Clin Proc. 2004 Feb; 79(2):197-210.
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16. Finkelstein A, Hausleiter J, Doherty T, Takizawa K, Bergman J, Liu M, Rukshin V, Fishbein M, Eigler N, Shah P, Rajavashisth T, Makkar R. Intracoronary beta-irradiation enhances balloon-injury-induced tissue factor expression in the porcine injury model. Int J Cardiovasc Intervent. 2004; 6(1):20-7.
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17. Doherty TM, Asotra K, Fitzpatrick LA, Qiao JH, Wilkin DJ, Detrano RC, Dunstan CR, Shah PK, Rajavashisth TB. Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11201-6.
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18. Doherty TM, Shah PK, Rajavashisth TB. Cellular origins of atherosclerosis: towards ontogenetic endgame? FASEB J. 2003 Apr; 17(6):592-7.
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19. Uzui H, Harpf A, Liu M, Doherty TM, Shukla A, Chai NN, Tripathi PV, Jovinge S, Wilkin DJ, Asotra K, Shah PK, Rajavashisth TB. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines. Circulation. 2002 Dec 10; 106(24):3024-30.
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20. Finkelstein A, Makkar R, Doherty TM, Vegesna VR, Tripathi P, Liu M, Bergman J, Fishbein M, Hausleiter J, Takizawa K, Rukshin V, Shah PK, Rajavashisth TB. Increased expression of macrophage colony-stimulating factor after coronary artery balloon injury is inhibited by intracoronary brachytherapy. Circulation. 2002 May 21; 105(20):2411-5.
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21. Doherty TM, Uzui H, Fitzpatrick LA, Tripathi PV, Dunstan CR, Asotra K, Rajavashisth TB. Rationale for the role of osteoclast-like cells in arterial calcification. FASEB J. 2002 Apr; 16(6):577-82.
  View in: PubMed
 
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Calcinosis


  • Arteriosclerosis


  • Macrophage Colony-Stimulating Factor


  • Osteoclasts


  • Plaque, Atherosclerotic


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Co-Authors  
Pan, Deyu
Shaheen, Magda
Singh, Rajan
Sinha, Satyesh
Sinha-Hikim, Indrani
See all (9) people
Physical Neighbors  
Vadgama, Jaydutt
Ghoneum, Mamdooh
Davidson, Mayer
Singh, Rajan
Friedman, Theodore


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