Victor V. Chaban, PhD
Title Professor
Institution Charles R. Drew University of Medicine and Science
Department Health & Life Sciences
School College of Science and Health
Address 1731 E. 120th Street, Hawkins Building


Telephone (323) 568-3350
Fax
Email
Overview
The primary focus of my research program is to elucidate the nociceptive pathways modulated by steroid hormones in nervous tissue. While a central site of this modulation has been widely accepted, I have continued to investigate how sex steroids act on primary nociceptors and modulate the response to pro- and anti-nociceptive signals, depending upon the nature of the signals interacting at the level of sensory neurons. Nociceptive systems are implicated in the etiology of functional disorders such as non- cardiac chest pain, interstitial cystitis, fibromyalgia, acute or chronic abdominal pain associated with functional bowel disorders, chronic pelvic pain. Incidence of episodic or persistent visceral pain associated with functional disorders is much higher in women than men; therefore, we have proposed a novel concept that suggests sex steroids may play a role in modulating peripheral cross-sensitization between different visceral organs. Our studies may provide important information about the actions of sex steroids on primary sensory neurons or a better understanding of gender differences observed in the clinical presentation of functional pain-associated disorders. Dr. Chaban received Wood-Whellan Award from International Union of Biochemistry and Molecular Biology and Fellowships from International Science Foundation, European Science Foundation and UNESCO. He also received 2008 President's Award for Excellence in Service to Charles R. Drew University of Medicine and Science and 2009 and 2015 CDU Life Sciences Institute Awards. In 2014 he received Special Recognition Award for Chairing 2nd International Conference on Endocrinology in Chicago. Currently he is Executive Editor of Journal of Autacoids and Hormones and Editor In Chief of International Journal of Research in Nursing http://thescipub.com/journals/ijrn/editors
Education & Training
Teaching
Publications
1. Chaban V. Visceral pain modulation in female primary afferent sensory neurons. Curr Trends Neurol. 2015; 9:111-114.
  View in: PubMed
 
2. Chaban VV. Visceral Pain: Basic Research Concepts and Therapeutic Interventions. Int J Res Nurs. 2015; 6(2):27-28.
  View in: PubMed
 
3. Chaban VV, Cho T, Reid CB, Norris KC. Physically disconnected non-diffusible cell-to-cell communication between neuroblastoma SH-SY5Y and DRG primary sensory neurons. Am J Transl Res. 2013; 5(1):69-79.
  View in: PubMed
 
4. Chaban V. Estrogen modulation of visceral nociceptors. Curr Trends Neurol. 2013; 7:51-55.
  View in: PubMed
 
5. Cho T, Chaban VV. Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-a and estrogen receptor-ß knockout mice. Neuroreport. 2012 Jun 20; 23(9):530-4.
  View in: PubMed
 
6. Chaban V. Estrogen and Visceral Nociception at the Level of Primary Sensory Neurons. Pain Res Treat. 2012 Jan 01; 2012(2012).
  View in: PubMed
 
7. Chaban V, Li J, McDonald JS, Rapkin A, Micevych P. Estradiol attenuates the adenosine triphosphate-induced increase of intracellular calcium through group II metabotropic glutamate receptors in rat dorsal root ganglion neurons. J Neurosci Res. 2011 Nov; 89(11):1707-10.
  View in: PubMed
 
8. Chaban VV. Peripheral sensitization of sensory neurons. Ethn Dis. 2010; 20(1 Suppl 1):S1-3-6.
  View in: PubMed
 
9. Li J, Micevych P, McDonald J, Rapkin A, Chaban V. Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res. 2008 Sep; 86(12):2746-52.
  View in: PubMed
 
10. Chaban VV. Visceral sensory neurons that innervate both uterus and colon express nociceptive TRPv1 and P2X3 receptors in rats. Ethn Dis. 2008; 18(2 Suppl 2):S2-20-4.
  View in: PubMed
 
11. Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, McDonald J, Micevych P. The same dorsal root ganglion neurons innervate uterus and colon in the rat. Neuroreport. 2007 Feb 12; 18(3):209-12.
  View in: PubMed
 
12. Micevych PE, Chaban V, Ogi J, Dewing P, Lu JK, Sinchak K. Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures. Endocrinology. 2007 Feb; 148(2):782-9.
  View in: PubMed
 
13. Chaban VV, Micevych PE. Estrogen receptor-alpha mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons. J Neurosci Res. 2005 Jul 01; 81(1):31-7.
  View in: PubMed
 
14. Chaban VV, Lakhter AJ, Micevych P. A membrane estrogen receptor mediates intracellular calcium release in astrocytes. Endocrinology. 2004 Aug; 145(8):3788-95.
  View in: PubMed
 
15. Micevych P, Chaban V, Quesada A, Sinchak K. Oestrogen modulates cholecystokinin: opioid interactions in the nervous system. Pharmacol Toxicol. 2002 Dec; 91(6):387-97.
  View in: PubMed
 
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Ganglia, Spinal


  • Neurons


  • Uterus


  • Colon


  • Sensory Receptor Cells


Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile:
 
Keyword
Last Name
Institution
Department
School
    
 
 
 
Keywords   
Ganglia, Spinal
Neurons
Uterus
Colon
Sensory Receptor Cells
See all (66) keywords
Physical Neighbors  
Basgen, John
Davidson, Mayer
Sinha, Satyesh
Pervin, Shehla
Friedman, Theodore


© Charles Drew University of Medicine And Science - Accelerating Excellence In Translational Science (AXIS), All rights reserved.