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Yanyuan Wu, MD

TitleAssociate Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-9389
FaxNot Available
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    Overview
    overview
    I am interested in understanding the molecular pathology of breast cancer and its treatment using targeted therapy in underserved populations. My current research has been focused on studying the oncogenic role of Akt and the transcription factors, Snail and Slug in HER2/neu over-expressing breast tumors.

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dutta P, Keung MY, Wu Y, Vadgama JV. Genetic variants in African-American and Hispanic patients with breast cancer. Oncol Lett. 2023 Feb; 25(2):51. PMID: 36644153; PMCID: PMC9811638.
      Citations:    
    2. Hao Q, Wu Y, Vadgama JV, Wang P. Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies. Biomolecules. 2022 09 16; 12(9). PMID: 36139145; PMCID: PMC9496067.
      Citations:    Fields:    Translation:Humans
    3. Yang S, Jackson C, Karapetyan E, Dutta P, Kermah D, Wu Y, Wu Y, Schloss J, Vadgama JV. Roles of Protein Disulfide Isomerase in Breast Cancer. Cancers (Basel). 2022 Jan 31; 14(3). PMID: 35159012; PMCID: PMC8833603.
      Citations: 2     
    4. Hao Q, Wu Y, Wu Y, Wang P, Vadgama JV. Tumor-Derived Exosomes in Tumor-Induced Immune Suppression. Int J Mol Sci. 2022 Jan 27; 23(3). PMID: 35163380; PMCID: PMC8836190.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    5. Wu Y, Dutta P, Clayton S, McCloud A, Vadgama JV. Elevated Baseline Serum PD-L1 Level May Predict Poor Outcomes from Breast Cancer in African-American and Hispanic Women. J Clin Med. 2022 Jan 06; 11(2). PMID: 35053979; PMCID: PMC8779890.
      Citations:    
    6. Wu Y, Sarkissyan M, Ogah O, Kim J, Vadgama JV. Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers. Cancers (Basel). 2020 Jul 16; 12(7). PMID: 32708561; PMCID: PMC7409266.
      Citations: 10     
    7. Dutta P, Paico K, Gomez G, Wu Y, Vadgama JV. Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. Cancers (Basel). 2020 May 21; 12(5). PMID: 32455851; PMCID: PMC7281677.
      Citations: 7     
    8. Keung MY, Wu Y, Badar F, Vadgama JV. Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status. J Clin Med. 2020 Mar 30; 9(4). PMID: 32235451; PMCID: PMC7231148.
      Citations: 35     
    9. Keung MYT, Wu Y, Vadgama JV. PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers. J Clin Med. 2019 Mar 30; 8(4). PMID: 30934991; PMCID: PMC6517993.
      Citations: 56     
    10. Nava M, Dutta P, Farias-Eisner R, Vadgama JV, Wu Y. Utilization of NGS technologies to investigate transcriptomic and epigenomic mechanisms in trastuzumab resistance. Sci Rep. 2019 03 26; 9(1):5141. PMID: 30914750; PMCID: PMC6435657.
      Citations: 4     Fields:    Translation:HumansCells
    11. Nava M, Dutta P, Zemke NR, Farias-Eisner R, Vadgama JV, Wu Y. Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. BMC Med Genomics. 2019 02 08; 12(1):32. PMID: 30736768; PMCID: PMC6368760.
      Citations: 4     Fields:    Translation:HumansCells
    12. Dutta P, Sarkissyan M, Paico K, Wu Y, Vadgama JV. MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis. Breast Cancer Res Treat. 2018 Aug; 170(3):477-486. PMID: 29594759; PMCID: PMC6022526.
      Citations: 45     Fields:    Translation:HumansCells
    13. Wu Y, Sarkissyan M, Clayton S, Chlebowski R, Vadgama JV. Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women. Cancers (Basel). 2017 Oct 24; 9(10). PMID: 29064397; PMCID: PMC5664083.
      Citations: 14     
    14. Bhat K, Sarkissyan M, Wu Y, Vadgama JV. GROa overexpression drives cell migration and invasion in triple negative breast cancer cells. Oncol Rep. 2017 Jul; 38(1):21-30. PMID: 28560447; PMCID: PMC5492847.
      Citations: 14     Fields:    Translation:HumansCells
    15. Wu Y, Tran T, Dwabe S, Sarkissyan M, Kim J, Nava M, Clayton S, Pietras R, Farias-Eisner R, Vadgama JV. A83-01 inhibits TGF-ß-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res Treat. 2017 Jun; 163(3):449-460. PMID: 28337662; PMCID: PMC5427117.
      Citations: 22     Fields:    Translation:HumansCells
    16. Wu Y, Sarkissyan M, Vadgama JV. Epithelial-Mesenchymal Transition and Breast Cancer. J Clin Med. 2016 Jan 26; 5(2). PMID: 26821054; PMCID: PMC4773769.
      Citations: 70     
    17. Li Y, Wu Y, Abbatiello TC, Wu WL, Kim JR, Sarkissyan M, Sarkissyan S, Chung SS, Elshimali Y, Vadgama JV. Slug contributes to cancer progression by direct regulation of ERa signaling pathway. Int J Oncol. 2015 Apr; 46(4):1461-72. PMID: 25652255; PMCID: PMC4356499.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    18. Wu Y, Sarkissyan M, Vadgama JV. Epigenetics in breast and prostate cancer. Methods Mol Biol. 2015; 1238:425-66. PMID: 25421674; PMCID: PMC4364390.
      Citations: 36     Fields:    Translation:HumansAnimals
    19. Wang P, Wang B, Chung S, Wu Y, Henning SM, Vadgama JV. Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. RSC Adv. 2014 Aug 05; 4(66):35242-35250. PMID: 25243063; PMCID: PMC4166488.
      Citations: 26     
    20. Sarkissyan S, Sarkissyan M, Wu Y, Cardenas J, Koeffler HP, Vadgama JV. IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. PLoS One. 2014; 9(7):e103534. PMID: 25062088; PMCID: PMC4111618.
      Citations: 26     Fields:    Translation:AnimalsCells
    21. Sarkissyan M, Wu Y, Chen Z, Mishra DK, Sarkissyan S, Giannikopoulos I, Vadgama JV. Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants. Cancer. 2014 May 01; 120(9):1387-93. PMID: 24510435; PMCID: PMC3999299.
      Citations: 21     Fields:    Translation:Humans
    22. Chung SS, Giehl N, Wu Y, Vadgama JV. STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits. Int J Oncol. 2014 Feb; 44(2):403-11. PMID: 24297508; PMCID: PMC3898805.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    23. Wu Y, Sarkissyan M, Elshimali Y, Vadgama JV. Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN. PLoS One. 2013; 8(10):e78259. PMID: 24167614; PMCID: PMC3805609.
      Citations: 35     Fields:    Translation:HumansCTClinical Trials
    24. Mishra DK, Wu Y, Sarkissyan M, Sarkissyan S, Chen Z, Shang X, Ong M, Heber D, Koeffler HP, Vadgama JV. Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. PLoS One. 2013; 8(3):e57967. PMID: 23554871; PMCID: PMC3595235.
      Citations: 34     Fields:    Translation:HumansCTClinical Trials
    25. Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D, Vadgama JV. Expression of Wnt3 activates Wnt/ß-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol Cancer Res. 2012 Dec; 10(12):1597-606. PMID: 23071104; PMCID: PMC3732195.
      Citations: 114     Fields:    Translation:HumansCells
    26. Wu Y, Shang X, Sarkissyan M, Slamon D, Vadgama JV. FOXO1A is a target for HER2-overexpressing breast tumors. Cancer Res. 2010 Jul 01; 70(13):5475-85. PMID: 20551062; PMCID: PMC2896450.
      Citations: 27     Fields:    Translation:HumansCells
    27. Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, Vadgama JV. Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Res. 2008; 10(1):R3. PMID: 18184439; PMCID: PMC2374954.
      Citations: 30     Fields:    Translation:Humans
    28. Wu Y, Shen D, Chen Z, Clayton S, Vadgama JV. Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis. 2007 Mar; 12(3):593-612. PMID: 17195090.
      Citations: 8     Fields:    Translation:HumansCells
    29. Vadgama JV, Scuric Z, Chakrabarti R, Marzo E, Shen D, Wu Y. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Int J Mol Med. 2006 Jul; 18(1):129-39. PMID: 16786164.
      Citations: 6     Fields:    Translation:HumansCells
    30. Wu Y, Saldana L, Chillar R, Vadgama JV. Plasma vascular endothelial growth factor is useful in assessing progression of breast cancer post surgery and during adjuvant treatment. Int J Oncol. 2002 Mar; 20(3):509-16. PMID: 11836562.
      Citations: 5     Fields:    Translation:Humans
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