Fawzia Bardag gorce, PhD
Title Associate Professor
Institution Charles R. Drew University of Medicine and Science
Department Health & Life Sciences
School College of Science and Health
Address 1731 E. 120th Street


Telephone
Fax
Email
Education & Training
Teaching
NIH Awarded Grants
Project TitleProject NumberFY
Publications
1. Oliva J, Bardag-Gorce F, Niihara Y. Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells. Int J Mol Sci. 2020 Jan 09; 21(2).
  View in: PubMed
 
2. Oliva J, Florentino A, Bardag-Gorce F, Niihara Y. Vitrification and storage of oral mucosa epithelial cell sheets. J Tissue Eng Regen Med. 2019 07; 13(7):1153-1163.
  View in: PubMed
 
3. Oliva J, Florentino A, Bardag-Gorce F, Niihara Y. Engineering, differentiation and harvesting of human adipose-derived stem cell multilayer cell sheets. Regen Med. 2019 03; 14(3):151-163.
  View in: PubMed
 
4. Bardag-Gorce F, Makalinao A, Meepe I, Hoft RH, Cortez D, Oliva J, Laporte A, Stark J, Gorce A, Di Lorenzo M, French SW, Lungo W, Niihara Y. Corneal keratin aggresome (CKAGG) formation and clearance by proteasome activation. Heliyon. 2018 Dec; 4(12):e01012.
  View in: PubMed
 
5. Oliva J, Ochiai K, Florentino A, Bardag-Gorce F, Wood A, Niihara Y. Feeder Cells Free Rabbit Oral Mucosa Epithelial Cell Sheet Engineering. Tissue Eng Regen Med. 2018 Jun; 15(3):321-332.
  View in: PubMed
 
6. Bardag-Gorce F, Hoft R, Meepe I, Garcia J, Tiger K, Wood A, Laporte A, Pan D, Makalinao A, Niihara R, Oliva J, Florentino A, Gorce AM, Stark J, Cortez D, French SW, Niihara Y. Proteasomes in corneal epithelial cells and cultured autologous oral mucosal epithelial cell sheet (CAOMECS) graft used for the ocular surface regeneration. Ocul Surf. 2017 10; 15(4):749-758.
  View in: PubMed
 
7. Bardag-Gorce F, Hoft RH, Wood A, Oliva J, Niihara H, Makalinao A, Thropay J, Pan D, Meepe I, Tiger K, Garcia J, Laporte A, French SW, Niihara Y. The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem Deficiency. J Ophthalmol. 2016; 2016:4805986.
  View in: PubMed
 
8. Bardag-Gorce F, Oliva J, Wood A, Hoft R, Pan D, Thropay J, Makalinao A, French SW, Niihara Y. Carrier-free cultured autologous oral mucosa epithelial cell sheet (CAOMECS) for corneal epithelium reconstruction: a histological study. Ocul Surf. 2015 Apr; 13(2):150-63.
  View in: PubMed
 
9. Bejaoui M, Zaouali MA, Folch-Puy E, Pantazi E, Bardag-Gorce F, Carbonell T, Oliva J, Rimola A, Abdennebi HB, Roselló-Catafau J. Bortezomib enhances fatty liver preservation in Institut George Lopez-1 solution through adenosine monophosphate activated protein kinase and Akt/mTOR pathways. J Pharm Pharmacol. 2014 Jan; 66(1):62-72.
  View in: PubMed
 
10. Zaouali MA, Bardag-Gorce F, Carbonell T, Oliva J, Pantazi E, Bejaoui M, Ben Abdennebi H, Rimola A, Roselló-Catafau J. Proteasome inhibitors protect the steatotic and non-steatotic liver graft against cold ischemia reperfusion injury. Exp Mol Pathol. 2013 Apr; 94(2):352-9.
  View in: PubMed
 
11. Kharbanda KK, Bardag-Gorce F, Barve S, Molina PE, Osna NA. Impact of altered methylation in cytokine signaling and proteasome function in alcohol and viral-mediated diseases. Alcohol Clin Exp Res. 2013 Jan; 37(1):1-7.
  View in: PubMed
 
12. Osna NA, Bardag-Gorce F, White RL, Weinman SA, Donohue TM, Kharbanda KK. Ethanol and hepatitis C virus suppress peptide-MHC class I presentation in hepatocytes by altering proteasome function. Alcohol Clin Exp Res. 2012 Dec; 36(12):2028-35.
  View in: PubMed
 
13. Padrissa-Altés S, Zaouali MA, Boncompagni E, Bonaccorsi-Riani E, Carbonell T, Bardag-Gorce F, Oliva J, French SW, Bartrons R, Roselló-Catafau J. The use of a reversible proteasome inhibitor in a model of Reduced-Size Orthotopic Liver transplantation in rats. Exp Mol Pathol. 2012 Aug; 93(1):99-110.
  View in: PubMed
 
14. Oliva J, French SW, Li J, Bardag-Gorce F. Proteasome inhibitor treatment reduced fatty acid, triacylglycerol and cholesterol synthesis. Exp Mol Pathol. 2012 Aug; 93(1):26-34.
  View in: PubMed
 
15. Bardag-Gorce F. Proteasome inhibitor treatment in alcoholic liver disease. World J Gastroenterol. 2011 May 28; 17(20):2558-62.
  View in: PubMed
 
16. Bardag-Gorce F, French SW. Delta-aminolevulinic dehydratase is a proteasome interacting protein. Exp Mol Pathol. 2011 Oct; 91(2):485-9.
  View in: PubMed
 
17. Oliva J, Bardag-Gorce F, Tillman B, French SW. Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro. Exp Mol Pathol. 2011 Jun; 90(3):295-9.
  View in: PubMed
 
18. Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Hum Mol Genet. 2011 May 01; 20(9):1820-33.
  View in: PubMed
 
19. Oliva J, Bardag-Gorce F, Li J, French BA, French SW. S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. Exp Mol Pathol. 2011 Jun; 90(3):239-43.
  View in: PubMed
 
20. Bardag-Gorce F, Oliva J, Lin A, Li J, French BA, French SW. Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. Exp Mol Pathol. 2011 Feb; 90(1):123-30.
  View in: PubMed
 
21. Bardag-Gorce F, Oliva J, Wong W, Fong S, Li J, French BA, French SW. S-adenosylmethionine decreases the peak blood alcohol levels 3 h after an acute bolus of ethanol by inducing alcohol metabolizing enzymes in the liver. Exp Mol Pathol. 2010 Dec; 89(3):217-21.
  View in: PubMed
 
22. French SW, Bardag-Gorce F, Li J, French BA, Oliva J. Mallory-Denk body pathogenesis revisited. World J Hepatol. 2010 Aug 27; 2(8):295-301.
  View in: PubMed
 
23. Oliva J, Bardag-Gorce F, French BA, Li J, French SW. Independent phenotype of binuclear hepatocytes and cellular localization of UbD. Exp Mol Pathol. 2010 Oct; 89(2):103-8.
  View in: PubMed
 
24. Tomasi ML, Ramani K, Lopitz-Otsoa F, Rodríguez MS, Li TW, Ko K, Yang H, Bardag-Gorce F, Iglesias-Ara A, Feo F, Pascale MR, Mato JM, Lu SC. S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes. Hepatology. 2010 Jun; 51(6):2152-61.
  View in: PubMed
 
25. Oliva J, Bardag-Gorce F, Lin A, French BA, French SW. The role of cytokines in UbD promoter regulation and Mallory-Denk body-like aggresomes. Exp Mol Pathol. 2010 Aug; 89(1):1-8.
  View in: PubMed
 
26. French SW, Oliva J, French BA, Li J, Bardag-Gorce F. Alcohol, nutrition and liver cancer: role of Toll-like receptor signaling. World J Gastroenterol. 2010 Mar 21; 16(11):1344-8.
  View in: PubMed
 
27. Bardag-Gorce F. Effects of ethanol on the proteasome interacting proteins. World J Gastroenterol. 2010 Mar 21; 16(11):1349-57.
  View in: PubMed
 
28. Bardag-Gorce F, Oliva J, Li J, French BA, French SW. SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model. Exp Mol Pathol. 2010 Jun; 88(3):353-62.
  View in: PubMed
 
29. Bardag-Gorce F, Oliva J, Lin A, Li J, French BA, French SW. SAMe prevents the up regulation of toll-like receptor signaling in Mallory-Denk body forming hepatocytes. Exp Mol Pathol. 2010 Jun; 88(3):376-9.
  View in: PubMed
 
30. Li J, Bardag-Gorce F, Oliva J, Dedes J, French BA, French SW. Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changes. Genes Nutr. 2010 Jun; 5(2):169-79.
  View in: PubMed
 
31. Bousquet-Dubouch MP, Nguen S, Bouyssié D, Burlet-Schiltz O, French SW, Monsarrat B, Bardag-Gorce F. Chronic ethanol feeding affects proteasome-interacting proteins. Proteomics. 2009 Jul; 9(13):3609-22.
  View in: PubMed
 
32. Oliva J, Bardag-Gorce F, French BA, Li J, French SW. The regulation of non-coding RNA expression in the liver of mice fed DDC. Exp Mol Pathol. 2009 Aug; 87(1):12-9.
  View in: PubMed
 
33. Bardag-Gorce F. Nuclear effects of ethanol-induced proteasome inhibition in liver cells. World J Gastroenterol. 2009 Mar 14; 15(10):1163-7.
  View in: PubMed
 
34. Oliva J, Dedes J, Li J, French SW, Bardag-Gorce F. Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically. World J Gastroenterol. 2009 Feb 14; 15(6):705-12.
  View in: PubMed
 
35. Oliva J, Bardag-Gorce F, Li J, French BA, Nguyen SK, Lu SC, French SW. Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms. Exp Mol Pathol. 2009 Apr; 86(2):77-86.
  View in: PubMed
 
36. Oliva J, French BA, Li J, Bardag-Gorce F, Fu P, French SW. Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. Exp Mol Pathol. 2008 Dec; 85(3):155-9.
  View in: PubMed
 
37. Li J, Bardag-Gorce F, Dedes J, French BA, Amidi F, Oliva J, French SW. S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory. Hepatology. 2008 Feb; 47(2):613-24.
  View in: PubMed
 
38. Oliva J, Bardag-Gorce F, French BA, Li J, McPhaul L, Amidi F, Dedes J, Habibi A, Nguyen S, French SW. Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. Exp Mol Pathol. 2008 Apr; 84(2):102-12.
  View in: PubMed
 
39. Bardag-Gorce F, Oliva J, Villegas J, Fraley S, Amidi F, Li J, Dedes J, French B, French SW. Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice. Exp Mol Pathol. 2008 Apr; 84(2):113-21.
  View in: PubMed
 
40. Bardag-Gorce F, Dedes J, French BA, Oliva JV, Li J, French SW. Mallory body formation is associated with epigenetic phenotypic change in hepatocytes in vivo. Exp Mol Pathol. 2007 Oct; 83(2):160-8.
  View in: PubMed
 
41. Bardag-Gorce F, French BA, Joyce M, Baires M, Montgomery RO, Li J, French S. Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels. Exp Mol Pathol. 2007 Apr; 82(2):197-202.
  View in: PubMed
 
42. Bardag-Gorce F, French BA, Nan L, Song H, Nguyen SK, Yong H, Dede J, French SW. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Exp Mol Pathol. 2006 Dec; 81(3):191-201.
  View in: PubMed
 
43. Zong C, Gomes AV, Drews O, Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F, Ping P. Regulation of murine cardiac 20S proteasomes: role of associating partners. Circ Res. 2006 Aug 18; 99(4):372-80.
  View in: PubMed
 
44. Gomes AV, Zong C, Edmondson RD, Li X, Stefani E, Zhang J, Jones RC, Thyparambil S, Wang GW, Qiao X, Bardag-Gorce F, Ping P. Mapping the murine cardiac 26S proteasome complexes. Circ Res. 2006 Aug 18; 99(4):362-71.
  View in: PubMed
 
45. Bardag-Gorce F, French BA, Dedes J, Li J, French SW. Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared. Exp Mol Pathol. 2006 Jun; 80(3):241-51.
  View in: PubMed
 
46. Roomi MW, Gaal K, Yuan QX, French BA, Fu P, Bardag-Gorce F, French SW. Preneoplastic liver cell foci expansion induced by thioacetamide toxicity in drug-primed mice. Exp Mol Pathol. 2006 Aug; 81(1):8-14.
  View in: PubMed
 
47. Nan L, Dedes J, French BA, Bardag-Gorce F, Li J, Wu Y, French SW. Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor. Exp Mol Pathol. 2006 Jun; 80(3):228-40.
  View in: PubMed
 
48. Nan L, Bardag-Gorce F, Wu Y, Li J, French BA, French SW. Mallory body forming cells express the preneoplastic hepatocyte phenotype. Exp Mol Pathol. 2006 Apr; 80(2):109-18.
  View in: PubMed
 
49. French BA, Dedes J, Bardag-Gorce F, Li J, Wilson L, Fu P, Nan L, French SW. Microarray analysis of gene expression in the liver during the urinary ethanol cycle in rats fed ethanol intragastrically at a constant rate. Exp Mol Pathol. 2005 Oct; 79(2):87-94.
  View in: PubMed
 
50. Bardag-Gorce F, Francis T, Nan L, Li J, He Lue Y, French BA, French SW. Modifications in P62 occur due to proteasome inhibition in alcoholic liver disease. Life Sci. 2005 Sep 30; 77(20):2594-602.
  View in: PubMed
 
51. Wu Y, Nan L, Bardag-Gorce F, Li J, French BA, Wilson LT, Dedes J, French SW. The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro study. Exp Mol Pathol. 2005 Aug; 79(1):1-8.
  View in: PubMed
 
52. Bardag-Gorce F, Wilson L, Nan L, Li J, French BA, Morgan TR, Morgan K, French SW. CYP2E1 inhibition enhances mallory body formation. Exp Mol Pathol. 2005 Jun; 78(3):207-11.
  View in: PubMed
 
53. Nan L, Wu Y, Bardag-Gorce F, Li J, French BA, Wilson LT, French SW. The p105/50 NF-kappaB pathway is essential for Mallory body formation. Exp Mol Pathol. 2005 Jun; 78(3):198-206.
  View in: PubMed
 
54. Nan L, Wu Y, Bardag-Gorce F, Li J, French BA, Wilson LT, Khanh Nguyen S, French SW. RNA interference of VCP/p97 increases Mallory body formation. Exp Mol Pathol. 2005 Feb; 78(1):1-9.
  View in: PubMed
 
55. Bardag-Gorce F, Li J, French BA, French SW. The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Exp Mol Pathol. 2005 Apr; 78(2):109-15.
  View in: PubMed
 
56. Nan L, Wu Y, Bardag-Gorce F, Li J, French BA, Fu AN, Francis T, Vu J, French SW. p62 is involved in the mechanism of Mallory body formation. Exp Mol Pathol. 2004 Dec; 77(3):168-75.
  View in: PubMed
 
57. Li J, French B, Wu Y, Vanketesh R, Montgomery R, Bardag-Gorce F, Kitto J, French SW. Liver hypoxia and lack of recovery after reperfusion at high blood alcohol levels in the intragastric feeding model of alcohol liver disease. Exp Mol Pathol. 2004 Dec; 77(3):184-92.
  View in: PubMed
 
58. Li J, French BA, Fu P, Bardag-Gorce F, French SW. Catecholamines are involved in the mechanism of the urinary alcohol level cycle in rats fed ethanol intragastrically at a constant rate. Life Sci. 2004 Nov 05; 75(25):3043-51.
  View in: PubMed
 
59. Bardag-Gorce F, Venkatesh R, Li J, French BA, French SW. Hyperphosphorylation of rat liver proteasome subunits: the effects of ethanol and okadaic acid are compared. Life Sci. 2004 Jun 18; 75(5):585-97.
  View in: PubMed
 
60. Bardag-Gorce F, Vu J, Nan L, Riley N, Li J, French SW. Proteasome inhibition induces cytokeratin accumulation in vivo. Exp Mol Pathol. 2004 Apr; 76(2):83-9.
  View in: PubMed
 
61. Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol. 2004 Mar; 65(3):550-7.
  View in: PubMed
 
62. Bardag-Gorce F, Riley NE, Nan L, Montgomery RO, Li J, French BA, Lue YH, French SW. The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation. Exp Mol Pathol. 2004 Feb; 76(1):9-16.
  View in: PubMed
 
63. Li J, French BA, Fu P, Bardag-Gorce F, French SW. Mechanism of the alcohol cyclic pattern: role of catecholamines. Am J Physiol Gastrointest Liver Physiol. 2003 Aug; 285(2):G442-8.
  View in: PubMed
 
64. Bardag-Gorce F, van Leeuwen FW, Nguyen V, French BA, Li J, Riley N, McPhaul LW, Lue YH, French SW. The role of the ubiquitin-proteasome pathway in the formation of mallory bodies. Exp Mol Pathol. 2002 Oct; 73(2):75-83.
  View in: PubMed
 
65. Bardag-Gorce F, French BA, Li J, Riley NE, Yuan QX, Valinluck V, Fu P, Ingelman-Sundberg M, Yoon S, French SW. The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats. Gastroenterology. 2002 Jul; 123(1):325-35.
  View in: PubMed
 
66. Bardag-Gorce F, Li J, French BA, French SW. Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341. Free Radic Biol Med. 2002 Jan 01; 32(1):17-21.
  View in: PubMed
 
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • Ethanol


  • Liver


  • Proteasome Endopeptidase Complex


  • Proteasome Inhibitors


  • Liver Diseases, Alcoholic


Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile:
 
Keyword
Last Name
Institution
Department
School
    
 
 
 
Keywords   
Ethanol
Liver
Proteasome Endopeptidase Complex
Proteasome Inhibitors
Liver Diseases, Alcoholic
See all (332) keywords
Physical Neighbors  
Shukla, Bikau
Lockett, Lejeune
Nealy, Schetema
Magee, Thomas
Chaban, Victor


© Charles Drew University of Medicine And Science - Accelerating Excellence In Translational Science (AXIS), All rights reserved.