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Jorge Artaza, PhD

TitleAssociate Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-4915
FaxNot Available
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    Biography
    awards and honors
    2004 - 2005Glaxo Smith-Kline Endocrinology Scholar Award, American Federation for Medical Research
    2004 - 2005Glenn Foundation Endocrinology and Aging Grant, Endocrine Society
    2007 - 2008Endocrinology Scholar Award, American Federation for Medical Research
    2009 - 2010Excellence in Research Award, NIDDK-NIH-NMRI
    2011 - 2012Basic Science Research Award, NIH-NIDDK-NMRI
    2012 - 2013AFMR Scholar Award, American Federation for Medical Research
    2015 - 2015UK Society for Endocrinology's Journal Award, UK Society for Endocrinology

    Overview
    overview
    Fibrosis is a leading cause of organ failure worldwide when normal tissue is replaced with an excess connective tissue. Recent studies have provided new evidence for an association between low serum Vitamin D and cardiovascular disease (CVD) risk factors, as well as other medical conditions such as stroke, prostate, colon, breast cancer, multiple sclerosis, and infections such as tuberculosis. The goal of my research is to establish whether vitamin D exerts an anti-fibrotic phenotype in specific cell lines and in selected animal models of tissue degeneration suggesting that supplementation with vitamin D could be used as an anti-fibrotic strategy in therapeutic treatment of chronic diseases such as renal, cardiac and lung fibrosis.

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nguyen S, Mangubat M, Eleswarapu S, Wilson JB, Molina J, Abraham A, Artaza JN, Friedman TC, Ferrini MG. The Combination of High-Fat Diet and Oral Marijuana Promotes the Development of Fibrosis in the Mouse Corpora Cavernosa. Sex Med. 2021 Apr; 9(2):100312. PMID: 33540365; PMCID: PMC8072182.
      Citations: 2     
    2. Rajfer RA, Flores M, Abraham A, Garcia E, Hinojosa N, Desai M, Artaza JN, Ferrini MG. Prevention of Osteoporosis in the Ovariectomized Rat by Oral Administration of a Nutraceutical Combination That Stimulates Nitric Oxide Production. J Osteoporos. 2019; 2019:1592328. PMID: 31275540; PMCID: PMC6582785.
      Citations: 5     
    3. Ferrini MG, Abraham A, Nguyen S, Luna R, Flores M, Artaza JN, Graciano L, Rajfer J. Exogenous l-ARGININE does not stimulate production OF NO or cGMP within the rat corporal smooth muscle cells in culture. Nitric Oxide. 2019 08 01; 89:64-70. PMID: 31075315; PMCID: PMC6786268.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Ferrini MG, Garcia E, Abraham A, Artaza JN, Nguyen S, Rajfer J. Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells. Nitric Oxide. 2018 06 01; 76:81-86. PMID: 29551532.
      Citations: 5     Fields:    Translation:AnimalsCells
    5. Braga M, Simmons Z, Norris KC, Ferrini MG, Artaza JN. Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells. Endocr Connect. 2017 Apr; 6(3):139-150. PMID: 28174253; PMCID: PMC5424772.
      Citations: 30     
    6. Kim IM, Norris KC, Artaza JN. Vitamin D and Cardiac Differentiation. Vitam Horm. 2016; 100:299-320. PMID: 26827957.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    7. Ferrini MG, Hlaing SM, Chan A, Artaza JN. Treatment with a combination of ginger, L-citrulline, muira puama and Paullinia cupana can reverse the progression of corporal smooth muscle loss, fibrosis and veno-occlusive dysfunction in the aging rat. Andrology (Los Angel). 2015 Jun; 4(1). PMID: 26405615; PMCID: PMC4578663.
      Citations: 9     
    8. Garcia LA, Hlaing SM, Gutierrez RA, Sanchez MD, Kovanecz I, Artaza JN, Ferrini MG. Sildenafil attenuates inflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damage. Int J Mol Sci. 2014 Sep 26; 15(10):17204-20. PMID: 25264738; PMCID: PMC4227157.
      Citations: 14     Fields:    Translation:AnimalsCells
    9. Hlaing SM, Garcia LA, Contreras JR, Norris KC, Ferrini MG, Artaza JN. 1,25-Vitamin D3 promotes cardiac differentiation through modulation of the WNT signaling pathway. J Mol Endocrinol. 2014 Dec; 53(3):303-17. PMID: 25139490; PMCID: PMC4198487.
      Citations: 17     Fields:    Translation:AnimalsCells
    10. Martins D, Meng YX, Tareen N, Artaza J, Lee JE, Farodolu C, Gibbons G, Norris K. The Effect of Short Term Vitamin D Supplementation on the Inflammatory and Oxidative Mediators of Arterial Stiffness. Health (Irvine Calif). 2014 Jun; 6(12):1503-1511. PMID: 25505940; PMCID: PMC4260399.
      Citations: 21     
    11. Garcia LA, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)(2)vitamin D(3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2)C(12) skeletal muscle cells. J Steroid Biochem Mol Biol. 2013 Jan; 133:1-11. PMID: 22982629; PMCID: PMC3513642.
      Citations: 26     Fields:    Translation:AnimalsCells
    12. Hlaing SM, Garcia LA, Kovanecz I, Martinez RA, Shah S, Artaza JN, Ferrini MG. Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat. BJU Int. 2013 Jan; 111(1):159-70. PMID: 22672418; PMCID: PMC3548048.
      Citations: 11     Fields:    Translation:AnimalsCells
    13. Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology. 2011 Aug; 152(8):2976-86. PMID: 21673099; PMCID: PMC3138228.
      Citations: 89     Fields:    Translation:AnimalsCells
    14. Sirad F, Hlaing S, Kovanecz I, Artaza JN, Garcia LA, Rajfer J, Ferrini MG. Sildenafil promotes smooth muscle preservation and ameliorates fibrosis through modulation of extracellular matrix and tissue growth factor gene expression after bilateral cavernosal nerve resection in the rat. J Sex Med. 2011 Apr; 8(4):1048-60. PMID: 21269401; PMCID: PMC3075874.
      Citations: 19     Fields:    Translation:AnimalsCells
    15. Artaza JN, Contreras S, Garcia LA, Mehrotra R, Gibbons G, Shohet R, Martins D, Norris KC. Vitamin D and cardiovascular disease: potential role in health disparities. J Health Care Poor Underserved. 2011; 22(4 Suppl):23-38. PMID: 22102304; PMCID: PMC3417128.
      Citations: 12     Fields:    Translation:Humans
    16. Artaza JN, Sirad F, Ferrini MG, Norris KC. 1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells. J Steroid Biochem Mol Biol. 2010 Mar; 119(1-2):73-83. PMID: 20064609; PMCID: PMC2828517.
      Citations: 31     Fields:    Translation:AnimalsCells
    17. Artaza JN, Mehrotra R, Norris KC. Vitamin D and the cardiovascular system. Clin J Am Soc Nephrol. 2009 Sep; 4(9):1515-22. PMID: 19696220.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    18. Artaza JN, Norris KC. Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. J Endocrinol. 2009 Feb; 200(2):207-21. PMID: 19036760; PMCID: PMC3787314.
      Citations: 74     Fields:    Translation:AnimalsCells
    19. Singh R, Bhasin S, Braga M, Artaza JN, Pervin S, Taylor WE, Krishnan V, Sinha SK, Rajavashisth TB, Jasuja R. Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology. 2009 Mar; 150(3):1259-68. PMID: 18948405; PMCID: PMC2654730.
      Citations: 56     Fields:    Translation:AnimalsCells
    20. Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF. Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol. 2008 Feb; 196(2):235-49. PMID: 18252947.
      Citations: 27     Fields:    Translation:AnimalsCells
    21. Artaza JN, Reisz-Porszasz S, Dow JS, Kloner RA, Tsao J, Bhasin S, Gonzalez-Cadavid NF. Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. J Endocrinol. 2007 Jul; 194(1):63-76. PMID: 17592022.
      Citations: 24     Fields:    Translation:AnimalsCells
    22. Magee TR, Artaza JN, Ferrini MG, Vernet D, Zuniga FI, Cantini L, Reisz-Porszasz S, Rajfer J, Gonzalez-Cadavid NF. Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. J Gene Med. 2006 Sep; 8(9):1171-81. PMID: 16810717.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    23. Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF, Bhasin S. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology. 2006 Jan; 147(1):141-54. PMID: 16210377; PMCID: PMC4417624.
      Citations: 129     Fields:    Translation:AnimalsCells
    24. Jasuja R, Catlin DH, Miller A, Chang YC, Herbst KL, Starcevic B, Artaza JN, Singh R, Datta G, Sarkissian A, Chandsawangbhuwana C, Baker M, Bhasin S. Tetrahydrogestrinone is an androgenic steroid that stimulates androgen receptor-mediated, myogenic differentiation in C3H10T1/2 multipotent mesenchymal cells and promotes muscle accretion in orchidectomized male rats. Endocrinology. 2005 Oct; 146(10):4472-8. PMID: 15976054.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Meerasahib MF, Fareez MM, Gonzalez-Cadavid NF. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology. 2005 Aug; 146(8):3547-57. PMID: 15878958.
      Citations: 77     Fields:    Translation:AnimalsCells
    26. Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 2005 Feb; 90(2):855-63. PMID: 15522925.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    27. Bhasin S, Taylor WE, Singh R, Artaza J, Sinha-Hikim I, Jasuja R, Choi H, Gonzalez-Cadavid NF. The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci. 2003 Dec; 58(12):M1103-10. PMID: 14684707.
      Citations: 55     Fields:    Translation:HumansCells
    28. Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF, Bhasin S. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology. 2003 Nov; 144(11):5081-8. PMID: 12960001.
      Citations: 159     Fields:    Translation:AnimalsCells
    29. Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Hogue A, Fielder TJ, Gonzalez-Cadavid NF. Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E876-88. PMID: 12824080.
      Citations: 109     Fields:    Translation:Animals
    30. Ma K, Mallidis C, Bhasin S, Mahabadi V, Artaza J, Gonzalez-Cadavid N, Arias J, Salehian B. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab. 2003 Aug; 285(2):E363-71. PMID: 12721153.
      Citations: 121     Fields:    Translation:Animals
    31. Sinha-Hikim I, Artaza J, Woodhouse L, Gonzalez-Cadavid N, Singh AB, Lee MI, Storer TW, Casaburi R, Shen R, Bhasin S. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab. 2002 Jul; 283(1):E154-64. PMID: 12067856.
      Citations: 101     Fields:    Translation:HumansCellsCTClinical Trials
    32. Artaza JN, Bhasin S, Mallidis C, Taylor W, Ma K, Gonzalez-Cadavid NF. Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells. J Cell Physiol. 2002 Feb; 190(2):170-9. PMID: 11807821.
      Citations: 36     Fields:    Translation:AnimalsCells
    33. Ma K, Mallidis C, Artaza J, Taylor W, Gonzalez-Cadavid N, Bhasin S. Characterization of 5'-regulatory region of human myostatin gene: regulation by dexamethasone in vitro. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1128-36. PMID: 11701425.
      Citations: 66     Fields:    Translation:HumansCells
    34. Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard DH, Kull FC, Gonzalez-Cadavid N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am J Physiol Endocrinol Metab. 2001 Feb; 280(2):E221-8. PMID: 11158924.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
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