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Nestor Gonzalez-Cadavid, PhD

TitleProfessor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-9330
FaxNot Available
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    Biography
    education and training
    University of Buenos Aires, ArgentinaM.Sc.1961Biochemistry
    University of Buenos Aires, ArgentinaPh.D.1964Biochemistry
    University of London, EnglandPh.D.1967Biochemistry

    Research
    research activities and funding
    U01ES020887     (GONZALEZ-CADAVID, NESTOR F)Sep 19, 2011 - May 31, 2016
    NIH
    Cellular-molecular signature and mechanism of BPA effects on penil erection
    Role: Principal Investigator
    R21ES019465     (GONZALEZ-CADAVID, NESTOR F)Aug 10, 2010 - Jul 31, 2013
    NIH
    BISPHENOL A EFFECTS ON THE PERIPHERAL MECHANISMS OF PENILE ERECTION
    Role: Principal Investigator
    R21DK070003     (GONZALEZ-CADAVID, NESTOR F)Aug 7, 2007 - Jul 31, 2010
    NIH
    CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYS
    Role: Principal Investigator
    R01DK053069     (GONZALEZ-CADAVID, NESTOR F)May 1, 1999 - Apr 30, 2008
    NIH
    ERECTILE DYSFUNCTION AND NITRIC OXIDE SYNTHASE IN AGING
    Role: Principal Investigator
    F33DK008514     (GONZALEZ-CADAVID, NESTOR F)Jan 1, 1991
    NIH
    ANDROGEN RECEPTOR GENE EXPRESSION IN PENILE GROWTH
    Role: Principal Investigator

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gonzalez-Cadavid NF, Kovanecz I. The Damage to the Stem Cells by Diabetic and Dyslipidemic Milieu. Clinical Implications for Erectile Dysfunction and LUTS. J Sex Med. 2022 Nov; 19(11):1596-1599. PMID: 35568667.
      Citations:    Fields:    Translation:HumansCells
    2. Kovanecz I, Gelfand R, Sharifzad S, Ohanian A, DeCastro WB, Cooper C, Lin G, Lue T, Gonzalez-Cadavid NF. Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence. Int J Mol Sci. 2020 Jul 17; 21(14). PMID: 32708907; PMCID: PMC7404394.
      Citations:    Fields:    Translation:AnimalsCells
    3. Kovanecz I, Gelfand R, Lin G, Sharifzad S, Ohanian A, Ricks R, Lue T, Gonzalez-Cadavid NF. Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo. Int J Mol Sci. 2019 Aug 19; 20(16). PMID: 31430893; PMCID: PMC6720976.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Masouminia M, Gelfand R, Kovanecz I, Vernet D, Tsao J, Salas R, Castro K, Loni L, Rajfer J, Gonzalez-Cadavid NF. Dyslipidemia Is a Major Factor in Stem Cell Damage Induced by Uncontrolled Long-Term Type 2 Diabetes and Obesity in the Rat, as Suggested by the Effects on Stem Cell Culture. J Sex Med. 2018 12; 15(12):1678-1697. PMID: 30527052; PMCID: PMC6645779.
      Citations: 5     Fields:    Translation:HumansAnimals
    5. Gonzalez-Cadavid NF, Rajfer J. The two phases of the clinical validation of preclinical translational mechanistic research on PDE5 inhibitors since Viagra's advent. A personal perspective. Int J Impot Res. 2019 Mar; 31(2):57-60. PMID: 30258189.
      Citations: 4     Fields:    Translation:HumansAnimals
    6. Kovanecz I, Masouminia M, Gelfand R, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Myostatin, a profibrotic factor and the main inhibitor of striated muscle mass, is present in the penile and vascular smooth muscle. Int J Impot Res. 2017 Sep; 29(5):194-201. PMID: 28539643.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Ferrini MG, Gonzalez-Cadavid NF, Rajfer J. Aging related erectile dysfunction-potential mechanism to halt or delay its onset. Transl Androl Urol. 2017 Feb; 6(1):20-27. PMID: 28217447; PMCID: PMC5313305.
      Citations: 16     
    8. Tsao J, Kovanecz I, Awadalla N, Gelfand R, Sinha-Hikim I, White RA, Gonzalez-Cadavid NF. Muscle Derived Stem Cells Stimulate Muscle Myofiber Repair and Counteract Fat Infiltration in a Diabetic Mouse Model of Critical Limb Ischemia. J Stem Cell Res Ther. 2016 Dec; 6(12). PMID: 28217409; PMCID: PMC5313052.
      Citations: 5     
    9. Gelfand R, Vernet D, Bruhn KW, Sarkissyan S, Heber D, Vadgama JV, Gonzalez-Cadavid NF. Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features. Int J Oncol. 2017 Jan; 50(1):49-65. PMID: 27959387; PMCID: PMC5182011.
      Citations: 10     Fields:    Translation:HumansCells
    10. Kovanecz I, Vernet D, Masouminia M, Gelfand R, Loni L, Aboagye J, Tsao J, Rajfer J, Gonzalez-Cadavid NF. Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity Is Impaired by Their Prior Exposure to the Diabetic Milieu. J Sex Med. 2016 05; 13(5):786-97. PMID: 27114192; PMCID: PMC4886867.
      Citations: 11     Fields:    Translation:AnimalsCells
    11. Gelfand R, Vernet D, Bruhn K, Vadgama J, Gonzalez-Cadavid NF. Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features. Int J Oncol. 2016 Jun; 48(6):2399-414. PMID: 27035792; PMCID: PMC4864041.
      Citations: 7     Fields:    Translation:HumansCells
    12. Musicki B, Bella AJ, Bivalacqua TJ, Davies KP, DiSanto ME, Gonzalez-Cadavid NF, Hannan JL, Kim NN, Podlasek CA, Wingard CJ, Burnett AL. Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction. J Sex Med. 2015 Dec; 12(12):2233-55. PMID: 26646025; PMCID: PMC4854187.
      Citations: 11     Fields:    Translation:HumansCells
    13. Gelfand RA, Vernet D, Kovanecz I, Rajfer J, Gonzalez-Cadavid NF. The transcriptional signatures of cells from the human Peyronie's disease plaque and the ability of these cells to generate a plaque in a rat model suggest potential therapeutic targets. J Sex Med. 2015 Feb; 12(2):313-27. PMID: 25496134; PMCID: PMC4339076.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    14. Kovanecz I, Gelfand R, Masouminia M, Gharib S, Segura D, Vernet D, Rajfer J, Li DK, Kannan K, Gonzalez-Cadavid NF. Oral Bisphenol A (BPA) given to rats at moderate doses is associated with erectile dysfunction, cavernosal lipofibrosis and alterations of global gene transcription. Int J Impot Res. 2014 Mar-Apr; 26(2):67-75. PMID: 24305612; PMCID: PMC4098849.
      Citations: 17     Fields:    Translation:Animals
    15. Kovanecz I, Gelfand R, Masouminia M, Gharib S, Segura D, Vernet D, Rajfer J, Li DK, Liao CY, Kannan K, Gonzalez-Cadavid NF. Chronic high dose intraperitoneal bisphenol A (BPA) induces substantial histological and gene expression alterations in rat penile tissue without impairing erectile function. J Sex Med. 2013 Dec; 10(12):2952-66. PMID: 24134786; PMCID: PMC4038545.
      Citations: 3     Fields:    Translation:AnimalsCells
    16. Tsao J, Vernet DA, Gelfand R, Kovanecz I, Nolazco G, Bruhn KW, Gonzalez-Cadavid NF. Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle. Stem Cell Res Ther. 2013 Jan 07; 4(1):4. PMID: 23295128; PMCID: PMC3706886.
      Citations: 18     Fields:    Translation:AnimalsCells
    17. Kovanecz I, Rivera S, Nolazco G, Vernet D, Segura D, Gharib S, Rajfer J, Gonzalez-Cadavid NF. Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage. J Sex Med. 2012 Nov; 9(11):2814-26. PMID: 22974131; PMCID: PMC3485410.
      Citations: 17     Fields:    Translation:AnimalsCells
    18. Wang JS, Kovanecz I, Vernet D, Nolazco G, Kopchok GE, Chow SL, White RA, Gonzalez-Cadavid NF. Effects of sildenafil and/or muscle derived stem cells on myocardial infarction. J Transl Med. 2012 Aug 07; 10:159. PMID: 22871104; PMCID: PMC3476974.
      Citations: 8     Fields:    Translation:AnimalsCells
    19. Ferrini MG, Moon J, Rivera S, Rajfer J, Gonzalez-Cadavid NF. Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-ß1 therapies in inducible nitric oxide synthase-deficient mice. BJU Int. 2012 Feb; 109(4):586-93. PMID: 21851542; PMCID: PMC3223318.
      Citations: 6     Fields:    Translation:Animals
    20. Toblli JE, Cao G, Giani JF, Angerosa M, Dominici FP, Gonzalez-Cadavid NF. Antifibrotic effects of pioglitazone at low doses on the diabetic rat kidney are associated with the improvement of markers of cell turnover, tubular and endothelial integrity, and angiogenesis. Kidney Blood Press Res. 2011; 34(1):20-33. PMID: 21071958; PMCID: PMC3068565.
      Citations: 13     Fields:    Translation:Animals
    21. Ferrini MG, Rivera S, Moon J, Vernet D, Rajfer J, Gonzalez-Cadavid NF. The genetic inactivation of inducible nitric oxide synthase (iNOS) intensifies fibrosis and oxidative stress in the penile corpora cavernosa in type 1 diabetes. J Sex Med. 2010 Sep; 7(9):3033-44. PMID: 20626593.
      Citations: 22     Fields:    Translation:Animals
    22. Ralph D, Gonzalez-Cadavid N, Mirone V, Perovic S, Sohn M, Usta M, Levine L. The management of Peyronie's disease: evidence-based 2010 guidelines. J Sex Med. 2010 Jul; 7(7):2359-74. PMID: 20497306.
      Citations: 89     Fields:    Translation:HumansAnimals
    23. Ralph D, Gonzalez-Cadavid N, Mirone V, Perovic S, Sohn M, Usta M, Levine L. Trauma, gender reassignment, and penile augmentation. J Sex Med. 2010 Apr; 7(4 Pt 2):1657-67. PMID: 20388163.
      Citations: 12     Fields:    Translation:Humans
    24. Gonzalez-Cadavid NF, Rajfer J. Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy. Nat Rev Urol. 2010 Apr; 7(4):215-21. PMID: 20212516.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    25. Ho MH, Heydarkhan S, Vernet D, Kovanecz I, Ferrini MG, Bhatia NN, Gonzalez-Cadavid NF. Stimulating vaginal repair in rats through skeletal muscle-derived stem cells seeded on small intestinal submucosal scaffolds. Obstet Gynecol. 2009 Aug; 114(2 Pt 1):300-309. PMID: 19622991; PMCID: PMC3217318.
      Citations: 22     Fields:    Translation:AnimalsCells
    26. Toblli JE, Ferrini MG, Cao G, Vernet D, Angerosa M, Gonzalez-Cadavid NF. Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus. Nephrol Dial Transplant. 2009 Aug; 24(8):2384-91. PMID: 19297362; PMCID: PMC2727296.
      Citations: 20     Fields:    Translation:Animals
    27. Gonzalez-Cadavid NF. Mechanisms of penile fibrosis. J Sex Med. 2009 Mar; 6 Suppl 3:353-62. PMID: 19267860.
      Citations: 47     Fields:    Translation:HumansCells
    28. Kovanecz I, Nolazco G, Ferrini MG, Toblli JE, Heydarkhan S, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunction. BJU Int. 2009 May; 103(10):1396-404. PMID: 19154511.
      Citations: 21     Fields:    Translation:AnimalsCells
    29. Ferrini MG, Kovanecz I, Sanchez S, Umeh C, Rajfer J, Gonzalez-Cadavid NF. Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat. J Sex Med. 2009 Feb; 6(2):415-28. PMID: 19138364; PMCID: PMC2756287.
      Citations: 37     Fields:    Translation:Animals
    30. Gonzalez-Cadavid NF, Rajfer J. Experimental models of Peyronie's disease. Implications for new therapies. J Sex Med. 2009 Feb; 6(2):303-13. PMID: 19138365.
      Citations: 16     Fields:    Translation:HumansAnimals
    31. Cantini LP, Ferrini MG, Vernet D, Magee TR, Qian A, Gelfand RA, Rajfer J, Gonzalez-Cadavid NF. Profibrotic role of myostatin in Peyronie's disease. J Sex Med. 2008 Jul; 5(7):1607-22. PMID: 18422491.
      Citations: 16     Fields:    Translation:AnimalsCells
    32. Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL, Gonzalez-Cadavid NF, Sinha-Hikim I. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis. 2008 Jun; 13(6):822-32. PMID: 18461459; PMCID: PMC4732709.
      Citations: 59     Fields:    Translation:AnimalsCells
    33. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, Gonzalez-Cadavid NF. Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int. 2008 May; 101(9):1156-64. PMID: 18294308.
      Citations: 44     Fields:    Translation:AnimalsCells
    34. Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF. Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol. 2008 Feb; 196(2):235-49. PMID: 18252947.
      Citations: 27     Fields:    Translation:AnimalsCells
    35. Kovanecz I, Rambhatla A, Ferrini MG, Vernet D, Sanchez S, Rajfer J, Gonzalez-Cadavid N. Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection. BJU Int. 2008 Jan; 101(2):203-10. PMID: 17888043.
      Citations: 55     Fields:    Translation:Animals
    36. Kovanecz I, Rambhatla A, Ferrini M, Vernet D, Sanchez S, Rajfer J, Gonzalez-Cadavid N. Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats. Int J Impot Res. 2008 Mar-Apr; 20(2):202-12. PMID: 17882231.
      Citations: 50     Fields:    Translation:Animals
    37. Rambhatla A, Kovanecz I, Ferrini M, Gonzalez-Cadavid NF, Rajfer J. Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review. Int J Impot Res. 2008 Jan-Feb; 20(1):30-4. PMID: 17673932.
      Citations: 19     Fields:    Translation:Humans
    38. Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Ageing-related corpora veno-occlusive dysfunction in the rat is ameliorated by pioglitazone. BJU Int. 2007 Oct; 100(4):867-74. PMID: 17662078.
      Citations: 7     Fields:    Translation:Animals
    39. Artaza JN, Reisz-Porszasz S, Dow JS, Kloner RA, Tsao J, Bhasin S, Gonzalez-Cadavid NF. Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. J Endocrinol. 2007 Jul; 194(1):63-76. PMID: 17592022.
      Citations: 24     Fields:    Translation:AnimalsCells
    40. Magee TR, Kovanecz I, Davila HH, Ferrini MG, Cantini L, Vernet D, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF. Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. J Sex Med. 2007 May; 4(3):633-643. PMID: 17433082.
      Citations: 22     Fields:    Translation:Animals
    41. Ferrini MG, Kovanecz I, Sanchez S, Vernet D, Davila HH, Rajfer J, Gonzalez-Cadavid NF. Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat. Biol Reprod. 2007 May; 76(5):915-23. PMID: 17287493.
      Citations: 32     Fields:    Translation:AnimalsCells
    42. Ferrini MG, Nolazco G, Vernet D, Gonzalez-Cadavid NF, Berman J. Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis. Fertil Steril. 2006 Oct; 86(4 Suppl):1152-63. PMID: 16978624.
      Citations: 4     Fields:    Translation:Animals
    43. Magee TR, Artaza JN, Ferrini MG, Vernet D, Zuniga FI, Cantini L, Reisz-Porszasz S, Rajfer J, Gonzalez-Cadavid NF. Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. J Gene Med. 2006 Sep; 8(9):1171-81. PMID: 16810717.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    44. Ferrini MG, Davila HH, Kovanecz I, Sanchez SP, Gonzalez-Cadavid NF, Rajfer J. Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat. Urology. 2006 Aug; 68(2):429-35. PMID: 16904479.
      Citations: 60     Fields:    Translation:Animals
    45. Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus. BJU Int. 2006 Jul; 98(1):116-24. PMID: 16831155.
      Citations: 23     Fields:    Translation:Animals
    46. Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's disease. BJU Int. 2006 Mar; 97(3):625-33. PMID: 16469038.
      Citations: 28     Fields:    Translation:Animals
    47. Vernet D, Magee T, Qian A, Nolazco G, Rajfer J, Gonzalez-Cadavid N. Phosphodiesterase type 5 is not upregulated by tadalafil in cultures of human penile cells. J Sex Med. 2006 Jan; 3(1):84-94; discussion 94-5. PMID: 16409221.
      Citations: 9     Fields:    Translation:HumansCells
    48. Rajfer J, Gore JL, Kaufman J, Gonzalez-Cadavid N. Case report: Avoidance of palpable corporal fibrosis due to priapism with upregulators of nitric oxide. J Sex Med. 2006 Jan; 3(1):173-6. PMID: 16409234.
      Citations: 12     Fields:    Translation:Humans
    49. Jack GS, Gonzalez-Cadavid N, Rajfer J. Conservative management options for Peyronie's disease. Curr Urol Rep. 2005 Nov; 6(6):454-60. PMID: 16238920.
      Citations: 3     Fields:    Translation:Humans
    50. Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF, Bhasin S. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology. 2006 Jan; 147(1):141-54. PMID: 16210377; PMCID: PMC4417624.
      Citations: 129     Fields:    Translation:AnimalsCells
    51. Vernet D, Nolazco G, Cantini L, Magee TR, Qian A, Rajfer J, Gonzalez-Cadavid NF. Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. Biol Reprod. 2005 Dec; 73(6):1199-210. PMID: 16093362.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    52. Gonzalez-Cadavid NF, Rajfer J. Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease. Nat Clin Pract Urol. 2005 Jun; 2(6):291-7. PMID: 16474811.
      Citations: 36     Fields:    Translation:Humans
    53. Hikim AP, Vera Y, Vernet D, Castanares M, Diaz-Romero M, Ferrini M, Swerdloff RS, Gonzalez-Cadavid NF, Wang C. Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway rats. J Gerontol A Biol Sci Med Sci. 2005 Jun; 60(6):702-8. PMID: 15983171.
      Citations: 6     Fields:    Translation:AnimalsCells
    54. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Meerasahib MF, Fareez MM, Gonzalez-Cadavid NF. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology. 2005 Aug; 146(8):3547-57. PMID: 15878958.
      Citations: 77     Fields:    Translation:AnimalsCells
    55. Davila HH, Magee TR, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF. Peyronie's disease associated with increase in plasminogen activator inhibitor in fibrotic plaque. Urology. 2005 Apr; 65(4):645-8. PMID: 15833499.
      Citations: 8     Fields:    Translation:Humans
    56. Gonzalez-Cadavid NF, Rajfer J. The pleiotropic effects of inducible nitric oxide synthase (iNOS) on the physiology and pathology of penile erection. Curr Pharm Des. 2005; 11(31):4041-6. PMID: 16378509.
      Citations: 12     Fields:    Translation:HumansCells
    57. Davila HH, Rajfer J, Gonzalez-Cadavid NF. Corporal veno-occlusive dysfunction in aging rats: evaluation by cavernosometry and cavernosography. Urology. 2004 Dec; 64(6):1261-6. PMID: 15596219.
      Citations: 9     Fields:    Translation:Animals
    58. Jalkut M, Gonzalez-Cadavid N, Rajfer J. New discoveries in the basic science understanding of Peyronie's disease. Curr Urol Rep. 2004 Dec; 5(6):478-84. PMID: 15541219.
      Citations: 5     Fields:    Translation:HumansAnimals
    59. Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 2005 Feb; 90(2):855-63. PMID: 15522925.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    60. Gonzalez-Cadavid NF, Rajfer J. Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1705-12. PMID: 15582286.
      Citations: 14     Fields:    Translation:Humans
    61. Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S. Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. J Clin Endocrinol Metab. 2004 Oct; 89(10):5245-55. PMID: 15472231.
      Citations: 86     Fields:    Translation:HumansCellsCTClinical Trials
    62. Qian A, Meals RA, Rajfer J, Gonzalez-Cadavid NF. Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture. Urology. 2004 Aug; 64(2):399-404. PMID: 15302515.
      Citations: 37     Fields:    Translation:HumansCells
    63. Davila HH, Magee TR, Vernet D, Rajfer J, Gonzalez-Cadavid NF. Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease. Biol Reprod. 2004 Nov; 71(5):1568-77. PMID: 15240426.
      Citations: 22     Fields:    Translation:Animals
    64. Gonzalez-Cadavid NF, Bhasin S. Role of myostatin in metabolism. Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):451-7. PMID: 15192449.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    65. Gonzalez-Cadavid NF, Rajfer J. Therapy of erectile dysfunction: potential future treatments. Endocrine. 2004 Mar-Apr; 23(2-3):167-76. PMID: 15146097.
      Citations: 3     Fields:    Translation:HumansAnimals
    66. Ferrini MG, Davila HH, Valente EG, Gonzalez-Cadavid NF, Rajfer J. Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media. Cardiovasc Res. 2004 Mar 01; 61(4):796-805. PMID: 14985077.
      Citations: 26     Fields:    Translation:AnimalsCells
    67. Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF. L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures. Nitric Oxide. 2003 Dec; 9(4):229-44. PMID: 14996430.
      Citations: 49     Fields:    Translation:HumansAnimals
    68. Bhasin S, Taylor WE, Singh R, Artaza J, Sinha-Hikim I, Jasuja R, Choi H, Gonzalez-Cadavid NF. The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci. 2003 Dec; 58(12):M1103-10. PMID: 14684707.
      Citations: 55     Fields:    Translation:HumansCells
    69. Liu W, Thomas SG, Asa SL, Gonzalez-Cadavid N, Bhasin S, Ezzat S. Myostatin is a skeletal muscle target of growth hormone anabolic action. J Clin Endocrinol Metab. 2003 Nov; 88(11):5490-6. PMID: 14602795.
      Citations: 33     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    70. Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF, Bhasin S. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology. 2003 Nov; 144(11):5081-8. PMID: 12960001.
      Citations: 159     Fields:    Translation:AnimalsCells
    71. Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Hogue A, Fielder TJ, Gonzalez-Cadavid NF. Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E876-88. PMID: 12824080.
      Citations: 109     Fields:    Translation:Animals
    72. Davila HH, Ferrini MG, Rajfer J, Gonzalez-Cadavid NF. Fibrin as an inducer of fibrosis in the tunica albuginea of the rat: a new animal model of Peyronie's disease. BJU Int. 2003 Jun; 91(9):830-8. PMID: 12780843.
      Citations: 29     Fields:    Translation:HumansAnimals
    73. Ma K, Mallidis C, Bhasin S, Mahabadi V, Artaza J, Gonzalez-Cadavid N, Arias J, Salehian B. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab. 2003 Aug; 285(2):E363-71. PMID: 12721153.
      Citations: 121     Fields:    Translation:Animals
    74. Berman JR, Almeida FG, Jolin J, Raz S, Chaudhuri G, Gonzalez-Cadavid NF. Correlation of androgen receptors, aromatase, and 5-alpha reductase in the human vagina with menopausal status. Fertil Steril. 2003 Apr; 79(4):925-31. PMID: 12749432.
      Citations: 12     Fields:    Translation:Humans
    75. Gholami SS, Gonzalez-Cadavid NF, Lin CS, Rajfer J, Lue TF. Peyronie's disease: a review. J Urol. 2003 Apr; 169(4):1234-41. PMID: 12629334.
      Citations: 24     Fields:    Translation:HumansCells
    76. Jalkut M, Gonzalez-Cadavid N, Rajfer J. Peyronie's Disease: A Review. Rev Urol. 2003; 5(3):142-8. PMID: 16985635; PMCID: PMC1473022.
      Citations: 10     
    77. Taylor WE, Bhasin S, Lalani R, Datta A, Gonzalez-Cadavid NF. Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight. J Gravit Physiol. 2002 Dec; 9(2):61-70. PMID: 14638460.
      Citations: 11     Fields:    Translation:Animals
    78. Vernet D, Ferrini MG, Valente EG, Magee TR, Bou-Gharios G, Rajfer J, Gonzalez-Cadavid NF. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric Oxide. 2002 Dec; 7(4):262-76. PMID: 12446175.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    79. Gonzalez-Cadavid NF, Magee TR, Ferrini M, Qian A, Vernet D, Rajfer J. Gene expression in Peyronie's disease. Int J Impot Res. 2002 Oct; 14(5):361-74. PMID: 12454687.
      Citations: 18     Fields:    Translation:HumansAnimals
    80. Magee TR, Ferrini M, Garban HJ, Vernet D, Mitani K, Rajfer J, Gonzalez-Cadavid NF. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod. 2002 Sep; 67(3):1033-41. PMID: 12222534.
      Citations: 9     Fields:    Translation:AnimalsCells
    81. Magee TR, Ferrini M, Garban HJ, Vernet D, Mitani K, Rajfer J, Gonzalez-Cadavid NF. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod. 2002 Jul; 67(1):20-8. PMID: 12079995.
      Citations: 8     Fields:    Translation:AnimalsCells
    82. Sinha-Hikim I, Artaza J, Woodhouse L, Gonzalez-Cadavid N, Singh AB, Lee MI, Storer TW, Casaburi R, Shen R, Bhasin S. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab. 2002 Jul; 283(1):E154-64. PMID: 12067856.
      Citations: 101     Fields:    Translation:HumansCellsCTClinical Trials
    83. Ferrini MG, Vernet D, Magee TR, Shahed A, Qian A, Rajfer J, Gonzalez-Cadavid NF. Antifibrotic role of inducible nitric oxide synthase. Nitric Oxide. 2002 May; 6(3):283-94. PMID: 12009846.
      Citations: 42     Fields:    Translation:HumansAnimals
    84. Magee TR, Qian A, Rajfer J, Sander FC, Levine LA, Gonzalez-Cadavid NF. Gene expression profiles in the Peyronie's disease plaque. Urology. 2002 Mar; 59(3):451-7. PMID: 11880101.
      Citations: 13     Fields:    Translation:HumansCells
    85. Artaza JN, Bhasin S, Mallidis C, Taylor W, Ma K, Gonzalez-Cadavid NF. Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells. J Cell Physiol. 2002 Feb; 190(2):170-9. PMID: 11807821.
      Citations: 36     Fields:    Translation:AnimalsCells
    86. Rajfer J, Magee T, Gonzalez-Cadavid N. Future strategies for treating erectile dysfunction. Rev Urol. 2002; 4 Suppl 3:S48-53. PMID: 16986014; PMCID: PMC1476023.
      Citations: 1     
    87. Wang C, Hikim AS, Ferrini M, Bonavera JJ, Vernet D, Leung A, Lue YH, Gonzalez-Cadavid NF, Swerdloff RS. Male reproductive ageing: using the brown Norway rat as a model for man. Novartis Found Symp. 2002; 242:82-95; discussion 95-7. PMID: 11855696.
      Citations: 8     Fields:    Translation:HumansAnimals
    88. Yarasheski KE, Bhasin S, Sinha-Hikim I, Pak-Loduca J, Gonzalez-Cadavid NF. Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. J Nutr Health Aging. 2002; 6(5):343-8. PMID: 12474026.
      Citations: 107     Fields:    
    89. Ma K, Mallidis C, Artaza J, Taylor W, Gonzalez-Cadavid N, Bhasin S. Characterization of 5'-regulatory region of human myostatin gene: regulation by dexamethasone in vitro. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1128-36. PMID: 11701425.
      Citations: 66     Fields:    Translation:HumansCells
    90. Ferrini M, Wang C, Swerdloff RS, Sinha Hikim AP, Rajfer J, Gonzalez-Cadavid NF. Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function. Neuroendocrinology. 2001 Jul; 74(1):1-11. PMID: 11435753.
      Citations: 9     Fields:    Translation:AnimalsCells
    91. Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard DH, Kull FC, Gonzalez-Cadavid N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am J Physiol Endocrinol Metab. 2001 Feb; 280(2):E221-8. PMID: 11158924.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    92. Lalani R, Bhasin S, Byhower F, Tarnuzzer R, Grant M, Shen R, Asa S, Ezzat S, Gonzalez-Cadavid NF. Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. J Endocrinol. 2000 Dec; 167(3):417-28. PMID: 11115768.
      Citations: 41     Fields:    Translation:Animals
    93. Gonzalez-Cadavid NF, Burnett AL, Magee TR, Zeller CB, Vernet D, Smith N, Gitter J, Rajfer J. Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves. Biol Reprod. 2000 Sep; 63(3):704-14. PMID: 10952911.
      Citations: 10     Fields:    Translation:AnimalsCells
    94. Gonzalez-Cadavid NF, Ryndin I, Vernet D, Magee TR, Rajfer J. Presence of NMDA receptor subunits in the male lower urogenital tract. J Androl. 2000 Jul-Aug; 21(4):566-78. PMID: 10901443.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    95. Gonzalez-Cadavid NF, Rajfer J. Therapeutic stimulation of penile nitric oxide synthase (NOS) and related pathways. Drugs Today (Barc). 2000 Feb-Mar; 36(2-3):163-74. PMID: 12879114.
      Citations: 1     Fields:    
    96. Zachwieja JJ, Smith SR, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. J Gravit Physiol. 1999 Oct; 6(2):11-5. PMID: 11543081.
      Citations: 17     Fields:    Translation:Humans
    97. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14938-43. PMID: 9843994; PMCID: PMC24554.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    98. Vernet D, Bonavera JJ, Swerdloff RS, Gonzalez-Cadavid NF, Wang C. Spontaneous expression of inducible nitric oxide synthase in the hypothalamus and other brain regions of aging rats. Endocrinology. 1998 Jul; 139(7):3254-61. PMID: 9645701.
      Citations: 13     Fields:    Translation:AnimalsCells
    99. Gelman J, Garbán H, Shen R, Ng C, Cai L, Rajfer J, Gonzalez-Cadavid NF. Transforming growth factor-beta1 (TGF-beta1) in penile and prostate growth in the rat during sexual maturation. J Androl. 1998 Jan-Feb; 19(1):50-7. PMID: 9537291.
      Citations: 1     Fields:    Translation:AnimalsCells
    100. Penson DF, Lugg JA, Coyne C, Sadeghi F, Freedman AL, Gonzalez-Cadavid NF, Rajfer J. Effect of cryptorchidism on testicular histology in a naturally cryptorchid animal model. J Urol. 1997 Nov; 158(5):1978-82. PMID: 9334653.
      Citations:    Fields:    Translation:Animals
    101. Penson DF, Ng C, Rajfer J, Gonzalez-Cadavid NF. Adrenal control of erectile function and nitric oxide synthase in the rat penis. Endocrinology. 1997 Sep; 138(9):3925-32. PMID: 9275083.
      Citations: 10     Fields:    Translation:Animals
    102. Moody JA, Vernet D, Laidlaw S, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term oral administration of L-arginine on the rat erectile response. J Urol. 1997 Sep; 158(3 Pt 1):942-7. PMID: 9258123.
      Citations: 7     Fields:    Translation:Animals
    103. Xie Y, Garban H, Ng C, Rajfer J, Gonzalez-Cadavid NF. Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. J Urol. 1997 Mar; 157(3):1121-6. PMID: 9072555.
      Citations: 18     Fields:    Translation:AnimalsPHPublic Health
    104. Shoskes DA, Xie Y, Gonzalez-Cadavid NF. Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat: implications for renal transplantation. Transplantation. 1997 Feb 27; 63(4):495-500. PMID: 9047140.
      Citations: 5     Fields:    Translation:Animals
    105. Lugg JA, Penson DF, Sadeghi F, Petrie B, Freedman AL, Gonzalez-Cadavid NF, Hikim AS, Rajfer J. Prevention of seminiferous tubular atrophy in a naturally cryptorchid rat model by early surgical intervention. J Androl. 1996 Nov-Dec; 17(6):726-32. PMID: 9016404.
      Citations: 4     Fields:    Translation:Animals
    106. Magee T, Fuentes AM, Garban H, Rajavashisth T, Marquez D, Rodriguez JA, Rajfer J, Gonzalez-Cadavid NF. Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract. Biochem Biophys Res Commun. 1996 Sep 04; 226(1):145-51. PMID: 8806605.
      Citations: 8     Fields:    Translation:AnimalsCells
    107. Shen R, Lin MC, Sadeghi F, Swerdloff RS, Rajfer J, Gonzalez-Cadavid NF. Androgens are not major down-regulators of androgen receptor levels during growth of the immature rat penis . J Steroid Biochem Mol Biol. 1996 Mar; 57(5-6):301-13. PMID: 8639466.
      Citations: 2     Fields:    Translation:AnimalsCells
    108. Garban H, Marquez D, Cai L, Rajfer J, Gonzalez-Cadavid NF. Restoration of normal adult penile erectile response in aged rats by long-term treatment with androgens. Biol Reprod. 1995 Dec; 53(6):1365-72. PMID: 8562693.
      Citations: 7     Fields:    Translation:AnimalsCells
    109. Vernet D, Cai L, Garban H, Babbitt ML, Murray FT, Rajfer J, Gonzalez-Cadavid NF. Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction. Endocrinology. 1995 Dec; 136(12):5709-17. PMID: 7588327.
      Citations: 23     Fields:    Translation:Animals
    110. Moriel EZ, Gonzalez-Cadavid N, Ignarro LJ, Byrns R, Rajfer J. Levels of nitric oxide metabolites do not increase during penile erection. Urology. 1993 Nov; 42(5):551-3. PMID: 8236600.
      Citations: 3     Fields:    Translation:Humans
    111. Gonzalez-Cadavid NF, Swerdloff RS, Lemmi CA, Rajfer J. Expression of the androgen receptor gene in rat penile tissue and cells during sexual maturation. Endocrinology. 1991 Sep; 129(3):1671-8. PMID: 1874196.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    112. Gonzalez-Cadavid N, Gatti RA, Neuwirth H. Automated direct sequencing of polymerase chain reaction-amplified fragments of the human Ha-ras gene. Anal Biochem. 1990 Dec; 191(2):359-64. PMID: 2085180.
      Citations:    Fields:    Translation:HumansCells
    113. Gonzalez-Cadavid NF, Zhou D, Battifora H, Bar-Eli M, Cline MJ. Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas. Oncogene. 1989 Sep; 4(9):1137-40. PMID: 2674856.
      Citations: 11     Fields:    Translation:Humans
    114. Bar-Eli M, Ahuja H, Gonzalez-Cadavid N, Foti A, Cline MJ. Analysis of N-RAS exon-1 mutations in myelodysplastic syndromes by polymerase chain reaction and direct sequencing. Blood. 1989 Jan; 73(1):281-3. PMID: 2642713.
      Citations: 14     Fields:    Translation:HumansCells
    115. Zhou DJ, Gonzalez-Cadavid N, Ahuja H, Battifora H, Moore GE, Cline MJ. A unique pattern of proto-oncogene abnormalities in ovarian adenocarcinomas. Cancer. 1988 Oct 15; 62(8):1573-6. PMID: 3167770.
      Citations: 12     Fields:    Translation:Humans
    116. Arvelo F, Perez JL, Antuna O, Gonzalez-Cadavid NF. Efficient malignant transformation of rat embryo fibroblasts by genomic DNA from Walker carcinoma cells. Anticancer Res. 1988 May-Jun; 8(3):459-65. PMID: 3389748.
      Citations:    Fields:    Translation:AnimalsCells
    117. Chomyn A, Mariottini P, Gonzalez-Cadavid N, Attardi G, Strong DD, Trovato D, Riley M, Doolittle RF. Identification of the polypeptides encoded in the ATPase 6 gene and in the unassigned reading frames 1 and 3 of human mtDNA. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5535-9. PMID: 6225122; PMCID: PMC384292.
      Citations: 13     Fields:    Translation:HumansCells
    118. Carmona A, Gonzalez-Cadavid NF. Comparative effect of a family of substituted thiopseudoureas on protein synthesis by rat liver and Walker carcinoma ribosomes. Chem Biol Interact. 1978 Sep; 22(2-3):309-27. PMID: 699180.
      Citations: 2     Fields:    Translation:AnimalsCells
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