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Gregory A. Brent, MD

TitleClinical Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
PhoneNot Available
FaxNot Available
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    Research
    research activities and funding
    R01DK098576     (BRENT, GREGORY A.)May 1, 2014 - Feb 28, 2019
    NIH
    Thyroid Hormone Receptor Isoform-Specific Actions
    Role: Principal Investigator
    I01BX001966     (BRENT, GREGORY A)Jan 1, 2014 - Mar 31, 2028
    NIH
    Thyroid Hormone and Neuronal Protection
    Role: Principal Investigator
    R01DK067233     (BRENT, GREGORY A.)Mar 1, 2004 - Feb 28, 2010
    NIH
    Thyroid Hormone Receptor Isoform-Specific Actions
    Role: Principal Investigator
    R01CA089364     (BRENT, GREGORY A.)Jan 12, 2001 - Apr 30, 2013
    NIH
    Regulation of the Sodium/Iodide Symporter in Breast
    Role: Principal Investigator
    R01DK043714     (BRENT, GREGORY A.)Feb 1, 1992 - Apr 30, 2001
    NIH
    ANIMAL AND CELLULAR MODELS OF THYROID HORMONE RESISTANCE
    Role: Principal Investigator

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Leung AM, Brent GA, Larson SM, Osborne JR, Flavell RR, Ringel MD, Sosa JA. Counseling Female Thyroid Cancer Patients on Radioactive Iodine and Fertility. Thyroid. 2026 May; 36(5):547-548. PMID: 41937615.
      Citations:    Fields:    
    2. Aguiari P, Villani V, Liu YY, Carraro G, Brent GA, Perin L, Milanesi A. Hypothyroidism impairs skeletal muscle regeneration after injury by altering myogenic and nonmyogenic pathways. JCI Insight. 2026 Mar 23; 11(6). PMID: 41869726; PMCID: PMC13043096.
      Citations:    Fields:    Translation:Animals
    3. Leung AM, Pearce EN, Brent GA, K?hrle J. Not So Fast: Incomplete Assumptions of Adverse Thyroid Effects from PFAS Exposure. Environ Sci Technol. 2025 Dec 16; 59(49):26313-26315. PMID: 41329804; PMCID: PMC12713778.
      Citations:    Fields:    
    4. Wang SY, Stofer R, Wang H, Brent GA, Shi L, Cai Y, Roosan M, Moin T. Bridging Efficacy and Adherence in Glucagon-Like Peptide-1 Receptor Agonist Therapy: The Emerging Role of Oral Agents. Diabetes Metab J. 2025 Nov; 49(6):1331-1333. PMID: 41243299; PMCID: PMC12620693.
      Citations:    
    5. Liu YY, Chen W, Aguiari P, Abe K, Milanesi A, Brent GA. Thyroxine Treatment after Traumatic Brain Injury Suppresses Astrogliosis and Enhances Neuronal Recovery in Mice. Thyroid. 2025 09; 35(9):1083-1094. PMID: 40853072; PMCID: PMC12935074.
      Citations:    Fields:    Translation:AnimalsCells
    6. Ringel MD, Sosa JA, Baloch Z, Bischoff L, Bloom G, Brent GA, Brock PL, Chou R, Flavell RR, Goldner W, Grubbs EG, Haymart M, Larson SM, Leung AM, Osborne JR, Ridge JA, Robinson B, Steward DL, Tufano RP, Wirth LJ. 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer. Thyroid. 2025 08; 35(8):841-985. PMID: 40844370; PMCID: PMC13090833.
      Citations: 126     Fields:    Translation:Humans
    7. Dillon CF, Weisman MH, Leung AM, Brent GA, Miller FW. Autoimmune Thyroid Disease in the United States: Population Prevalence, Diagnosis Rates, and Trends. J Endocr Soc. 2025 Oct; 9(10):bvaf120. PMID: 40980542; PMCID: PMC12449141.
      Citations: 2     
    8. Ko M, Barai R, Brent G. Phosphate Binder Impairs Levothyroxine Absorption in a Hypothyroid Patient With End-Stage Renal Disease. Cureus. 2024 Oct; 16(10):e71551. PMID: 39544577; PMCID: PMC11563566.
      Citations: 1     
    9. Leung AM, Brent GA. Pregnancy-Does Promotion of Growth Extend to Thyroid Cancer? J Clin Endocrinol Metab. 2024 Jun 17; 109(7):e1552-e1553. PMID: 38041866.
      Citations: 1     Fields:    Translation:Humans
    10. Lechner MG, Brent GA. A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer. Clin Cancer Res. 2024 04 01; 30(7):1220-1222. PMID: 38197869; PMCID: PMC10984766.
      Citations:    Fields:    Translation:Animals
    11. Milanesi A, Brent GA. Weighing in on Thyroid Signaling in the Hypothalamus: Mechanisms and Interface with Metabolic Regulators. Thyroid. 2024 02; 34(2):141-143. PMID: 38269429.
      Citations: 1     Fields:    Translation:HumansCells
    12. You AS, Kalantar-Zadeh K, Brent GA, Narasaki Y, Daza A, Sim JJ, Kovesdy CP, Nguyen DV, Rhee CM. Impact of Thyroid Status on Incident Kidney Dysfunction and Chronic Kidney Disease Progression in a Nationally Representative Cohort. Mayo Clin Proc. 2024 Jan; 99(1):39-56. PMID: 38176833; PMCID: PMC10795379.
      Citations: 8     Fields:    Translation:Humans
    13. Rhee CM, You AS, Narasaki Y, Brent GA, Sim JJ, Kovesdy CP, Kalantar-Zadeh K, Nguyen DV. Development and Validation of a Prediction Model for Incident Hypothyroidism in a National Chronic Kidney Disease Cohort. J Clin Endocrinol Metab. 2023 10 18; 108(11):e1374-e1383. PMID: 37186674; PMCID: PMC11009786.
      Citations: 3     Fields:    Translation:Humans
    14. Brent GA. A Historical Reflection on Scientific Advances in Understanding Thyroid Hormone Action. Thyroid. 2023 10; 33(10):1140-1149. PMID: 37594753.
      Citations: 9     Fields:    Translation:HumansAnimals
    15. Praw SS, Brent GA. Approach to the Patient With a Suppressed TSH. J Clin Endocrinol Metab. 2023 01 17; 108(2):472-482. PMID: 36329632.
      Citations: 6     Fields:    Translation:Humans
    16. Abe K, Li J, Liu YY, Brent GA. Thyroid Hormone-mediated Histone Modification Protects Cortical Neurons From the Toxic Effects of Hypoxic Injury. J Endocr Soc. 2022 Oct 11; 6(11):bvac139. PMID: 36817622; PMCID: PMC9562813.
      Citations: 6     
    17. Rhee CM, Budoff M, Brent G, You AS, Stenvinkel P, Novoa A, Flores F, Hamal S, Dailing C, Kinninger A, Nakata T, Kovesdy CP, Nguyen DV, Kalantar-Zadeh K. Serum Thyrotropin Elevation and Coronary Artery Calcification in Hemodialysis Patients. Cardiorenal Med. 2022; 12(3):106-116. PMID: 35551382; PMCID: PMC9452456.
      Citations: 5     Fields:    Translation:Humans
    18. Chou R, Dana T, Brent GA, Goldner W, Haymart M, Leung AM, Ringel MD, Sosa JA. Serum Thyroglobulin Measurement Following Surgery Without Radioactive Iodine for Differentiated Thyroid Cancer: A Systematic Review. Thyroid. 2022 06; 32(6):613-639. PMID: 35412871; PMCID: PMC11265617.
      Citations: 32     Fields:    Translation:Humans
    19. Liu YY, Jiang J, Ke S, Milanesi A, Abe K, Gastelum G, Li J, Brent GA. Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores. Sci Rep. 2021 12 16; 11(1):24105. PMID: 34916557; PMCID: PMC8677787.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    20. Ke S, Liu YY, Karthikraj R, Kannan K, Jiang J, Abe K, Milanesi A, Brent GA. Thyroid hormone receptor ? sumoylation is required for thyrotropin regulation and thyroid hormone production. JCI Insight. 2021 08 23; 6(16). PMID: 34237030; PMCID: PMC8410017.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. You AS, Budoff M, Zeb I, Ahmadi N, Novoa A, Flores F, Hamal S, Kinninger A, Dailing C, Nakata T, Kovesdy CP, Nguyen DV, Brent GA, Kalantar-Zadeh K, Rhee CM. Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort. Hemodial Int. 2022 01; 26(1):57-65. PMID: 34231302; PMCID: PMC10753993.
      Citations: 5     Fields:    Translation:Humans
    22. Liu YY, Brent GA. The Role of Thyroid Hormone in Neuronal Protection. Compr Physiol. 2021 06 01; 11(3):2075-2095. PMID: 34061976.
      Citations: 20     Fields:    Translation:HumansAnimals
    23. Aguiari P, Liu YY, Petrosyan A, Cheng SY, Brent GA, Perin L, Milanesi A. Persistent COUP-TFII expression underlies the myopathy and impaired muscle regeneration observed in resistance to thyroid hormone-alpha. Sci Rep. 2021 02 25; 11(1):4601. PMID: 33633251; PMCID: PMC7907286.
      Citations: 2     Fields:    Translation:AnimalsCells
    24. Inoue K, Ritz B, Brent GA, Ebrahimi R, Rhee CM, Leung AM. Association of Subclinical Hypothyroidism and Cardiovascular Disease With Mortality. JAMA Netw Open. 2020 02 05; 3(2):e1920745. PMID: 32031647; PMCID: PMC12064075.
      Citations: 98     Fields:    Translation:Humans
    25. You AS, Sim JJ, Kovesdy CP, Streja E, Nguyen DV, Brent GA, Kalantar-Zadeh K, Rhee CM. Association of thyroid status prior to transition to end-stage renal disease with early dialysis mortality. Nephrol Dial Transplant. 2019 12 01; 34(12):2095-2104. PMID: 30299498; PMCID: PMC6887739.
      Citations: 11     Fields:    Translation:Humans
    26. Li J, Abe K, Milanesi A, Liu YY, Brent GA. Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis. Endocrinology. 2019 10 01; 160(10):2243-2256. PMID: 31095291.
      Citations: 19     Fields:    Translation:AnimalsCells
    27. Granville L, Brent GA, Pregler J. Older Adults with Cognitive Impairment Have Sex: More Evidence Against the Medical Myth of Sexless Aging. J Am Geriatr Soc. 2018 10; 66(10):1870-1871. PMID: 30207596.
      Citations: 2     Fields:    Translation:Humans
    28. Gourdain PA, Brent G, Greenly JB, Hammer DA, Shapovalov RV. The generation of mega-gauss fields on the Cornell beam research accelerator. Rev Sci Instrum. 2018 Sep; 89(9):095102. PMID: 30278768.
      Citations:    Fields:    
    29. Rhee CM, Kalantar-Zadeh K, Ravel V, Streja E, You AS, Brunelli SM, Nguyen DV, Brent GA, Kovesdy CP. Thyroid Status and Death Risk in US Veterans With Chronic Kidney Disease. Mayo Clin Proc. 2018 05; 93(5):573-585. PMID: 29728200; PMCID: PMC6049829.
      Citations: 18     Fields:    Translation:Humans
    30. Liu YY, Brent GA. Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury. Pharmacol Ther. 2018 06; 186:176-185. PMID: 29378220; PMCID: PMC5962384.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    31. Teng X, Liu YY, Teng W, Brent GA. COUP-TF1 Modulates Thyroid Hormone Action in an Embryonic Stem-Cell Model of Cortical Pyramidal Neuronal Differentiation. Thyroid. 2018 05; 28(5):667-678. PMID: 29205104; PMCID: PMC5952340.
      Citations: 7     Fields:    Translation:AnimalsCells
    32. Liu YY, Brent GA. Posttranslational Modification of Thyroid Hormone Nuclear Receptor by Phosphorylation. Methods Mol Biol. 2018; 1801:39-46. PMID: 29892815.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    33. Liu YY, Brent GA. Posttranslational Modification of Thyroid Hormone Nuclear Receptor by Sumoylation. Methods Mol Biol. 2018; 1801:47-59. PMID: 29892816.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    34. Milanesi A, Lee JW, Yang A, Liu YY, Sedrakyan S, Cheng SY, Perin L, Brent GA. Thyroid Hormone Receptor Alpha is Essential to Maintain the Satellite Cell Niche During Skeletal Muscle Injury and Sarcopenia of Aging. Thyroid. 2017 10; 27(10):1316-1322. PMID: 28847239; PMCID: PMC5649408.
      Citations: 20     Fields:    Translation:AnimalsCells
    35. Rhee CM, Chen Y, You AS, Brunelli SM, Kovesdy CP, Budoff MJ, Brent GA, Kalantar-Zadeh K, Nguyen DV. Thyroid Status, Quality of Life, and Mental Health in Patients on Hemodialysis. Clin J Am Soc Nephrol. 2017 Aug 07; 12(8):1274-1283. PMID: 28705886; PMCID: PMC5544520.
      Citations: 19     Fields:    Translation:HumansCells
    36. Rhee CM, Kovesdy CP, Ravel VA, Streja E, Brunelli SM, Soohoo M, Sumida K, Molnar MZ, Brent GA, Nguyen DV, Kalantar-Zadeh K. Association of Glycemic Status During Progression of Chronic Kidney Disease With Early Dialysis Mortality in Patients With Diabetes. Diabetes Care. 2017 08; 40(8):1050-1057. PMID: 28592525; PMCID: PMC5521972.
      Citations: 18     Fields:    Translation:Humans
    37. Li J, Donangelo I, Abe K, Scremin O, Ke S, Li F, Milanesi A, Liu YY, Brent GA. Thyroid hormone treatment activates protective pathways in both in?vivo and in?vitro models of neuronal injury. Mol Cell Endocrinol. 2017 09 05; 452:120-130. PMID: 28549992.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    38. Rhee CM, You AS, Nguyen DV, Brunelli SM, Budoff MJ, Streja E, Nakata T, Kovesdy CP, Brent GA, Kalantar-Zadeh K. Thyroid Status and Mortality in a Prospective Hemodialysis Cohort. J Clin Endocrinol Metab. 2017 05 01; 102(5):1568-1577. PMID: 28324018; PMCID: PMC5443328.
      Citations: 29     Fields:    Translation:Humans
    39. Milanesi A, Brent GA. Beam Me In: Thyroid Hormone Analog Targets Alternative Transporter in Mouse Model of X-Linked Adrenoleukodystrophy Endocrinology. 2017 04 29; 158(5):1116-1119. PMID: 28609836; PMCID: PMC5460838.
      Citations: 1     Fields:    
    40. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017 03; 27(3):315-389. PMID: 28056690.
      Citations: 963     Fields:    Translation:Humans
    41. Rhee CM, Ravel VA, Streja E, Mehrotra R, Kim S, Wang J, Nguyen DV, Kovesdy CP, Brent GA, Kalantar-Zadeh K. Thyroid Functional Disease and Mortality in a National Peritoneal Dialysis Cohort. J Clin Endocrinol Metab. 2016 11; 101(11):4054-4061. PMID: 27525529; PMCID: PMC5095247.
      Citations: 21     Fields:    Translation:Humans
    42. Leung AM, Korevaar TI, Peeters RP, Zoeller RT, K?hrle J, Duntas LH, Brent GA, Demeneix BA. Exposure to Thyroid-Disrupting Chemicals: A Transatlantic Call for Action. Thyroid. 2016 Apr; 26(4):479-80. PMID: 26906244; PMCID: PMC4827314.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    43. Milanesi A, Lee JW, Kim NH, Liu YY, Yang A, Sedrakyan S, Kahng A, Cervantes V, Tripuraneni N, Cheng SY, Perin L, Brent GA. Thyroid Hormone Receptor a Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury. Endocrinology. 2016 Jan; 157(1):4-15. PMID: 26451739; PMCID: PMC4701883.
      Citations: 31     Fields:    Translation:AnimalsCells
    44. Teng X, Jin T, Brent GA, Wu A, Teng W, Shan Z. A Patient With a Thyrotropin-Secreting Microadenoma and Resistance to Thyroid Hormone (P453T). J Clin Endocrinol Metab. 2015 Jul; 100(7):2511-4. PMID: 25867808; PMCID: PMC5393528.
      Citations: 26     Fields:    Translation:Humans
    45. Rhee CM, Nguyen DV, Moradi H, Brunelli SM, Dukkipati R, Jing J, Nakata T, Kovesdy CP, Brent GA, Kalantar-Zadeh K. Association of Adiponectin With Body Composition and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2015 Aug; 66(2):313-21. PMID: 25824125; PMCID: PMC4516594.
      Citations: 34     Fields:    Translation:Humans
    46. Rhee CM, Kim S, Gillen DL, Oztan T, Wang J, Mehrotra R, Kuttykrishnan S, Nguyen DV, Brunelli SM, Kovesdy CP, Brent GA, Kalantar-Zadeh K. Association of thyroid functional disease with mortality in a national cohort of incident hemodialysis patients. J Clin Endocrinol Metab. 2015 Apr; 100(4):1386-95. PMID: 25632971; PMCID: PMC4399303.
      Citations: 42     Fields:    Translation:Humans
    47. Liu YY, Ayers S, Milanesi A, Teng X, Rabi S, Akiba Y, Brent GA. Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation. J Biol Chem. 2015 Mar 20; 290(12):7402-15. PMID: 25572392; PMCID: PMC4367250.
      Citations: 15     Fields:    Translation:HumansCells
    48. Labadzhyan A, Brent GA, Hershman JM, Leung AM. Thyrotoxicosis of Pregnancy. J Clin Transl Endocrinol. 2014 Dec 01; 1(4):140-144. PMID: 25243108; PMCID: PMC4166486.
      Citations: 11     
    49. Lee SY, Rhee CM, Leung AM, Braverman LE, Brent GA, Pearce EN. A review: Radiographic iodinated contrast media-induced thyroid dysfunction. J Clin Endocrinol Metab. 2015 Feb; 100(2):376-83. PMID: 25375985; PMCID: PMC4318903.
      Citations: 81     Fields:    Translation:Humans
    50. Brent GA. Perchlorate exposure in pregnancy and cognitive outcomes in children: it's not your mother's thyroid. J Clin Endocrinol Metab. 2014 Nov; 99(11):4066-8. PMID: 25372124; PMCID: PMC4223440.
      Citations: 4     Fields:    Translation:Humans
    51. Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014 Apr; 94(2):355-82. PMID: 24692351; PMCID: PMC4044302.
      Citations: 940     Fields:    Translation:HumansAnimalsCells
    52. Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. Thyroid. 2014 Mar; 24(3):407-9. PMID: 24588711; PMCID: PMC3950730.
      Citations: 17     Fields:    Translation:Humans
    53. Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. Eur Thyroid J. 2014 Mar; 3(1):7-9. PMID: 24847459; PMCID: PMC4005262.
      Citations: 13     Fields:    
    54. Rhee CM, Leung AM, Kovesdy CP, Lynch KE, Brent GA, Kalantar-Zadeh K. Updates on the management of diabetes in dialysis patients. Semin Dial. 2014 Mar; 27(2):135-45. PMID: 24588802; PMCID: PMC3960718.
      Citations: 56     Fields:    Translation:Humans
    55. Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. J Clin Endocrinol Metab. 2014 Mar; 99(3):768-70. PMID: 24823702; PMCID: PMC3942236.
      Citations: 26     Fields:    Translation:Humans
    56. Rhee CM, Brent GA, Kovesdy CP, Soldin OP, Nguyen D, Budoff MJ, Brunelli SM, Kalantar-Zadeh K. Thyroid functional disease: an under-recognized cardiovascular risk factor in kidney disease patients. Nephrol Dial Transplant. 2015 May; 30(5):724-37. PMID: 24574542; PMCID: PMC4425477.
      Citations: 51     Fields:    Translation:HumansAnimals
    57. Brent GA. Commentary on: "American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models," Bianco et al. Thyroid. 2014 Jan; 24(1):1-2. PMID: 24303889; PMCID: PMC3887401.
      Citations: 1     Fields:    Translation:HumansAnimals
    58. Leung AM, Brent GA. Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8-9 years of age. Evid Based Nurs. 2014 Jul; 17(3):86. PMID: 24336752; PMCID: PMC4055540.
      Citations:    Fields:    Translation:Humans
    59. Brent GA, Kogai T. Cancer: Novel target to enhance radioiodine uptake in thyroid cancer. Nat Rev Endocrinol. 2013 Sep; 9(9):508-9. PMID: 23817292.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    60. Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012 Sep; 122(9):3035-43. PMID: 22945636; PMCID: PMC3433956.
      Citations: 483     Fields:    Translation:HumansAnimalsCells
    61. Liu YY, Kogai T, Schultz JJ, Mody K, Brent GA. Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation. J Biol Chem. 2012 Oct 19; 287(43):36499-508. PMID: 22930759; PMCID: PMC3476315.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    62. Kogai T, Brent GA. The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics. Pharmacol Ther. 2012 Sep; 135(3):355-70. PMID: 22750642; PMCID: PMC3408573.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    63. Brent GA. The debate over thyroid-function screening in pregnancy. N Engl J Med. 2012 Feb 09; 366(6):562-3. PMID: 22316450.
      Citations: 17     Fields:    Translation:Humans
    64. Kogai T, Liu YY, Mody K, Shamsian DV, Brent GA. Regulation of sodium iodide symporter gene expression by Rac1/p38? mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells. J Biol Chem. 2012 Jan 27; 287(5):3292-300. PMID: 22157753; PMCID: PMC3270984.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    65. Milanesi A, Brent GA. Management of hypothyroidism in pregnancy. Curr Opin Endocrinol Diabetes Obes. 2011 Oct; 18(5):304-9. PMID: 21841481.
      Citations: 4     Fields:    Translation:Humans
    66. Soldin OP, Brent GA, Kloos RT. Publication of industry-sponsored medical research: guidelines from the Consortium of Laboratory Medicine Journal Editors. Thyroid. 2011 Jul; 21(7):693. PMID: 21707435.
      Citations:    Fields:    
    67. Liu YY, Nakatani T, Kogai T, Mody K, Brent GA. Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression. Endocrinology. 2011 Mar; 152(3):1143-53. PMID: 21266512; PMCID: PMC3040047.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    68. Brent GA. Environmental exposures and autoimmune thyroid disease. Thyroid. 2010 Jul; 20(7):755-61. PMID: 20578899; PMCID: PMC2935336.
      Citations: 58     Fields:    Translation:HumansAnimalsPHPublic Health
    69. Brent GA. The impact of perchlorate exposure in early pregnancy: is it safe to drink the water? J Clin Endocrinol Metab. 2010 Jul; 95(7):3154-7. PMID: 20610607; PMCID: PMC2928898.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    70. Kogai T, Liu YY, Richter LL, Mody K, Kagechika H, Brent GA. Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8). J Biol Chem. 2010 Aug 27; 285(35):27279-27288. PMID: 20573951; PMCID: PMC2930727.
      Citations: 16     Fields:    Translation:AnimalsCells
    71. Liu YY, Brent GA. Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. Trends Endocrinol Metab. 2010 Mar; 21(3):166-73. PMID: 20015660; PMCID: PMC2831161.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    72. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology. 2010 Jan; 151(1):432-40. PMID: 19906816; PMCID: PMC2817565.
      Citations: 57     Fields:    Translation:AnimalsCells
    73. Ohashi E, Kogai T, Kagechika H, Brent GA. Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells. Cancer Res. 2009 Apr 15; 69(8):3443-50. PMID: 19351850; PMCID: PMC2852426.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    74. Kogai T, Sajid-Crockett S, Newmarch LS, Liu YY, Brent GA. Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells. J Endocrinol. 2008 Nov; 199(2):243-52. PMID: 18762555.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    75. Brent GA. Clinical practice. Graves' disease. N Engl J Med. 2008 Jun 12; 358(24):2594-605. PMID: 18550875.
      Citations: 192     Fields:    Translation:Humans
    76. Liu YY, Brent GA. Stealth sequences in reporter gene vectors confound studies of T3-regulated negative gene expression. Thyroid. 2008 Jun; 18(6):593-5. PMID: 18578606.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    77. Kogai T, Ohashi E, Jacobs MS, Sajid-Crockett S, Fisher ML, Kanamoto Y, Brent GA. Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways. J Clin Endocrinol Metab. 2008 May; 93(5):1884-92. PMID: 18319322; PMCID: PMC2386284.
      Citations: 14     Fields:    Translation:HumansCells
    78. Brent GA, Braverman LE, Zoeller RT. Thyroid health and the environment. Thyroid. 2007 Sep; 17(9):807-9. PMID: 17956154.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    79. Brent GA. Diagnosing thyroid dysfunction in pregnant women: Is case finding enough? J Clin Endocrinol Metab. 2007 Jan; 92(1):39-41. PMID: 17209222.
      Citations: 8     Fields:    Translation:Humans
    80. O'Barr SA, Oh JS, Ma C, Brent GA, Schultz JJ. Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models. Thyroid. 2006 Dec; 16(12):1207-13. PMID: 17199430.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    81. Liu YY, Heymann RS, Moatamed F, Schultz JJ, Sobel D, Brent GA. A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation. Endocrinology. 2007 Mar; 148(3):1206-17. PMID: 17122078.
      Citations: 36     Fields:    Translation:AnimalsCells
    82. Kogai T, Taki K, Brent GA. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr Relat Cancer. 2006 Sep; 13(3):797-826. PMID: 16954431.
      Citations: 82     Fields:    Translation:HumansCells
    83. Zhang L, Sharma S, Hershman JM, Brent GA, Dubinett SM, Huang M. Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation. Cancer Gene Ther. 2006 Jan 01; 13(1):74-81. PMID: 16052231.
      Citations: 1     Fields:    Translation:HumansCells
    84. Heymann RS, Brent GA, Hershman JM. Anaplastic thyroid carcinoma with thyrotoxicosis and hypoparathyroidism. Endocr Pract. 2005 Jul-Aug; 11(4):281-4. PMID: 16006301.
      Citations: 4     Fields:    Translation:Humans
    85. Kogai T, Kanamoto Y, Li AI, Che LH, Ohashi E, Taki K, Chandraratna RA, Saito T, Brent GA. Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells. Endocrinology. 2005 Jul; 146(7):3059-69. PMID: 15817668.
      Citations: 22     Fields:    Translation:HumansCells
    86. Heymann R, Brent GA. Rapid progression from subclinical to symptomatic overt hypothyroidism. Endocr Pract. 2005 Mar-Apr; 11(2):115-9. PMID: 15901527.
      Citations: 3     Fields:    Translation:Humans
    87. Fukata S, Brent GA, Sugawara M. Resistance to thyroid hormone in Hashimoto's thyroiditis. N Engl J Med. 2005 Feb 03; 352(5):517-8. PMID: 15689599.
      Citations: 8     Fields:    Translation:Humans
    88. Shen X, Li QL, Brent GA, Friedman TC. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E236-45. PMID: 15585599.
      Citations: 3     Fields:    Translation:AnimalsCells
    89. Brent G, Boyle CA. Introduction. The impact of maternal thyroid diseases on the developing fetus: implications for diagnosis, treatment, and screening. Summary of proceedings, workshop organization, program, and participants. Thyroid. 2005 Jan; 15(1):36-40. PMID: 15687821.
      Citations:    Fields:    Translation:Humans
    90. Smallridge RC, Glinoer D, Hollowell JG, Brent G. Thyroid function inside and outside of pregnancy: what do we know and what don't we know? Thyroid. 2005 Jan; 15(1):54-9. PMID: 15687824.
      Citations: 17     Fields:    Translation:Humans
    91. Liu YY, Brent GA. Thyroid hormone-dependent gene expression in differentiated embryonic stem cells and embryonal carcinoma cells: identification of novel thyroid hormone target genes by deoxyribonucleic acid microarray analysis. Endocrinology. 2005 Feb; 146(2):776-83. PMID: 15550503.
      Citations: 8     Fields:    Translation:AnimalsCells
    92. Shen X, Li QL, Brent GA, Friedman TC. Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements. J Mol Endocrinol. 2004 Aug; 33(1):21-33. PMID: 15291740.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    93. Kogai T, Kanamoto Y, Che LH, Taki K, Moatamed F, Schultz JJ, Brent GA. Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models. Cancer Res. 2004 Jan 01; 64(1):415-22. PMID: 14729653.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    94. Xu J, Moatamed F, Caldwell JS, Walker JR, Kraiem Z, Taki K, Brent GA, Hershman JM. Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J Clin Endocrinol Metab. 2003 Oct; 88(10):4990-6. PMID: 14557485.
      Citations: 39     Fields:    Translation:HumansCells
    95. Freitas FR, Moriscot AS, Jorgetti V, Soares AG, Passarelli M, Scanlan TS, Brent GA, Bianco AC, Gouveia CH. Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1135-41. PMID: 12965872.
      Citations: 23     Fields:    Translation:Animals
    96. Lafranchi SH, Snyder DB, Sesser DE, Skeels MR, Singh N, Brent GA, Nelson JC. Follow-up of newborns with elevated screening T4 concentrations. J Pediatr. 2003 Sep; 143(3):296-301. PMID: 14517508.
      Citations: 52     Fields:    Translation:HumansPHPublic Health
    97. Zhang L, Sharma S, Zhu LX, Kogai T, Hershman JM, Brent GA, Dubinett SM, Huang M. Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells. Cancer Res. 2003 Aug 15; 63(16):5065-72. PMID: 12941836.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    98. Liu YY, Schultz JJ, Brent GA. A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem. 2003 Oct 03; 278(40):38913-20. PMID: 12869545.
      Citations: 54     Fields:    Translation:AnimalsCells
    99. Kogai T, Kanamoto Y, Brent GA. The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells. Breast Cancer Res Treat. 2003 Mar; 78(1):119-26. PMID: 12611464.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    100. Liu YY, Brent GA. A complex deoxyribonucleic acid response element in the rat Ca(2+)/calmodulin-dependent protein kinase IV gene 5'-flanking region mediates thyroid hormone induction and chicken ovalbumin upstream promoter transcription factor 1 repression. Mol Endocrinol. 2002 Nov; 16(11):2439-51. PMID: 12403833.
      Citations: 16     Fields:    Translation:AnimalsCells
    101. Taki K, Kogai T, Kanamoto Y, Hershman JM, Brent GA. A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells. Mol Endocrinol. 2002 Oct; 16(10):2266-82. PMID: 12351692.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    102. Gouveia CH, Schultz JJ, Jackson DJ, Williams GR, Brent GA. Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis. Thyroid. 2002 Aug; 12(8):663-71. PMID: 12225634.
      Citations: 1     Fields:    Translation:AnimalsCells
    103. Liu YY, Tachiki KH, Brent GA. A targeted thyroid hormone receptor alpha gene dominant-negative mutation (P398H) selectively impairs gene expression in differentiated embryonic stem cells. Endocrinology. 2002 Jul; 143(7):2664-72. PMID: 12072400.
      Citations: 13     Fields:    Translation:AnimalsCells
    104. Langton JE, Brent GA. Nonthyroidal illness syndrome: evaluation of thyroid function in sick patients. Endocrinol Metab Clin North Am. 2002 Mar; 31(1):159-72. PMID: 12055987.
      Citations: 21     Fields:    Translation:Humans
    105. Xu J, Kogai T, Brent GA, Hershman JM. A GC box in the human sodium iodide symporter gene promoter is essential for full activity. Thyroid. 2002 Feb; 12(2):107-14. PMID: 11916279.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    106. An J, Lichtenstein AK, Brent G, Rettig MB. The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. Blood. 2002 Jan 15; 99(2):649-54. PMID: 11781250.
      Citations: 52     Fields:    Translation:HumansCells
    107. Gouveia CH, Schultz JJ, Bianco AC, Brent GA. Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms. J Endocrinol. 2001 Sep; 170(3):667-75. PMID: 11524248.
      Citations: 16     Fields:    Translation:AnimalsCells
    108. Huang M, Batra RK, Kogai T, Lin YQ, Hershman JM, Lichtenstein A, Sharma S, Zhu LX, Brent GA, Dubinett SM. Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer. Cancer Gene Ther. 2001 Aug; 8(8):612-8. PMID: 11571539; PMCID: PMC1471880.
      Citations: 30     Fields:    Translation:HumansCells
    109. Kogai T, Hershman JM, Motomura K, Endo T, Onaya T, Brent GA. Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cells. Endocrinology. 2001 Aug; 142(8):3369-79. PMID: 11459780.
      Citations: 12     Fields:    Translation:HumansCells
    110. Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA. Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. J Clin Invest. 2001 Jul; 108(1):97-105. PMID: 11435461; PMCID: PMC209342.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    111. Li QL, Jansen E, Brent GA, Friedman TC. Regulation of prohormone convertase 1 (PC1) by thyroid hormone. Am J Physiol Endocrinol Metab. 2001 Jan; 280(1):E160-70. PMID: 11120670.
      Citations: 7     Fields:    Translation:AnimalsCells
    112. Kogai T, Curcio F, Hyman S, Cornford EM, Brent GA, Hershman JM. Induction of follicle formation in long-term cultured normal human thyroid cells treated with thyrotropin stimulates iodide uptake but not sodium/iodide symporter messenger RNA and protein expression. J Endocrinol. 2000 Oct; 167(1):125-35. PMID: 11018760.
      Citations: 23     Fields:    Translation:Humans
    113. Li QL, Jansen E, Brent GA, Naqvi S, Wilber JF, Friedman TC. Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor. Endocrinology. 2000 Sep; 141(9):3256-66. PMID: 10965896.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    114. Kogai T, Schultz JJ, Johnson LS, Huang M, Brent GA. Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8519-24. PMID: 10890895; PMCID: PMC26980.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    115. Brent GA. Tissue-specific actions of thyroid hormone: insights from animal models. Rev Endocr Metab Disord. 2000 Jan; 1(1-2):27-33. PMID: 11704989.
      Citations: 39     Fields:    Translation:Animals
    116. Brent GA. Maternal hypothyroidism: recognition and management. Thyroid. 1999 Jul; 9(7):661-5. PMID: 10447011.
      Citations: 8     Fields:    Translation:Humans
    117. Brent GA. Thyroid hormone action: down novel paths. Focus on "thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells". Am J Physiol. 1999 05; 276(5):C1012-3. PMID: 10329947.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    118. Hsu JH, Brent GA. Thyroid hormone receptor gene knockouts. Trends Endocrinol Metab. 1998 Apr; 9(3):103-12. PMID: 18406250.
      Citations: 21     Fields:    
    119. Motomura K, Brent GA. Mechanisms of thyroid hormone action. Implications for the clinical manifestation of thyrotoxicosis. Endocrinol Metab Clin North Am. 1998 Mar; 27(1):1-23. PMID: 9534024.
      Citations: 21     Fields:    Translation:HumansCells
    120. Lu W, Peissel B, Babakhanlou H, Pavlova A, Geng L, Fan X, Larson C, Brent G, Zhou J. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet. 1997 Oct; 17(2):179-81. PMID: 9326937.
      Citations: 146     Fields:    Translation:HumansAnimals
    121. Brent GA. Maternal thyroid function: interpretation of thyroid function tests in pregnancy. Clin Obstet Gynecol. 1997 Mar; 40(1):3-15. PMID: 9103946.
      Citations: 19     Fields:    Translation:Humans
    122. Simonides WS, Brent GA, Thelen MH, van der Linden CG, Larsen PR, van Hardeveld C. Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness. J Biol Chem. 1996 Dec 13; 271(50):32048-56. PMID: 8943255.
      Citations: 18     Fields:    Translation:AnimalsCells
    123. Zavacki AM, Harney JW, Brent GA, Larsen PR. Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor. Endocrinology. 1996 Jul; 137(7):2833-41. PMID: 8770904.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    124. Mandel SJ, Brent GA, Weinblatt M, Larsen PR. Prospective studies of thyroid function in patients receiving gold therapy. Thyroid. 1995 Apr; 5(2):113-6. PMID: 7647570.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    125. Hsu JH, Zavacki AM, Harney JW, Brent GA. Retinoid-X receptor (RXR) differentially augments thyroid hormone response in cell lines as a function of the response element and endogenous RXR content. Endocrinology. 1995 Feb; 136(2):421-30. PMID: 7835272.
      Citations: 12     Fields:    Translation:AnimalsCells
    126. Brent GA. The molecular basis of thyroid hormone action. N Engl J Med. 1994 Sep 29; 331(13):847-53. PMID: 8078532.
      Citations: 80     Fields:    Translation:HumansCells
    127. Lee LR, Mortensen RM, Larson CA, Brent GA. Thyroid hormone receptor-alpha inhibits retinoic acid-responsive gene expression and modulates retinoic acid-stimulated neural differentiation in mouse embryonic stem cells. Mol Endocrinol. 1994 Jun; 8(6):746-56. PMID: 7935490.
      Citations: 10     Fields:    Translation:AnimalsCells
    128. Williams GR, Zavacki AM, Harney JW, Brent GA. Thyroid hormone receptor binds with unique properties to response elements that contain hexamer domains in an inverted palindrome arrangement. Endocrinology. 1994 Apr; 134(4):1888-96. PMID: 8137757.
      Citations: 8     Fields:    Translation:AnimalsCells
    129. Mandel SJ, Brent GA, Larsen PR. Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis. Thyroid. 1994; 4(1):129-33. PMID: 7519913.
      Citations: 21     Fields:    Translation:Humans
    130. Zavacki AM, Harney JW, Brent GA, Larsen PR. Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. Mol Endocrinol. 1993 Oct; 7(10):1319-30. PMID: 8264663.
      Citations: 17     Fields:    Translation:AnimalsCells
    131. Mandel SJ, Brent GA, Larsen PR. Levothyroxine therapy in patients with thyroid disease. Ann Intern Med. 1993 Sep 15; 119(6):492-502. PMID: 8357116.
      Citations: 58     Fields:    Translation:Humans
    132. Williams GR, Brent GA. Specificity of nuclear hormone receptor action: who conducts the orchestra? J Endocrinol. 1992 Nov; 135(2):191-4. PMID: 1335469.
      Citations: 2     Fields:    Translation:Cells
    133. Williams GR, Harney JW, Moore DD, Larsen PR, Brent GA. Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol. 1992 Oct; 6(10):1527-37. PMID: 1333048.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    134. Brent GA, Williams GR, Harney JW, Forman BM, Samuels HH, Moore DD, Larsen PR. Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements. Mol Endocrinol. 1992 Apr; 6(4):502-14. PMID: 1584220.
      Citations: 19     Fields:    Translation:AnimalsCells
    135. Williams GR, Harney JW, Forman BM, Samuels HH, Brent GA. Oligomeric binding of T3 receptor is required for maximal T3 response. J Biol Chem. 1991 Oct 15; 266(29):19636-44. PMID: 1918070.
      Citations: 14     Fields:    Translation:AnimalsCells
    136. Brent GA, Williams GR, Harney JW, Forman BM, Samuels HH, Moore DD, Larsen PR. Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine. Mol Endocrinol. 1991 Apr; 5(4):542-8. PMID: 1922086.
      Citations: 7     Fields:    Translation:AnimalsCells
    137. Brent GA, Moore DD, Larsen PR. Thyroid hormone regulation of gene expression. Annu Rev Physiol. 1991; 53:17-35. PMID: 2042958.
      Citations: 51     Fields:    Translation:HumansAnimals
    138. Mandel SJ, Larsen PR, Seely EW, Brent GA. Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med. 1990 Jul 12; 323(2):91-6. PMID: 2359428.
      Citations: 44     Fields:    Translation:Humans
    139. Koenig RJ, Brent GA, Larsen PR, Moore DD. Direct repeats. Nature. 1990 Jun 14; 345(6276):584. PMID: 2161503.
      Citations:    Fields:    Translation:AnimalsCells
    140. Brent GA, Dunn MK, Harney JW, Gulick T, Larsen PR, Moore DD. Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol. 1989 Dec; 1(3):329-36. PMID: 2562125.
      Citations: 41     Fields:    Translation:AnimalsCells
    141. Brent GA, Harney JW, Chen Y, Warne RL, Moore DD, Larsen PR. Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol Endocrinol. 1989 Dec; 3(12):1996-2004. PMID: 2628734.
      Citations: 53     Fields:    Translation:AnimalsCells
    142. Seely EW, Conlin PR, Brent GA, Dluhy RG. Adrenocorticotropin stimulation of aldosterone: prolonged continuous versus pulsatile infusion. J Clin Endocrinol Metab. 1989 Nov; 69(5):1028-32. PMID: 2551915.
      Citations: 14     Fields:    Translation:Humans
    143. Koenig RJ, Lazar MA, Hodin RA, Brent GA, Larsen PR, Chin WW, Moore DD. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature. 1989 Feb 16; 337(6208):659-61. PMID: 2537467.
      Citations: 88     Fields:    Translation:AnimalsCells
    144. Brent GA, Canessa M, Dluhy RG. Reversible alteration of red cell lithium-sodium countertransport in patients with thyroid disease. J Clin Endocrinol Metab. 1989 Feb; 68(2):322-8. PMID: 2918049.
      Citations:    Fields:    Translation:HumansCells
    145. Brent GA, Larsen PR, Harney JW, Koenig RJ, Moore DD. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem. 1989 Jan 05; 264(1):178-82. PMID: 2909514.
      Citations: 40     Fields:    Translation:AnimalsCells
    146. Brent GA, LeBoff MS, Seely EW, Conlin PR, Brown EM. Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. J Clin Endocrinol Metab. 1988 Nov; 67(5):944-50. PMID: 3141451.
      Citations: 26     Fields:    Translation:Humans
    147. Brent GA, Harney JW, Moore DD, Larsen PR. Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids. Mol Endocrinol. 1988 Sep; 2(9):792-8. PMID: 2845256.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    148. Koenig RJ, Warne RL, Brent GA, Harney JW, Larsen PR, Moore DD. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5031-5. PMID: 2899322; PMCID: PMC281681.
      Citations: 36     Fields:    Translation:AnimalsCells
    149. Koenig RJ, Brent GA, Warne RL, Larsen PR, Moore DD. Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone. Proc Natl Acad Sci U S A. 1987 Aug; 84(16):5670-4. PMID: 3475698; PMCID: PMC298924.
      Citations: 39     Fields:    Translation:AnimalsCells
    150. Brent GA, Hershman JM, Braunstein GD. Patients with severe nonthyroidal illness and serum thyrotropin concentrations in the hypothyroid range. Am J Med. 1986 Sep; 81(3):463-6. PMID: 3752147.
      Citations: 4     Fields:    Translation:Humans
    151. Brent GA, Hershman JM. Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration. J Clin Endocrinol Metab. 1986 Jul; 63(1):1-8. PMID: 3011834.
      Citations: 65     Fields:    Translation:HumansCTClinical Trials
    152. Brent GA, Hershman JM, Reed AW, Sastre A, Lieberman J. Serum angiotensin-converting enzyme in severe nonthyroidal illnesses associated with low serum thyroxine concentration. Ann Intern Med. 1984 May; 100(5):680-3. PMID: 6324625.
      Citations:    Fields:    Translation:Humans
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