"Chlormethiazole" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.
| Descriptor ID |
D002719
|
| MeSH Number(s) |
D02.886.675.180 D03.383.129.708.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Chlormethiazole".
Below are MeSH descriptors whose meaning is more specific than "Chlormethiazole".
This graph shows the total number of publications written about "Chlormethiazole" by people in this website by year, and whether "Chlormethiazole" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chlormethiazole" by people in Profiles.
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Mallory body forming cells express the preneoplastic hepatocyte phenotype. Exp Mol Pathol. 2006 Apr; 80(2):109-18.
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The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro study. Exp Mol Pathol. 2005 Aug; 79(1):1-8.
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CYP2E1 inhibition enhances mallory body formation. Exp Mol Pathol. 2005 Jun; 78(3):207-11.
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The p105/50 NF-kappaB pathway is essential for Mallory body formation. Exp Mol Pathol. 2005 Jun; 78(3):198-206.
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p62 is involved in the mechanism of Mallory body formation. Exp Mol Pathol. 2004 Dec; 77(3):168-75.
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The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation. Exp Mol Pathol. 2004 Feb; 76(1):9-16.
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Heat shock proteins are present in mallory bodies (cytokeratin aggresomes) in human liver biopsy specimens. Exp Mol Pathol. 2003 Apr; 74(2):168-72.
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The role of the ubiquitin-proteasome pathway in the formation of mallory bodies. Exp Mol Pathol. 2002 Oct; 73(2):75-83.