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Victor Chaban, PhD

InstitutionCharles R. Drew University of Medicine and Science
DepartmentBiomedical Science Education
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 568-3350
FaxNot Available
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    The primary focus of my research program is to elucidate the nociceptive pathways modulated by steroid hormones in nervous tissue. While a central site of this modulation has been widely accepted, I have continued to investigate how sex steroids act on primary nociceptors and modulate the response to pro- and anti-nociceptive signals, depending upon the nature of the signals interacting at the level of sensory neurons. Nociceptive systems are implicated in the etiology of functional disorders such as non- cardiac chest pain, interstitial cystitis, fibromyalgia, acute or chronic abdominal pain associated with functional bowel disorders, chronic pelvic pain. Incidence of episodic or persistent visceral pain associated with functional disorders is much higher in women than men; therefore, we have proposed a novel concept that suggests sex steroids may play a role in modulating peripheral cross-sensitization between different visceral organs. Our studies may provide important information about the actions of sex steroids on primary sensory neurons or a better understanding of gender differences observed in the clinical presentation of functional pain-associated disorders. Dr. Chaban received Wood-Whellan Award from International Union of Biochemistry and Molecular Biology and Fellowships from International Science Foundation, European Science Foundation and UNESCO. He also received 2008 President's Award for Excellence in Service to Charles R. Drew University of Medicine and Science and 2009 and 2015 CDU Life Sciences Institute Awards. In 2014 he received Special Recognition Award for Chairing 2nd International Conference on Endocrinology in Chicago. Currently he is Executive Editor of Journal of Autacoids and Hormones and Editor In Chief of International Journal of Research in Nursing http://thescipub.com/journals/ijrn/editors

    SC1NS063939     (CHABAN, VICTOR V)Aug 20, 2008 - Jan 31, 2015
    Estrogen Receptors and Nociceptive Signaling in Primary Afferent Neurons
    Role: Principal Investigator

    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chaban VV. Mechanisms and Management of Chronic Pain. Int J Res Nurs. 2021; 12(1):1-2. PMID: 35821964; PMCID: PMC9273131.
    2. Chaban VV. Peripheral modulation of chronic visceral pain. Curr Trends Neurol. 2020; 14:103-109. PMID: 35813119; PMCID: PMC9268209.
    3. Chaban V. Neural reorganization associated with visceral pain. Curr Trends Neurol. 2018; 12:75-79. PMID: 36655036; PMCID: PMC9844827.
    4. Chaban V. Visceral nociception and functional diseases. Curr Trends Neurol. 2017; 11:49-51. PMID: 36654534; PMCID: PMC9844826.
    5. Chaban VV. Visceral Pain: Basic Research Concepts and Therapeutic Interventions. Int J Res Nurs. 2015; 6(2):27-28. PMID: 26962411; PMCID: PMC4780356.
    6. Chaban V. Visceral pain modulation in female primary afferent sensory neurons. Curr Trends Neurol. 2015; 9:111-114. PMID: 26962272; PMCID: PMC4780352.
      Citations: 1     
    7. Chaban VV, Cho T, Reid CB, Norris KC. Physically disconnected non-diffusible cell-to-cell communication between neuroblastoma SH-SY5Y and DRG primary sensory neurons. Am J Transl Res. 2013; 5(1):69-79. PMID: 23390567; PMCID: PMC3560476.
      Citations: 4     
    8. Chaban V. Estrogen modulation of visceral nociceptors. Curr Trends Neurol. 2013; 7:51-55. PMID: 26752851; PMCID: PMC4704695.
      Citations: 7     
    9. Cho T, Chaban VV. Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-a and estrogen receptor-ß knockout mice. Neuroreport. 2012 Jun 20; 23(9):530-4. PMID: 22581043; PMCID: PMC3358513.
      Citations: 22     Fields:    Translation:AnimalsCells
    10. Cho T, Chaban VV. Interaction between P2X3 and oestrogen receptor (ER)a/ERß in ATP-mediated calcium signalling in mice sensory neurones. J Neuroendocrinol. 2012 May; 24(5):789-97. PMID: 22175770; PMCID: PMC3319164.
      Citations: 21     Fields:    Translation:AnimalsCells
    11. Chaban V. Estrogen and Visceral Nociception at the Level of Primary Sensory Neurons. Pain Res Treat. 2012 Jan 01; 2012(2012). PMID: 21984961; PMCID: PMC3186056.
      Citations: 12     
    12. Chaban V, Li J, McDonald JS, Rapkin A, Micevych P. Estradiol attenuates the adenosine triphosphate-induced increase of intracellular calcium through group II metabotropic glutamate receptors in rat dorsal root ganglion neurons. J Neurosci Res. 2011 Nov; 89(11):1707-10. PMID: 21793040; PMCID: PMC3171520.
      Citations: 39     Fields:    Translation:AnimalsCells
    13. Chaban VV. Peripheral sensitization of sensory neurons. Ethn Dis. 2010; 20(1 Suppl 1):S1-3-6. PMID: 20521376; PMCID: PMC3121896.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Li J, Micevych P, McDonald J, Rapkin A, Chaban V. Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res. 2008 Sep; 86(12):2746-52. PMID: 18478547; PMCID: PMC4755493.
      Citations: 25     Fields:    Translation:AnimalsCells
    15. Chaban VV. Visceral sensory neurons that innervate both uterus and colon express nociceptive TRPv1 and P2X3 receptors in rats. Ethn Dis. 2008; 18(2 Suppl 2):S2-20-4. PMID: 18646315.
      Citations: 15     Fields:    Translation:AnimalsCells
    16. Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, McDonald J, Micevych P. The same dorsal root ganglion neurons innervate uterus and colon in the rat. Neuroreport. 2007 Feb 12; 18(3):209-12. PMID: 17314658.
      Citations: 8     Fields:    Translation:AnimalsCells
    17. Micevych PE, Chaban V, Ogi J, Dewing P, Lu JK, Sinchak K. Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures. Endocrinology. 2007 Feb; 148(2):782-9. PMID: 17095591.
      Citations: 70     Fields:    Translation:AnimalsCells
    18. Chaban VV, Micevych PE. Estrogen receptor-alpha mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons. J Neurosci Res. 2005 Jul 01; 81(1):31-7. PMID: 15952176.
      Citations: 40     Fields:    Translation:AnimalsCells
    19. Chaban VV, Lakhter AJ, Micevych P. A membrane estrogen receptor mediates intracellular calcium release in astrocytes. Endocrinology. 2004 Aug; 145(8):3788-95. PMID: 15131017.
      Citations: 83     Fields:    Translation:AnimalsCells
    20. Chaban VV, Li J, Ennes HS, Nie J, Mayer EA, McRoberts JA. N-methyl-D-aspartate receptors enhance mechanical responses and voltage-dependent Ca2+ channels in rat dorsal root ganglia neurons through protein kinase C. Neuroscience. 2004; 128(2):347-57. PMID: 15350646.
      Citations: 10     Fields:    Translation:AnimalsCells
    21. Chaban VV, Mayer EA, Ennes HS, Micevych PE. Estradiol inhibits atp-induced intracellular calcium concentration increase in dorsal root ganglia neurons. Neuroscience. 2003; 118(4):941-8. PMID: 12732239.
      Citations: 60     Fields:    Translation:AnimalsCells
    22. Micevych P, Chaban V, Quesada A, Sinchak K. Oestrogen modulates cholecystokinin: opioid interactions in the nervous system. Pharmacol Toxicol. 2002 Dec; 91(6):387-97. PMID: 12688384.
      Citations: 3     Fields:    Translation:Animals
    23. Chaban VV, McRoberts JA, Ennes HS, Mayer EA. Nitric oxide synthase inhibitors enhance mechanosensitive Ca(2+) influx in cultured dorsal root ganglion neurons. Brain Res. 2001 Jun 08; 903(1-2):74-85. PMID: 11382390.
      Citations: 5     Fields:    Translation:AnimalsCells
    24. McRoberts JA, Coutinho SV, Marvizón JC, Grady EF, Tognetto M, Sengupta JN, Ennes HS, Chaban VV, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett NW, Mayer EA. Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology. 2001 Jun; 120(7):1737-48. PMID: 11375955.
      Citations: 66     Fields:    Translation:AnimalsCells
    25. Gschossmann JM, Chaban VV, McRoberts JA, Raybould HE, Young SH, Ennes HS, Lembo T, Mayer EA. Mechanical activation of dorsal root ganglion cells in vitro: comparison with capsaicin and modulation by kappa-opioids. Brain Res. 2000 Feb 21; 856(1-2):101-10. PMID: 10677616.
      Citations: 5     Fields:    Translation:AnimalsCells
    26. Young SH, Ennes HS, McRoberts JA, Chaban VV, Dea SK, Mayer EA. Calcium waves in colonic myocytes produced by mechanical and receptor-mediated stimulation. Am J Physiol. 1999 05; 276(5):G1204-12. PMID: 10330011.
      Citations: 7     Fields:    Translation:AnimalsCells
    27. Woodruff ML, Chaban VV, Worley CM, Dirksen ER. PKC role in mechanically induced Ca2+ waves and ATP-induced Ca2+ oscillations in airway epithelial cells. Am J Physiol. 1999 04; 276(4):L669-78. PMID: 10198365.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Felix JA, Chaban VV, Woodruff ML, Dirksen ER. Mechanical stimulation initiates intercellular Ca2+ signaling in intact tracheal epithelium maintained under normal gravity and simulated microgravity. Am J Respir Cell Mol Biol. 1998 May; 18(5):602-10. PMID: 9569230.
      Citations: 6     Fields:    Translation:AnimalsCells
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