Header Logo

Jaydutt Vadgama, PhD

TitleProfessor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-9397
FaxNot Available
vCardDownload vCard

    Research
    research activities and funding
    U54CA143931     (VADGAMA, JAYDUTT V)Sep 29, 2009 - Aug 31, 2021
    NIH
    CDU-UCLA Cancer Center Partnership to Eliminate Cancer Health Disparities
    Role: Principal Investigator
    U54MD007598     (VADGAMA, JAYDUTT V)Sep 28, 2009 - Feb 29, 2024
    NIH
    Accelerating Excellence in Translational Science (AXIS)
    Role: Principal Investigator
    R25DK067015     (VADGAMA, JAYDUTT V)Sep 30, 2003 - Jul 31, 2009
    NIH
    Charles R. Drew Student Scholar Program
    Role: Principal Investigator
    U56CA101599     (VADGAMA, JAYDUTT V)Sep 5, 2003 - Jul 31, 2010
    NIH
    Drew/UCLA Cancer Partnership Program
    Role: Principal Investigator
    R29DK039147     (VADGAMA, JAYDUTT V)Aug 1, 1987 - Nov 30, 1992
    NIH
    REGULATION OF AMINO ACID TRANSPORT IN ERYTHROID CELLS
    Role: Principal Investigator

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu Y, Vadgama JV. Advancing Cancer Research: Insights and Innovations in Pathogenesis and Targeted Therapies. J Pers Med. 2023 Feb 21; 13(3). PMID: 36983557; PMCID: PMC10051869.
      Citations:    
    2. Shum HCE, Wu K, Vadgama J, Wu Y. Potential Therapies Targeting the Metabolic Reprogramming of Diabetes-Associated Breast Cancer. J Pers Med. 2023 Jan 14; 13(1). PMID: 36675817; PMCID: PMC9861470.
      Citations:    
    3. Dutta P, Keung MY, Wu Y, Vadgama JV. Genetic variants in African-American and Hispanic patients with breast cancer. Oncol Lett. 2023 Feb; 25(2):51. PMID: 36644153; PMCID: PMC9811638.
      Citations:    
    4. He Q, Hao Q, Wu Y, Vadgama JV, Jiang Y. CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. Life Sci. 2023 Jan 01; 312:121128. PMID: 36334805; PMCID: PMC10078949.
      Citations:    Fields:    Translation:HumansCells
    5. Sterling C, M?rquez-Garb?n D, Vadgama JV, Pietras RJ. Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression. Cancers (Basel). 2022 Oct 21; 14(20). PMID: 36291938; PMCID: PMC9601113.
      Citations:    
    6. Hao Q, Wu Y, Vadgama JV, Wang P. Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies. Biomolecules. 2022 09 16; 12(9). PMID: 36139145; PMCID: PMC9496067.
      Citations:    Fields:    Translation:Humans
    7. Tian S, Su R, Wu K, Zhou X, Vadgama JV, Wu Y. Diaporine Potentiates the Anticancer Effects of Oxaliplatin and Doxorubicin on Liver Cancer Cells. J Pers Med. 2022 Aug 16; 12(8). PMID: 36013267; PMCID: PMC9410505.
      Citations:    
    8. Liu D, Hao Q, Li J, Li Q, Wang K, Geng Q, Wu Y, Vadgama JV, Wu Y. ZBED2 expression enhances interferon signaling and predicts better survival of estrogen receptor-negative breast cancer patients. Cancer Commun (Lond). 2022 Apr 29. PMID: 35486908.
      Citations:    Fields:    Translation:HumansCells
    9. Yang S, Jackson C, Karapetyan E, Dutta P, Kermah D, Wu Y, Wu Y, Schloss J, Vadgama JV. Roles of Protein Disulfide Isomerase in Breast Cancer. Cancers (Basel). 2022 Jan 31; 14(3). PMID: 35159012; PMCID: PMC8833603.
      Citations: 2     
    10. Hao Q, Wu Y, Wu Y, Wang P, Vadgama JV. Tumor-Derived Exosomes in Tumor-Induced Immune Suppression. Int J Mol Sci. 2022 Jan 27; 23(3). PMID: 35163380; PMCID: PMC8836190.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    11. Hao Q, Huang Z, Li Q, Liu D, Wang P, Wang K, Li J, Cao W, Deng W, Wu K, Su R, Liu Z, Vadgama J, Wu Y. A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer. Adv Sci (Weinh). 2022 02; 9(6):e2102303. PMID: 35023320; PMCID: PMC8867195.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    12. Wu Y, Dutta P, Clayton S, McCloud A, Vadgama JV. Elevated Baseline Serum PD-L1 Level May Predict Poor Outcomes from Breast Cancer in African-American and Hispanic Women. J Clin Med. 2022 Jan 06; 11(2). PMID: 35053979; PMCID: PMC8779890.
      Citations:    
    13. Deng W, Hao Q, Vadgama J, Wu Y. Wild-Type TP53 Predicts Poor Prognosis in Patients with Gastric Cancer. J Cancer Sci Clin Ther. 2021 Mar 18; 5(1):134-153. PMID: 34950877; PMCID: PMC8694034.
      Citations: 2     
    14. Liu D, Vadgama J, Wu Y. Basal-like breast cancer with low TGFß and high TNFa pathway activity is rich in activated memory CD4 T cells and has a good prognosis. Int J Biol Sci. 2021; 17(3):670-682. PMID: 33767579; PMCID: PMC7975701.
      Citations: 8     Fields:    Translation:HumansCells
    15. DeAngelo C, Tarasiewicz MB, Strother A, Taggart H, Gray C, Shanahan M, Glowacki C, Khandalavala J, Talaska E, Kinnan A, Coté JJ, Edwards AP, Harper-Harrison G, Casey MJ, Hirai TL, Schultz S, Stines L, Vora R, Boudreau D, Burgart J, Shama M, Watson T, Strasheim L, Thompson R, Lawlor R, Joyce K, Magnuson CM, Driano J, Elger B, Lentino A, Driscoll M, Tidwell E, Sharma A, Walker SR, Jones G, Sharma P, Stessman H, Wu Y, Vadgama J, Chase D, Conrad L, Reddy ST, Farias-Eisner R. Endometriosis: A Malignant Fingerprint. J Cancer Res Ther Oncol. 2020 Apr; 8(2). PMID: 33644256; PMCID: PMC7909468.
      Citations: 3     
    16. Hao Q, Wang P, Dutta P, Chung S, Li Q, Wang K, Li J, Cao W, Deng W, Geng Q, Schrode K, Shaheen M, Wu K, Zhu D, Chen QH, Chen G, Elshimali Y, Vadgama J, Wu Y. Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA. Cell Death Dis. 2020 12 11; 11(12):1052. PMID: 33311440; PMCID: PMC7733521.
      Citations: 5     Fields:    Translation:HumansCells
    17. Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419. PMID: 33414685; PMCID: PMC7752272.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    18. Wu Y, Sarkissyan M, Ogah O, Kim J, Vadgama JV. Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers. Cancers (Basel). 2020 Jul 16; 12(7). PMID: 32708561; PMCID: PMC7409266.
      Citations: 10     
    19. Hao Q, Vadgama JV, Wang P. CCL2/CCR2 signaling in cancer pathogenesis. Cell Commun Signal. 2020 05 29; 18(1):82. PMID: 32471499; PMCID: PMC7257158.
      Citations: 70     Fields:    Translation:HumansAnimals
    20. Dillard C, Kiyohara M, Mah V, McDermott SP, Bazzoun D, Tsui J, Chan AM, Haddad G, Pellegrini M, Chang YL, Elshimali Y, Wu Y, Vadgama JV, Kim SR, Goodglick L, Law SM, Patel DD, Dhawan P, O'Brien NA, Gordon LK, Braun J, Lazar G, Wicha MS, Wadehra M. EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells. Mol Cancer Ther. 2020 08; 19(8):1682-1695. PMID: 32451329; PMCID: PMC7415657.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Dutta P, Paico K, Gomez G, Wu Y, Vadgama JV. Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. Cancers (Basel). 2020 May 21; 12(5). PMID: 32455851; PMCID: PMC7281677.
      Citations: 7     
    22. Keung MY, Wu Y, Badar F, Vadgama JV. Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status. J Clin Med. 2020 Mar 30; 9(4). PMID: 32235451; PMCID: PMC7231148.
      Citations: 35     
    23. Hao Q, Diaz T, Verduzco ADR, Magyar CE, Zhong J, Elshimali Y, Rettig MB, Henning SM, Vadgama JV, Wang P. Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor. Sci Rep. 2020 Jan 29; 10(1):1403. PMID: 31996731; PMCID: PMC6989655.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    24. Deng W, Li J, Dorrah K, Jimenez-Tapia D, Arriaga B, Hao Q, Cao W, Gao Z, Vadgama J, Wu Y. The role of PPM1D in cancer and advances in studies of its inhibitors. Biomed Pharmacother. 2020 May; 125:109956. PMID: 32006900; PMCID: PMC7080581.
      Citations: 13     Fields:    Translation:Cells
    25. Su F, Gm A, Palgunachari MN, White CR, Stessman H, Wu Y, Vadgama J, Pietras R, Nguyen D, Reddy ST, Farias-Eisner R. Bovine HDL and Dual Domain HDL-Mimetic Peptides Inhibit Tumor Development in Mice. J Cancer Res Ther Oncol. 2020; 8(1). PMID: 32462055; PMCID: PMC7252215.
      Citations: 1     
    26. Li Q, Hao Q, Cao W, Li J, Wu K, Elshimali Y, Zhu D, Chen QH, Chen G, Pollack JR, Vadgama J, Wu Y. PP2Cd inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer. Sci Adv. 2019 10; 5(10):eaaw8417. PMID: 31663018; PMCID: PMC6795508.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    27. Chung SS, Dutta P, Chard N, Wu Y, Chen QH, Chen G, Vadgama J. A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-?B inactivation in colorectal cancer cells. Oncotarget. 2019 Jul 16; 10(44):4516-4531. PMID: 31360301; PMCID: PMC6642039.
      Citations: 12     Fields:    
    28. Keung MYT, Wu Y, Vadgama JV. PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers. J Clin Med. 2019 Mar 30; 8(4). PMID: 30934991; PMCID: PMC6517993.
      Citations: 56     
    29. Nava M, Dutta P, Farias-Eisner R, Vadgama JV, Wu Y. Utilization of NGS technologies to investigate transcriptomic and epigenomic mechanisms in trastuzumab resistance. Sci Rep. 2019 03 26; 9(1):5141. PMID: 30914750; PMCID: PMC6435657.
      Citations: 4     Fields:    Translation:HumansCells
    30. Kaufman M, Cruz A, Thompson J, Reddy S, Bansal N, Cohen JG, Wu Y, Vadgama J, Farias-Eisner R. A review of the effects of healthcare disparities on the experience and survival of ovarian cancer patients of different racial and ethnic backgrounds. J Cancer Metastasis Treat. 2019; 5. PMID: 31236478; PMCID: PMC6590085.
      Citations: 5     
    31. Ofili EO, Tchounwou PB, Fernandez-Repollet E, Yanagihara R, Akintobi TH, Lee JE, Malouhi M, Garner ST, Hayes TT, Baker AR, Dent AL, Abdelrahim M, Rollins L, Chang SP, Sy A, Hernandez BY, Bullard PL, Noel RJ, Shiramizu B, Hedges JR, Berry MJ, Bond VC, Lima MF, Mokuau N, Kirken RA, Cruz-Correa M, Sarpong DF, Vadgama J, Yates C, Kahn SA, Soliman KF, Perry G, Pezzano M, Luciano CA, Barnett ME, Oyekan A, Kumar D, Norris KC, RCMI Investigators and RTRN Team Members. The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research. Ethn Dis. 2019; 29(Suppl 1):135-144. PMID: 30906162; PMCID: PMC6428183.
      Citations: 13     Fields:    Translation:Humans
    32. Cao W, Li J, Hao Q, Vadgama JV, Wu Y. AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer. Breast Cancer Res. 2019 02 21; 21(1):29. PMID: 30791936; PMCID: PMC6385460.
      Citations: 31     Fields:    Translation:HumansCells
    33. Nava M, Dutta P, Zemke NR, Farias-Eisner R, Vadgama JV, Wu Y. Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. BMC Med Genomics. 2019 02 08; 12(1):32. PMID: 30736768; PMCID: PMC6368760.
      Citations: 4     Fields:    Translation:HumansCells
    34. Li J, Hao Q, Cao W, Vadgama JV, Wu Y. Celecoxib in breast cancer prevention and therapy. Cancer Manag Res. 2018; 10:4653-4667. PMID: 30464589; PMCID: PMC6208493.
      Citations: 23     
    35. Austin D, Hamilton N, Elshimali Y, Pietras R, Wu Y, Vadgama J. Estrogen receptor-beta is a potential target for triple negative breast cancer treatment. Oncotarget. 2018 Sep 21; 9(74):33912-33930. PMID: 30338035; PMCID: PMC6188058.
      Citations: 24     Fields:    
    36. Chung SS, Dutta P, Austin D, Wang P, Awad A, Vadgama JV. Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Oncotarget. 2018 Aug 31; 9(68):32943-32957. PMID: 30250641; PMCID: PMC6152483.
      Citations: 20     Fields:    
    37. Wu K, Yu X, Huang Z, Zhu D, Yi X, Wu YL, Hao Q, Kemp KT, Elshimali Y, Iyer R, Nguyen KT, Zheng S, Chen G, Chen QH, Wang G, Vadgama JV, Wu Y. Targeting of PP2Cd By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo. Antioxid Redox Signal. 2019 06 10; 30(17):1983-1998. PMID: 29808718; PMCID: PMC6486665.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    38. Dutta P, Sarkissyan M, Paico K, Wu Y, Vadgama JV. MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis. Breast Cancer Res Treat. 2018 Aug; 170(3):477-486. PMID: 29594759; PMCID: PMC6022526.
      Citations: 45     Fields:    Translation:HumansCells
    39. Elshimali YI, Wu Y, Khaddour H, Wu Y, Gradinaru D, Sukhija H, Chung SS, Vadgama JV. Optimization Of Cancer Treatment Through Overcoming Drug Resistance. J Cancer Res Oncobiol. 2018; 1(2). PMID: 29932172; PMCID: PMC6007995.
      Citations: 8     
    40. Petersen SS, Sarkissyan M, Wu Y, Clayton S, Vadgama JV. Time to Clinical Follow-up after Abnormal Mammogram among African American and Hispanic Women. J Health Care Poor Underserved. 2018; 29(1):448-462. PMID: 29503311; PMCID: PMC6614556.
      Citations: 1     Fields:    Translation:Humans
    41. Hamilton N, Austin D, Márquez-Garbán D, Sanchez R, Chau B, Foos K, Wu Y, Vadgama J, Pietras R. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int J Mol Sci. 2017 Nov 02; 18(11). PMID: 29099049; PMCID: PMC5713274.
      Citations: 3     Fields:    Translation:HumansCells
    42. Wu Y, Sarkissyan M, Clayton S, Chlebowski R, Vadgama JV. Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women. Cancers (Basel). 2017 Oct 24; 9(10). PMID: 29064397; PMCID: PMC5664083.
      Citations: 14     
    43. Chung SS, Wu Y, Okobi Q, Adekoya D, Atefi M, Clarke O, Dutta P, Vadgama JV. Proinflammatory Cytokines IL-6 and TNF-a Increased Telomerase Activity through NF-?B/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells. Mediators Inflamm. 2017; 2017:5958429. PMID: 28676732; PMCID: PMC5476880.
      Citations: 32     Fields:    Translation:HumansCells
    44. Bhat K, Sarkissyan M, Wu Y, Vadgama JV. GROa overexpression drives cell migration and invasion in triple negative breast cancer cells. Oncol Rep. 2017 Jul; 38(1):21-30. PMID: 28560447; PMCID: PMC5492847.
      Citations: 14     Fields:    Translation:HumansCells
    45. Wang P, Solorzano W, Diaz T, Magyar CE, Henning SM, Vadgama JV. Arctigenin inhibits prostate tumor cell growth in vitro and in vivo. Clin Nutr Exp. 2017 Jun; 13:1-11. PMID: 29062885; PMCID: PMC5650108.
      Citations: 17     
    46. Wu Y, Tran T, Dwabe S, Sarkissyan M, Kim J, Nava M, Clayton S, Pietras R, Farias-Eisner R, Vadgama JV. A83-01 inhibits TGF-ß-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res Treat. 2017 Jun; 163(3):449-460. PMID: 28337662; PMCID: PMC5427117.
      Citations: 22     Fields:    Translation:HumansCells
    47. Chung SS, Adekoya D, Enenmoh I, Clarke O, Wang P, Sarkyssian M, Wu Y, Vadgama JV. Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells. Anticancer Res. 2017 02; 37(2):445-453. PMID: 28179289; PMCID: PMC5425246.
      Citations: 12     Fields:    Translation:HumansCells
    48. Wu Y, Yu X, Yi X, Wu K, Dwabe S, Atefi M, Elshimali Y, Kemp KT, Bhat K, Haro J, Sarkissyan M, Vadgama JV. Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis. Cancer Res. 2017 03 15; 77(6):1383-1394. PMID: 28115363; PMCID: PMC5354968.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    49. Wu Y, Dong Y, Atefi M, Liu Y, Elshimali Y, Vadgama JV. Lactate, a Neglected Factor for Diabetes and Cancer Interaction. Mediators Inflamm. 2016; 2016:6456018. PMID: 28077918; PMCID: PMC5203906.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    50. Gelfand R, Vernet D, Bruhn KW, Sarkissyan S, Heber D, Vadgama JV, Gonzalez-Cadavid NF. Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features. Int J Oncol. 2017 Jan; 50(1):49-65. PMID: 27959387; PMCID: PMC5182011.
      Citations: 10     Fields:    Translation:HumansCells
    51. Wu Y, Vadgama JV. Androgen Receptor as a Potential Target for Treatment of Breast Cancer. Int J Cancer Res Mol Mech. 2017 Apr; 3(1). PMID: 28474005; PMCID: PMC5412726.
      Citations: 4     
    52. Chung SS, Oliva B, Dwabe S, Vadgama JV. Combination treatment with flavonoid morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug; 49(2):487-98. PMID: 27279256; PMCID: PMC4922839.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    53. Wang P, Henning SM, Magyar CE, Elshimali Y, Heber D, Vadgama JV. Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy. J Exp Clin Cancer Res. 2016 May 06; 35:73. PMID: 27151407; PMCID: PMC4858851.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    54. Gelfand R, Vernet D, Bruhn K, Vadgama J, Gonzalez-Cadavid NF. Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features. Int J Oncol. 2016 Jun; 48(6):2399-414. PMID: 27035792; PMCID: PMC4864041.
      Citations: 7     Fields:    Translation:HumansCells
    55. Wu Y, Liu Y, Dong Y, Vadgama J. Diabetes-associated dysregulated cytokines and cancer. Integr Cancer Sci Ther. 2016 Feb; 3(1):370-378. PMID: 29930868; PMCID: PMC6007890.
      Citations: 3     
    56. Wu Y, Sarkissyan M, Vadgama JV. Epithelial-Mesenchymal Transition and Breast Cancer. J Clin Med. 2016 Jan 26; 5(2). PMID: 26821054; PMCID: PMC4773769.
      Citations: 70     
    57. Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama JV. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PLoS One. 2015; 10(8):e0134948. PMID: 26258407; PMCID: PMC4530953.
      Citations: 6     Fields:    Translation:HumansCells
    58. Bazargan M, Lucas-Wright A, Jones L, Vargas R, Vadgama JV, Evers-Manly S, Maxwell AE. Understanding Perceived Benefit of Early Cancer Detection: Community-Partnered Research with African American Women in South Los Angeles. J Womens Health (Larchmt). 2015 Sep; 24(9):755-61. PMID: 26131760; PMCID: PMC4589099.
      Citations: 5     Fields:    Translation:Humans
    59. Wu Y, Sarkissyan M, Mcghee E, Lee S, Vadgama JV. Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing. Breast Cancer Res Treat. 2015 Jun; 151(3):529-39. PMID: 25975952; PMCID: PMC4668274.
      Citations: 23     Fields:    Translation:HumansCells
    60. Hamilton N, Márquez-Garbán D, Mah V, Fernando G, Elshimali Y, Garbán H, Elashoff D, Vadgama J, Goodglick L, Pietras R. Biologic roles of estrogen receptor-ß and insulin-like growth factor-2 in triple-negative breast cancer. Biomed Res Int. 2015; 2015:925703. PMID: 25874233; PMCID: PMC4385615.
      Citations: 24     Fields:    Translation:HumansCells
    61. Li Y, Wu Y, Abbatiello TC, Wu WL, Kim JR, Sarkissyan M, Sarkissyan S, Chung SS, Elshimali Y, Vadgama JV. Slug contributes to cancer progression by direct regulation of ERa signaling pathway. Int J Oncol. 2015 Apr; 46(4):1461-72. PMID: 25652255; PMCID: PMC4356499.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    62. Wang P, Henning SM, Heber D, Vadgama JV. Sensitization to docetaxel in prostate cancer cells by green tea and quercetin. J Nutr Biochem. 2015 Apr; 26(4):408-15. PMID: 25655047; PMCID: PMC4375039.
      Citations: 31     Fields:    Translation:HumansCells
    63. Wu Y, Sarkissyan M, Vadgama JV. Epigenetics in breast and prostate cancer. Methods Mol Biol. 2015; 1238:425-66. PMID: 25421674; PMCID: PMC4364390.
      Citations: 36     Fields:    Translation:HumansAnimals
    64. Chung SS, Vadgama JV. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NF?B signaling. Anticancer Res. 2015 Jan; 35(1):39-46. PMID: 25550533; PMCID: PMC4290892.
      Citations: 79     Fields:    Translation:HumansCells
    65. Hamilton N, Marquez-Garban D, Mah VH, Elshimali Y, Elashoff D, Garon EB, Vadgama J, Pietras R. Estrogen Receptor-ß and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer. Crit Rev Oncog. 2015; 20(5-6):373-90. PMID: 27279236; PMCID: PMC5495464.
      Citations: 4     Fields:    Translation:Humans
    66. Wang P, Phan T, Gordon D, Chung S, Henning SM, Vadgama JV. Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells. Mol Nutr Food Res. 2015 Feb; 59(2):250-61. PMID: 25380086; PMCID: PMC4314369.
      Citations: 18     Fields:    Translation:HumansCells
    67. Wang P, Wang B, Chung S, Wu Y, Henning SM, Vadgama JV. Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. RSC Adv. 2014 Aug 05; 4(66):35242-35250. PMID: 25243063; PMCID: PMC4166488.
      Citations: 26     
    68. Sarkissyan S, Sarkissyan M, Wu Y, Cardenas J, Koeffler HP, Vadgama JV. IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. PLoS One. 2014; 9(7):e103534. PMID: 25062088; PMCID: PMC4111618.
      Citations: 26     Fields:    Translation:AnimalsCells
    69. Wu Y, Kim J, Elshimali Y, Sarkissyan M, Vadgama JV. Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice. BMC Cancer. 2014 Apr 17; 14:266. PMID: 24742286; PMCID: PMC4021211.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    70. Sarkissyan M, Wu Y, Chen Z, Mishra DK, Sarkissyan S, Giannikopoulos I, Vadgama JV. Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants. Cancer. 2014 May 01; 120(9):1387-93. PMID: 24510435; PMCID: PMC3999299.
      Citations: 21     Fields:    Translation:Humans
    71. Lucas-Wright A, Bazargan M, Jones L, Vadgama JV, Vargas R, Sarkissyan M, Smith J, Yazdanshenas H, Maxwell AE. Correlates of perceived risk of developing cancer among African-Americans in South Los Angeles. J Community Health. 2014 Feb; 39(1):173-80. PMID: 24026303; PMCID: PMC3889655.
      Citations: 10     Fields:    Translation:Humans
    72. Chung SS, Aroh C, Vadgama JV. Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells. PLoS One. 2013; 8(12):e83971. PMID: 24386318; PMCID: PMC3875492.
      Citations: 58     Fields:    Translation:HumansCells
    73. Chung SS, Giehl N, Wu Y, Vadgama JV. STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits. Int J Oncol. 2014 Feb; 44(2):403-11. PMID: 24297508; PMCID: PMC3898805.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    74. Wu Y, Sarkissyan M, Elshimali Y, Vadgama JV. Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN. PLoS One. 2013; 8(10):e78259. PMID: 24167614; PMCID: PMC3805609.
      Citations: 35     Fields:    Translation:HumansCTClinical Trials
    75. Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea. J Nutr Biochem. 2014 Jan; 25(1):73-80. PMID: 24314868; PMCID: PMC3858726.
      Citations: 28     Fields:    Translation:AnimalsCells
    76. Elshimali YI, Khaddour H, Sarkissyan M, Wu Y, Vadgama JV. The clinical utilization of circulating cell free DNA (CCFDNA) in blood of cancer patients. Int J Mol Sci. 2013 Sep 13; 14(9):18925-58. PMID: 24065096; PMCID: PMC3794814.
      Citations: 97     Fields:    Translation:HumansCells
    77. Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6109-14. PMID: 23536305; PMCID: PMC3625360.
      Citations: 35     Fields:    Translation:HumansCells
    78. Mishra DK, Wu Y, Sarkissyan M, Sarkissyan S, Chen Z, Shang X, Ong M, Heber D, Koeffler HP, Vadgama JV. Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. PLoS One. 2013; 8(3):e57967. PMID: 23554871; PMCID: PMC3595235.
      Citations: 34     Fields:    Translation:HumansCTClinical Trials
    79. Jones L, Bazargan M, Lucas-Wright A, Vadgama JV, Vargas R, Smith J, Otoukesh S, Maxwell AE. Comparing perceived and test-based knowledge of cancer risk and prevention among Hispanic and African Americans: an example of community participatory research. Ethn Dis. 2013; 23(2):210-6. PMID: 23530303; PMCID: PMC3747224.
      Citations: 3     Fields:    Translation:Humans
    80. Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D, Vadgama JV. Expression of Wnt3 activates Wnt/ß-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol Cancer Res. 2012 Dec; 10(12):1597-606. PMID: 23071104; PMCID: PMC3732195.
      Citations: 114     Fields:    Translation:HumansCells
    81. Wu Y, Elshimali Y, Sarkissyan M, Mohamed H, Clayton S, Vadgama JV. Expression of FOXO1 is associated with GATA3 and Annexin-1 and predicts disease-free survival in breast cancer. Am J Cancer Res. 2012; 2(1):104-15. PMID: 22206049; PMCID: PMC3236574.
      Citations: 24     
    82. Sarkissyan M, Mishra DK, Wu Y, Shang X, Sarkissyan S, Vadgama JV. IGF gene polymorphisms and breast cancer in African-American and Hispanic women. Int J Oncol. 2011 Jun; 38(6):1663-73. PMID: 21455574; PMCID: PMC3743668.
      Citations: 8     Fields:    Translation:Humans
    83. Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP. Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol. 2011 Jun; 38(6):1741-7. PMID: 21455569; PMCID: PMC3711677.
      Citations: 37     Fields:    Translation:HumansCells
    84. Sarkissyan M, Wu Y, Vadgama JV. Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles. Cancer. 2011 Aug 15; 117(16):3814-23. PMID: 21305540; PMCID: PMC3139738.
      Citations: 16     Fields:    Translation:Humans
    85. Yin D, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said JW, Black KL, Koeffler HP. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. Int J Cancer. 2010 Nov 15; 127(10):2257-67. PMID: 20162579; PMCID: PMC2946420.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    86. Wu Y, Shang X, Sarkissyan M, Slamon D, Vadgama JV. FOXO1A is a target for HER2-overexpressing breast tumors. Cancer Res. 2010 Jul 01; 70(13):5475-85. PMID: 20551062; PMCID: PMC2896450.
      Citations: 27     Fields:    Translation:HumansCells
    87. Wu Y, Alvarez M, Slamon DJ, Koeffler P, Vadgama JV. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010 Feb 04; 10:32. PMID: 20132554; PMCID: PMC2824712.
      Citations: 32     Fields:    Translation:HumansCells
    88. Mishra DK, Chen Z, Wu Y, Sarkissyan M, Koeffler HP, Vadgama JV. Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. Mol Cancer Ther. 2010 Jan; 9(1):33-45. PMID: 20053773; PMCID: PMC2806502.
      Citations: 37     Fields:    Translation:HumansCells
    89. Thant AA, Wu Y, Lee J, Mishra DK, Garcia H, Koeffler HP, Vadgama JV. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008 Nov-Dec; 28(6A):3579-92. PMID: 19189638; PMCID: PMC3771536.
      Citations: 13     Fields:    Translation:HumansCells
    90. Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, Vadgama JV. Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Res. 2008; 10(1):R3. PMID: 18184439; PMCID: PMC2374954.
      Citations: 30     Fields:    Translation:Humans
    91. Padda M, Vadgama J, Sandhu P, Dev A, Giannikopoulos I. Clinical significance of incidental colorectal wall thickening on computed tomography scan in African-American and Hispanic patients. Dig Dis Sci. 2007 Nov; 52(11):3159-64. PMID: 17404851.
      Citations: 11     Fields:    Translation:Humans
    92. Wu Y, Shen D, Chen Z, Clayton S, Vadgama JV. Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis. 2007 Mar; 12(3):593-612. PMID: 17195090.
      Citations: 8     Fields:    Translation:HumansCells
    93. Vadgama JV, Scuric Z, Chakrabarti R, Marzo E, Shen D, Wu Y. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Int J Mol Med. 2006 Jul; 18(1):129-39. PMID: 16786164.
      Citations: 6     Fields:    Translation:HumansCells
    94. O'Kelly J, Uskokovic M, Lemp N, Vadgama J, Koeffler HP. Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway. J Steroid Biochem Mol Biol. 2006 Aug; 100(4-5):107-16. PMID: 16777406.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    95. Gery S, Tanosaki S, Bose S, Bose N, Vadgama J, Koeffler HP. Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer. Clin Cancer Res. 2005 May 01; 11(9):3184-90. PMID: 15867211.
      Citations: 40     Fields:    Translation:HumansCells
    96. Bhat HK, Calaf G, Hei TK, Loya T, Vadgama JV. Critical role of oxidative stress in estrogen-induced carcinogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):3913-8. PMID: 12655060; PMCID: PMC153022.
      Citations: 51     Fields:    Translation:Animals
    97. Wu Y, Saldana L, Chillar R, Vadgama JV. Plasma vascular endothelial growth factor is useful in assessing progression of breast cancer post surgery and during adjuvant treatment. Int J Oncol. 2002 Mar; 20(3):509-16. PMID: 11836562.
      Citations: 5     Fields:    Translation:Humans
    98. Bhat HK, Vadgama JV. Role of estrogen receptor in the regulation of estrogen induced amino acid transport of System A in breast cancer and other receptor positive tumor cells. Int J Mol Med. 2002 Mar; 9(3):271-9. PMID: 11836633.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    99. Liu W, Vadgama JV. Identification and characterization of amino acid starvation-induced CD24 gene in MCF-7 human breast cancer cells. Int J Oncol. 2000 May; 16(5):1049-54. PMID: 10762644.
      Citations: 5     Fields:    Translation:HumansCells
    100. Vadgama JV, Wu Y, Shen D, Hsia S, Block J. Effect of selenium in combination with Adriamycin or Taxol on several different cancer cells. Anticancer Res. 2000 May-Jun; 20(3A):1391-414. PMID: 10928049.
      Citations: 20     Fields:    Translation:HumansCells
    101. Shen D, Wu Y, Chillar R, Vadgama JV. Missense alterations of BRCA1 gene detected in diverse cancer patients. Anticancer Res. 2000 Mar-Apr; 20(2B):1129-32. PMID: 10810408.
      Citations: 2     Fields:    Translation:HumansCells
    102. Bhat HK, Vadgama JV. Hamster estrogen receptor cDNA: cloning and mRNA expression. J Steroid Biochem Mol Biol. 2000 Jan-Feb; 72(1-2):47-53. PMID: 10731637.
      Citations:    Fields:    Translation:HumansAnimalsCells
    103. Shen D, Wu Y, Subbarao M, Bhat H, Chillar R, Vadgama JV. Mutation analysis of BRCA1 gene in African-American patients with breast cancer. J Natl Med Assoc. 2000 Jan; 92(1):29-35. PMID: 10800284; PMCID: PMC2640500.
      Citations: 7     Fields:    Translation:Humans
    104. Vadgama JV, Wu Y, Datta G, Khan H, Chillar R. Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women. Oncology. 1999 Nov; 57(4):330-40. PMID: 10575321.
      Citations: 27     Fields:    Translation:Humans
    105. Wu Y, Khan H, Chillar R, Vadgama JV. Prognostic value of plasma HER-2/neu in African American and Hispanic women with breast cancer. Int J Oncol. 1999 Jun; 14(6):1021-37. PMID: 10339653.
      Citations: 7     Fields:    Translation:Humans
    106. Shen D, Vadgama JV. BRCA1 and BRCA2 gene mutation analysis: visit to the Breast Cancer Information Core (BIC). Oncol Res. 1999; 11(2):63-9. PMID: 10489161.
      Citations: 8     Fields:    Translation:Humans
    107. Qing DP, Ding H, Vadgama J, Wu YY, Kopple JD. Elevated myocardial cytosolic calcium impairs insulin-like growth factor-1-stimulated protein synthesis in chronic renal failure. J Am Soc Nephrol. 1999 Jan; 10(1):84-92. PMID: 9890313.
      Citations: 6     Fields:    Translation:AnimalsCells
    108. Bhat HK, Vadgama JV, Liehr JG. Accumulation of albumin in renal cytosol of hamsters treated with estradiol and in estrogen-induced hamster kidney tumors. Int J Oncol. 1998 Nov; 13(5):1087-91. PMID: 9772304.
      Citations:    Fields:    Translation:AnimalsCells
    109. Fong RL, Vadgama JV, Laguer MR, Ward HJ. Low density lipoprotein receptors mediate intracellular calcium signals in microalbuminuric hypertensives. Am J Hypertens. 1998 Jan; 11(1 Pt 1):113-6. PMID: 9504458.
      Citations:    Fields:    Translation:HumansCells
    110. Liu JY, Diaz TG, Vadgama JV, Henry JP. Tail sectioning: a rapid and simple method for repeated blood sampling of the rat for corticosterone determination. Lab Anim Sci. 1996 Apr; 46(2):243-5. PMID: 8723250.
      Citations: 4     Fields:    Translation:Animals
    111. Ding H, Gao XL, Hirschberg R, Vadgama JV, Kopple JD. Impaired actions of insulin-like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect. J Clin Invest. 1996 Feb 15; 97(4):1064-75. PMID: 8613530; PMCID: PMC507154.
      Citations: 25     Fields:    Translation:AnimalsCells
    112. Vadgama JV, Evered DF. Absorption of amino acids from the human mouth. Amino Acids. 1992 Oct; 3(3):271-86. PMID: 24193127.
      Citations:    Fields:    
    113. Vadgama JV, Chan MN, Wu JM. Differential expression of amino acid transport systems A and ASC during erythroleukemia cell differentiation. Am J Physiol. 1991 Mar; 260(3 Pt 1):C392-9. PMID: 1900666.
      Citations: 1     Fields:    Translation:HumansCells
    114. Vadgama JV, Christensen HN. Discrimination of Na+-independent transport systems L, T, and asc in erythrocytes. Na+ independence of the latter a consequence of cell maturation? J Biol Chem. 1985 Mar 10; 260(5):2912-21. PMID: 3919011.
      Citations: 15     Fields:    Translation:HumansCells
    115. Vadgama JV, Christensen HN. A new Na+-independent transport system for dipolar amino acids apparently corresponding to systems persisting after erythrocyte maturation in some mammalian genotypes. Ann N Y Acad Sci. 1985; 456:454-6. PMID: 3937471.
      Citations: 1     Fields:    Translation:AnimalsCells
    116. Vadgama JV, Christensen HN. Comparison of system N in fetal hepatocytes and in related cell lines. J Biol Chem. 1983 May 25; 258(10):6422-9. PMID: 6304040.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    Vadgama's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (482)
    Explore
    _
    Co-Authors (22)
    Explore
    _
    Similar People (59)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _