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One or more keywords matched the following properties of Rajavashisth, Tripathi
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overview Our seminal research work on linking inflammatory pathways to lipid dysfunctions to the genesis and progression of vascular pathologies is globally recognized. We importantly contributed to research findings revealing aspects of lineage commitment of stem cells to differentiated mononuclear phagocytic lineage cells and their pathological migration, growth and survival inside the vessel wall. The current research in our laboratory combines biochemical, molecular and genetic approaches to study the role of pro-inflammatory molecules in the development and disruption of atherosclerotic plaques. We are also experimenting on therapeutic approaches to inhibit the development of arterial lesions in animal models. Additionally, our laboratory is involved in studies using a variety of novel interventional approaches to favorably modify inflammatory cell signaling pathways. These studies have resulted in US and international patent applications. The titles of individual research project in my laboratory are as follows: a) M-CSF isoforms in atherosclerosis; b) Role of M-CSF in the pathogenesis of atherosclerosis: the next phase; c) M-CSF inhibition for prevention of atherosclerosis and restenosis; d) Mechanisms of calcification in atherosclerotic plaque; and e) Medicinal effects of Cannabis on inflammatory syndromes. In our research on medicinal effects of Cannabis in collaboration with Omics Biotechnology, Inc, we have observed that low to moderate doses of Cannabis have beneficial effects on diabetes mellitus(DM) and other conditions that ultimately precipitate in some form of CVD in South Asian Indian human populations. Recently, using the NHANES III database on Cannabis use, we have observed a similar decreased prevalence of DM in Cannabis users. These results have led us to systematically perform animal experimentation. Though many sources of genomic information exist on the World Wide Web, a source of concise cardio-neurovascular information in general and on minorities in particular does not currently exist. To provide this information, we have initiated the development of the Cardio-NeuroVascular-database (Canvas) to study the functional genome of diverse cardiovascular and neurovascular pathologies. Canvas provides information on potential candidate genes for mutational analysis, genes for custom microarray analysis, and information for additional research and clinical interests. The format of the database allows continuous updates as additional information becomes available. Canvas provides an invaluable service to those interested in obtaining information on cardiovascular and neurovascular genes and diseases to explore hypotheses that may provide new insights into specific polymorphisms and haplotype variants linked to clinical outcomes and found preferentially in minority populations.
One or more keywords matched the following items that are connected to Rajavashisth, Tripathi
Item TypeName
Academic Article Structure, evolution, and regulation of chicken apolipoprotein A-I.
Academic Article Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA.
Academic Article Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract.
Academic Article Human stem cell factor promoter deoxyribonucleic acid sequence and regulation by cyclic 3',5'-adenosine monophosphate in a Sertoli cell line.
Academic Article Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction.
Academic Article Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.
Academic Article Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease.
Academic Article Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL.
Academic Article Intracoronary beta-irradiation enhances balloon-injury-induced tissue factor expression in the porcine injury model.
Academic Article Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.
Academic Article Molecular, endocrine, and genetic mechanisms of arterial calcification.
Academic Article Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis.
Academic Article Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit.
Academic Article Amino-terminal amino acid sequence of murine colony-stimulating factor 1.
Academic Article Polymeric-based perivascular delivery of a nitric oxide donor inhibits intimal thickening after balloon denudation arterial injury: role of nuclear factor-kappaB.
Academic Article Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL. Involvement of nuclear factor-kappa B.
Academic Article Cellular origins of atherosclerosis: towards ontogenetic endgame?
Academic Article Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads.
Academic Article Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways.
Academic Article Significance of apoptosis in the temporal and stage-specific loss of germ cells in the adult rat after gonadotropin deprivation.
Academic Article Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.
Academic Article Regulation of mouse colony-stimulating factor-1 gene promoter activity by AP1 and cellular nucleic acid-binding protein.
Academic Article Rationale for the role of osteoclast-like cells in arterial calcification.
Academic Article Increased expression of macrophage colony-stimulating factor after coronary artery balloon injury is inhibited by intracoronary brachytherapy.
Academic Article A comparison of anion-exchange and steric-exclusion HPLC assays of mouse plasma lipoproteins.
Academic Article A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice.
Academic Article Expression of inducible nitric oxide synthase in smooth muscle cells from rat penile corpora cavernosa.
Academic Article Genetic determinants of arterial calcification associated with atherosclerosis.
Academic Article Evolutionary distinct mechanisms regulate apolipoprotein A-I gene expression: differences between avian and mammalian apoA-I gene transcription control regions.
Academic Article Role of macrophage colony-stimulating factor in the development of neointimal thickening following arterial injury.
Academic Article Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24.
Academic Article NIH3T3 transforming gene not a general feature of atherosclerotic plaque DNA (atherosclerosis/oncogene/NIH3T3 transfection assay).
Concept Animals
Concept Disease Models, Animal
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