"Forkhead Box Protein L2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).
| Descriptor ID |
D000074842
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| MeSH Number(s) |
D12.776.260.950.249.032 D12.776.930.977.249.032
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein L2".
Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein L2".
This graph shows the total number of publications written about "Forkhead Box Protein L2" by people in this website by year, and whether "Forkhead Box Protein L2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Forkhead Box Protein L2" by people in Profiles.
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Mouse forkhead L2 maintains repression of FSH-dependent genes in the granulosa cell. Reproduction. 2012 Oct; 144(4):485-94.
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Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation. Endocrinology. 2011 Oct; 152(10):3917-29.
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Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology. Endocrinology. 2011 Apr; 152(4):1199-208.
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LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E101-9.
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Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2. Fertil Steril. 2010 Jun; 94(1):353-6.
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Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene. Cell Signal. 2009 Dec; 21(12):1935-44.
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Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Biochem Biophys Res Commun. 2005 Oct 28; 336(3):876-81.
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Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Endocrinology. 2004 Jul; 145(7):3424-33.