"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Descriptor ID |
D007515
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MeSH Number(s) |
A03.734.414 A06.407.414
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Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
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Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2000 | 0 | 1 | 1 |
2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology. 2005 Oct; 146(10):4514-23.
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Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. J Clin Invest. 2000 Apr; 105(7):955-65.
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Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin gene. Mol Cell Biol. 1992 Aug; 12(8):3531-9.
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Glyburide-stimulated glucose transport in cultured muscle cells via protein kinase C-mediated pathway requiring new protein synthesis. Diabetes. 1991 Nov; 40(11):1531-8.
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The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism. 1979 Jun; 28(6):688-705.