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Ekihiro Seki to Humans

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This is a "connection" page, showing publications Ekihiro Seki has written about Humans.
Ekihiro Seki
Connection Strength
2.627
Humans
  1. Metastatic tumor growth in steatotic liver is promoted by HAS2-mediated fibrotic tumor microenvironment. J Clin Invest. 2025 Feb 13; 135(7).
    View in: PubMed
    Score: 0.109
  2. Unveiling the cancer risk nexus of the steatotic liver. Trends Endocrinol Metab. 2024 Aug; 35(8):708-719.
    View in: PubMed
    Score: 0.102
  3. Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment. Cell Metab. 2023 07 11; 35(7):1209-1226.e13.
    View in: PubMed
    Score: 0.096
  4. Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets. Hepatol Commun. 2023 04 01; 7(4).
    View in: PubMed
    Score: 0.095
  5. FAP: Not Just a Biomarker but Druggable Target in Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2023; 15(4):1018-1019.
    View in: PubMed
    Score: 0.094
  6. Experimental Workflow for Preclinical Studies of Human Antifibrotic Therapies. Methods Mol Biol. 2023; 2669:285-306.
    View in: PubMed
    Score: 0.094
  7. Crossing the Rubicon: Adipose Tissue Autophagy Breaks Out NAFLD. Cell Mol Gastroenterol Hepatol. 2021; 12(5):1877-1878.
    View in: PubMed
    Score: 0.086
  8. Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43. Cell Metab. 2021 02 02; 33(2):229-230.
    View in: PubMed
    Score: 0.082
  9. The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix. Food Chem Toxicol. 2020 Sep; 143:111556.
    View in: PubMed
    Score: 0.079
  10. Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis. Semin Liver Dis. 2020 Aug; 40(3):307-320.
    View in: PubMed
    Score: 0.078
  11. Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration?of Ethanol-Induced Hepatic Injury. Cell Mol Gastroenterol Hepatol. 2020; 9(1):187-188.
    View in: PubMed
    Score: 0.075
  12. Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. Sci Transl Med. 2019 06 12; 11(496).
    View in: PubMed
    Score: 0.073
  13. Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets. Semin Liver Dis. 2019 02; 39(1):26-42.
    View in: PubMed
    Score: 0.071
  14. Chemokines and Chemokine Receptors in the Development of NAFLD. Adv Exp Med Biol. 2018; 1061:45-53.
    View in: PubMed
    Score: 0.066
  15. Finding a new role for NEMO: A key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1. Hepatology. 2016 07; 64(1):295-7.
    View in: PubMed
    Score: 0.059
  16. Exosome Migration Inhibitory Factor as a Marker and Therapeutic Target for Pancreatic Cancer. Gastroenterology. 2016 Apr; 150(4):1033-5.
    View in: PubMed
    Score: 0.058
  17. Basic and Clinical Advances in Chronic Liver Inflammation. Mediators Inflamm. 2016; 2016:1571457.
    View in: PubMed
    Score: 0.058
  18. MafG, A Novel Target of FXR that Regulates Bile Acid Homeostasis. Gastroenterology. 2015 Dec; 149(7):1981-3.
    View in: PubMed
    Score: 0.057
  19. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci. 2015 Jul; 22(7):512-8.
    View in: PubMed
    Score: 0.055
  20. Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology. 2015 Mar; 61(3):1066-79.
    View in: PubMed
    Score: 0.054
  21. Microbiome-obesity-liver cancer interaction: senescence of hepatic stellate cells and bile acids play new roles. Gastroenterology. 2014 Mar; 146(3):860-1.
    View in: PubMed
    Score: 0.051
  22. TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol. 2014 Feb; 49(2):185-94.
    View in: PubMed
    Score: 0.051
  23. Transcriptional repression of the transforming growth factor ? (TGF-?) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF-? signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-7091.
    View in: PubMed
    Score: 0.051
  24. Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol. 2013 Aug; 28 Suppl 1:38-42.
    View in: PubMed
    Score: 0.049
  25. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20.
    View in: PubMed
    Score: 0.045
  26. Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. J Physiol. 2012 Feb 01; 590(3):447-58.
    View in: PubMed
    Score: 0.044
  27. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70.
    View in: PubMed
    Score: 0.037
  28. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35.
    View in: PubMed
    Score: 0.034
  29. A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy. Cancer Res. 2025 Jul 15; 85(14):2714-2725.
    View in: PubMed
    Score: 0.028
  30. A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis. Exp Mol Med. 2025 Feb; 57(2):450-465.
    View in: PubMed
    Score: 0.027
  31. The role of forkhead box M1-methionine adenosyltransferase 2?A/2B axis in liver inflammation and fibrosis. Nat Commun. 2024 Sep 27; 15(1):8388.
    View in: PubMed
    Score: 0.026
  32. S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver. Int J Biol Sci. 2024; 20(4):1218-1237.
    View in: PubMed
    Score: 0.025
  33. Hepatic prohibitin 1 and methionine adenosyltransferase a1 defend against primary and secondary liver cancer metastasis. J Hepatol. 2024 Mar; 80(3):443-453.
    View in: PubMed
    Score: 0.025
  34. Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. J Hepatol. 2023 04; 78(4):805-819.
    View in: PubMed
    Score: 0.024
  35. Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B. Can J Gastroenterol Hepatol. 2022; 2022:1048104.
    View in: PubMed
    Score: 0.023
  36. Depletion of mitochondrial methionine adenosyltransferase a1 triggers mitochondrial dysfunction in alcohol-associated liver disease. Nat Commun. 2022 01 28; 13(1):557.
    View in: PubMed
    Score: 0.022
  37. Deregulated 14-3-3? and methionine adenosyltransferase a1 interplay promotes liver cancer tumorigenesis in mice and humans. Oncogene. 2021 09; 40(39):5866-5879.
    View in: PubMed
    Score: 0.021
  38. Modeling alcohol-associated liver disease in a human Liver-Chip. Cell Rep. 2021 07 20; 36(3):109393.
    View in: PubMed
    Score: 0.021
  39. Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. J Clin Invest. 2021 06 01; 131(11).
    View in: PubMed
    Score: 0.021
  40. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 06 14; 39(6):866-882.e11.
    View in: PubMed
    Score: 0.021
  41. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
    View in: PubMed
    Score: 0.021
  42. Reciprocal Regulation Between Forkhead Box M1/NF-?B and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 11; 72(5):1682-1700.
    View in: PubMed
    Score: 0.020
  43. Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling. Gut. 2019 12; 68(12):2214-2227.
    View in: PubMed
    Score: 0.018
  44. MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell Death Dis. 2019 02 11; 10(2):120.
    View in: PubMed
    Score: 0.018
  45. The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. J Biol Chem. 2019 02 08; 294(6):1984-1996.
    View in: PubMed
    Score: 0.018
  46. Ga12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. J Clin Invest. 2018 12 03; 128(12):5587-5602.
    View in: PubMed
    Score: 0.018
  47. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888.
    View in: PubMed
    Score: 0.017
  48. MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis. Arch Toxicol. 2018 09; 92(9):2935-2946.
    View in: PubMed
    Score: 0.017
  49. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6.
    View in: PubMed
    Score: 0.017
  50. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018 08; 155(2):557-571.e14.
    View in: PubMed
    Score: 0.017
  51. LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis. Sci Rep. 2016 10 18; 6:35610.
    View in: PubMed
    Score: 0.015
  52. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948.
    View in: PubMed
    Score: 0.015
  53. Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells. PLoS One. 2016; 11(3):e0150893.
    View in: PubMed
    Score: 0.015
  54. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
    View in: PubMed
    Score: 0.014
  55. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93.
    View in: PubMed
    Score: 0.014
  56. Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2015 Mar; 13(3):561-568.e1.
    View in: PubMed
    Score: 0.013
  57. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451.
    View in: PubMed
    Score: 0.013
  58. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44.
    View in: PubMed
    Score: 0.013
  59. NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7.
    View in: PubMed
    Score: 0.013
  60. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91.
    View in: PubMed
    Score: 0.013
  61. p38a inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24.
    View in: PubMed
    Score: 0.012
  62. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther. 2012 Jul; 36(1):22-9.
    View in: PubMed
    Score: 0.011
  63. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25.
    View in: PubMed
    Score: 0.010
  64. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-8619.
    View in: PubMed
    Score: 0.010
  65. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53.
    View in: PubMed
    Score: 0.009
  66. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38.
    View in: PubMed
    Score: 0.009
  67. Spontaneous decapitation of a small colorectal cancer: follow-up of the spontaneous course. Endoscopy. 2007 Feb; 39 Suppl 1:E290-1.
    View in: PubMed
    Score: 0.008
  68. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72.
    View in: PubMed
    Score: 0.007
  69. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900.
    View in: PubMed
    Score: 0.007
  70. Cytokine-induced inflammatory liver injuries. Curr Mol Med. 2003 Sep; 3(6):545-59.
    View in: PubMed
    Score: 0.006
  71. Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 2003 Aug; 94(8):679-85.
    View in: PubMed
    Score: 0.006
  72. Association of seropositivity for antibody to Chlamydia-specific lipopolysaccharide and coronary artery disease in Japanese men. Jpn Circ J. 2001 Mar; 65(3):182-7.
    View in: PubMed
    Score: 0.005
  73. Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects. J Hum Hypertens. 2000 Aug; 14(8):519-23.
    View in: PubMed
    Score: 0.005
  74. Metastatic gastrinoma to the liver 20 years after primary resection. J Gastroenterol. 2000; 35(9):717-20.
    View in: PubMed
    Score: 0.005
  75. Mononuclear odontoclast participation in tooth resorption: the distribution of nuclei in human odontoclasts. Anat Rec. 1997 12; 249(4):449-57.
    View in: PubMed
    Score: 0.004
  76. A case of liposarcoma originating in the chest wall. Nihon Geka Hokan. 1995 Nov 01; 64(6):131-8.
    View in: PubMed
    Score: 0.004
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The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.