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Ekihiro Seki, MD, PhD

TitleProfessor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentBiomedical Science Education
Address1731 E. 120th Street
Los Angeles CA 90059
PhoneNot Available
FaxNot Available
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    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E. Correction: Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2023 Apr 18; 12. PMID: 37071069; PMCID: PMC10112883.
      Citations:    Fields:    
    2. Kim J, Seki E. Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets. Hepatol Commun. 2023 04 01; 7(4). PMID: 36930869; PMCID: PMC10027054.
      Citations:    Fields:    Translation:HumansCells
    3. Tao L, Yang G, Sun T, Zhu C, Yu H, Cheng Y, Yang Z, Xu M, Jiang Y, Zhang W, Wang Z, Ma W, Wu L, Xue D, Wang D, Yang W, Zhao Y, Horsefield S, Kobe B, Zhang Z, Tang Z, Li Q, Zhai Q, Dooley S, Seki E, Liu P, Xu J, Chen H, Liu C. Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. J Hepatol. 2023 04; 78(4):805-819. PMID: 36669703.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Kim J, Seki E. FAP: Not Just a Biomarker but Druggable Target in Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2023; 15(4):1018-1019. PMID: 36681094; PMCID: PMC10040959.
      Citations:    Fields:    Translation:Humans
    5. Liu C, Mohan SC, Wei J, Seki E, Liu M, Basho R, Giuliano AE, Zhao Y, Cui X. Breast cancer liver metastasis: Pathogenesis and clinical implications. Front Oncol. 2022; 12:1043771. PMID: 36387238; PMCID: PMC9641291.
      Citations:    
    6. Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E. Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2022 10 04; 11. PMID: 36193675; PMCID: PMC9531947.
      Citations:    Fields:    Translation:AnimalsCells
    7. Yang G, Zhuang L, Sun T, Yeo YH, Tao L, Zhang W, Ma W, Wu L, Yang Z, Yang Y, Xue D, Zhang J, Feng R, Matthias P E, Dooley S, Seki E, Liu P, Liu C. Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B. Can J Gastroenterol Hepatol. 2022; 2022:1048104. PMID: 35855954; PMCID: PMC9288342.
      Citations: 1     Fields:    Translation:Humans
    8. Kim SM, Song GY, Shim A, Lee JH, Eom CB, Liu C, Yang YM, Seki E. Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. Exp Mol Med. 2022 06; 54(6):739-752. PMID: 35662287; PMCID: PMC9256637.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Barbier-Torres L, Murray B, Yang JW, Wang J, Matsuda M, Robinson A, Binek A, Fan W, Fern?ndez-Ramos D, Lopitz-Otsoa F, Luque-Urbano M, Millet O, Mavila N, Peng H, Ramani K, Gottlieb R, Sun Z, Liangpunsakul S, Seki E, Van Eyk JE, Mato JM, Lu SC. Depletion of mitochondrial methionine adenosyltransferase a1 triggers mitochondrial dysfunction in alcohol-associated liver disease. Nat Commun. 2022 01 28; 13(1):557. PMID: 35091576; PMCID: PMC8799735.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Zhao J, Hu L, Gui W, Xiao L, Wang W, Xia J, Fan H, Li Z, Zhu Q, Hou X, Chu H, Seki E, Yang L. Hepatocyte TGF-? Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let-7b-5p. Hepatol Commun. 2022 06; 6(6):1301-1321. PMID: 35018737; PMCID: PMC9134819.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Wang W, Gao W, Zhu Q, Alasbahi A, Seki E, Yang L. TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis. Front Cell Dev Biol. 2021; 9:734749. PMID: 34722513; PMCID: PMC8551703.
      Citations: 3     
    12. Kim J, Seki E. An Intestine-Derived HDL as a Novel Regulator of the Activity of Gut-Derived LPS: Ushering in a New Era of Research on the Gut-Liver Axis. Gastroenterology. 2022 02; 162(2):651-652. PMID: 34571025; PMCID: PMC8792181.
      Citations:    Fields:    
    13. Kim J, Seki E. Crossing the Rubicon: Adipose Tissue Autophagy Breaks Out NAFLD. Cell Mol Gastroenterol Hepatol. 2021; 12(5):1877-1878. PMID: 34461065; PMCID: PMC8591194.
      Citations: 1     Fields:    Translation:Humans
    14. Lu L, Zhang J, Fan W, Li Y, Wang J, Li TWH, Barbier-Torres L, Mato JM, Liu T, Seki E, Matsuda M, Tomasi ML, Bhowmick NA, Yang H, Lu SC. Deregulated 14-3-3? and methionine adenosyltransferase a1 interplay promotes liver cancer tumorigenesis in mice and humans. Oncogene. 2021 09; 40(39):5866-5879. PMID: 34349244; PMCID: PMC9611740.
      Citations: 2     Fields:    Translation:HumansAnimals
    15. Nawroth JC, Petropolis DB, Manatakis DV, Maulana TI, Burchett G, Schl?nder K, Witt A, Shukla A, Kodella K, Ronxhi J, Kulkarni G, Hamilton G, Seki E, Lu S, Karalis KC. Modeling alcohol-associated liver disease in a human Liver-Chip. Cell Rep. 2021 07 20; 36(3):109393. PMID: 34289365; PMCID: PMC8342038.
      Citations: 6     Fields:    Translation:HumansCells
    16. Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 Jun 14; 39(6):883. PMID: 34129825; PMCID: PMC8532387.
      Citations: 11     Fields:    
    17. Bhattacharjee S, Hamberger F, Ravichandra A, Miller M, Nair A, Affo S, Filliol A, Chin L, Savage TM, Yin D, Wirsik NM, Mehal A, Arpaia N, Seki E, Mack M, Zhu D, Sims PA, Kalluri R, Stanger BZ, Olive KP, Schmidt T, Wells RG, Mederacke I, Schwabe RF. Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. J Clin Invest. 2021 06 01; 131(11). PMID: 33905375; PMCID: PMC8159701.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    18. Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 06 14; 39(6):866-882.e11. PMID: 33930309; PMCID: PMC8241235.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    19. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-G?mez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ?lvarez ?MC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Ant?n Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Ara?jo WL, Araya J, Arden C, Ar?valo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnaun?-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, ?valos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, B?nr?ti ?, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Baril? D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touz? N, Bellarosa C, Belleudi F, Bell? P?rez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Bur?n MI, Bustos V, B?ttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cair? M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cant? C, Cao B, Caraglia M, Caram?s B, Carchman EH, Cardenal-Mu?oz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751; PMCID: PMC7996087.
      Citations: 616     Fields:    Translation:HumansAnimalsCells
    20. Yang YM, Seki E. Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43. Cell Metab. 2021 02 02; 33(2):229-230. PMID: 33535096; PMCID: PMC8407036.
      Citations: 2     Fields:    Translation:Humans
    21. Yang YM, Wang Z, Matsuda M, Seki E. Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient L-amino acid-defined diet-induced murine model. Arch Pharm Res. 2021 Feb; 44(2):230-240. PMID: 33486695; PMCID: PMC8407017.
      Citations: 3     Fields:    Translation:Animals
    22. Wang Q, Kim SY, Matsushita H, Wang Z, Pandyarajan V, Matsuda M, Ohashi K, Tsuchiya T, Roh YS, Kiani C, Zhao Y, Chan M, Devkota S, Lu SC, Hayashi T, Carson DA, Seki E. Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). PMID: 33443222; PMCID: PMC7817133.
      Citations: 11     Fields:    Translation:AnimalsCells
    23. Noureddin N, Yang JD, Alkhouri N, Noreen SM, Toll AE, Todo T, Ayoub W, Kuo A, Voidonikolas G, Kotler HG, Pelphrey MD, Durand BJ, Kosari K, Brennan TV, Kim I, Klein AS, Seki E, Nissen NN, Lu SC, Sundaram V, Noureddin M. Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004-2018 Analysis. Transplant Direct. 2020 Nov; 6(11):e612. PMID: 33134488; PMCID: PMC7546885.
      Citations:    
    24. Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC. Reciprocal Regulation Between Forkhead Box M1/NF-?B and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 11; 72(5):1682-1700. PMID: 32080887; PMCID: PMC7442711.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    25. Wang Q, Wang Z, Xu M, Tu W, Hsin IF, Stotland A, Kim JH, Liu P, Naiki M, Gottlieb RA, Seki E. Neurotropin Inhibits Lipid Accumulation by Maintaining Mitochondrial Function in Hepatocytes via AMPK Activation. Front Physiol. 2020; 11:950. PMID: 32848877; PMCID: PMC7424056.
      Citations: 1     
    26. Matsuda M, Seki E. The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix. Food Chem Toxicol. 2020 Sep; 143:111556. PMID: 32640349; PMCID: PMC7484466.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    27. Matsuda M, Seki E. Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis. Semin Liver Dis. 2020 Aug; 40(3):307-320. PMID: 32242330; PMCID: PMC7484001.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    28. Czech TY, Seki E. Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration?of Ethanol-Induced Hepatic Injury. Cell Mol Gastroenterol Hepatol. 2020; 9(1):187-188. PMID: 31669157; PMCID: PMC6926269.
      Citations:    Fields:    Translation:HumansCells
    29. Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E. Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. J Biol Chem. 2019 08 16; 294(33):12359-12369. PMID: 31235522; PMCID: PMC6699832.
      Citations: 14     Fields:    Translation:AnimalsCells
    30. Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E. Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. Sci Transl Med. 2019 06 12; 11(496). PMID: 31189722; PMCID: PMC6589184.
      Citations: 44     Fields:    Translation:HumansCells
    31. Tao L, Ma W, Wu L, Xu M, Yang Y, Zhang W, Sha W, Li H, Xu J, Feng R, Xue D, Zhang J, Dooley S, Seki E, Liu P, Liu C. Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling. Gut. 2019 12; 68(12):2214-2227. PMID: 31171625; PMCID: PMC6842044.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    32. Ohashi K, Wang Z, Yang YM, Billet S, Tu W, Pimienta M, Cassel SL, Pandol SJ, Lu SC, Sutterwala FS, Bhowmick N, Seki E. NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019 11; 70(5):1582-1599. PMID: 31044438; PMCID: PMC6819206.
      Citations: 21     Fields:    Translation:AnimalsCells
    33. Wang P, Song X, Utpatel K, Shang R, Yang YM, Xu M, Zhang J, Che L, Gordan J, Cigliano A, Seki E, Evert M, Calvisi DF, Hu X, Chen X. MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell Death Dis. 2019 02 11; 10(2):120. PMID: 30741922; PMCID: PMC6370758.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    34. Pimienta M, Beletsky A, Seki E. Intestinal Lipolysis Mitigates Nonalcoholic Fatty Liver Disease: New Roles for Carboxylesterase 2c in the Intestine. Hepatol Commun. 2019 Feb; 3(2):177-179. PMID: 30766955; PMCID: PMC6357825.
      Citations:    Fields:    
    35. Yang YM, Kim SY, Seki E. Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets. Semin Liver Dis. 2019 02; 39(1):26-42. PMID: 30809789; PMCID: PMC6616367.
      Citations: 120     Fields:    Translation:HumansCells
    36. Ohashi K, Pimienta M, Seki E. Alcoholic liver disease: A current molecular and clinical perspective. Liver Res. 2018 Dec; 2(4):161-172. PMID: 31214376; PMCID: PMC6581514.
      Citations: 26     
    37. Yang JW, Murray B, Barbier-Torres L, Liu T, Liu Z, Yang H, Fan W, Wang J, Li Y, Seki E, Mato JM, Lu SC. The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. J Biol Chem. 2019 02 08; 294(6):1984-1996. PMID: 30523154; PMCID: PMC6369293.
      Citations: 9     Fields:    Translation:HumansCells
    38. Kim TH, Yang YM, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG. Ga12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. J Clin Invest. 2018 12 03; 128(12):5587-5602. PMID: 30300140; PMCID: PMC6264648.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    39. Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888. PMID: 30287485; PMCID: PMC6196518.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    40. Pandyarajan V, Seki E. Nuclear Receptors: Opening Up New Avenues of Pediatric Fatty Liver Research. Hepatol Commun. 2018 Oct; 2(10):1157-1159. PMID: 30288469; PMCID: PMC6167071.
      Citations:    Fields:    
    41. Tao L, Xue D, Shen D, Ma W, Zhang J, Wang X, Zhang W, Wu L, Pan K, Yang Y, Nwosu ZC, Dooley S, Seki E, Liu C. MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis. Arch Toxicol. 2018 09; 92(9):2935-2946. PMID: 30097701; PMCID: PMC6590087.
      Citations: 22     Fields:    Translation:HumansCells
    42. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. PMID: 30046112; PMCID: PMC6329306.
      Citations: 346     Fields:    Translation:AnimalsCells
    43. Yang YM, Fukui M, Wang Z, Miao F, Karriker MJ, Seki E. Interventional Potential of Recombinant Feline Hepatocyte Growth Factor in a Mouse Model of Non-alcoholic Steatohepatitis. Front Endocrinol (Lausanne). 2018; 9:378. PMID: 30083132; PMCID: PMC6064873.
      Citations: 8     Fields:    
    44. Pimienta M, Seki E. Tumor Suppressor Down-Regulation Promotes Hepatocyte Proliferation: A New GANKster on the Block. Cell Mol Gastroenterol Hepatol. 2018; 6(3):345-346. PMID: 30182043; PMCID: PMC6120958.
      Citations:    Fields:    Translation:Cells
    45. Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6. PMID: 29894692; PMCID: PMC6005359.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    46. Liu T, Yang H, Fan W, Tu J, Li TWH, Wang J, Shen H, Yang J, Xiong T, Steggerda J, Liu Z, Noureddin M, Maldonado SS, Annamalai A, Seki E, Mato JM, Lu SC. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018 08; 155(2):557-571.e14. PMID: 29733835; PMCID: PMC6067975.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    47. Wang Q, Seki E. Astrocyte elevated gene-1 (AEG-1): a new potential therapeutic target for the treatment of nonalcoholic steatohepatitis (NASH). Hepatobiliary Surg Nutr. 2018 Feb; 7(1):44-47. PMID: 29531945; PMCID: PMC5835612.
      Citations:    
    48. Czech TY, Wang Q, Seki E. A new mechanism of action of glucagon-like peptide-1 agonist in hepatic steatosis: Promotion of hepatic insulin clearance through induction of carcinoembryonic antigen-related cell adhesion molecule 1. Hepatol Commun. 2018 01; 2(1):9-12. PMID: 29404506; PMCID: PMC5776878.
      Citations:    Fields:    
    49. Roh YS, Seki E. Chemokines and Chemokine Receptors in the Development of NAFLD. Adv Exp Med Biol. 2018; 1061:45-53. PMID: 29956205.
      Citations: 31     Fields:    Translation:HumansAnimals
    50. Song IJ, Yang YM, Inokuchi-Shimizu S, Roh YS, Yang L, Seki E. The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer. 2018 01 01; 142(1):81-91. PMID: 28875549; PMCID: PMC5790193.
      Citations: 24     Fields:    Translation:AnimalsCells
    51. Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC. S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. Oncotarget. 2017 Oct 03; 8(45):78851-78869. PMID: 29108270; PMCID: PMC5668003.
      Citations: 14     Fields:    
    52. Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh YS, Seki E. TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice. Cell Mol Gastroenterol Hepatol. 2017 May; 3(3):469-483. PMID: 28462384; PMCID: PMC5403956.
      Citations: 29     Fields:    
    53. Odena G, Chen J, Lozano JJ, Altamirano J, Rodrigo-Torres D, Affo S, Morales-Ibanez O, Matsushita H, Zou J, Dumitru R, Caballeria J, Gines P, Arroyo V, You M, Rautou PE, Valla D, Crews F, Seki E, Sancho-Bru P, Bataller R. LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis. Sci Rep. 2016 10 18; 6:35610. PMID: 27752144; PMCID: PMC5067590.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    54. Seki E. Acrolein, a New Villain in the Development of Alcoholic Liver Disease. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5):544-545. PMID: 28174735; PMCID: PMC5042884.
      Citations: 1     Fields:    
    55. Hsin IF, Montano E, Seki E. Finding a new role for NEMO: A key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1. Hepatology. 2016 07; 64(1):295-7. PMID: 27122117; PMCID: PMC4917439.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    56. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948. PMID: 27211490; PMCID: PMC4907799.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    57. Siegmund SV, Schlosser M, Schildberg FA, Seki E, De Minicis S, Uchinami H, Kuntzen C, Knolle PA, Strassburg CP, Schwabe RF. Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells. PLoS One. 2016; 11(3):e0150893. PMID: 26937641; PMCID: PMC4777566.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    58. Matsushita H, Yang YM, Pandol SJ, Seki E. Exosome Migration Inhibitory Factor as a Marker and Therapeutic Target for Pancreatic Cancer. Gastroenterology. 2016 Apr; 150(4):1033-5. PMID: 26922869; PMCID: PMC4905572.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    59. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. PMID: 26919428; PMCID: PMC4769378.
      Citations: 437     Fields:    Translation:AnimalsCells
    60. Enomoto H, Tamori A, Yoshiji H, Seki E. Basic and Clinical Advances in Chronic Liver Inflammation. Mediators Inflamm. 2016; 2016:1571457. PMID: 27006527; PMCID: PMC4783579.
      Citations:    Fields:    Translation:HumansAnimals
    61. Seki E. HEDGEHOG Signal in hepatocytes mediates macrophage recruitment: A new mechanism and potential therapeutic target for fatty liver disease. Hepatology. 2016 Apr; 63(4):1071-3. PMID: 26638191; PMCID: PMC4805480.
      Citations: 4     Fields:    Translation:AnimalsCells
    62. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Alg?l H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, B?nhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolom? A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, B?dard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, B?nard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, B?ckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouch? M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, B?tikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ce?a V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977.
      Citations: 2698     Fields:    Translation:HumansAnimals
    63. Yang YM, Roh YS, Seki E. MafG, A Novel Target of FXR that Regulates Bile Acid Homeostasis. Gastroenterology. 2015 Dec; 149(7):1981-3. PMID: 26501563; PMCID: PMC4744927.
      Citations: 2     Fields:    Translation:HumansAnimals
    64. Yang YM, Seki E. TNFa in liver fibrosis. Curr Pathobiol Rep. 2015 Dec; 3(4):253-261. PMID: 26726307; PMCID: PMC4693602.
      Citations: 56     
    65. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D, Genetics of NAFLD in Twins Consortium. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. PMID: 26299412; PMCID: PMC4663110.
      Citations: 133     Fields:    Translation:Humans
    66. Roh YS, Zhang B, Loomba R, Seki E. TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 01; 309(1):G30-41. PMID: 25930080; PMCID: PMC4491507.
      Citations: 64     Fields:    Translation:AnimalsCells
    67. Seki E, Brenner DA. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci. 2015 Jul; 22(7):512-8. PMID: 25869468; PMCID: PMC4668270.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    68. Maricic I, Sheng H, Marrero I, Seki E, Kisseleva T, Chaturvedi S, Molle N, Mathews SA, Gao B, Kumar V. Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice. Hepatology. 2015 Apr; 61(4):1357-69. PMID: 25477000; PMCID: PMC4376634.
      Citations: 46     Fields:    Translation:AnimalsCells
    69. Seki E, Schwabe RF. Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology. 2015 Mar; 61(3):1066-79. PMID: 25066777; PMCID: PMC4306641.
      Citations: 354     Fields:    Translation:HumansCells
    70. Seki E. TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. Mol Cell Oncol. 2014; 1(4). PMID: 26709386; PMCID: PMC4687902.
      Citations: 5     
    71. Zhang B, Roh YS, Liang S, Liu C, Naiki M, Masuda K, Seki E. Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-?B and JNK in hepatocytes. PLoS One. 2014; 9(12):e114071. PMID: 25470242; PMCID: PMC4254918.
      Citations: 8     Fields:    Translation:AnimalsCells
    72. Roh YS, Loomba R, Seki E. The TM6SF2 variants, novel genetic predictors for nonalcoholic steatohepatitis. Gastroenterology. 2015 Jan; 148(1):252-4. PMID: 25451657; PMCID: PMC4718074.
      Citations: 10     Fields:    
    73. Patel NS, Doycheva I, Peterson MR, Hooker J, Kisselva T, Schnabl B, Seki E, Sirlin CB, Loomba R. Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2015 Mar; 13(3):561-568.e1. PMID: 25218667; PMCID: PMC4333065.
      Citations: 51     Fields:    Translation:Humans
    74. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. PMID: 25132496; PMCID: PMC4165611.
      Citations: 229     Fields:    Translation:AnimalsCells
    75. Yang L, Seki E. Reply: To PMID 23996730. Hepatology. 2014 Sep; 60(3):1114-5. PMID: 24443149; PMCID: PMC4328032.
      Citations:    Fields:    Translation:AnimalsCells
    76. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451. PMID: 25043713; PMCID: PMC4107319.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    77. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
      Citations: 67     Fields:    Translation:AnimalsCells
    78. Kudoh K, Uchinami H, Yoshioka M, Seki E, Yamamoto Y. Nrf2 activation protects the liver from ischemia/reperfusion injury in mice. Ann Surg. 2014 Jul; 260(1):118-27. PMID: 24368646; PMCID: PMC4047210.
      Citations: 44     Fields:    Translation:AnimalsCells
    79. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44. PMID: 24910242; PMCID: PMC4079758.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    80. Roh YS, Park S, Kim JW, Lim CW, Seki E, Kim B. Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. Hepatology. 2014 Jul; 60(1):237-49. PMID: 24375615; PMCID: PMC4273749.
      Citations: 21     Fields:    Translation:AnimalsCells
    81. Liang S, Zhong Z, Seki E. Novel fate-tracing strategies show that hepatic stellate cells mediate fibrosis in vivo. Gastroenterology. 2014 Jun; 146(7):1823-5. PMID: 24768331; PMCID: PMC4743044.
      Citations: 2     Fields:    Translation:AnimalsCells
    82. Seki E. Microbiome-obesity-liver cancer interaction: senescence of hepatic stellate cells and bile acids play new roles. Gastroenterology. 2014 Mar; 146(3):860-1. PMID: 24468171; PMCID: PMC4717838.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    83. Roh YS, Song J, Seki E. TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol. 2014 Feb; 49(2):185-94. PMID: 24443058; PMCID: PMC3952073.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    84. Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. Transcriptional repression of the transforming growth factor ? (TGF-?) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF-? signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-7091. PMID: 24448807; PMCID: PMC3945368.
      Citations: 43     Fields:    Translation:HumansCells
    85. Dhar D, Seki E, Karin M. NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7. PMID: 24411937; PMCID: PMC3947913.
      Citations: 10     Fields:    Translation:HumansAnimals
    86. Yang L, Roh YS, Song J, Zhang B, Liu C, Loomba R, Seki E. Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology. 2014 Feb; 59(2):483-95. PMID: 23996730; PMCID: PMC3946696.
      Citations: 112     Fields:    Translation:AnimalsCells
    87. Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91. PMID: 24333183; PMCID: PMC3960359.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    88. Patel NS, Peterson MR, Lin GY, Feldstein A, Schnabl B, Bettencourt R, Seki E, Sirlin CB, Loomba R. Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls. Gastroenterol Res Pract. 2013; 2013:498296. PMID: 24348536; PMCID: PMC3855930.
      Citations: 22     
    89. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96. PMID: 24120137; PMCID: PMC4015514.
      Citations: 218     Fields:    Translation:AnimalsCells
    90. Roh YS, Seki E. Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol. 2013 Aug; 28 Suppl 1:38-42. PMID: 23855294; PMCID: PMC3721430.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    91. Yang L, Inokuchi S, Roh YS, Song J, Loomba R, Park EJ, Seki E. Transforming growth factor-? signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 2013 May; 144(5):1042-1054.e4. PMID: 23391818; PMCID: PMC3752402.
      Citations: 71     Fields:    Translation:AnimalsCells
    92. Miura K, Yang L, van Rooijen N, Brenner DA, Ohnishi H, Seki E. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89. PMID: 22987396; PMCID: PMC3566276.
      Citations: 129     Fields:    Translation:AnimalsCells
    93. Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. p38a inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24. PMID: 23271722; PMCID: PMC3605785.
      Citations: 34     Fields:    Translation:HumansAnimals
    94. Seki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. PMID: 22705006; PMCID: PMC3523093.
      Citations: 231     Fields:    Translation:HumansAnimalsCells
    95. Font-Burgada J, Seki E, Karin M. CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2. PMID: 22698394; PMCID: PMC4718070.
      Citations: 3     Fields:    
    96. Brenner DA, Kisseleva T, Scholten D, Paik YH, Iwaisako K, Inokuchi S, Schnabl B, Seki E, De Minicis S, Oesterreicher C, Taura K. Origin of myofibroblasts in liver fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S17. PMID: 23259769; PMCID: PMC3368775.
      Citations: 55     
    97. Yang L, Seki E. Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms. Front Physiol. 2012; 3:138. PMID: 22661952; PMCID: PMC3357552.
      Citations: 86     
    98. Abe Y, Uchinami H, Kudoh K, Nakagawa Y, Ise N, Watanabe G, Sato T, Seki E, Yamamoto Y. Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes. Surgery. 2012 Nov; 152(5):869-78. PMID: 22575885; PMCID: PMC4589249.
      Citations: 8     Fields:    Translation:AnimalsCells
    99. Permutt Z, Le TA, Peterson MR, Seki E, Brenner DA, Sirlin C, Loomba R. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther. 2012 Jul; 36(1):22-9. PMID: 22554256; PMCID: PMC3437221.
      Citations: 154     Fields:    Translation:Humans
    100. Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 01; 302(11):G1310-21. PMID: 22442158; PMCID: PMC3378163.
      Citations: 225     Fields:    Translation:AnimalsCells
    101. Seki E, Schnabl B. Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. J Physiol. 2012 Feb 01; 590(3):447-58. PMID: 22124143; PMCID: PMC3379693.
      Citations: 189     Fields:    Translation:HumansAnimals
    102. Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 2011 Oct 07; 286(40):34800-8. PMID: 21841000; PMCID: PMC3186417.
      Citations: 34     Fields:    Translation:AnimalsCells
    103. Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res. 2011 Jul; 41(7):683-6. PMID: 21711427; PMCID: PMC3341613.
      Citations: 22     
    104. Seki E, Park E, Fujimoto J. Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis. Hepatol Res. 2011 Jul; 41(7):597-610. PMID: 21696522; PMCID: PMC3754784.
      Citations: 12     
    105. Szabo G, Billiar TR, Machida K, Crispe IN, Seki E. Toll-like receptor signaling in liver diseases. Gastroenterol Res Pract. 2010; 2010:971270. PMID: 21789039; PMCID: PMC3123973.
      Citations: 6     
    106. Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41. PMID: 21384410; PMCID: PMC3082608.
      Citations: 100     Fields:    Translation:AnimalsCells
    107. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. PMID: 21463341; PMCID: PMC3131439.
      Citations: 92     Fields:    Translation:AnimalsCells
    108. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25. PMID: 21252049; PMCID: PMC3774265.
      Citations: 112     Fields:    Translation:HumansCells
    109. Miura K, Seki E, Ohnishi H, Brenner DA. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract. 2010; 2010:362847. PMID: 21274430; PMCID: PMC3026974.
      Citations: 68     
    110. Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner DA. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-8619. PMID: 21193410; PMCID: PMC3048743.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    111. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. PMID: 21163859; PMCID: PMC3058702.
      Citations: 20     Fields:    Translation:AnimalsCells
    112. Aoyama T, Inokuchi S, Brenner DA, Seki E. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400. PMID: 20683935; PMCID: PMC2947579.
      Citations: 86     Fields:    Translation:AnimalsCells
    113. De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner DA. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30. PMID: 20690191; PMCID: PMC2947612.
      Citations: 39     Fields:    Translation:AnimalsCells
    114. Aoyama T, Paik YH, Seki E. Toll-like receptor signaling and liver fibrosis. Gastroenterol Res Pract. 2010; 2010. PMID: 20706677; PMCID: PMC2913673.
      Citations: 66     
    115. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. PMID: 20347818; PMCID: PMC4631262.
      Citations: 346     Fields:    Translation:AnimalsCells
    116. Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology. 2010 Jan; 51(1):237-45. PMID: 19821528.
      Citations: 26     Fields:    Translation:AnimalsCells
    117. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. PMID: 20080763; PMCID: PMC2818947.
      Citations: 153     Fields:    Translation:AnimalsCells
    118. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38. PMID: 19650157; PMCID: PMC4734904.
      Citations: 58     Fields:    Translation:AnimalsCells
    119. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. PMID: 20023766.
      Citations: 23     Fields:    Translation:AnimalsCells
    120. Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97. PMID: 19441102; PMCID: PMC2705470.
      Citations: 195     Fields:    Translation:Animals
    121. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70. PMID: 19603542; PMCID: PMC2701864.
      Citations: 220     Fields:    Translation:HumansAnimalsCells
    122. Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5. PMID: 19549522; PMCID: PMC2757473.
      Citations: 89     Fields:    Translation:AnimalsCells
    123. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. PMID: 19171902; PMCID: PMC2635765.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    124. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. PMID: 19025999.
      Citations: 42     Fields:    Translation:AnimalsCells
    125. Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38. PMID: 18823985.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    126. Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. PMID: 18506843.
      Citations: 281     Fields:    Translation:HumansAnimalsCells
    127. Seki E, Kondo Y, Iimuro Y, Naka T, Son G, Kishimoto T, Fujimoto J, Tsutsui H, Nakanishi K. Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings. J Hepatol. 2008 Feb; 48(2):237-45. PMID: 18068850.
      Citations: 23     Fields:    Translation:AnimalsCells
    128. Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52. PMID: 17668872.
      Citations: 29     Fields:    Translation:AnimalsCells
    129. Tomiki Y, Gonda H, Seki E, Maeda T, Kitamura D. Spontaneous decapitation of a small colorectal cancer: follow-up of the spontaneous course. Endoscopy. 2007 Feb; 39 Suppl 1:E290-1. PMID: 17957612.
      Citations:    Fields:    Translation:Humans
    130. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32. PMID: 17952090.
      Citations: 860     Fields:    Translation:AnimalsCells
    131. Son G, Iimuro Y, Seki E, Hirano T, Kaneda Y, Fujimoto J. Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Sep; 293(3):G631-9. PMID: 17640975.
      Citations: 50     Fields:    Translation:AnimalsCells
    132. Iimuro Y, Seki E, Son G, Tsutsui H, Nakanishi K, Fujimoto J. Role of innate immune response in liver regeneration. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S57-8. PMID: 17567467.
      Citations: 8     Fields:    Translation:AnimalsCells
    133. Seki E, Brenner DA. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. PMID: 17566588; PMCID: PMC2739234.
      Citations: 8     Fields:    
    134. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46. PMID: 17484886.
      Citations: 204     Fields:    Translation:AnimalsCells
    135. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. PMID: 17032415.
      Citations: 10     Fields:    Translation:AnimalsCells
    136. Uchinami H, Seki E, Brenner DA, D'Armiento J. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. PMID: 16871591.
      Citations: 84     Fields:    Translation:AnimalsCells
    137. Son G, Hirano T, Seki E, Iimuro Y, Nukiwa T, Matsumoto K, Nakamura T, Fujimoto J. Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice. J Hepatol. 2006 Nov; 45(5):688-95. PMID: 16839638.
      Citations: 14     Fields:    Translation:AnimalsCells
    138. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72. PMID: 16697719.
      Citations: 100     Fields:    Translation:Humans
    139. Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900. PMID: 16697751.
      Citations: 165     Fields:    Translation:HumansCells
    140. Siegmund SV, Seki E, Osawa Y, Uchinami H, Cravatt BF, Schwabe RF. Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J Biol Chem. 2006 Apr 14; 281(15):10431-8. PMID: 16418162.
      Citations: 44     Fields:    Translation:AnimalsCells
    141. Seki E, Tsutsui H, Iimuro Y, Naka T, Son G, Akira S, Kishimoto T, Nakanishi K, Fujimoto J. Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology. 2005 Mar; 41(3):443-50. PMID: 15723296.
      Citations: 54     Fields:    Translation:AnimalsCells
    142. Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells. 2004 Nov; 9(11):1055-67. PMID: 15507117.
      Citations: 75     Fields:    Translation:AnimalsCells
    143. Adachi K, Tsutsui H, Seki E, Nakano H, Takeda K, Okumura K, Van Kaer L, Nakanishi K. Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int Immunol. 2004 Jun; 16(6):787-98. PMID: 15096477.
      Citations: 16     Fields:    Translation:AnimalsCells
    144. Tsuji NM, Tsutsui H, Seki E, Kuida K, Okamura H, Nakanishi K, Flavell RA. Roles of caspase-1 in Listeria infection in mice. Int Immunol. 2004 Feb; 16(2):335-43. PMID: 14734619.
      Citations: 66     Fields:    Translation:AnimalsCells
    145. Tsutsui H, Adachi K, Seki E, Nakanishi K. Cytokine-induced inflammatory liver injuries. Curr Mol Med. 2003 Sep; 3(6):545-59. PMID: 14527086.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    146. Ogushi I, Iimuro Y, Seki E, Son G, Hirano T, Hada T, Tsutsui H, Nakanishi K, Morishita R, Kaneda Y, Fujimoto J. Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatology. 2003 Aug; 38(2):335-44. PMID: 12883477.
      Citations: 21     Fields:    Translation:AnimalsCells
    147. Kato T, Miyamoto M, Date T, Yasui K, Taya C, Yonekawa H, Ohue C, Yagi S, Seki E, Hirano T, Fujimoto J, Shirai T, Wakita T. Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 2003 Aug; 94(8):679-85. PMID: 12901792.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    148. Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol. 2001 Nov 15; 167(10):5928-34. PMID: 11698470.
      Citations: 66     Fields:    Translation:AnimalsCells
    149. Shimada K, Daida H, Mokuno H, Watanabe Y, Sawano M, Iwama Y, Seki E, Kurata T, Sato H, Ohashi S, Suzuki H, Miyauchi K, Takaya J, Sakurai H, Yamaguchi H. Association of seropositivity for antibody to Chlamydia-specific lipopolysaccharide and coronary artery disease in Japanese men. Jpn Circ J. 2001 Mar; 65(3):182-7. PMID: 11266192.
      Citations: 2     Fields:    Translation:HumansCells
    150. Seki E, Tsutsui H, Nakano H, Tsuji N, Hoshino K, Adachi O, Adachi K, Futatsugi S, Kuida K, Takeuchi O, Okamura H, Fujimoto J, Akira S, Nakanishi K. Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol. 2001 Feb 15; 166(4):2651-7. PMID: 11160328.
      Citations: 97     Fields:    Translation:AnimalsCells
    151. Kawasaki T, Seki E, Osajima K, Yoshida M, Asada K, Matsui T, Osajima Y. Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects. J Hum Hypertens. 2000 Aug; 14(8):519-23. PMID: 10962520.
      Citations: 26     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    152. Okuzawa A, Kobayashi S, Sakamoto K, Uchida Y, Suzuki Y, Ono K, Seki E, Tomiki Y, Iwanuma Y, Hayashida Y, Kamano T, Tsurumaru M. Metastatic gastrinoma to the liver 20 years after primary resection. J Gastroenterol. 2000; 35(9):717-20. PMID: 11023045.
      Citations: 2     Fields:    Translation:Humans
    153. Matsufuji H, Matsui T, Seki E, Osajima K, Nakashima M, Osajima Y. Angiotensin I-converting enzyme inhibitory peptides in an alkaline protease hydrolyzate derived from sardine muscle. Biosci Biotechnol Biochem. 1994 Dec; 58(12):2244-5. PMID: 7765718.
      Citations: 15     Fields:    Translation:AnimalsCells
    154. Matsui T, Matsufuji H, Seki E, Osajima K, Nakashima M, Osajima Y. Inhibition of angiotensin I-converting enzyme by Bacillus licheniformis alkaline protease hydrolyzates derived from sardine muscle. Biosci Biotechnol Biochem. 1993 Jun; 57(6):922-5. PMID: 7763878.
      Citations: 3     Fields:    Translation:AnimalsCells
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