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Mamdooh Ghoneum, PhD

TitleAssociate Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentSurgery
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-5953
FaxNot Available
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    Overview
    overview
    Dr. Ghoneum is an internationally recognized immunologist who is an expert in the area of cancer immune therapy. He has published 90 articles and 130 abstracts, including 11 books in Japanese and in English related to cancer immunology. He holds 3 patents for inventing 3 biological response modifiers (BRMs) for the treatment of cancer. Dr. Ghoneum's contribution to immunotherapy is introducing and patenting several new non-toxic BRMs that activate different arms of the immune system such as NK, T, and dendritic cells and induce apoptosis of cancer cells. The most extensively studied of these BRMs is called arabinoxylan MGN-3. In the most recent human clinical trials, MGN-3 was demonstrated to enhance the anti-cancer activity of chemotherapy for the treatment of hepatocellular carcinoma (HCC). This is the first time that a natural BRM was shown to be effective for the treatment of HCC. Dr. Ghoenum has received several international awards from: The American Cancer Society (1993), Japan Functional Food Research Association (JAFRA) (2002), and The Filipino-Chinese Medical Society (2005). In 2007 he was nominated for the annual $1 million prestigious Gotham Prize in Cancer Research for his novel discovery of using baker's yeast for the treatment of cancer. He created a video to educate the public about a new cancer therapy. He had special accelerated promotion. He has been awarded numerous research grants from NIH-MBRS and major research institutions in Japan. He has been a reviewer for the NIH Study Section Member. He has been an organizer for annual workshops between the Japanese Immunology Society and Charles Drew University since 1990. He is a member of several Scientific Societies, including the American Association for Cancer Research (AACR). Dr. Ghoneum's goal is to expand MGN-3 immunotherapy for the treatment of cancer in multiple clinical trials, and in addition to emphasize the importance of his novel approach for using yeast therapy for the treatment of cancer metastasis.

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. El-Mahdi MBM, Rabie SA, Hassanine RME, Hassan AA, Abo Elhussien OF, Ghoneum M, El-Gerbed MSA. Molecular Identification, Pathogenesis, and Life Cycle of Sarcocystis cruzi from Cattle (Bos taurus) in New Valley Governorate, Egypt. J Parasitol Res. 2023; 2023:7829290. PMID: 36937557; PMCID: PMC10017224.
      Citations:    
    2. Ghoneum M, Abdulmalek S, Fadel HH. Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study. Nutrients. 2023 Jan 15; 15(2). PMID: 36678324.
      Citations:    Fields:    
    3. Ghoneum M, Alaa El-Dein M, Badr El-Din NK. Anticancer potential of Marina Crystal Minerals (MCM) against the growth of murine mammary adenocarcinoma cells in vivo. Biomed Pharmacother. 2022 Nov 11; 157:113975. PMID: 36371853.
      Citations:    Fields:    
    4. Abdou HM, Hamaad FA, Ali EY, Ghoneum MH. Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomed Pharmacother. 2022 May; 149:112838. PMID: 35344738.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Badr El-Din NK, Othman AI, Amer ME, Ghoneum M. Thymax, a gross thymic extract, exerts cell cycle arrest and apoptosis in Ehrlich ascites carcinoma in vivo. Heliyon. 2022 Mar; 8(3):e09047. PMID: 35299600; PMCID: PMC8920936.
      Citations:    
    6. Elsaid AF, Agrawal S, Agrawal A, Ghoneum M. Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial. Nutrients. 2021 Nov 19; 13(11). PMID: 34836388; PMCID: PMC8618540.
      Citations: 1     Fields:    Translation:HumansCells
    7. Ghoneum M, Abdulmalek S. KDP, a Lactobacilli Product from Kimchi, Enhances Mucosal Immunity by Increasing Secretory IgA in Mice and Exhibits Antimicrobial Activity. Nutrients. 2021 Nov 04; 13(11). PMID: 34836191; PMCID: PMC8618749.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Ghoneum M, El-Gerbed MSA. Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses. Cancer Chemother Pharmacol. 2021 12; 88(6):961-971. PMID: 34505929; PMCID: PMC8536621.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. El Sayed NS, Kandil EA, Ghoneum MH. Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer's Disease Model in Mice. Front Pharmacol. 2021; 12:666502. PMID: 34366841; PMCID: PMC8346028.
      Citations: 8     
    10. El Sayed NS, Kandil EA, Ghoneum MH. Probiotics Fermentation Technology, a Novel Kefir Product, Ameliorates Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer's Disease in Mice. Oxid Med Cell Longev. 2021; 2021:5525306. PMID: 34306309; PMCID: PMC8282381.
      Citations: 6     Fields:    Translation:AnimalsCells
    11. Ghoneum MH, El Sayed NS. Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways. Oxid Med Cell Longev. 2021; 2021:8845064. PMID: 33574982; PMCID: PMC7857904.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. El Sayed NS, Ghoneum MH. Antia, a Natural Antioxidant Product, Attenuates Cognitive Dysfunction in Streptozotocin-Induced Mouse Model of Sporadic Alzheimer's Disease by Targeting the Amyloidogenic, Inflammatory, Autophagy, and Oxidative Stress Pathways. Oxid Med Cell Longev. 2020; 2020:4386562. PMID: 32655767; PMCID: PMC7320293.
      Citations: 14     Fields:    Translation:AnimalsCells
    13. Badr El-Din NK, Shabana SM, Abdulmajeed BA, Ghoneum M. A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation. BMC Complement Med Ther. 2020 Apr 28; 20(1):127. PMID: 32345289; PMCID: PMC7189677.
      Citations: 7     Fields:    Translation:AnimalsCells
    14. Badr El-Din NK, Ali DA, Othman R, French SW, Ghoneum M. Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats. Biomed Pharmacother. 2020 Jun; 126:110064. PMID: 32278271.
      Citations: 6     Fields:    Translation:Animals
    15. Ghoneum M, Abdulmalek S, Pan D. Reversal of age-associated oxidative stress in mice by PFT, a novel kefir product. Int J Immunopathol Pharmacol. 2020 Jan-Dec; 34:2058738420950149. PMID: 32862733; PMCID: PMC7466882.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Badr El-Din NK, Areida SK, Ahmed KO, Ghoneum M. Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma†. J Radiat Res. 2019 Nov 22; 60(6):747-758. PMID: 31504707; PMCID: PMC6873627.
      Citations: 2     Fields:    Translation:Animals
    17. Elsaid AF, Fahmi RM, Shaheen M, Ghoneum M. The enhancing effects of Biobran/MGN-3, an arabinoxylan rice bran, on healthy old adults' health-related quality of life: a randomized, double-blind, placebo-controlled clinical trial. Qual Life Res. 2020 Feb; 29(2):357-367. PMID: 31489525.
      Citations: 3     Fields:    Translation:HumansAnimals
    18. Ghoneum M, Badr El-Din NK, Mahmoud AZ, Tolentino L, Pan D, Hassan TA. Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor. Oncol Rep. 2019 Jun; 41(6):3155-3166. PMID: 31002367; PMCID: PMC6489018.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Ghoneum MH, Gimzewski JK, Ghoneum AD, Agrawal S. Potential role of MRN-100, an iron-based compound, in upregulating production of cytokine IL-10 in human dendritic cells to promote an anti-inflammatory response in vitro. Int J Immunopathol Pharmacol. 2019 Jan-Dec; 33:2058738419844932. PMID: 30994016; PMCID: PMC6472165.
      Citations: 1     Fields:    Translation:HumansCells
    20. Ghoneum MH, Gimzewski JK, Ghoneum A, Katano H, Paw U CN, Agrawal A. Inhibition of TRPV1 Channel Activity in Human CD4? T Cells by Nanodiamond and Nanoplatinum Liquid, DPV576. Nanomaterials (Basel). 2018 Sep 29; 8(10). PMID: 30274279; PMCID: PMC6215208.
      Citations: 6     
    21. Elwakkad A, Ghoneum M, El-Sawi M, Mohamed SI, Gamal El Din AA, Pan D, Elqattan GM. Baker's Yeast Induces Apoptotic Effects and Histopathological Changes on Skin Tumors in Mice. Cogent Med. 2018; 5(1). PMID: 31098389; PMCID: PMC6516756.
      Citations: 1     
    22. Elsaid AF, Shaheen M, Ghoneum M. Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial. Exp Ther Med. 2018 Mar; 15(3):2313-2320. PMID: 29456638; PMCID: PMC5795547.
      Citations: 9     
    23. Ghoneum MH, Ogura T, Gimzewski JK, Ghoneum AD, Henary MC, Agrawal S. Marina crystal minerals (MCM) activate human dendritic cells to induce CD4+ and CD8+ T cell responses in vitro. Int J Immunopathol Pharmacol. 2018 Jan-Dec; 32:2058738418797768. PMID: 30270704; PMCID: PMC6168724.
      Citations: 1     Fields:    Translation:HumansCells
    24. Badr El-Din NK, Mahmoud AZ, Hassan TA, Ghoneum M. Baker's Yeast Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro. Integr Cancer Ther. 2018 06; 17(2):542-550. PMID: 29161917; PMCID: PMC6041900.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    25. Ghoneum MH, Katano H, Agrawal S, Ganguly S, Agrawal A. Effect of Nanodiamond and Nanoplatinum Liquid, DPV576, on Human Primary Keratinocytes. J Biomed Nanotechnol. 2017 Jan; 13(1):110-16. PMID: 29373005.
      Citations: 2     Fields:    Translation:HumansCells
    26. Salama H, Medhat E, Shaheen M, Zekri AN, Darwish T, Ghoneum M. Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial. Int J Immunopathol Pharmacol. 2016 Dec; 29(4):647-653. PMID: 27799299; PMCID: PMC5806823.
      Citations: 5     Fields:    Translation:HumansAnimalsCTClinical Trials
    27. Badr El-Din NK, Ali DA, Alaa El-Dein M, Ghoneum M. Enhancing the Apoptotic Effect of a Low Dose of Paclitaxel on Tumor Cells in Mice by Arabinoxylan Rice Bran (MGN-3/Biobran). Nutr Cancer. 2016 Aug-Sep; 68(6):1010-20. PMID: 27367621.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L, Ghoneum M. Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integr Cancer Ther. 2016 12; 15(4):NP26-NP34. PMID: 27151588; PMCID: PMC5739167.
      Citations: 11     Fields:    Translation:AnimalsCells
    29. Ghoneum M, Felo N, Agrawal S, Agrawal A. A novel kefir product (PFT) activates dendritic cells to induce CD4+T and CD8+T cell responses in vitro. Int J Immunopathol Pharmacol. 2015 Dec; 28(4):488-96. PMID: 26384392.
      Citations: 10     Fields:    Translation:HumansCells
    30. Ghoneum M, Felo N. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep. 2015 Oct; 34(4):1659-66. PMID: 26251956; PMCID: PMC4564078.
      Citations: 14     Fields:    Translation:HumansCells
    31. Ghoneum MH, Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L. Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci. 2015; 11(3):295-303. PMID: 25678848; PMCID: PMC4323369.
      Citations: 5     Fields:    Translation:AnimalsCells
    32. Ghoneum M, Agrawal S. Mgn-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells. Int J Immunopathol Pharmacol. 2014 Oct-Dec; 27(4):523-30. PMID: 25572732.
      Citations: 11     Fields:    Translation:HumansCells
    33. Ghoneum M, Gimzewski J. Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. Int J Oncol. 2014 Mar; 44(3):830-7. PMID: 24430613; PMCID: PMC3928472.
      Citations: 19     Fields:    Translation:HumansCells
    34. Ghoneum M, Badr El-Din NK, Ali DA, El-Dein MA. Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro. Anticancer Res. 2014 Jan; 34(1):81-7. PMID: 24403447.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    35. Ghoneum M, Elbaghdady HA, El-Shebly AA, Pan D, Assanah E, Lawson G. Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in ?-radiated Nile tilapia, Oreochromis niloticus. J Radiat Res. 2013 Sep; 54(5):852-62. PMID: 23589025; PMCID: PMC3766301.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    36. Ghoneum M, Badr El-Din NK, Abdel Fattah SM, Tolentino L. Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body ?-irradiation in mice via restoration of hematopoietic tissues. J Radiat Res. 2013 May; 54(3):419-29. PMID: 23287771; PMCID: PMC3650744.
      Citations: 14     Fields:    Translation:AnimalsPHPublic Health
    37. Ghoneum M, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran). Int J Immunopathol Pharmacol. 2011 Oct-Dec; 24(4):941-8. PMID: 22230400.
      Citations: 18     Fields:    Translation:HumansCells
    38. Ghoneum M, Gollapudi S. Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro. Neoplasma. 2011; 58(2):118-23. PMID: 21275460.
      Citations: 11     Fields:    Translation:HumansCells
    39. Bang MH, Van Riep T, Thinh NT, Song le H, Dung TT, Van Truong L, Van Don L, Ky TD, Pan D, Shaheen M, Ghoneum M. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 2010 Dec; 30(12):5145-51. PMID: 21187503.
      Citations: 16     Fields:    Translation:Humans
    40. Ghoneum M, Ghoneum A, Gimzewski J. Nanodiamond and nanoplatinum liquid, DPV576, activates human monocyte-derived dendritic cells in vitro. Anticancer Res. 2010 Oct; 30(10):4075-9. PMID: 21036722.
      Citations: 11     Fields:    Translation:HumansCells
    41. Badr El-Din NK, Noaman E, Fattah SM, Ghoneum M. Reversal of age-associated oxidative stress in rats by MRN-100, a hydro-ferrate fluid. In Vivo. 2010 Jul-Aug; 24(4):525-33. PMID: 20668320.
      Citations: 6     Fields:    Translation:AnimalsCells
    42. Ghoneum M, Ghoneum A, Tolentino L, Gimzewski J. Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material. In Vivo. 2010 Mar-Apr; 24(2):141-6. PMID: 20363985.
      Citations: 5     Fields:    Translation:AnimalsCells
    43. Ghoneum M, Seto Y, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extract. Anticancer Res. 2009 Nov; 29(11):4367-71. PMID: 20032380.
      Citations: 1     Fields:    Translation:HumansCells
    44. Ghoneum M, Tolentino L, Seto Y. Phenotypic correction of Age-associated functional decline in murine immune cells by Thymax, a thymic extract. In Vivo. 2009 Nov-Dec; 23(6):895-902. PMID: 20023230.
      Citations: 1     Fields:    Translation:AnimalsCells
    45. Ghoneum M, Gollapudi S. Susceptibility of the human LNCaP prostate cancer cells to the apoptotic effect of marina crystal minerals (MCM) in vitro. Oncol Rep. 2009 Jul; 22(1):155-9. PMID: 19513518.
      Citations: 2     Fields:    Translation:HumansCells
    46. Ghoneum M, Matsuura M, Gollapudi S. An iron-based beverage, HydroFerrate fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitro. Nutr J. 2009 May 02; 8:18. PMID: 19409106; PMCID: PMC2683876.
      Citations: 3     Fields:    Translation:AnimalsCells
    47. Ghoneum M, Matsuura M, Braga M, Gollapudi S. S. cerevisiae induces apoptosis in human metastatic breast cancer cells by altering intracellular Ca2+ and the ratio of Bax and Bcl-2. Int J Oncol. 2008 Sep; 33(3):533-9. PMID: 18695883.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    48. Noaman E, Badr El-Din NK, Bibars MA, Abou Mossallam AA, Ghoneum M. Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett. 2008 Sep 18; 268(2):348-59. PMID: 18554778.
      Citations: 24     Fields:    Translation:AnimalsCells
    49. Ghoneum M, Seto Y, Sato S, Ghoneum A, Braga M, Gollapudi S. Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway. Anticancer Res. 2008 May-Jun; 28(3A):1603-9. PMID: 18630518.
      Citations: 3     Fields:    Translation:HumansCells
    50. Gollapudi S, Ghoneum M. MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer Detect Prev. 2008; 32(1):1-6. PMID: 18406070.
      Citations: 12     Fields:    Translation:HumansCells
    51. Ghoneum M, Shaheen M. MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro. Evid Based Complement Alternat Med. 2010 Dec; 7(4):427-32. PMID: 18955328; PMCID: PMC2892344.
      Citations: 3     
    52. Ghoneum M, Matsuura M, Gollapudi S. Modified arabinoxylan rice bran (MGN3/Biobran) enhances intracellular killing of microbes by human phagocytic cells in vitro. Int J Immunopathol Pharmacol. 2008 Jan-Mar; 21(1):87-95. PMID: 18336734.
      Citations: 11     Fields:    Translation:HumansCells
    53. Badr El-Din NK, Noaman E, Ghoneum M. In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice. Nutr Cancer. 2008; 60(2):235-44. PMID: 18444156.
      Citations: 18     Fields:    Translation:AnimalsCells
    54. Ghoneum M, Badr El-Din NK, Noaman E, Tolentino L. Saccharomyces cerevisiae, the Baker's Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice. Cancer Immunol Immunother. 2008 Apr; 57(4):581-92. PMID: 17891396.
      Citations: 9     Fields:    Translation:Animals
    55. Ghoneum M, Wang L, Agrawal S, Gollapudi S. Yeast therapy for the treatment of breast cancer: a nude mice model study. In Vivo. 2007 Mar-Apr; 21(2):251-8. PMID: 17436573.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    56. Ghoneum M, Gollapudi S. Apoptosis of breast cancer MCF-7 cells in vitro is induced specifically by yeast and not by fungal mycelia. Anticancer Res. 2006 May-Jun; 26(3A):2013-22. PMID: 16827138.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    57. Ghoneum M, Gollapudi S. Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells. Anticancer Res. 2005 Nov-Dec; 25(6B):4187-96. PMID: 16309215.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    58. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):859-70. PMID: 15868920.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    59. Ghoneum M, Hamilton J, Brown J, Gollapudi S. Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):981-9. PMID: 15868937.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    60. Ghoneum M, Abedi S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J Pharm Pharmacol. 2004 Dec; 56(12):1581-8. PMID: 15563765.
      Citations: 23     Fields:    Translation:AnimalsCells
    61. Ghoneum M, Matsuura M. Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran). Int J Immunopathol Pharmacol. 2004 Sep-Dec; 17(3):283-92. PMID: 15461862.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    62. Ghoneum M, Saglie R, Brown J, Regala C. Actinobacillus actinomycetemcomitans suppresses rat natural killer cell activity in vivo. Acta Otolaryngol. 2004 Jun; 124(5):621-7. PMID: 15267183.
      Citations:    Fields:    Translation:AnimalsCells
    63. Ghoneum M, Gollapudi S. Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2004 May-Jun; 24(3a):1455-63. PMID: 15274310.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    64. Ghoneum M, Gollapudi S. Phagocytosis of Candida albicans by metastatic and non metastatic human breast cancer cell lines in vitro. Cancer Detect Prev. 2004; 28(1):17-26. PMID: 15041073.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    65. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett. 2003 Nov 10; 201(1):41-9. PMID: 14580685.
      Citations: 10     Fields:    Translation:HumansCells
    66. Ghoneum M, Grewal I, Brown J, Osborne R, Elembabi H, Gill G. Phagocytosis of candida albicans by lymphatic tumour cells in vitro. Acta Histochem. 2003; 105(2):127-33. PMID: 12831164.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    67. Ghoneum M, Jewett A. Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro. Cancer Detect Prev. 2000; 24(4):314-24. PMID: 11059563.
      Citations: 16     Fields:    Translation:HumansCells
    68. Ghoneum M. Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran. Biochem Biophys Res Commun. 1998 Feb 04; 243(1):25-9. PMID: 9473473.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    69. Vojdani A, Ghoneum M, Choppa PC, Magtoto L, Lapp CW. Elevated apoptotic cell population in patients with chronic fatigue syndrome: the pivotal role of protein kinase RNA. J Intern Med. 1997 Dec; 242(6):465-78. PMID: 9437407.
      Citations: 11     Fields:    Translation:HumansCells
    70. Ghoneum M, Vojdani A, Banionis A, Oppenheimer S, Lagos N, Gill G. The effects of carcinogenic methylcholanthrene on carbohydrate residues of NK cells. Toxicol Ind Health. 1997 Nov-Dec; 13(6):727-41. PMID: 9399418.
      Citations:    Fields:    Translation:AnimalsCells
    71. Ghoneum M, Suzuki K, Gollapudi S. Phorbol myristate acetate corrects impaired NK function of old mice. Scand J Immunol. 1991 Oct; 34(4):391-7. PMID: 1925408.
      Citations: 3     Fields:    Translation:AnimalsCells
    72. Ghoneum M, Hussein AE, Gill G, Alfred LJ. Suppression of murine natural killer cell activity by tributyltin: in vivo and in vitro assessment. Environ Res. 1990 Aug; 52(2):178-86. PMID: 2394205.
      Citations: 8     Fields:    Translation:AnimalsCells
    73. Ghoneum M, Grewal IS. Change in tumour cell-lymphocyte interactions with age. Hematol Oncol. 1990 Mar-Apr; 8(2):71-80. PMID: 2344998.
      Citations:    Fields:    Translation:AnimalsCells
    74. Ghoneum M, Cooper EL, Sadek I. Variability of natural killer cell activity in anuran amphibians. Dev Comp Immunol. 1990; 14(3):359-65. PMID: 2210011.
      Citations: 2     Fields:    Translation:AnimalsCells
    75. Ghoneum M, Egami N, Ijiri K. Effect of oestrogen treatment on the survival of irradiated fish of the species Oryzias latipes. Folia Morphol (Praha). 1988; 36(1):25-31. PMID: 3391453.
      Citations: 1     Fields:    Translation:AnimalsPHPublic Health
    76. Ghoneum M, Salem F, Allen H, Gill G. Phagocytosis of autologous lymphocytes by cervical preneoplastic and neoplastic cells. Nat Immun Cell Growth Regul. 1988; 7(4):239-48. PMID: 3237234.
      Citations: 2     Fields:    Translation:HumansCells
    77. Ghoneum M, Faisal M, Peters G, Ahmed II, Cooper EL. Suppression of natural cytotoxic cell activity by social aggressiveness in Tilapia. Dev Comp Immunol. 1988; 12(3):595-602. PMID: 3169355.
      Citations: 1     Fields:    Translation:AnimalsCells
    78. Ghoneum M, Grimes PE, Gill G, Kelly AP. Natural cell-mediated cytotoxicity in vitiligo. J Am Acad Dermatol. 1987 Oct; 17(4):600-5. PMID: 3668006.
      Citations: 2     Fields:    Translation:HumansCells
    79. Ghoneum M, Wojdani A, Alfred L. Effect of methylcholanthrene on human natural killer cell cytotoxicity and lymphokine production in vitro. Immunopharmacology. 1987 Sep; 14(1):27-33. PMID: 2960636.
      Citations: 1     Fields:    Translation:HumansCells
    80. Ghoneum M, Gill G, Assanah P, Stevens W. Susceptibility of natural killer cell activity of old rats to stress. Immunology. 1987 Mar; 60(3):461-5. PMID: 3570358; PMCID: PMC1453256.
      Citations: 3     Fields:    Translation:AnimalsCells
    81. Ghoneum M, Gill G, Wojdani A, Payne C, Alfred LJ. Suppression of basal and Corynebacterium parvum-augmented NK activity during chemically induced tumor development. Int J Immunopharmacol. 1987; 9(1):71-8. PMID: 3583504.
      Citations: 1     Fields:    Translation:AnimalsCells
    82. Ghoneum M, Salem F, Shum SS, Perry L, Gill G. In situ lymphophagocytosis by nonlymphoreticular neoplasms. Nat Immun Cell Growth Regul. 1987; 6(2):77-87. PMID: 3600677.
      Citations: 2     Fields:    Translation:HumansCells
    83. Ghoneum M, Cooper EL, Smith C. Inhibition of SK cell activity in frogs by certain drugs and sugars. Dev Comp Immunol. 1987; 11(2):363-73. PMID: 3497828.
      Citations:    Fields:    Translation:HumansAnimalsCells
    84. Ghoneum M, Smith CT, Cooper EL. Membrane markers and mitogenic responses of cytotoxic cells in anuran amphibians. Cell Mol Biol. 1987; 33(6):807-17. PMID: 3501971.
      Citations:    Fields:    Translation:AnimalsCells
    85. Ghoneum MH, Cooper EL. Inhibition of frog SK effector-target cell binding. Dev Comp Immunol. 1987; 11(1):167-78. PMID: 3109969.
      Citations:    Fields:    Translation:AnimalsCells
    86. Wojdani A, Ghoneum M. In vivo augmentation of natural killer cell activity by Candida albicans. Int J Immunopharmacol. 1987; 9(7):827-32. PMID: 3323078.
      Citations:    Fields:    Translation:AnimalsCells
    87. Ghoneum M, Gill G, Perry L. Natural killer cell activity in patients with carcinoma of the larynx and hypopharynx. Laryngoscope. 1986 Nov; 96(11):1300. PMID: 3773632.
      Citations:    Fields:    Translation:HumansCells
    88. Grimes PE, Ghoneum M, Stockton T, Payne C, Kelly AP, Alfred L. T cell profiles in vitiligo. J Am Acad Dermatol. 1986 Feb; 14(2 Pt 1):196-201. PMID: 2936773.
      Citations: 7     Fields:    Translation:HumansCells
    89. Ghoneum MH, Egami N, Ijiri K, Cooper EL. Effect of corticosteroids on the thymus of the fish Oryzias latipes. Dev Comp Immunol. 1986; 10(1):35-44. PMID: 3699223.
      Citations: 3     Fields:    Translation:Animals
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