"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
| Descriptor ID |
D017209
|
| MeSH Number(s) |
G04.146.160
|
| Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 2 | 0 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 3 | 5 | 8 |
| 2002 | 3 | 2 | 5 |
| 2003 | 7 | 1 | 8 |
| 2004 | 3 | 3 | 6 |
| 2005 | 7 | 2 | 9 |
| 2006 | 5 | 5 | 10 |
| 2007 | 2 | 3 | 5 |
| 2008 | 6 | 4 | 10 |
| 2009 | 5 | 4 | 9 |
| 2010 | 1 | 6 | 7 |
| 2011 | 2 | 3 | 5 |
| 2012 | 1 | 2 | 3 |
| 2013 | 1 | 9 | 10 |
| 2014 | 7 | 3 | 10 |
| 2015 | 1 | 1 | 2 |
| 2016 | 6 | 2 | 8 |
| 2017 | 1 | 4 | 5 |
| 2018 | 2 | 2 | 4 |
| 2019 | 0 | 6 | 6 |
| 2020 | 3 | 5 | 8 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 5 | 5 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 3 | 4 |
| 2025 | 0 | 3 | 3 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Arctigenin Suppresses Breast Cancer Growth In Vitro and In Vivo Through Subtype-Specific Multi-Targeting Activity. Int J Mol Sci. 2026 Jun 03; 27(11).
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NAD Metabolism Regulates Proliferation of Macrophages in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2025 11; 45(11):1997-2014.
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Trimethylamine-N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2025 10; 45(10):1784-1798.
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Protective Effect of Biobran/MGN-3, an Arabinoxylan from Rice Bran, Against the Cytotoxic Effects of Polyethylene Nanoplastics in Normal Mouse Hepatocytes: An In Vitro and In Silico Study. Nutrients. 2025 Jun 13; 17(12).
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Wip1 phosphatase activator QGC-8-52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells. Drug Resist Updat. 2025 Mar; 79:101196.
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Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models. Nutrients. 2024 Jul 22; 16(14).
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Targeting the long non-coding RNA MIAT for the treatment of fibroids in an animal model. Clin Sci (Lond). 2024 Jun 19; 138(12):699-709.
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Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer. Int J Biol Sci. 2024; 20(1):15-28.
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A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models. BMC Cancer. 2023 Jun 02; 23(1):499.
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Circular RNA circGlis3 protects against islet ?-cell dysfunction and apoptosis in obesity. Nat Commun. 2023 01 21; 14(1):351.