"Necrosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
| Descriptor ID |
D009336
|
| MeSH Number(s) |
C23.550.717 G04.146.638
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Necrosis".
Below are MeSH descriptors whose meaning is more specific than "Necrosis".
This graph shows the total number of publications written about "Necrosis" by people in this website by year, and whether "Necrosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 3 | 3 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Necrosis" by people in Profiles.
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Prospective derivation and validation of a necrotizing soft tissue infections score: An EASTmulticenter trial. J Trauma Acute Care Surg. 2024 12 01; 97(6):910-917.
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Anti-Tumor Necrosis Factor Therapy and Risk of Kidney Function Decline and Mortality in Inflammatory Bowel Disease. JAMA Netw Open. 2024 04 01; 7(4):e246822.
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Calcium, mitochondria and the initiation of acute pancreatitis. Pancreatology. 2022 Nov; 22(7):838-845.
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Protein kinase D: A therapeutic target in experimental alcoholic pancreatitis. Biochim Biophys Acta Mol Basis Dis. 2022 11 01; 1868(11):166486.
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Short Courses of Antibiotics Are Safe in Necrotizing Soft Tissue Infections. Am Surg. 2021 Dec; 87(10):1666-1671.
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Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis. Biochim Biophys Acta Mol Basis Dis. 2021 01 01; 1867(1):165987.
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The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. Gastroenterology. 2017 12; 153(6):1674-1686.
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Necrotic ulcer on the thigh. Cutis. 2017 Aug; 100(2):80;91.
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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut. 2016 08; 65(8):1333-46.
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Genetic inhibition of protein kinase Ce attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 01; 307(5):G550-63.