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Shehla Pervin, PhD

TitleAssociate Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-9342
FaxNot Available
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    Research
    research activities and funding
    SC1CA232319     (PERVIN, SHEHLA)Jul 6, 2018 - Jun 30, 2022
    NIH
    Beige Adipocytes and African American Breast Tumors
    Role: Principal Investigator
    SC1CA165865     (PERVIN, SHEHLA)Jul 11, 2011 - Dec 31, 2017
    NIH
    Targeting pERK1/2 in Human Mammary Cancer Stem Cells
    Role: Principal Investigator
    R25DK078384     (PERVIN, SHEHLA)Jun 1, 2007 - Feb 28, 2017
    NIH
    Drew National High School Student Summer Research Apprentice Program
    Role: Principal Investigator
    R03HD053888     (PERVIN, SHEHLA)Jun 1, 2007 - May 31, 2009
    NIH
    p38 MAP Kinase and Akt Interaction in HUVEC
    Role: Principal Investigator

    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Singh R, Barrios A, Dirakvand G, Pervin S. Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues. Cells. 2021 11 05; 10(11). PMID: 34831253; PMCID: PMC8616549.
      Citations: 9     Fields:    Translation:HumansAnimals
    2. Pervin S, Reddy ST, Singh R. Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-ß Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders. Front Endocrinol (Lausanne). 2021; 12:653179. PMID: 33897620; PMCID: PMC8062757.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    3. Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419. PMID: 33414685; PMCID: PMC7752272.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Jimenez T, Barrios A, Tucker A, Collazo J, Arias N, Fazel S, Baker M, Halim M, Huynh T, Singh R, Pervin S. DUSP9-mediated reduction of pERK1/2 supports cancer stem cell-like traits and promotes triple negative breast cancer. Am J Cancer Res. 2020; 10(10):3487-3506. PMID: 33163285; PMCID: PMC7642669.
      Citations: 7     
    5. Singh R, Pervin S, Lee SJ, Kuo A, Grijalva V, David J, Vergnes L, Reddy ST. Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases. Diabetes Metab Syndr Obes. 2018; 11:65-84. PMID: 29618935; PMCID: PMC5875402.
      Citations: 5     
    6. Pervin S, Singh V, Tucker A, Collazo J, Singh R. Modulation of transforming growth factor-ß/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders. Horm Mol Biol Clin Investig. 2017 Sep 09; 31(2). PMID: 28888087; PMCID: PMC5790157.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    7. Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S. Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017 05 01; 158(5):1217-1230. PMID: 28324027; PMCID: PMC5460830.
      Citations: 24     Fields:    Translation:AnimalsCells
    8. Howard CB, McDowell R, Feleke K, Deer E, Stamps S, Thames E, Singh V, Pervin S. Chemotherapeutic Vulnerability of Triple-negative Breast Cancer Cell-derived Tumors to Pretreatment with Vernonia amygdalina Aqueous Extracts. Anticancer Res. 2016 Aug; 36(8):3933-43. PMID: 27466496; PMCID: PMC5226471.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Martinez L, Thames E, Kim J, Chaudhuri G, Singh R, Pervin S. Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis. BMC Cancer. 2016 07 29; 16:559. PMID: 27473585; PMCID: PMC4966744.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    10. Howard CB, Johnson WK, Pervin S, Izevbigie EB. Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina. Botanics. 2015; 5:65-76. PMID: 27226742; PMCID: PMC4876981.
      Citations: 4     
    11. Singh R, Parveen M, Basgen JM, Fazel S, Meshesha MF, Thames EC, Moore B, Martinez L, Howard CB, Vergnes L, Reue K, Pervin S. Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res. 2016 Jan; 14(1):78-92. PMID: 26464213; PMCID: PMC4749269.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    12. Singh R, Braga M, Pervin S. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling. Front Cell Dev Biol. 2014; 2:60. PMID: 25364764; PMCID: PMC4207030.
      Citations: 32     
    13. Braga M, Reddy ST, Vergnes L, Pervin S, Grijalva V, Stout D, David J, Li X, Tomasian V, Reid CB, Norris KC, Devaskar SU, Reue K, Singh R. Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res. 2014 Mar; 55(3):375-84. PMID: 24443561; PMCID: PMC3934723.
      Citations: 49     Fields:    Translation:AnimalsCells
    14. Singh R, Avliyakulov NK, Braga M, Haykinson MJ, Martinez L, Singh V, Parveen M, Chaudhuri G, Pervin S. Proteomic identification of mitochondrial targets of arginase in human breast cancer. PLoS One. 2013; 8(11):e79242. PMID: 24223914; PMCID: PMC3818427.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    15. Braga M, Pervin S, Norris K, Bhasin S, Singh R. Inhibition of in vitro and in vivo brown fat differentiation program by myostatin. Obesity (Silver Spring). 2013 Jun; 21(6):1180-8. PMID: 23868854; PMCID: PMC3735638.
      Citations: 27     Fields:    Translation:AnimalsCells
    16. Pervin S, Tran L, Urman R, Braga M, Parveen M, Li SA, Chaudhuri G, Singh R. Oxidative stress specifically downregulates survivin to promote breast tumour formation. Br J Cancer. 2013 Mar 05; 108(4):848-58. PMID: 23403820; PMCID: PMC3590675.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    17. Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, Chaudhuri G, Norris K, Singh R. Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy. PLoS One. 2013; 8(1):e53287. PMID: 23341935; PMCID: PMC3544824.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    18. Braga M, Bhasin S, Jasuja R, Pervin S, Singh R. Testosterone inhibits transforming growth factor-ß signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Mol Cell Endocrinol. 2012 Mar 05; 350(1):39-52. PMID: 22138414; PMCID: PMC3264813.
      Citations: 34     Fields:    Translation:AnimalsCells
    19. Pervin S, Tran A, Tran L, Urman R, Braga M, Chaudhuri G, Singh R. Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells. Br J Cancer. 2011 Jul 26; 105(3):428-37. PMID: 21730980; PMCID: PMC3172901.
      Citations: 7     Fields:    Translation:HumansCells
    20. Pervin S, Chaudhuri G, Singh R. NO to breast: when, why and why not? Curr Pharm Des. 2010; 16(4):451-62. PMID: 20236074; PMCID: PMC4417623.
      Citations: 6     Fields:    Translation:HumansAnimals
    21. Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15; 22(22):3121-34. PMID: 19056892; PMCID: PMC2593606.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    22. Singh R, Bhasin S, Braga M, Artaza JN, Pervin S, Taylor WE, Krishnan V, Sinha SK, Rajavashisth TB, Jasuja R. Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology. 2009 Mar; 150(3):1259-68. PMID: 18948405; PMCID: PMC2654730.
      Citations: 56     Fields:    Translation:AnimalsCells
    23. Pervin S, Tran AH, Zekavati S, Fukuto JM, Singh R, Chaudhuri G. Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis. Cancer Res. 2008 Jun 15; 68(12):4862-74. PMID: 18559534; PMCID: PMC4416651.
      Citations: 12     Fields:    Translation:HumansCells
    24. Pervin S, Singh R, Chaudhuri G. Nitric oxide, N omega-hydroxy-L-arginine and breast cancer. Nitric Oxide. 2008 Sep; 19(2):103-6. PMID: 18474257.
      Citations: 13     Fields:    Translation:Humans
    25. Pervin S, Singh R, Hernandez E, Wu G, Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 2007 Jan 01; 67(1):289-99. PMID: 17210710.
      Citations: 51     Fields:    Translation:HumansCells
    26. Pervin S, Singh R, Freije WA, Chaudhuri G. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer Res. 2003 Dec 15; 63(24):8853-60. PMID: 14695202.
      Citations: 30     Fields:    Translation:HumansCells
    27. Pervin S, Singh R, Chaudhuri G. Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt. Cancer Res. 2003 Sep 01; 63(17):5470-9. PMID: 14500383.
      Citations: 19     Fields:    Translation:HumansCells
    28. Singh R, Pervin S, Chaudhuri G. Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-L-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine. J Biol Chem. 2002 Oct 04; 277(40):37630-6. PMID: 12145284.
      Citations: 13     Fields:    Translation:HumansCells
    29. Singh R, Pervin S, Wu G, Chaudhuri G. Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines. Carcinogenesis. 2001 Nov; 22(11):1863-9. PMID: 11698350.
      Citations: 8     Fields:    Translation:HumansCells
    30. Pervin S, Singh R, Gau CL, Edamatsu H, Tamanoi F, Chaudhuri G. Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer. Cancer Res. 2001 Jun 15; 61(12):4701-6. PMID: 11406540.
      Citations: 13     Fields:    Translation:HumansCells
    31. Pervin S, Singh R, Chaudhuri G. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3583-8. PMID: 11248121; PMCID: PMC30696.
      Citations: 46     Fields:    Translation:HumansCells
    32. Singh R, Pervin S, Karimi A, Cederbaum S, Chaudhuri G. Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. Cancer Res. 2000 Jun 15; 60(12):3305-12. PMID: 10866325.
      Citations: 65     Fields:    Translation:HumansCells
    33. Singh R, Pervin S, Shryne J, Gorski R, Chaudhuri G. Castration increases and androgens decrease nitric oxide synthase activity in the brain: physiologic implications. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3672-7. PMID: 10725371; PMCID: PMC16298.
      Citations: 12     Fields:    Translation:Animals
    34. Nathan L, Pervin S, Singh R, Rosenfeld M, Chaudhuri G. Estradiol inhibits leukocyte adhesion and transendothelial migration in rabbits in vivo : possible mechanisms for gender differences in atherosclerosis. Circ Res. 1999 Aug 20; 85(4):377-85. PMID: 10455066.
      Citations: 31     Fields:    Translation:AnimalsCells
    35. Pervin S, Singh R, Rosenfeld ME, Navab M, Chaudhuri G, Nathan L. Estradiol suppresses MCP-1 expression In vivo : implications for atherosclerosis. Arterioscler Thromb Vasc Biol. 1998 Oct; 18(10):1575-82. PMID: 9763529.
      Citations: 16     Fields:    Translation:Animals
    36. Zhang RS, Guth PH, Scremin OU, Singh R, Pervin S, Chaudhuri G. Regulation of endometrial blood flow in ovariectomized rats: assessment of the role of nitric oxide. Am J Physiol. 1997 10; 273(4):H2009-17. PMID: 9362273.
      Citations: 2     Fields:    Translation:Animals
    37. Singh R, Pervin S, Rogers NE, Ignarro LJ, Chaudhuri G. Evidence for the presence of an unusual nitric oxide- and citrulline-producing enzyme in rat kidney. Biochem Biophys Res Commun. 1997 Mar 27; 232(3):672-7. PMID: 9126334.
      Citations: 7     Fields:    Translation:Animals
    38. Pervin S, Chakraborty M, Bhattacharya-Chatterjee M, Zeytin H, Foon KA, Chatterjee SK. Induction of antitumor immunity by an anti-idiotype antibody mimicking carcinoembryonic antigen. Cancer Res. 1997 Feb 15; 57(4):728-34. PMID: 9044852.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    39. Buga GM, Singh R, Pervin S, Rogers NE, Schmitz DA, Jenkinson CP, Cederbaum SD, Ignarro LJ. Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. Am J Physiol. 1996 Nov; 271(5 Pt 2):H1988-98. PMID: 8945918.
      Citations: 58     Fields:    Translation:AnimalsCells
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