Ekihiro Seki to Mice
This is a "connection" page, showing publications Ekihiro Seki has written about Mice.
Connection Strength
4.233
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Loss of fungal sensing exacerbates liver injury in a murine model of MASLD. JCI Insight. 2026 Apr 22; 11(8).
Score: 0.202
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Metastatic tumor growth in steatotic liver is promoted by HAS2-mediated fibrotic tumor microenvironment. J Clin Invest. 2025 Feb 13; 135(7).
Score: 0.187
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Repurposing of the analgesic Neurotropin for MASLD/MASH treatment. Hepatol Commun. 2024 08 01; 8(8).
Score: 0.180
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Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2022 10 04; 11.
Score: 0.159
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Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. Exp Mol Med. 2022 06; 54(6):739-752.
Score: 0.155
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Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient L-amino acid-defined diet-induced murine model. Arch Pharm Res. 2021 Feb; 44(2):230-240.
Score: 0.141
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Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).
Score: 0.141
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Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. J Biol Chem. 2019 08 16; 294(33):12359-12369.
Score: 0.127
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NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019 11; 70(5):1582-1599.
Score: 0.126
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The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer. 2018 01 01; 142(1):81-91.
Score: 0.112
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Finding a new role for NEMO: A key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1. Hepatology. 2016 07; 64(1):295-7.
Score: 0.102
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Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-?B and JNK in hepatocytes. PLoS One. 2014; 9(12):e114071.
Score: 0.092
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TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78.
Score: 0.090
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Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology. 2014 Feb; 59(2):483-95.
Score: 0.086
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Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol. 2013 Aug; 28 Suppl 1:38-42.
Score: 0.084
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Transforming growth factor-? signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 2013 May; 144(5):1042-1054.e4.
Score: 0.081
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Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89.
Score: 0.081
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A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20.
Score: 0.078
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Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 01; 302(11):G1310-21.
Score: 0.077
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Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18.
Score: 0.072
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CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400.
Score: 0.069
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Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7.
Score: 0.067
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Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9.
Score: 0.066
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CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97.
Score: 0.063
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CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70.
Score: 0.063
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Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings. J Hepatol. 2008 Feb; 48(2):237-45.
Score: 0.057
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TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32.
Score: 0.056
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Single-cell and spatial omics in liver identify cell-cell communication regulators in aging and insulin resistance. Metabolism. 2026 Aug; 181:156630.
Score: 0.051
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Selective inhibition of long isoforms of phosphodiesterase 4D mitigates liver fibrosis in mouse models. J Clin Invest. 2026 01 02; 136(1).
Score: 0.049
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A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy. Cancer Res. 2025 Jul 15; 85(14):2714-2725.
Score: 0.048
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Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology. 2005 Mar; 41(3):443-50.
Score: 0.047
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A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis. Exp Mol Med. 2025 Feb; 57(2):450-465.
Score: 0.047
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Suppression of intestinal Ticam1 ameliorated MASH via Akkermansia muciniphila QAA37749.1 mediated betaine transformation. Biochim Biophys Acta Mol Basis Dis. 2025 Jan; 1871(1):167571.
Score: 0.046
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The role of forkhead box M1-methionine adenosyltransferase 2?A/2B axis in liver inflammation and fibrosis. Nat Commun. 2024 Sep 27; 15(1):8388.
Score: 0.046
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Hepatic prohibitin 1 and methionine adenosyltransferase a1 defend against primary and secondary liver cancer metastasis. J Hepatol. 2024 Mar; 80(3):443-453.
Score: 0.043
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Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. J Hepatol. 2023 04; 78(4):805-819.
Score: 0.041
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Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol. 2002 Oct 01; 169(7):3863-8.
Score: 0.040
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Hepatocyte TGF-? Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let-7b-5p. Hepatol Commun. 2022 06; 6(6):1301-1321.
Score: 0.038
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Deregulated 14-3-3? and methionine adenosyltransferase a1 interplay promotes liver cancer tumorigenesis in mice and humans. Oncogene. 2021 09; 40(39):5866-5879.
Score: 0.037
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Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol. 2001 Feb 15; 166(4):2651-7.
Score: 0.036
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Reciprocal Regulation Between Forkhead Box M1/NF-?B and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 11; 72(5):1682-1700.
Score: 0.035
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Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling. Gut. 2019 12; 68(12):2214-2227.
Score: 0.032
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MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell Death Dis. 2019 02 11; 10(2):120.
Score: 0.031
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Ga12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. J Clin Invest. 2018 12 03; 128(12):5587-5602.
Score: 0.030
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Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888.
Score: 0.030
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203.
Score: 0.030
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Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018 08; 155(2):557-571.e14.
Score: 0.029
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LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis. Sci Rep. 2016 10 18; 6:35610.
Score: 0.026
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p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948.
Score: 0.026
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NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910.
Score: 0.025
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Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice. Hepatology. 2015 Apr; 61(4):1357-69.
Score: 0.023
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ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343.
Score: 0.023
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Nrf2 activation protects the liver from ischemia/reperfusion injury in mice. Ann Surg. 2014 Jul; 260(1):118-27.
Score: 0.022
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Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44.
Score: 0.022
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Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. Hepatology. 2014 Jul; 60(1):237-49.
Score: 0.022
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A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91.
Score: 0.022
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Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96.
Score: 0.021
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p38a inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24.
Score: 0.020
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L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 2011 Oct 07; 286(40):34800-8.
Score: 0.018
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The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41.
Score: 0.018
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Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-8619.
Score: 0.018
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Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44.
Score: 0.018
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Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30.
Score: 0.017
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Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology. 2010 Jan; 51(1):237-45.
Score: 0.016
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Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38.
Score: 0.016
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Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24.
Score: 0.016
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c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5.
Score: 0.016
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Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53.
Score: 0.015
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Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26.
Score: 0.015
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Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38.
Score: 0.015
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Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52.
Score: 0.014
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Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Sep; 293(3):G631-9.
Score: 0.014
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Role of innate immune response in liver regeneration. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S57-8.
Score: 0.014
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Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46.
Score: 0.013
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Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47.
Score: 0.013
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Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9.
Score: 0.013
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Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice. J Hepatol. 2006 Nov; 45(5):688-95.
Score: 0.013
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Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J Biol Chem. 2006 Apr 14; 281(15):10431-8.
Score: 0.012
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ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells. 2004 Nov; 9(11):1055-67.
Score: 0.011
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Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int Immunol. 2004 Jun; 16(6):787-98.
Score: 0.011
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Roles of caspase-1 in Listeria infection in mice. Int Immunol. 2004 Feb; 16(2):335-43.
Score: 0.011
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Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatology. 2003 Aug; 38(2):335-44.
Score: 0.011
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Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 2003 Aug; 94(8):679-85.
Score: 0.011
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SOCS-1 participates in negative regulation of LPS responses. Immunity. 2002 Nov; 17(5):677-87.
Score: 0.010
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Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol. 2001 Nov 15; 167(10):5928-34.
Score: 0.009