"Keratins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
| Descriptor ID |
D007633
|
| MeSH Number(s) |
D05.750.078.593.450 D12.776.220.475.450 D12.776.860.607
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Keratins".
Below are MeSH descriptors whose meaning is more specific than "Keratins".
This graph shows the total number of publications written about "Keratins" by people in this website by year, and whether "Keratins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 3 | 0 | 3 |
| 2004 | 2 | 1 | 3 |
| 2006 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Keratins" by people in Profiles.
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Expression of epithelial membrane antigen and cytokeratin among Indian workers exposed to cotton fibre dust in textile industries. East Mediterr Health J. 2022 Feb 27; 28(2):152-157.
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SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model. Exp Mol Pathol. 2010 Jun; 88(3):353-62.
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Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis. J Clin Pathol. 2007 May; 60(5):472-5.
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Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor. Exp Mol Pathol. 2006 Jun; 80(3):228-40.
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p62 is involved in the mechanism of Mallory body formation. Exp Mol Pathol. 2004 Dec; 77(3):168-75.
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Proteasome inhibition induces cytokeratin accumulation in vivo. Exp Mol Pathol. 2004 Apr; 76(2):83-9.
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The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation. Exp Mol Pathol. 2004 Feb; 76(1):9-16.
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Microtubules are required for cytokeratin aggresome (Mallory body) formation in hepatocytes: an in vitro study. Exp Mol Pathol. 2003 Apr; 74(2):173-9.
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Heat shock proteins are present in mallory bodies (cytokeratin aggresomes) in human liver biopsy specimens. Exp Mol Pathol. 2003 Apr; 74(2):168-72.
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The mechanism of cytokeratin aggresome formation: the role of mutant ubiquitin (UBB+1). Exp Mol Pathol. 2003 Apr; 74(2):160-7.