"Cytochrome P-450 CYP2E1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
| Descriptor ID |
D019392
|
| MeSH Number(s) |
D08.244.453.491.375 D08.811.682.662.582.338 D08.811.682.690.708.170.450.375 D12.776.422.220.453.491.375
|
| Concept/Terms |
Cytochrome P-450 CYP2E1- Cytochrome P-450 CYP2E1
- Cytochrome P 450 CYP2E1
- Cytochrome P-450-J
- Cytochrome P 450 J
- 4-Nitrophenol-2-Hydroxylase
- 4 Nitrophenol 2 Hydroxylase
- Dimethylnitrosamine N-Demethylase
- Dimethylnitrosamine N Demethylase
- Cytochrome P450 2E1
- N-Nitrosodimethylamine Demethylase
- N Nitrosodimethylamine Demethylase
- CYP 2E1
- Cytochrome P-450 IIE1
- Cytochrome P 450 IIE1
- CYP IIE1
- CYPIIE1
- Cytochrome P-450 (ALC)
- CYP2E1
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2E1".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2E1".
This graph shows the total number of publications written about "Cytochrome P-450 CYP2E1" by people in this website by year, and whether "Cytochrome P-450 CYP2E1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 2 | 3 |
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP2E1" by people in Profiles.
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Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro. Exp Mol Pathol. 2011 Jun; 90(3):295-9.
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Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. Exp Mol Pathol. 2011 Feb; 90(1):123-30.
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Chronic ethanol feeding affects proteasome-interacting proteins. Proteomics. 2009 Jul; 9(13):3609-22.
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CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Exp Mol Pathol. 2006 Dec; 81(3):191-201.
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CYP2E1 inhibition enhances mallory body formation. Exp Mol Pathol. 2005 Jun; 78(3):207-11.
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The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Exp Mol Pathol. 2005 Apr; 78(2):109-15.
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Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341. Free Radic Biol Med. 2002 Jan 01; 32(1):17-21.
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Oral low-carbohydrate alcohol liquid diet induces experimental steatohepatitis in the rat. Exp Mol Pathol. 2001 Oct; 71(2):132-6.
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The ubiquitin-proteasome 26s pathway in liver cell protein turnover: effect of ethanol and drugs. Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):225S-229S.
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Mallory bodies formed in proteasome-depleted hepatocytes: an immunohistochemical study. Exp Mol Pathol. 2001 Feb; 70(1):7-18.