"Granulosa Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).
| Descriptor ID |
D006107
|
| MeSH Number(s) |
A05.360.319.114.630.535.200 A06.407.312.497.535.300 A11.382.812 A11.436.329
|
| Concept/Terms |
Granulosa Cells- Granulosa Cells
- Cell, Granulosa
- Cells, Granulosa
- Granulosa Cell
|
Below are MeSH descriptors whose meaning is more general than "Granulosa Cells".
Below are MeSH descriptors whose meaning is more specific than "Granulosa Cells".
This graph shows the total number of publications written about "Granulosa Cells" by people in this website by year, and whether "Granulosa Cells" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2011 | 3 | 0 | 3 |
| 2012 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Granulosa Cells" by people in Profiles.
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An induced pluripotent stem cell-derived granulosa cell model revealed hyperactive CREB signaling in polycystic ovary syndrome subjects. Fertil Steril. 2019 09; 112(3):480-481.
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Mouse forkhead L2 maintains repression of FSH-dependent genes in the granulosa cell. Reproduction. 2012 Oct; 144(4):485-94.
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Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human. Fertil Steril. 2012 Aug; 98(2):471-9.e1.
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Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation. Endocrinology. 2011 Oct; 152(10):3917-29.
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Relative expression of genes encoding SMAD signal transduction factors in human granulosa cells is correlated with oocyte quality. J Assist Reprod Genet. 2011 Sep; 28(10):931-8.
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Evidences for the existence of a low dopaminergic tone in polycystic ovarian syndrome: implications for OHSS development and treatment. J Clin Endocrinol Metab. 2011 Aug; 96(8):2484-92.
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Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology. Endocrinology. 2011 Apr; 152(4):1199-208.
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Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2. Fertil Steril. 2010 Jun; 94(1):353-6.
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Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene. Cell Signal. 2009 Dec; 21(12):1935-44.
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Expression of forkhead transcription factors in human granulosa cells. Fertil Steril. 2009 Apr; 91(4 Suppl):1392-4.