Inositol 1,4,5-Trisphosphate
"Inositol 1,4,5-Trisphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
| Descriptor ID |
D015544
|
| MeSH Number(s) |
D02.033.800.519.400.350 D09.853.519.400.350 D09.894.480.350
|
| Concept/Terms |
Inositol 1,4,5-Trisphosphate- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Triphosphate
- Myoinositol 1,4,5-Triphosphate
- 1,4,5-InsP3
- 1,4,5-IP3
- Myo-Inositol 1,4,5-Trisphosphate
|
Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate".
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate" by people in Profiles.
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Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells. Int Arch Allergy Immunol. 2012; 158(1):18-26.
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Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. J Pharmacol Exp Ther. 2007 Feb; 320(2):728-37.
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Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase. Am J Physiol Gastrointest Liver Physiol. 2004 Dec; 287(6):G1200-12.
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Acyl-coenzyme A causes Ca2+ release in pancreatic acinar cells. J Biol Chem. 1997 Dec 12; 272(50):31435-40.
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Cellular mechanisms and physiological implications of quantal Ca2+ release in pancreatic acinar cells. Am J Physiol. 1994 Dec; 267(6 Pt 1):G1058-66.
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Sphingosine regulates Ca(2+)-ATPase and reloading of intracellular Ca2+ stores in the pancreatic acinar cell. Biochim Biophys Acta. 1994 Oct 12; 1195(1):45-50.
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Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. J Biol Chem. 1993 May 25; 268(15):10808-12.
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Hormone-evoked calcium release from intracellular stores is a quantal process. J Biol Chem. 1989 Jan 05; 264(1):205-12.
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Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum. Proc Natl Acad Sci U S A. 1985 Jul; 82(13):4433-7.