Genetic Predisposition to Disease
"Genetic Predisposition to Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
| Descriptor ID |
D020022
|
| MeSH Number(s) |
C23.550.291.687.500 G05.380.355
|
| Concept/Terms |
Genetic Predisposition to Disease- Genetic Predisposition to Disease
- Genetic Susceptibility
- Genetic Susceptibilities
- Susceptibilities, Genetic
- Susceptibility, Genetic
- Genetic Predisposition
- Genetic Predispositions
- Predispositions, Genetic
- Predisposition, Genetic
|
Below are MeSH descriptors whose meaning is more general than "Genetic Predisposition to Disease".
Below are MeSH descriptors whose meaning is more specific than "Genetic Predisposition to Disease".
This graph shows the total number of publications written about "Genetic Predisposition to Disease" by people in this website by year, and whether "Genetic Predisposition to Disease" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 3 | 3 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 2 | 3 |
| 2015 | 2 | 4 | 6 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 3 | 4 |
| 2018 | 1 | 5 | 6 |
| 2019 | 3 | 5 | 8 |
| 2020 | 2 | 2 | 4 |
| 2021 | 4 | 2 | 6 |
| 2023 | 1 | 2 | 3 |
| 2024 | 2 | 1 | 3 |
| 2025 | 3 | 3 | 6 |
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Below are the most recent publications written about "Genetic Predisposition to Disease" by people in Profiles.
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BRCA1-, BRCA2-, and PALB2-related Fanconi anemia: Scope to expand disease phenotypic features and predict breast cancer risk in heterozygotes. Am J Hum Genet. 2025 12 04; 112(12):2902-2921.
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A quantitative, Bayesian-informed approach to gene-specific variant classification: Updated Expert Panel recommendations improve classification of TP53 germline variants for Li-Fraumeni syndrome. Genome Med. 2025 10 22; 17(1):128.
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Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC and renal cancer. Genet Med. 2025 Nov; 27(11):101565.
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Characteristics predicting reduced penetrance variants in the high-risk cancer predisposition gene TP53. HGG Adv. 2025 Oct 09; 6(4):100484.
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Association of gene variant type and location with breast cancer risk in the general population. Ann Oncol. 2025 Aug; 36(8):954-963.
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Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma In Situ of the Breast. Clin Cancer Res. 2025 Jan 06; 31(1):130-138.
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Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel. Am J Hum Genet. 2024 Sep 05; 111(9):2044-2058.
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High frequency of germline variants in CFTR identified in PDAC patients enrolled in an expanded panel multi-gene panel testing program. HPB (Oxford). 2024 08; 26(8):1082-1085.
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Functional analysis and clinical classification of 462 germline BRCA2 missense variants affecting the DNA binding domain. Am J Hum Genet. 2024 03 07; 111(3):584-593.
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CHEK2 is not a Li-Fraumeni syndrome gene: time to update public resources. J Med Genet. 2023 11 27; 60(12):1215-1217.