"Trypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
| Descriptor ID |
D014357
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| MeSH Number(s) |
D08.811.277.656.300.760.895 D08.811.277.656.959.350.895
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trypsin".
Below are MeSH descriptors whose meaning is more specific than "Trypsin".
This graph shows the total number of publications written about "Trypsin" by people in this website by year, and whether "Trypsin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 1 | 2 |
| 2006 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trypsin" by people in Profiles.
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Wild-Type Human PRSS2 and PRSS1R122H Cooperatively Initiate Spontaneous Hereditary Pancreatitis in Transgenic Mice. Gastroenterology. 2022 07; 163(1):313-315.e4.
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Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H. J Clin Invest. 2020 01 02; 130(1):189-202.
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Relationship between circulating levels of pancreatic proteolytic enzymes and pancreatic hormones. Pancreatology. 2017 Nov - Dec; 17(6):876-883.
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Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk. Gut. 2013 Nov; 62(11):1616-24.
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Cholinergic mediation of alcohol-induced experimental pancreatitis. Alcohol Clin Exp Res. 2010 Oct; 34(10):1768-81.
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Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest. 2009 Nov; 119(11):3340-55.
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A new severe acute necrotizing pancreatitis model induced by L-ornithine in rats. Crit Care Med. 2008 Jul; 36(7):2117-27.
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Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis. Pancreas. 2006 Oct; 33(3):221-7.
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Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice. Gastroenterology. 2006 Sep; 131(3):885-99.
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Acute pancreatitis. Curr Opin Gastroenterol. 2006 Sep; 22(5):481-6.