"Proprotein Convertase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
Descriptor ID |
D045706
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MeSH Number(s) |
D08.811.277.656.300.760.646 D08.811.277.656.837.562 D08.811.277.656.959.350.646
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Concept/Terms |
Proprotein Convertase 2- Proprotein Convertase 2
- PC2 Prohormone Convertase
- PC2 Protein
- Endopeptidase PC2
- PC2, Endopeptidase
- Prohormone Convertase 2
- Convertase 2, Prohormone
- Prohormone Convertase PC2
- Convertase PC2, Prohormone
- Proinsulin Convertase 2
- Convertase 2, Proinsulin
- Prohormone Convertase, PC2
- Convertase, PC2 Prohormone
- PC2 Endoprotease
- Endoprotease, PC2
- Neuroendocrine Convertase PC2
- Convertase PC2, Neuroendocrine
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Below are MeSH descriptors whose meaning is more general than "Proprotein Convertase 2".
Below are MeSH descriptors whose meaning is more specific than "Proprotein Convertase 2".
This graph shows the total number of publications written about "Proprotein Convertase 2" by people in this website by year, and whether "Proprotein Convertase 2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 2 | 2 |
1996 | 0 | 1 | 1 |
2000 | 0 | 2 | 2 |
2001 | 0 | 1 | 1 |
2003 | 1 | 0 | 1 |
2004 | 1 | 0 | 1 |
2005 | 1 | 1 | 2 |
2006 | 0 | 2 | 2 |
2008 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proprotein Convertase 2" by people in Profiles.
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Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence. Neuroscience. 2016 08 04; 329:318-25.
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Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109.
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Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Neuroscience. 2008 Oct 15; 156(3):788-99.
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Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86.
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Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 2006 Jun; 147(6):2705-16.
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Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. J Mol Endocrinol. 2005 Jun; 34(3):739-51.
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Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E236-45.
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Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest. 2004 Aug; 114(3):357-69.
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Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues. Regul Pept. 2003 Feb 28; 110(3):197-205.
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Up-regulation of splenic prohormone convertases PC1 and PC2 in diabetic rats. Regul Pept. 2001 Dec 15; 102(2-3):135-45.