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Kabirullah Lutfy, PhD

TitleAssistant Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
PhoneNot Available
FaxNot Available
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    Bibliographic
    selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Iqbal A, Hamid A, Ahmad SM, Lutfy K. The Role of Mu Opioid Receptors in High Fat Diet-Induced Reward and Potentiation of the Rewarding Effect of Oxycodone. Life (Basel). 2023 Feb 23; 13(3). PMID: 36983775; PMCID: PMC10055773.
      Citations:    
    2. Escolero V, Tolentino L, Muhammad AB, Hamid A, Lutfy K. The Involvement of Endogenous Enkephalins in Glucose Homeostasis. Biomedicines. 2023 Feb 22; 11(3). PMID: 36979650; PMCID: PMC10045905.
      Citations:    
    3. Tolentino L, Iqbal A, Rahman S, Lutfy K. The Role of Beta-Endorphin in Food Deprivation-Mediated Increases in Food Intake and Binge-Eating. Brain Sci. 2023 Jan 27; 13(2). PMID: 36831755; PMCID: PMC9954518.
      Citations:    
    4. Alzarea S, Abbas M, Ronan PJ, Lutfy K, Rahman S. The Effect of an a-7 Nicotinic Allosteric Modulator PNU120596 and NMDA Receptor Antagonist Memantine on Depressive-like Behavior Induced by LPS in Mice: The Involvement of Brain Microglia. Brain Sci. 2022 Nov 03; 12(11). PMID: 36358419; PMCID: PMC9688168.
      Citations:    
    5. Kanamori K, Ahmad SM, Shin CS, Hamid A, Lutfy K. Identification of 5-Hydroxycotinine in the Plasma of Nicotine-Treated Mice: Implications for Cotinine Metabolism and Disposition in Vivo. Drug Metab Dispos. 2022 Dec; 50(12):1454-1463. PMID: 36184079.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Vukmanovic Nosrat I, Palacios JL, Kezian S, Luong G, Tran A, Vu K, Henson BS, Nosrat P, Lutfy K, Nosrat CA. Brain-derived neurotrophic factor overexpression in taste buds diminishes chemotherapy induced taste loss. Eur J Neurosci. 2022 10; 56(7):4967-4982. PMID: 35986485.
      Citations:    Fields:    Translation:AnimalsCells
    7. Lutfy K, Hipolito L, Ferretti V, Vendruscolo LF, Kallupi M. Editorial: The Role of Neuropeptides in Drug Addiction and Other Psychiatric Disorders. Front Behav Neurosci. 2022; 16:952551. PMID: 35836486; PMCID: PMC9274266.
      Citations:    
    8. Sureshkumar K, Saenz A, Ahmad SM, Lutfy K. The PACAP/PAC1 Receptor System and Feeding. Brain Sci. 2021 Dec 23; 12(1). PMID: 35053757; PMCID: PMC8773599.
      Citations: 3     
    9. Singh PK, Lutfy K. The Role of Beta-Endorphin in Cocaine-Induced Conditioned Place Preference, Its Extinction, and Reinstatement in Male and Female Mice. Front Behav Neurosci. 2021; 15:763336. PMID: 34955777; PMCID: PMC8702804.
      Citations:    
    10. Chen G, Ghazal M, Rahman S, Lutfy K. The impact of adolescent nicotine exposure on alcohol use during adulthood: The role of neuropeptides. Int Rev Neurobiol. 2022; 161:53-93. PMID: 34801174.
      Citations:    Fields:    Translation:Humans
    11. Rahman S, Rahman ZI, Ronan PJ, Lutfy K, Bell RL. Adolescent opioid abuse: Role of glial and neuroimmune mechanisms. Int Rev Neurobiol. 2022; 161:147-165. PMID: 34801168.
      Citations:    Fields:    Translation:HumansCells
    12. Nawrocka A, Poznanski P, Lazarczyk M, Gorzalczynski M, Skiba D, Wolinska R, Bujalska-Zadrozny M, Lutfy K, Sadowski B, Sacharczuk M. The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System. Brain Sci. 2021 May 13; 11(5). PMID: 34067974; PMCID: PMC8152237.
      Citations: 1     
    13. Wang Y, Wang J, Yang R, Wang P, Porche R, Kim S, Lutfy K, Liu L, Friedman TC, Jiang M, Liu Y. Decreased 11ß-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice. Hypertension. 2021 06; 77(6):1940-1952. PMID: 33813843; PMCID: PMC8119334.
      Citations: 2     Fields:    Translation:AnimalsCells
    14. Stojakovic A, Ahmad SM, Lutfy K. Alterations of Amphetamine Reward by Prior Nicotine and Alcohol Treatment: The Role of Age and Dopamine. Brain Sci. 2021 Mar 26; 11(4). PMID: 33810331; PMCID: PMC8065622.
      Citations: 1     
    15. Nguyen K, Kanamori K, Shin CS, Hamid A, Lutfy K. The Impact of Sex on Changes in Plasma Corticosterone and Cotinine Levels Induced by Nicotine in C57BL/6J Mice. Brain Sci. 2020 Oct 03; 10(10). PMID: 33023022; PMCID: PMC7601418.
      Citations: 5     
    16. Lutfy K. Opioid Crisis-An Emphasis on Fentanyl Analogs. Brain Sci. 2020 Jul 27; 10(8). PMID: 32726995; PMCID: PMC7465217.
      Citations: 3     
    17. Nega S, Marquez P, Hamid A, Ahmad SM, Lutfy K. The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal. J Neurosci Res. 2020 08; 98(8):1549-1560. PMID: 32476165.
      Citations: 2     Fields:    Translation:Animals
    18. Stojakovic A, Ahmad SM, Malhotra S, Afzal Z, Ahmed M, Lutfy K. The role of pituitary adenylyl cyclase-activating polypeptide in the motivational effects of addictive drugs. Neuropharmacology. 2020 07; 171:108109. PMID: 32325064.
      Citations: 6     Fields:    Translation:HumansAnimals
    19. Wang J, Wang Y, Liu L, Lutfy K, Friedman TC, Liu Y, Jiang M, Liu Y. Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 11 15; 133(21):2189-2202. PMID: 31696216; PMCID: PMC7493827.
      Citations: 1     Fields:    Translation:Animals
    20. Hassanzadah M, Bitar AH, Khanfar NM, Khasawneh FT, Lutfy K, Shankar GS. A retrospective cohort study of the prevalence of anxiety and agitation in schizophrenic smokers and the unmet needs of smoking cessation programs. Medicine (Baltimore). 2019 Oct; 98(40):e17375. PMID: 31577741; PMCID: PMC6783193.
      Citations:    Fields:    Translation:Humans
    21. Shao XM, Lopez B, Nathan D, Wilson J, Bankole E, Tumoyan H, Munoz A, Espinoza-Derout J, Hasan KM, Chang S, Du C, Sinha-Hikim AP, Lutfy K, Friedman TC. A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 10 01; 326:108376. PMID: 31361999; PMCID: PMC6717674.
      Citations: 15     Fields:    Translation:Animals
    22. Lutfy K, Shankar G. Emerging evidence for the role of pituitary adenylate cyclase-activating peptide in neuropsychiatric disorders. Prog Mol Biol Transl Sci. 2019; 167:143-157. PMID: 31601402.
      Citations: 13     Fields:    Translation:HumansAnimals
    23. Tseng A, Singh P, Marquez P, Hamid A, Lutfy K. The role of endogenous pituitary adenylyl cyclase activating polypeptide (PACAP) in nicotine self-administration, reward and aversion. Pharmacol Biochem Behav. 2019 06; 181:46-52. PMID: 31028757.
      Citations: 3     Fields:    Translation:Animals
    24. Zaveri NT, Marquez PV, Meyer ME, Hamid A, Lutfy K. The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice. Front Psychiatry. 2018; 9:638. PMID: 30555362; PMCID: PMC6281746.
      Citations: 10     
    25. Liu L, Wang Y, Wang J, Dong Y, Chang S, Liu X, Lutfy K, Chen H, Friedman TC, Jiang M, Liu Y. Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity. Int J Obes (Lond). 2018 12; 42(12):1999-2011. PMID: 29568102; PMCID: PMC6105561.
      Citations: 4     Fields:    Translation:AnimalsCells
    26. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360; PMCID: PMC5776480.
      Citations: 12     Fields:    Translation:AnimalsCells
    27. Zaveri NT, Marquez PV, Meyer ME, Polgar WE, Hamid A, Lutfy K. A Novel and Selective Nociceptin Receptor (NOP) Agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) Decreases Acquisition of Ethanol-Induced Conditioned Place Preference in Mice. Alcohol Clin Exp Res. 2018 Feb; 42(2):461-471. PMID: 29215139; PMCID: PMC5785446.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    28. Stojakovic A, Espinosa EP, Farhad OT, Lutfy K. Effects of nicotine on homeostatic and hedonic components of food intake. J Endocrinol. 2017 Oct; 235(1):R13-R31. PMID: 28814527; PMCID: PMC5578410.
      Citations: 19     Fields:    Translation:HumansAnimals
    29. Meyer LC, Paisley CE, Mohamed E, Bigbee JW, Kordula T, Richard H, Lutfy K, Sato-Bigbee C. Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes. Glia. 2017 12; 65(12):2003-2023. PMID: 28906039; PMCID: PMC5766282.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    30. Singh PK, Lutfy K. Nicotine pretreatment reduced cocaine-induced CPP and its reinstatement in a sex- and dose-related manner in adult C57BL/6J mice. Pharmacol Biochem Behav. 2017 08; 159:84-89. PMID: 28735686.
      Citations: 1     Fields:    Translation:Animals
    31. Lutfy K, Parikh D, Lee DL, Liu Y, Ferrini MG, Hamid A, Friedman TC. Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence. Neuroscience. 2016 08 04; 329:318-25. PMID: 27208618; PMCID: PMC4933571.
      Citations: 2     Fields:    Translation:Animals
    32. Yan C, Yang H, Wang Y, Dong Y, Yu F, Wu Y, Wang W, Adaku U, Lutfy K, Friedman TC, Tian S, Liu Y. Increased glycogen synthase kinase-3ß and hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to glucocorticoid-induced mouse visceral adiposity. Int J Obes (Lond). 2016 08; 40(8):1233-41. PMID: 27102048; PMCID: PMC4970937.
      Citations: 5     Fields:    Translation:AnimalsCells
    33. Lutfy K, Zaveri NT. The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction. Prog Mol Biol Transl Sci. 2016; 137:149-81. PMID: 26810001; PMCID: PMC5555398.
      Citations: 8     Fields:    Translation:Humans
    34. Chan P, Lutfy K. Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System. Prog Mol Biol Transl Sci. 2016; 137:203-27. PMID: 26810003.
      Citations: 11     Fields:    Translation:Humans
    35. Begum AN, Guoynes C, Cho J, Hao J, Lutfy K, Hong Y. Rapid generation of sub-type, region-specific neurons and neural networks from human pluripotent stem cell-derived neurospheres. Stem Cell Res. 2015 Nov; 15(3):731-741. PMID: 26613348; PMCID: PMC4698048.
      Citations: 19     Fields:    Translation:HumansCells
    36. Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015 Mar 12; 519(7542):242-6. PMID: 25533952; PMCID: PMC4447235.
      Citations: 450     Fields:    Translation:HumansAnimalsCells
    37. Wang Y, Yan C, Liu L, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y. 11ß-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab. 2015 Jan 01; 308(1):E84-95. PMID: 25389364; PMCID: PMC4281684.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    38. Taylor AM, Roberts KW, Pradhan AA, Akbari HA, Walwyn W, Lutfy K, Carroll FI, Cahill CM, Evans CJ. Anti-nociception mediated by a ? opioid receptor agonist is blocked by a d receptor agonist. Br J Pharmacol. 2015 Jan; 172(2):691-703. PMID: 24923251; PMCID: PMC4292979.
      Citations: 8     Fields:    Translation:Animals
    39. Wang Y, Liu L, Du H, Nagaoka Y, Fan W, Lutfy K, Friedman TC, Jiang M, Liu Y. Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab. 2014 Mar 01; 306(5):E543-51. PMID: 24381005; PMCID: PMC3948972.
      Citations: 6     Fields:    Translation:AnimalsCells
    40. Ren X, Lutfy K, Mangubat M, Ferrini MG, Lee ML, Liu Y, Friedman TC. Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes. 2013; 2013:764742. PMID: 24073333; PMCID: PMC3773431.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Nie Y, Ferrini MG, Liu Y, Anghel A, Paez Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109. PMID: 23891651; PMCID: PMC3787842.
      Citations: 1     Fields:    Translation:Animals
    42. Tseng A, Nguyen K, Hamid A, Garg M, Marquez P, Lutfy K. The role of endogenous beta-endorphin and enkephalins in ethanol reward. Neuropharmacology. 2013 Oct; 73:290-300. PMID: 23770261; PMCID: PMC3766483.
      Citations: 16     Fields:    Translation:Animals
    43. Marquez P, Hamid A, Lutfy K. The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice. Eur J Pharmacol. 2013 May 05; 707(1-3):41-5. PMID: 23524092; PMCID: PMC3652801.
      Citations: 9     Fields:    Translation:Animals
    44. Du H, Liu L, Wang Y, Nakagawa Y, Lyzlov A, Lutfy K, Friedman TC, Peng X, Liu Y. Specific reduction of G6PT may contribute to downregulation of hepatic 11ß-HSD1 in diabetic mice. J Mol Endocrinol. 2013 Apr; 50(2):167-78. PMID: 23267038; PMCID: PMC3763023.
      Citations: 7     Fields:    Translation:AnimalsCells
    45. Tweed JO, Hsia SH, Lutfy K, Friedman TC. The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab. 2012 Jul; 23(7):334-42. PMID: 22561025; PMCID: PMC3389568.
      Citations: 67     Fields:    Translation:HumansAnimals
    46. Nguyen AT, Marquez P, Hamid A, Kieffer B, Friedman TC, Lutfy K. The rewarding action of acute cocaine is reduced in ß-endorphin deficient but not in µ opioid receptor knockout mice. Eur J Pharmacol. 2012 Jul 05; 686(1-3):50-4. PMID: 22575525; PMCID: PMC3367137.
      Citations: 15     Fields:    Translation:Animals
    47. Nguyen AT, Marquez P, Hamid A, Lutfy K. The role of mu opioid receptors in psychomotor stimulation and conditioned place preference induced by morphine-6-glucuronide. Eur J Pharmacol. 2012 May 05; 682(1-3):86-91. PMID: 22374262; PMCID: PMC3319697.
      Citations: 5     Fields:    Translation:Animals
    48. Lutfy K, Aimiuwu O, Mangubat M, Shin CS, Nerio N, Gomez R, Liu Y, Friedman TC. Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. J Neurochem. 2012 Mar; 120(6):1108-16. PMID: 22191943; PMCID: PMC3296864.
      Citations: 15     Fields:    Translation:Animals
    49. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. PMID: 22138237; PMCID: PMC3444240.
      Citations: 29     Fields:    Translation:Animals
    50. Nguyen K, Tseng A, Marquez P, Hamid A, Lutfy K. The role of endogenous dynorphin in ethanol-induced state-dependent CPP. Behav Brain Res. 2012 Feb 01; 227(1):58-63. PMID: 22074899; PMCID: PMC4701201.
      Citations: 10     Fields:    Translation:Animals
    51. Wang Y, Nakagawa Y, Liu L, Wang W, Ren X, Anghel A, Lutfy K, Friedman TC, Liu Y. Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. Diabetologia. 2011 Feb; 54(2):440-50. PMID: 21052977; PMCID: PMC3795617.
      Citations: 18     Fields:    Translation:AnimalsCells
    52. Parikh D, Hamid A, Friedman TC, Nguyen K, Tseng A, Marquez P, Lutfy K. Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration. Eur J Pharmacol. 2011 Jan 15; 650(2-3):563-7. PMID: 21044625; PMCID: PMC3033575.
      Citations: 31     Fields:    Translation:AnimalsCells
    53. Farhang B, Pietruszewski L, Lutfy K, Wagner EJ. The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons. Neuropharmacology. 2010 Sep; 59(3):190-200. PMID: 20510254; PMCID: PMC2946834.
      Citations: 29     Fields:    Translation:AnimalsCells
    54. Bebawy D, Marquez P, Samboul S, Parikh D, Hamid A, Lutfy K. Orphanin FQ/nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice. Biol Psychiatry. 2010 Aug 01; 68(3):223-30. PMID: 20359694; PMCID: PMC2896563.
      Citations: 15     Fields:    Translation:Animals
    55. Anghel A, Jamieson CA, Ren X, Young J, Porche R, Ozigbo E, Ghods DE, Lee ML, Liu Y, Lutfy K, Friedman TC. Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience. 2010 May 05; 167(2):554-66. PMID: 20144693; PMCID: PMC2859888.
      Citations: 9     Fields:    Translation:Animals
    56. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010 Feb; 31(1):98-132. PMID: 19903933; PMCID: PMC2852206.
      Citations: 166     Fields:    Translation:HumansAnimals
    57. Marquez P, Bebawy D, Lelièvre V, Coûté AC, Evans CJ, Waschek JA, Lutfy K. The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice. Psychopharmacology (Berl). 2009 Jun; 204(3):457-63. PMID: 19199096; PMCID: PMC4429892.
      Citations: 11     Fields:    Translation:Animals
    58. Espinosa VP, Liu Y, Ferrini M, Anghel A, Nie Y, Tripathi PV, Porche R, Jansen E, Stuart RC, Nillni EA, Lutfy K, Friedman TC. Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Neuroscience. 2008 Oct 15; 156(3):788-99. PMID: 18771713; PMCID: PMC2596639.
      Citations: 11     Fields:    Translation:AnimalsCells
    59. Marquez P, Borse J, Nguyen AT, Hamid A, Lutfy K. The role of the opioid receptor-like (ORL1) receptor in motor stimulatory and rewarding actions of buprenorphine and morphine. Neuroscience. 2008 Aug 26; 155(3):597-602. PMID: 18634857; PMCID: PMC2631239.
      Citations: 10     Fields:    Translation:AnimalsCells
    60. Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC. Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J Mol Endocrinol. 2008 Aug; 41(2):53-64. PMID: 18524870; PMCID: PMC2954685.
      Citations: 18     Fields:    Translation:AnimalsCells
    61. Lutfy K, Lam H, Narayanan S. Alterations in the level of OFQ/N-IR in rat brain regions by cocaine. Neuropharmacology. 2008 Aug; 55(2):198-203. PMID: 18572206; PMCID: PMC2613325.
      Citations: 5     Fields:    Translation:Animals
    62. Marquez P, Baliram R, Dabaja I, Gajawada N, Lutfy K. The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice. Psychopharmacology (Berl). 2008 Apr; 197(3):443-8. PMID: 18176854; PMCID: PMC2408690.
      Citations: 20     Fields:    Translation:Animals
    63. Marquez P, Nguyen AT, Hamid A, Lutfy K. The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine. Neuropharmacology. 2008 Mar; 54(3):564-8. PMID: 18082848; PMCID: PMC2276976.
      Citations: 24     Fields:    Translation:Animals
    64. Marquez P, Baliram R, Kieffer BL, Lutfy K. The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference. Neuropharmacology. 2007 May; 52(6):1336-41. PMID: 17367825; PMCID: PMC2267901.
      Citations: 20     Fields:    Translation:Animals
    65. Lutfy K, Brown MC, Nerio N, Aimiuwu O, Tran B, Anghel A, Friedman TC. Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis. J Neurochem. 2006 Dec; 99(5):1321-7. PMID: 17064351.
      Citations: 19     Fields:    Translation:Animals
    66. Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86. PMID: 16926379.
      Citations: 4     Fields:    Translation:AnimalsCells
    67. Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006 Nov; 147(11):5061-8. PMID: 16873540.
      Citations: 28     Fields:    Translation:AnimalsCells
    68. Marquez P, Baliram R, Gajawada N, Friedman TC, Lutfy K. Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine. Behav Neurosci. 2006 Feb; 120(1):10-5. PMID: 16492112; PMCID: PMC2268890.
      Citations: 16     Fields:    Translation:Animals
    69. Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes. 2005 Jan; 54(1):32-40. PMID: 15616008.
      Citations: 38     Fields:    Translation:AnimalsCells
    70. Lutfy K, Cowan A. Buprenorphine: a unique drug with complex pharmacology. Curr Neuropharmacol. 2004 Oct; 2(4):395-402. PMID: 18997874; PMCID: PMC2581407.
      Citations: 113     Fields:    
    71. Narayanan S, Lam H, Carroll FI, Lutfy K. Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats. J Psychiatry Neurosci. 2004 Mar; 29(2):116-23. PMID: 15069465; PMCID: PMC383343.
      Citations: 12     Fields:    Translation:Animals
    72. Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. J Neurosci. 2003 Nov 12; 23(32):10331-7. PMID: 14614092; PMCID: PMC6741014.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    73. Lutfy K, Khaliq I, Carroll FI, Maidment NT. Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats. Psychopharmacology (Berl). 2002 Nov; 164(2):168-76. PMID: 12404079; PMCID: PMC2268895.
      Citations: 23     Fields:    Translation:Animals
    74. Lutfy K, Maidment NT. Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine. Brain Res Bull. 2002 May; 58(1):7-12. PMID: 12121806.
      Citations: 1     Fields:    Translation:AnimalsCells
    75. Narayanan S, Lutfy K, Maidment N. Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin. Behav Brain Res. 2002 Apr 01; 131(1-2):97-103. PMID: 11844576.
      Citations: 1     Fields:    Translation:Animals
    76. Lutfy K, Hossain SM, Khaliq I, Maidment NT. Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats. Br J Pharmacol. 2001 Oct; 134(3):529-34. PMID: 11588106; PMCID: PMC1572978.
      Citations: 17     Fields:    Translation:Animals
    77. Lutfy K, Do T, Maidment NT. Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. Psychopharmacology (Berl). 2001 Feb; 154(1):1-7. PMID: 11291998; PMCID: PMC2288655.
      Citations: 43     Fields:    Translation:AnimalsCells
    78. Lutfy K, Maidment NT. Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test. Br J Pharmacol. 2000 Dec; 131(8):1684-8. PMID: 11139447; PMCID: PMC1572505.
      Citations: 2     Fields:    Translation:Animals
    79. Lutfy K, Doan P, Nguyen M, Weber E. Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance. Eur J Pharmacol. 1999 Nov 12; 384(1):1-5. PMID: 10611412.
      Citations: 1     Fields:    Translation:AnimalsCells
    80. Lutfy K, Doan P, Weber E. ACEA-1328, a NMDA receptor/glycine site antagonist, acutely potentiates antinociception and chronically attenuates tolerance induced by morphine. Pharmacol Res. 1999 Nov; 40(5):435-42. PMID: 10527659.
      Citations: 3     Fields:    Translation:Animals
    81. Lutfy K, Sharza SA, Maidment NT. Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat. Neuroreport. 1999 Jan 18; 10(1):103-6. PMID: 10094142.
      Citations: 4     Fields:    Translation:Animals
    82. Lutfy K, Doan P, Nugyen M, Weber E. ACEA-1328, an NMDA receptor antagonist, increases the potency of morphine and U50,488H in the tail flick test in mice. Pharmacol Res. 1998 Dec; 38(6):453-60. PMID: 9990654.
      Citations: 1     Fields:    Translation:Animals
    83. Lutfy K, Weber E. Tolerance develops to the antinociceptive and motor impairing effects of ACEA-1416, a NMDA receptor antagonist, in the formalin and rotarod test in mice. Pharmacol Res. 1998 Apr; 37(4):295-302. PMID: 9634646.
      Citations: 1     Fields:    Translation:Animals
    84. Lutfy K, Cai SX, Woodward RM, Weber E. Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice. Pain. 1997 Mar; 70(1):31-40. PMID: 9106807.
      Citations: 13     Fields:    Translation:AnimalsCells
    85. Lutfy K, Weber E. Attenuation of nociceptive responses by ACEA-1021, a competitive NMDA receptor/glycine site antagonist, in the mice. Brain Res. 1996 Dec 16; 743(1-2):17-23. PMID: 9017225.
      Citations: 2     Fields:    Translation:Animals
    86. Lutfy K, Shen KZ, Woodward RM, Weber E. Inhibition of morphine tolerance by NMDA receptor antagonists in the formalin test. Brain Res. 1996 Aug 26; 731(1-2):171-81. PMID: 8883867.
      Citations: 3     Fields:    Translation:AnimalsCells
    87. Lutfy K, Sadowski B, Marek P, Kwon IS, Keana JF, Weber E. Differential sensitivity of mice bred for stress-induced analgesia to morphine and ACEA-1011 in the formalin test. Pharmacol Biochem Behav. 1996 Jun; 54(2):495-500. PMID: 8743614.
      Citations: 2     Fields:    Translation:Animals
    88. Lutfy K, Shen KZ, Kwon IS, Cai SX, Woodward RM, Keana JF, Weber E. Blockade of morphine tolerance by ACEA-1328, a novel NMDA receptor/glycine site antagonist. Eur J Pharmacol. 1995 Jan 24; 273(1-2):187-9. PMID: 7737313.
      Citations: 6     Fields:    Translation:AnimalsCells
    89. Lutfy K, Keana JF, Weber E. ACEA-1011, a novel NMDA receptor/glycine site antagonist, produces antinociception but not tolerance in the formalin test in mice. NIDA Res Monogr. 1995; 147:220-33. PMID: 8742789.
      Citations:    Fields:    Translation:Animals
    90. Lutfy K, Sadowski B, Kwon IS, Weber E. Morphine analgesia and tolerance in mice selectively bred for divergent swim stress-induced analgesia. Eur J Pharmacol. 1994 Nov 24; 265(3):171-4. PMID: 7875233.
      Citations: 3     Fields:    Translation:Animals
    91. Lutfy K, Woodward RM, Keana JF, Weber E. Inhibition of clonic seizure-like excitatory effects induced by intrathecal morphine using two NMDA receptor antagonists: MK-801 and ACEA-1011. Eur J Pharmacol. 1994 Feb 11; 252(3):261-6. PMID: 8162948.
      Citations: 3     Fields:    Translation:AnimalsCells
    92. Lutfy K, Hurlbut DE, Weber E. Blockade of morphine-induced analgesia and tolerance in mice by MK-801. Brain Res. 1993 Jul 09; 616(1-2):83-8. PMID: 8358631.
      Citations: 10     Fields:    Translation:AnimalsCells
    93. Candido J, Lutfy K, Billings B, Sierra V, Duttaroy A, Inturrisi CE, Yoburn BC. Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation. Pharmacol Biochem Behav. 1992 Aug; 42(4):685-92. PMID: 1325057.
      Citations: 13     Fields:    Translation:AnimalsCells
    94. Sierra V, Duttaroy A, Lutfy K, Candido J, Billings B, Zito SW, Yoburn BC. Potentiation of opioid analgesia by cocaine: the role of spinal and supraspinal receptors. Life Sci. 1992; 50(8):591-7. PMID: 1346544.
      Citations: 1     Fields:    Translation:Animals
    95. Chang SC, Lutfy K, Sierra V, Yoburn BC. Dissociation of opioid receptor upregulation and functional supersensitivity. Pharmacol Biochem Behav. 1991 Apr; 38(4):853-9. PMID: 1651519.
      Citations: 4     Fields:    Translation:AnimalsCells
    96. Lutfy K, Chang SC, Candido J, Jang Y, Sierra V, Yoburn BC. Modification of morphine-induced analgesia and toxicity by pertussis toxin. Brain Res. 1991 Mar 29; 544(2):191-5. PMID: 2039936.
      Citations: 3     Fields:    Translation:Animals
    97. Lutfy K, Yoburn BC. The role of opioid receptor density in morphine tolerance. J Pharmacol Exp Ther. 1991 Feb; 256(2):575-80. PMID: 1847202.
      Citations: 3     Fields:    Translation:AnimalsCells
    98. Yoburn BC, Lutfy K, Candido J. Species differences in mu- and delta-opioid receptors. Eur J Pharmacol. 1991 Jan 25; 193(1):105-8. PMID: 1646725.
      Citations: 7     Fields:    Translation:Animals
    99. Yoburn BC, Sierra V, Lutfy K. Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation. Brain Res. 1990 Oct 08; 529(1-2):143-8. PMID: 2178026.
      Citations: 4     Fields:    Translation:AnimalsCells
    100. Yoburn BC, Lutfy K, Sierra V, Tortella FC. Tolerance develops to spinal morphine analgesia but not morphine-induced convulsions. Eur J Pharmacol. 1990 Jan 25; 176(1):63-7. PMID: 2311659.
      Citations:    Fields:    Translation:Animals
    101. Yoburn BC, Lutfy K, Sierra V. In vitro d-amphetamine and cocaine increase opioid binding in mouse brain homogenate. NIDA Res Monogr. 1990; 105:522-3. PMID: 1876107.
      Citations:    Fields:    Translation:Animals
    102. Yoburn BC, Lutfy K, Azimuddin S, Sierra V. Differentiation of spinal and supraspinal opioid receptors by morphine tolerance. Life Sci. 1990; 46(5):343-50. PMID: 2154656.
      Citations: 3     Fields:    Translation:Animals
    103. Yoburn BC, Sierra V, Lutfy K. Chronic opioid antagonist treatment: assessment of receptor upregulation. Eur J Pharmacol. 1989 Nov 07; 170(3):193-200. PMID: 2559854.
      Citations: 8     Fields:    Translation:AnimalsCells
    104. Yoburn BC, Paul D, Azimuddin S, Lutfy K, Sierra V. Chronic opioid antagonist treatment increases mu and delta receptor mediated spinal opioid analgesia. Brain Res. 1989 Apr 17; 485(1):176-8. PMID: 2541864.
      Citations: 1     Fields:    Translation:Animals
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