"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Descriptor ID |
D003042
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MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
2001 | 2 | 0 | 2 |
2002 | 3 | 0 | 3 |
2007 | 1 | 0 | 1 |
2008 | 2 | 0 | 2 |
2010 | 0 | 1 | 1 |
2011 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Nicotine pretreatment reduced cocaine-induced CPP and its reinstatement in a sex- and dose-related manner in adult C57BL/6J mice. Pharmacol Biochem Behav. 2017 08; 159:84-89.
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The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice. Eur J Pharmacol. 2013 May 05; 707(1-3):41-5.
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The rewarding action of acute cocaine is reduced in ß-endorphin deficient but not in µ opioid receptor knockout mice. Eur J Pharmacol. 2012 Jul 05; 686(1-3):50-4.
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Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 2011 Jun; 16(6):563-73.
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Orphanin FQ/nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice. Biol Psychiatry. 2010 Aug 01; 68(3):223-30.
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Alterations in the level of OFQ/N-IR in rat brain regions by cocaine. Neuropharmacology. 2008 Aug; 55(2):198-203.
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The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice. Psychopharmacology (Berl). 2008 Apr; 197(3):443-8.
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The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine. Neuropharmacology. 2008 Mar; 54(3):564-8.
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Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats. Psychopharmacology (Berl). 2002 Nov; 164(2):168-76.
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Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine. Brain Res Bull. 2002 May; 58(1):7-12.