"MutL Protein Homolog 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
| Descriptor ID |
D000070957
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| MeSH Number(s) |
D08.811.074.766.500 D08.811.277.040.025.215.500 D12.776.260.540.500
|
| Concept/Terms |
MutL Protein Homolog 1- MutL Protein Homolog 1
- MLH1 Protein
- Colon Cancer, Nonpolyposis Type 2 Protein
- MutL Homolog 1
- COCA2 Protein
|
Below are MeSH descriptors whose meaning is more general than "MutL Protein Homolog 1".
Below are MeSH descriptors whose meaning is more specific than "MutL Protein Homolog 1".
This graph shows the total number of publications written about "MutL Protein Homolog 1" by people in this website by year, and whether "MutL Protein Homolog 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "MutL Protein Homolog 1" by people in Profiles.
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Case-case analysis addressing ascertainment bias for multigene panel testing implicates BRCA1 and PALB2 in endometrial cancer. Hum Mutat. 2021 10; 42(10):1265-1278.
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Clinicopathologic characteristics and outcomes of endometrial Cancer patients with mismatch repair deficiency in the era of universal Lynch syndrome screening. Gynecol Oncol. 2020 12; 159(3):712-720.
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Tumour characteristics provide evidence for germline mismatch repair missense variant pathogenicity. J Med Genet. 2020 Jan; 57(1):62-69.
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Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer. JAMA Oncol. 2017 Sep 01; 3(9):1190-1196.