"C-Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Descriptor ID |
D002096
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MeSH Number(s) |
D06.472.699.587.200.500.250 D12.644.548.586.200.500.250
|
Concept/Terms |
C-Peptide- C-Peptide
- C Peptide
- Connecting Peptide
- Proinsulin C-Peptide
- Proinsulin C Peptide
- C-Peptide, Proinsulin
- C Peptide, Proinsulin
|
Below are MeSH descriptors whose meaning is more general than "C-Peptide".
Below are MeSH descriptors whose meaning is more specific than "C-Peptide".
This graph shows the total number of publications written about "C-Peptide" by people in this website by year, and whether "C-Peptide" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "C-Peptide" by people in Profiles.
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U-500 regular insulin: clinical experience and pharmacokinetics in obese, severely insulin-resistant type 2 diabetic patients. Diabetes Care. 2010 Feb; 33(2):281-3.
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Maximal dose glyburide therapy in markedly symptomatic patients with type 2 diabetes: a new use for an old friend. J Clin Endocrinol Metab. 1996 Jul; 81(7):2423-7.
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Effect of isocaloric substitution of chocolate cake for potato in type I diabetic patients. Diabetes Care. 1990 Aug; 13(8):888-92.
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Peripheral and hepatic insulin antagonism in hyperthyroidism. J Clin Endocrinol Metab. 1988 Mar; 66(3):565-9.
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Inverse relationship of metabolic clearance rate of insulin to body mass index. Metabolism. 1987 Mar; 36(3):219-22.
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Insulin antagonism is not a primary abnormality of amyotrophic lateral sclerois but is related to disease severity. J Clin Endocrinol Metab. 1986 Jul; 63(1):41-6.
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Effects of chromium and yeast supplements on carbohydrate and lipid metabolism in diabetic men. Diabetes Care. 1983 Jul-Aug; 6(4):319-27.