"Renin-Angiotensin System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
| Descriptor ID |
D012084
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| MeSH Number(s) |
G03.820 G09.330.380.813
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Renin-Angiotensin System".
Below are MeSH descriptors whose meaning is more specific than "Renin-Angiotensin System".
This graph shows the total number of publications written about "Renin-Angiotensin System" by people in this website by year, and whether "Renin-Angiotensin System" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Renin-Angiotensin System" by people in Profiles.
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A randomized study to compare oral potassium binders in the treatment of acute hyperkalemia. BMC Nephrol. 2023 04 05; 24(1):89.
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Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients. Rev Endocr Metab Disord. 2021 12; 22(4):1157-1170.
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Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial. Am Heart J. 2019 11; 217:72-83.
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Renin-angiotensin system: an old player with novel functions in skeletal muscle. Med Res Rev. 2015 May; 35(3):437-63.
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Maternal high-fat diet programs rat offspring hypertension and activates the adipose renin-angiotensin system. Am J Obstet Gynecol. 2013 Sep; 209(3):262.e1-8.
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Plasma renin activity (PRA) levels and antihypertensive drug use in a large healthcare system. Am J Hypertens. 2012 Mar; 25(3):379-88.
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Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38.