11-beta-Hydroxysteroid Dehydrogenase Type 1
"11-beta-Hydroxysteroid Dehydrogenase Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.
| Descriptor ID |
D043205
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| MeSH Number(s) |
D08.811.682.047.436.174.300 D08.811.682.047.820.100.300
|
| Concept/Terms |
11-beta-Hydroxysteroid Dehydrogenase Type 1- 11-beta-Hydroxysteroid Dehydrogenase Type 1
- 11beta-HSD1 Reductase
- 11beta HSD1 Reductase
- 11beta-HSD1
- 11beta-Hydroxysteroid Dehydrogenase Type 1
- 11beta Hydroxysteroid Dehydrogenase Type 1
- 11 beta-Hydroxysteroid Dehydrogenase Type 1
|
Below are MeSH descriptors whose meaning is more general than "11-beta-Hydroxysteroid Dehydrogenase Type 1".
Below are MeSH descriptors whose meaning is more specific than "11-beta-Hydroxysteroid Dehydrogenase Type 1".
This graph shows the total number of publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 1" by people in this website by year, and whether "11-beta-Hydroxysteroid Dehydrogenase Type 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 1" by people in Profiles.
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Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 11 15; 133(21):2189-2202.
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11ß-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab. 2015 Jan 01; 308(1):E84-95.
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Specific reduction of G6PT may contribute to downregulation of hepatic 11ß-HSD1 in diabetic mice. J Mol Endocrinol. 2013 Apr; 50(2):167-78.
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Altered placental development in undernourished rats: role of maternal glucocorticoids. Reprod Biol Endocrinol. 2011 Aug 01; 9:105.
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Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. Diabetologia. 2011 Feb; 54(2):440-50.
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Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J Mol Endocrinol. 2008 Aug; 41(2):53-64.
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Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006 Nov; 147(11):5061-8.
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Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes. 2005 Jan; 54(1):32-40.
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Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes. 2003 Jun; 52(6):1409-16.