"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Descriptor ID |
D004815
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MeSH Number(s) |
D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
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Concept/Terms |
Epidermal Growth Factor- Epidermal Growth Factor
- Growth Factor, Epidermal
- Urogastrone
- Epidermal Growth Factor-Urogastrone
- Growth Factor-Urogastrone, Epidermal
- Human Urinary Gastric Inhibitor
- beta-Urogastrone
- beta Urogastrone
- EGF
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Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".
This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2001 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.
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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. BMC Med Genomics. 2019 02 08; 12(1):32.
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Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Cancer Lett. 2016 May 01; 374(2):279-91.
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Sildenafil promotes smooth muscle preservation and ameliorates fibrosis through modulation of extracellular matrix and tissue growth factor gene expression after bilateral cavernosal nerve resection in the rat. J Sex Med. 2011 Apr; 8(4):1048-60.
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Targeting aromatase and estrogen signaling in human non-small cell lung cancer. Ann N Y Acad Sci. 2009 Feb; 1155:194-205.
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Epidermal growth factor receptor and tyrosine phosphorylation of estrogen receptor. Endocrine. 2001 Nov; 16(2):73-81.