"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptor ID |
D015398
|
MeSH Number(s) |
G02.111.820 G04.835
|
Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 2 | 0 | 2 |
1999 | 0 | 1 | 1 |
2003 | 2 | 3 | 5 |
2004 | 0 | 2 | 2 |
2005 | 4 | 5 | 9 |
2006 | 2 | 2 | 4 |
2007 | 7 | 3 | 10 |
2008 | 3 | 6 | 9 |
2009 | 2 | 8 | 10 |
2010 | 2 | 5 | 7 |
2011 | 1 | 10 | 11 |
2012 | 0 | 1 | 1 |
2013 | 3 | 5 | 8 |
2014 | 3 | 10 | 13 |
2015 | 2 | 5 | 7 |
2016 | 2 | 6 | 8 |
2017 | 1 | 7 | 8 |
2018 | 1 | 4 | 5 |
2019 | 2 | 6 | 8 |
2020 | 1 | 6 | 7 |
2021 | 0 | 5 | 5 |
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click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway. Am J Physiol Regul Integr Comp Physiol. 2021 11 01; 321(5):R791-R801.
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Fibroid stiffness: a cellular modulator of progesterone receptor signaling. Fertil Steril. 2021 07; 116(1):91.
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Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-ß Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders. Front Endocrinol (Lausanne). 2021; 12:653179.
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Basal-like breast cancer with low TGFß and high TNFa pathway activity is rich in activated memory CD4 T cells and has a good prognosis. Int J Biol Sci. 2021; 17(3):670-682.
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A RAC-GEF network critical for early intestinal tumourigenesis. Nat Commun. 2021 01 04; 12(1):56.
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Progesterone Receptor Signaling in the Breast Tumor Microenvironment. Adv Exp Med Biol. 2021; 1329:443-474.
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Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).
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Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA. Cell Death Dis. 2020 12 11; 11(12):1052.
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Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):220-233.
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Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life. Theranostics. 2020; 10(25):11820-11836.