"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.820 G04.835
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 3 | 4 |
| 2004 | 0 | 1 | 1 |
| 2005 | 4 | 6 | 10 |
| 2006 | 1 | 3 | 4 |
| 2007 | 7 | 3 | 10 |
| 2008 | 3 | 8 | 11 |
| 2009 | 2 | 8 | 10 |
| 2010 | 1 | 6 | 7 |
| 2011 | 3 | 12 | 15 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 5 | 7 |
| 2014 | 4 | 8 | 12 |
| 2015 | 2 | 3 | 5 |
| 2016 | 2 | 5 | 7 |
| 2017 | 1 | 7 | 8 |
| 2018 | 1 | 5 | 6 |
| 2019 | 0 | 5 | 5 |
| 2020 | 1 | 6 | 7 |
| 2021 | 0 | 5 | 5 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 3 | 4 |
| 2025 | 1 | 1 | 2 |
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click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-?B and p38 MAPK Signaling Pathways. Oxid Med Cell Longev. 2025; 2025:3673280.
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Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. PLoS One. 2025; 20(2):e0316798.
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Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC. Oncogene. 2025 Feb; 44(3):130-146.
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Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models. Nutrients. 2024 Jul 22; 16(14).
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In utero chronic intermittent nicotine aerosol exposure increases ischemic heart injury in adult offspring via programming of Angiotensin II receptor-derived TGF?/ROS/Akt signaling pathway. Reprod Toxicol. 2024 09; 128:108650.
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Neurotherapeutic effects of quercetin-loaded nanoparticles and Biochanin-A extracted from Trifolium alexandrinum on PI3K/Akt/GSK-3? signaling in the cerebral cortex of male diabetic rats. PLoS One. 2024; 19(4):e0301355.
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Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2201859119.
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Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway. Am J Physiol Regul Integr Comp Physiol. 2021 11 01; 321(5):R791-R801.
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Fibroid stiffness: a cellular modulator of progesterone receptor signaling. Fertil Steril. 2021 07; 116(1):91.
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Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-ß Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders. Front Endocrinol (Lausanne). 2021; 12:653179.