"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.820 G04.835
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 2 | 0 | 2 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 2 | 5 | 7 |
| 2004 | 0 | 3 | 3 |
| 2005 | 5 | 8 | 13 |
| 2006 | 2 | 8 | 10 |
| 2007 | 10 | 6 | 16 |
| 2008 | 5 | 11 | 16 |
| 2009 | 2 | 14 | 16 |
| 2010 | 1 | 8 | 9 |
| 2011 | 5 | 14 | 19 |
| 2012 | 2 | 3 | 5 |
| 2013 | 2 | 7 | 9 |
| 2014 | 5 | 8 | 13 |
| 2015 | 3 | 6 | 9 |
| 2016 | 4 | 7 | 11 |
| 2017 | 1 | 7 | 8 |
| 2018 | 2 | 8 | 10 |
| 2019 | 1 | 9 | 10 |
| 2020 | 1 | 8 | 9 |
| 2021 | 0 | 5 | 5 |
| 2022 | 1 | 2 | 3 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 7 | 8 |
| 2025 | 1 | 4 | 5 |
| 2026 | 0 | 3 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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In vivo inhibition of TDO2 in fibroids results in widespread alteration in the tumor transcriptome. Clin Sci (Lond). 2026 Jun 10; 140(6):1099-1117.
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Transcriptomic and functional analysis of fibroid extracellular vesicles. Clin Sci (Lond). 2026 May 20; 140(5):805-824.
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Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss. Nat Commun. 2026 Jan 08; 17(1):1325.
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c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT. Mol Cancer. 2025 Dec 15; 25(1):16.
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HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liver. Int J Biol Sci. 2025; 21(15):6907-6925.
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Trimethylamine-N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2025 10; 45(10):1784-1798.
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Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-?B and p38 MAPK Signaling Pathways. Oxid Med Cell Longev. 2025; 2025:3673280.
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Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. PLoS One. 2025; 20(2):e0316798.
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Wip1 phosphatase activator QGC-8-52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells. Drug Resist Updat. 2025 Mar; 79:101196.
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Epigenetic Upregulation of Carotid Body Angiotensin Signaling Increases Blood Pressure. Hypertension. 2025 Feb; 82(2):293-305.