"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Descriptor ID |
D015536
|
MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 2 | 2 |
1996 | 0 | 1 | 1 |
1998 | 1 | 2 | 3 |
2000 | 0 | 2 | 2 |
2001 | 0 | 1 | 1 |
2002 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2006 | 0 | 2 | 2 |
2007 | 0 | 1 | 1 |
2008 | 0 | 2 | 2 |
2009 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2011 | 1 | 3 | 4 |
2012 | 0 | 1 | 1 |
2013 | 2 | 1 | 3 |
2014 | 0 | 2 | 2 |
2015 | 0 | 4 | 4 |
2016 | 0 | 1 | 1 |
2018 | 1 | 0 | 1 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas by Sponging MiR-29 Family. Endocrinology. 2021 11 01; 162(11).
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Tumor Suppressor Down-Regulation Promotes Hepatocyte Proliferation: A New GANKster on the Block. Cell Mol Gastroenterol Hepatol. 2018; 6(3):345-346.
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Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integr Cancer Ther. 2016 12; 15(4):NP26-NP34.
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Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma. Fertil Steril. 2016 Jan; 105(1):236-45.e1.
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miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids. Am J Physiol Cell Physiol. 2015 Jul 15; 309(2):C117-25.
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Sensitization to docetaxel in prostate cancer cells by green tea and quercetin. J Nutr Biochem. 2015 Apr; 26(4):408-15.
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Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NF?B signaling. Anticancer Res. 2015 Jan; 35(1):39-46.
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miR-200c regulates IL8 expression by targeting IKBKB: a potential mediator of inflammation in leiomyoma pathogenesis. PLoS One. 2014; 9(4):e95370.
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Transcriptional repression of the transforming growth factor ? (TGF-?) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF-? signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-7091.
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Specific reduction of G6PT may contribute to downregulation of hepatic 11ß-HSD1 in diabetic mice. J Mol Endocrinol. 2013 Apr; 50(2):167-78.