"Drug Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Descriptor ID |
D004361
|
MeSH Number(s) |
G07.690.773.992
|
Concept/Terms |
Drug Tolerance- Drug Tolerance
- Drug Tolerances
- Tolerance, Drug
- Tolerances, Drug
|
Below are MeSH descriptors whose meaning is more general than "Drug Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Drug Tolerance".
This graph shows the total number of publications written about "Drug Tolerance" by people in this website by year, and whether "Drug Tolerance" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 0 | 1 |
1995 | 0 | 2 | 2 |
1996 | 1 | 0 | 1 |
1998 | 0 | 1 | 1 |
1999 | 0 | 3 | 3 |
2001 | 1 | 0 | 1 |
2002 | 0 | 3 | 3 |
2006 | 1 | 0 | 1 |
2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Tolerance" by people in Profiles.
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Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence. Neuroscience. 2016 08 04; 329:318-25.
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Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine. Behav Neurosci. 2006 Feb; 120(1):10-5.
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Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats. Psychopharmacology (Berl). 2002 Nov; 164(2):168-76.
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Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine. Brain Res Bull. 2002 May; 58(1):7-12.
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Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin. Behav Brain Res. 2002 Apr 01; 131(1-2):97-103.
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Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats. Br J Pharmacol. 2001 Oct; 134(3):529-34.
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Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance. Eur J Pharmacol. 1999 Nov 12; 384(1):1-5.
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ACEA-1328, a NMDA receptor/glycine site antagonist, acutely potentiates antinociception and chronically attenuates tolerance induced by morphine. Pharmacol Res. 1999 Nov; 40(5):435-42.
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Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat. Neuroreport. 1999 Jan 18; 10(1):103-6.
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Tolerance develops to the antinociceptive and motor impairing effects of ACEA-1416, a NMDA receptor antagonist, in the formalin and rotarod test in mice. Pharmacol Res. 1998 Apr; 37(4):295-302.