MAP Kinase Signaling System
"MAP Kinase Signaling System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Descriptor ID |
D020935
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MeSH Number(s) |
G02.111.820.560 G03.493.560 G04.835.560
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Concept/Terms |
ERK1-2 Pathway- ERK1-2 Pathway
- ERK1 2 Pathway
- ERK1-2 Pathways
- Pathway, ERK1-2
- Pathways, ERK1-2
- ERK1 and ERK2 Pathway
p38 Kinase Pathway- p38 Kinase Pathway
- Kinase Pathway, p38
- Kinase Pathways, p38
- Pathway, p38 Kinase
- Pathways, p38 Kinase
- p38 Kinase Pathways
- p38 Kinase Signaling Pathway
MAP Kinase Cascade- MAP Kinase Cascade
- Cascade, MAP Kinase
- Kinase Cascade, MAP
- MAP Kinase Cascades
- MAP Kinase Modules
- MAP Kinase Module
- Module, MAP Kinase
- MAP Kinase Signaling Cascades
MEK-ERK Pathway- MEK-ERK Pathway
- MEK ERK Pathway
- MEK-ERK Pathways
- Pathway, MEK-ERK
- Pathways, MEK-ERK
JNK Pathway- JNK Pathway
- JNK Pathways
- Pathway, JNK
- Pathways, JNK
- JNK Signaling Pathway
- JNK Signaling Pathways
- Pathway, JNK Signaling
- Pathways, JNK Signaling
- Signaling Pathway, JNK
- Signaling Pathways, JNK
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Signaling System".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Signaling System".
This graph shows the total number of publications written about "MAP Kinase Signaling System" by people in this website by year, and whether "MAP Kinase Signaling System" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 0 | 1 | 1 |
2008 | 1 | 0 | 1 |
2012 | 0 | 1 | 1 |
2014 | 1 | 1 | 2 |
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Below are the most recent publications written about "MAP Kinase Signaling System" by people in Profiles.
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IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. PLoS One. 2014; 9(7):e103534.
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TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol. 2014 Feb; 49(2):185-94.
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A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20.
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Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biol Reprod. 2009 Apr; 80(4):771-80.
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Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 2007 Jan 01; 67(1):289-99.