"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
| Descriptor ID |
D025801
|
| MeSH Number(s) |
D12.776.947.500
|
| Concept/Terms |
Ubiquitin- Ubiquitin
- ATP-Dependent Proteolysis Factor 1
- ATP Dependent Proteolysis Factor 1
- HMG-20
- APF-1
- High Mobility Protein 20
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".
This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 2 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Ubiquitin" by people in Profiles.
-
FAT10 knock out mice livers fail to develop Mallory-Denk bodies in the DDC mouse model. Exp Mol Pathol. 2012 Dec; 93(3):309-14.
-
Effects of ethanol on the proteasome interacting proteins. World J Gastroenterol. 2010 Mar 21; 16(11):1349-57.
-
SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model. Exp Mol Pathol. 2010 Jun; 88(3):353-62.
-
Modifications in P62 occur due to proteasome inhibition in alcoholic liver disease. Life Sci. 2005 Sep 30; 77(20):2594-602.
-
CYP2E1 inhibition enhances mallory body formation. Exp Mol Pathol. 2005 Jun; 78(3):207-11.
-
p62 is involved in the mechanism of Mallory body formation. Exp Mol Pathol. 2004 Dec; 77(3):168-75.
-
Microtubules are required for cytokeratin aggresome (Mallory body) formation in hepatocytes: an in vitro study. Exp Mol Pathol. 2003 Apr; 74(2):173-9.
-
Heat shock proteins are present in mallory bodies (cytokeratin aggresomes) in human liver biopsy specimens. Exp Mol Pathol. 2003 Apr; 74(2):168-72.
-
The mechanism of cytokeratin aggresome formation: the role of mutant ubiquitin (UBB+1). Exp Mol Pathol. 2003 Apr; 74(2):160-7.
-
Gene expression profiles in the Peyronie's disease plaque. Urology. 2002 Mar; 59(3):451-7.