"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Descriptor ID |
D003609
|
MeSH Number(s) |
D03.633.300.200 D04.345.566.252 D12.644.641.252
|
Concept/Terms |
Cosmegen- Cosmegen
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Lyovac-Cosmegen
- Lyovac Cosmegen
- LyovacCosmegen
|
Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1995 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Dactinomycin" by people in Profiles.
-
Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-?B and JNK in hepatocytes. PLoS One. 2014; 9(12):e114071.
-
Identification and characterization of amino acid starvation-induced CD24 gene in MCF-7 human breast cancer cells. Int J Oncol. 2000 May; 16(5):1049-54.
-
Expression of inducible nitric oxide synthase in smooth muscle cells from rat penile corpora cavernosa. J Androl. 1995 Nov-Dec; 16(6):469-81.