"MicroRNAs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Descriptor ID |
D035683
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MeSH Number(s) |
D13.150.650.319 D13.444.735.150.319 D13.444.735.790.552.500
|
Concept/Terms |
MicroRNAs- MicroRNAs
- MicroRNA
- miRNAs
- Micro RNA
- RNA, Micro
- miRNA
Primary MicroRNA- Primary MicroRNA
- MicroRNA, Primary
- Primary miRNA
- miRNA, Primary
- pri-miRNA
- pri miRNA
|
Below are MeSH descriptors whose meaning is more general than "MicroRNAs".
Below are MeSH descriptors whose meaning is more specific than "MicroRNAs".
This graph shows the total number of publications written about "MicroRNAs" by people in this website by year, and whether "MicroRNAs" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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2010 | 0 | 1 | 1 |
2012 | 1 | 0 | 1 |
2013 | 0 | 2 | 2 |
2014 | 2 | 1 | 3 |
2015 | 3 | 0 | 3 |
2016 | 1 | 1 | 2 |
2017 | 2 | 0 | 2 |
2018 | 3 | 1 | 4 |
2019 | 1 | 1 | 2 |
2020 | 2 | 3 | 5 |
2021 | 2 | 1 | 3 |
2022 | 3 | 1 | 4 |
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Below are the most recent publications written about "MicroRNAs" by people in Profiles.
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CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. Life Sci. 2023 Jan 01; 312:121128.
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Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. Exp Mol Med. 2022 06; 54(6):739-752.
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Tumor-Derived Exosomes in Tumor-Induced Immune Suppression. Int J Mol Sci. 2022 Jan 27; 23(3).
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Hepatocyte TGF-? Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let-7b-5p. Hepatol Commun. 2022 06; 6(6):1301-1321.
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Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues. Cells. 2021 11 05; 10(11).
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Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas by Sponging MiR-29 Family. Endocrinology. 2021 11 01; 162(11).
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MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies. Sci Rep. 2021 04 26; 11(1):8980.
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Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).
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Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA. Cell Death Dis. 2020 12 11; 11(12):1052.
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Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life. Theranostics. 2020; 10(25):11820-11836.